Chemosensitization by phenothiazines in human lung cancer cells: Impaired resolution of γh2AX and increased oxidative stress elicit apoptosis associated with lysosomal expansion and intense vacuolation

Cell Death and Disease

Volumn 2, Issue 7, 2011, Pages

  Zong, D ^a   Haag P ^a   Yakymovych, I ^a   Lewensohn, R ^a   Viktorsson, K ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

H2AX; apoptosis; checkpoint recovery; lysosomes; oxidative stress; phenothiazine

Indexed keywords

CASPASE; CHLORPROMAZINE; DNA; FLUPHENAZINE; GAMMA H2AX PROTEIN; HISTONE H2AX; PHENOTHIAZINE; REACTIVE OXYGEN METABOLITE; TRIFLUOPERAZINE; TRIFLUPROMAZINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BAFILOMYCIN A; ENZYME INHIBITOR; H2AFX PROTEIN, HUMAN; HISTONE; MACROLIDE; PHENOTHIAZINE DERIVATIVE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL EXPANSION; CELL VACUOLE; CHEMOSENSITIZATION; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; LUNG CANCER; LUNG NON SMALL CELL CANCER; LYSOSOME; MITOSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; LUNG TUMOR; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; DNA DAMAGE; ENZYME INHIBITORS; HISTONES; HUMANS; LUNG NEOPLASMS; LYSOSOMES; MACROLIDES; OXIDATIVE STRESS; PHENOTHIAZINES; PROTON-TRANSLOCATING ATPASES;

EID: 80051503951     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2011.62     Document Type: Article

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