The function and roles of ADAMTS-7 in inflammatory diseases

Mediators of Inflammation

Volumn 2015, Issue , 2015, Pages

  Zhang, Yuying ^a   Lin, Jiqiang ^b   Wei, Fanhua ^c  

^a UNIVERSITY OF JINAN   (China)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NINGXIA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMTS1 PROTEIN; ADAMTS7 PROTEIN; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAMTS PROTEIN; ADAMTS12 PROTEIN, HUMAN; ADAMTS7 PROTEIN, HUMAN; CATECHOL METHYLTRANSFERASE; COMT PROTEIN, HUMAN;

ARTHRITIS; ARTICLE; ATHEROSCLEROSIS; ENZYME ACTIVITY; GENE CONTROL; HUMAN; INFLAMMATORY DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; CHEMISTRY; GENETICS; INFLAMMATION; METABOLISM; PHYSIOLOGY;

ADAM PROTEINS; ADAMTS PROTEINS; ADAMTS7 PROTEIN; ARTHRITIS; ATHEROSCLEROSIS; CATECHOL O-METHYLTRANSFERASE; HUMANS; INFLAMMATION;

EID: 84950138776     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2015/801546     Document Type: Article

References (138)

1. L. Wagstaff, R. Kelwick, J. Decock, and D. R. Edwards, "The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis," Frontiers in Bioscience, vol. 16, no. 5, pp. 1861-1872, 2011.
2. K. Kuno, N. Kanada, E. Nakashirma, F. Fujiki, F. Ichimura, and K. Matsushima, "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene," Journal of Biological Chemistry, vol. 272, no. 1, pp. 556-562, 1997.
3. A. C. Nicholson, S.-B. Malik, J. M. Logsdon Jr., and E. G. Van Meir, "Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization," BMC Evolutionary Biology, vol. 5, article 11, 2005.
4. G. C. Jones and G. P. Riley, "ADAMTS proteinases: a multidomain, multi-functional family with roles in extracellular matrix turnover and arthritis," Arthritis Research and Therapy, vol. 7, no. 4, pp. 160-169, 2005.
5. A. Colige, S.-W. Li, A. L. Sieron, B. V. Nusgens, D. J. Prockop, and C. M. Lapiere, "cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components," Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 6, pp. 2374-2379, 1997.
6. W.-M. Wang, S. Lee, B. M. Steiglitz et al., "Transforming growth factor-β induces secretion of activated ADAMTS-2. A procollagen III N-proteinase," Journal of Biological Chemistry, vol. 278, no. 21, pp. 19549-19557, 2003.
7. R. J. Fernandes, S. Hirohata, J. M. Engle et al., "Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis," Journal of Biological Chemistry, vol. 276, no. 34, pp. 31502-31509, 2001.
8. A. Colige, I. Vandenberghe, M. Thiry et al., "Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3," Journal of Biological Chemistry, vol. 277, no. 8, pp. 5756-5766, 2002.
9. K. Soejima, M. Matsumoto, K. Kokame et al., "ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage," Blood, vol. 102, no. 9, pp. 3232-3237, 2003.
10. Y. Luan, L. Kong, D. R. Howell et al., "Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by α-2-macroglobulin," Osteoarthritis and Cartilage, vol. 16, no. 11, pp. 1413-1420, 2008.
11. C.-J. Liu, W. Kong, K. Xu et al., "ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein," The Journal of Biological Chemistry, vol. 281, no. 23, pp. 15800-15808, 2006.
12. C.-J. Liu, W. Kong, K. Ilalov et al., "ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein.," The FASEB Journal, vol. 20, no. 7, pp. 988-990, 2006.
13. R. P. T. Somerville, J.-M. Longpre, E. D. Apel et al., "ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain," The Journal of Biological Chemistry, vol. 279, no. 34, pp. 35159-35175, 2004.
14. C.-J. Liu, "The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis," Nature Clinical Practice Rheumatology, vol. 5, no. 1, pp. 38-45, 2009.
15. H. A. Hanby and X. L. Zheng, "Biochemistry and physiological functions of ADAMTS7 metalloprotease," Advances in Biochemistry, vol. 1, no. 3, pp. 43-50, 2013.
16. S. Porter, I. M. Clark, L. Kevorkian, and D. R. Edwards, "The ADMTS metalloproteinases," Biochemical Journal, vol. 386, no. 1, pp. 15-27, 2005.
17. H. Stanton, J. Melrose, C. B. Little, and A. J. Fosang, "Proteoglycan degradation by the ADAMTS family of proteinases," Biochimica et Biophysica Acta, vol. 1812, no. 12, pp. 1616-1629, 2011.
18. L. Mosyak, K. Georgiadis, T. Shane et al., "Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5," Protein Science, vol. 17, no. 1, pp. 16-21, 2008.
