Brief exposure to copper activates lysosomal exocytosis

Cell Calcium

Volumn 57, Issue 4, 2015, Pages 257-262

  Peña, Karina ^a   Coblenz, Jessica ^a   Kiselyov, Kirill ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Calcium; Copper; Exocytosis; Lysosomes

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE B; CALCIUM; COPPER; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; PROTEIN VAMP 7; RNA; SNARE PROTEIN; UNCLASSIFIED DRUG; WILSON DISEASE PROTEIN; ADENOSINE TRIPHOSPHATASE; BETA N ACETYLHEXOSAMINIDASE; CATION TRANSPORT PROTEIN; SMALL INTERFERING RNA; SYNAPTOBREVIN; VAMP7 PROTEIN, HUMAN;

ARTICLE; ATP7B GENE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME RELEASE; EXOCYTOSIS; EXTRACELLULAR FLUID; GENE SILENCING; HUMAN; HUMAN CELL; LYSOSOME MEMBRANE; OXIDATIVE STRESS; PRIORITY JOURNAL; RNA INTERFERENCE; DRUG EFFECTS; EXTRACELLULAR SPACE; GENETICS; HELA CELL LINE; LYSOSOME; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT;

ADENOSINE TRIPHOSPHATASES; BETA-N-ACETYLHEXOSAMINIDASES; CALCIUM; CATION TRANSPORT PROTEINS; CELL MEMBRANE; COPPER; EXOCYTOSIS; EXTRACELLULAR SPACE; HELA CELLS; HUMANS; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOMES; OXIDATIVE STRESS; PROTEIN TRANSPORT; R-SNARE PROTEINS; RNA, SMALL INTERFERING;

EID: 84930380295     PISSN: 01434160     EISSN: 15321991     Source Type: Journal    
DOI: 10.1016/j.ceca.2015.01.005     Document Type: Article

References (17)

1. Reddy A., Caler E.V., Andrews N.W. Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes. Cell 2001, 106(2):157-169.
2. Rao S.K., et al. Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis. J. Biol. Chem. 2004, 279(19):20471-20479.
3. Polishchuk E.V., et al. Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis. Dev. Cell 2014, 29:686-700.
4. Kukic I., Kelleher S.L., Kiselyov K. Zinc efflux through lysosomal exocytosis prevents zinc-induced toxicity. J. Cell Sci. 2014, 127(Pt 14):3094-3103.
5. Bleackley M.R., Macgillivray R.T. Transition metal homeostasis: from yeast to human disease. Biometals 2011, 24(5):785-809.
6. Graper M.L., et al. Introduction to human disorders of copper metabolism. Ann. N. Y. Acad. Sci. 2014, 1314:v-vi.
7. Hegde M.L., et al. Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword. J. Alzheimers Dis. 2011, 24(Suppl. 2):183-198.
8. Hayashi H., et al. Compound overload of copper and iron in patients with Wilson's disease. Med. Mol. Morphol. 2006, 39(3):121-126.
9. Harada M., et al. The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein. Am. J. Pathol. 2005, 166(2):499-510.
10. McCormick N.H., et al. The biology of zinc transport in mammary epithelial cells: implications for mammary gland development, lactation, and involution. J. Mammary Gland Biol. Neoplasia 2014, 19(1):59-71.
11. Andrews G.K. Cellular zinc sensors: MTF-1 regulation of gene expression. Biometals 2001, 14(3-4):223-237.
12. Bouron A., Kiselyov K., Oberwinkler J. Permeation, regulation and control of expression of TRP channels by trace metal ions. Pflugers Arch. 2014, (in press).
13. Gaetke L.M., Chow C.K. Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology 2003, 189(1-2):147-163.
14. Scheiber I.F., Mercer J.F., Dringen R. Metabolism and functions of copper in brain. Prog. Neurobiol. 2014, 116:33-57.
15. Coblentz J., St Croix C., Kiselyov K. Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV?. Biochem. J. 2014, 457(2):361-368.
16. Alam J., et al. Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor. J. Biol. Chem. 2000, 275(36):27694-27702.
17. Dong X., et al. The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature 2008, 455(7215):992-996.