19. M. Llamazares, S. Cal, V. Quesada, and C. Lopez-Otin, "Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain," The Journal of Biological Chemistry, vol. 278, no. 15, pp. 13382-13389, 2003.
20. F. Guo, Y. Lai, Q. Tian, E. A. Lin, L. Kong, and C. Liu, "Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein," Arthritis and Rheumatism, vol. 62, no. 7, pp. 2023-2036, 2010.
21. Y. Du, C. Gao, Z. Liu et al., "Upregulation of a disintegrin and metalloproteinase with thrombospondin motifs-7 by miR-29 repression mediates vascular smooth muscle calcification," Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, no. 11, pp. 2580-2588, 2012.
22. S. Abdul-Majeed, B. Mell, S. M. Nauli, and B. Joe, "Cryptorchidism and infertility in rats with targeted disruption of the Adamts16 locus," PLoS ONE, vol. 9, no. 7, Article ID e100967, 2014.
23. L. Wang, J. Zheng, Y. Du et al., "Cartilage oligomeric matrix proteinmaintains the contractile phenotype of vascular smooth muscle cells by interacting with α7β1 integrin," Circulation Research, vol. 106, no. 3, pp. 514-525, 2010.
24. J. Buckland, "Osteoarthritis: positive feedback between ADAMTS-7 and TNF in OA," Nature Reviews Rheumatology, vol. 9, no. 10, article 566, 2013.
25. Y. Lai, X. Bai, Y. Zhao et al., "ADAMTS-7 forms a positive feedback loop with TNF-alpha in the pathogenesis of osteoarthritis," Annals of the Rheumatic Diseases, vol. 73, no. 8, pp. 1575-1584, 2014.
26. E. Hedbom, P. Antonsson, A. Hjerpe et al., "Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage," Journal of Biological Chemistry, vol. 267, no. 9, pp. 6132-6136, 1992.
27. M. D. Briggs, S. M. G. Huffman, L. M. King et al., "Pseudoachondroplasia andmultiple epiphyseal dysplasia due tomutations in the cartilage oligomeric matrix protein gene," Nature Genetics, vol. 10, no. 3, pp. 330-336, 1995.
28. M. D. Briggs, G. R. Mortier, W. G. Cole et al., "Diversemutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum," The American Journal of Human Genetics, vol. 62, no. 2, pp. 311-319, 1998.
29. H.-R. Song, K.-S. Lee, Q.-W. Li, S. K. Koo, and S.-C. Jung, "Identification of cartilage oligomeric matrix protein (COMP) gene mutations in patients with pseudoachondroplasia and multiple epiphyseal dysplasia," Journal of Human Genetics, vol. 48, no. 5, pp. 222-225, 2003.
30. D. H. Cohn, M. D. Briggs, L. M. King et al., "Mutations in the cartilage oligomeric matrix protein (COMP) gene in pseudoachondroplasia and multiple epiphyseal dysplasia," Annals of the New York Academy of Sciences, vol. 785, pp. 188-194, 1996.
31. I. Chan, L. Liu, T. Hamada, G. Sethuraman, and J. A. Mcgrath, "The molecular basis of lipoid proteinosis: mutations in extracellularmatrix protein 1," Experimental Dermatology, vol. 16, no. 11, pp. 881-890, 2007.
32. P. E. Di Cesare, F. S. Chen, M. Moergelin et al., "Matrixmatrix interaction of cartilage oligomeric matrix protein and fibronectin," Matrix Biology, vol. 21, no. 5, pp. 461-470, 2002.
33. B. Mansson, D. Carey, M. Alini et al., "Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism," Journal of Clinical Investigation, vol. 95, no. 3, pp. 1071-1077, 1995.
34. K. Rosenberg, H. Olsson, M. Morgelin, and D. Heinegard, "Cartilage oligomeric matrix protein shows high affinity zincdependent interaction with triple helical collagen," The Journal of Biological Chemistry, vol. 273, no. 32, pp. 20397-20403, 1998.
35. M. Neidhart, N. Hauser, M. Paulsson, P. E. Dicesare, B. A. Michel, and H. J. Hauselmann, "Small fragments of cartilage oligomeric matrix protein in synovial fluid and serum as markers for cartilage degradation," British Journal of Rheumatology, vol. 36, no. 11, pp. 1151-1160, 1997.
36. T. Saxne and D. Heinegard, "Cartilage oligomeric matrix protein: a novelmarker of cartilage turnover detectable in synovial fluid and blood," British Journal of Rheumatology, vol. 31, no. 9, pp. 583-591, 1992.
37. V. Ganu, R. Goldberg, J. Peppard et al., "Inhibition of interleukin-1α-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage bymatrixmetalloproteinase inhibitors: potential role for matrix metalloproteinases in the generation of cartilage oligomeric matrix protein fragments in arthritic synovial fluid," Arthritis and Rheumatism, vol. 41, no. 12, pp. 2143-2151, 1998.
38. J. O. Stracke, A. J. Fosang, K. Last et al., "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)," FEBS Letters, vol. 478, no. 1-2, pp. 52-56, 2000.
39. S. C. Dickinson, M. N. Vankemmelbeke, D. J. Buttle, K. Rosenberg, D. Heinegard, and A. P. Hollander, "Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs,"Matrix Biology, vol. 22, no. 3, pp. 267-278, 2003.
40. J. Martel-Pelletier, D. J. Welsch, and J.-P. Pelletier, "Metalloproteases and inhibitors in arthritic diseases," Best Practice and Research: Clinical Rheumatology, vol. 15, no. 5, pp. 805-829, 2001.
41. Y. Lai, X.-P. Yu, Y. Zhang et al., "Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA," Osteoarthritis and Cartilage, vol. 20, no. 8, pp. 854-862, 2012.
42. Y. Zhang, F. Wei, and C. J. Liu, "Overexpression of ADAMTS-7 leads to accelerated initiation and progression of collageninduced arthritis in mice,"Molecular and Cellular Biochemistry, vol. 404, no. 1-2, pp. 171-179, 2015.
43. X.-H. Bai, D.-W. Wang, L. Kong et al., "ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor,"Molecular and Cellular Biology, vol. 29, no. 15, pp. 4201-4219, 2009.
44. O. O. Anakwe and G. L. Gerton, "Acrosome biogenesis begins during meiosis: evidence from the synthesis and distribution of an acrosomal glycoprotein, acrogranin, during guinea pig spermatogenesis," Biology of Reproduction, vol. 42, no. 2, pp. 317-328, 1990.
45. C. H. P. Ong and A. Bateman, "Progranulin (granulin-epithelin precursor, PC-cell derived growth factor, acrogranin) in proliferation and tumorigenesis," Histology and Histopathology, vol. 18, no. 4, pp. 1275-1288, 2003.
46. W. Tang, Y. Lu, Q.-Y. Tian et al., "The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice," Science, vol. 332, no. 6028, pp. 478-484, 2011.
47. K. Xu, Y. Zhang, K. Ilalov et al., "Cartilage oligomeric matrix protein associates with Granulin-Epithelin Precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation,"The Journal of Biological Chemistry, vol. 282, no. 15, pp. 11347-11355, 2007.
48. J. Konopka, B. Richbourgh, and C. Liu, "The role of PGRN in musculoskeletal development and disease," Frontiers in Bioscience, vol. 19, no. 4, pp. 662-671, 2014.
49. Y.-P. Zhao, B. Liu, Q.-Y. Tian, J.-L. Wei, B. Richbourgh, and C.-J. Liu, "Progranulin protects against osteoarthritis through interacting with TNF-α and β-catenin signalling," Annals of the Rheumatic Diseases, vol. 74, no. 12, pp. 2244-2253, 2014.
50. Y.-P. Zhao, Q.-Y. Tian, S. Frenkel, and C.-J. Liu, "The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling," Biomaterials, vol. 34, no. 27, pp. 6412-6421, 2013.
51. Z. He and A. Bateman, "Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis," Journal ofMolecular Medicine, vol. 81, no. 10, pp. 600-612, 2003.
52. R. K. Davidson, J. G. Waters, L. Kevorkian et al., "Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage," Arthritis Research and Therapy, vol. 8, no. 4, article R124, 2006.
53. L. Kevorkian, D. A. Young, C. Darrah et al., "Expression profiling of metalloproteinases and their inhibitors in cartilage," Arthritis and Rheumatism, vol. 50, no. 1, pp. 131-141, 2004.
54. J. Wei, B. Richbourgh, T. Jia, and C. Liu, "ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation," Mediators of Inflammation, vol. 2014, Article ID 649718, 12 pages, 2014.
55. S.-S. Nah, S. Lee, J. Joo et al., "Association of ADAMTS12 polymorphisms with rheumatoid arthritis," Molecular Medicine Reports, vol. 6, no. 1, pp. 227-231, 2012.
56. R. C. Salter, T. G. Ashlin, A. P. L. Kwan, and D. P. Ramji, "ADAMTS proteases: key roles in atherosclerosis?" Journal of Molecular Medicine, vol. 88, no. 12, pp. 1203-1211, 2010.
57. C. K. Glass and J. L. Witztum, "Atherosclerosis: the road ahead," Cell, vol. 104, no. 4, pp. 503-516, 2001.
58. A. C. Newby and A. B. Zaltsman, "Molecular mechanisms in intimal hyperplasia," The Journal of Pathology, vol. 190, no. 3, pp. 300-309, 2000.
59. M. G. Davies and P.-O. Hagen, "Pathobiology of intimal hyperplasia," British Journal of Surgery, vol. 81, no. 9, pp. 1254-1269, 1994.
60. A. Rudijanto, "The role of vascular smooth muscle cells on the pathogenesis of atherosclerosis," Acta Medica Indonesiana, vol. 39, no. 2, pp. 86-93, 2007.
61. J. Hu, P. E. Van den Steen, Q.-X. A. Sang, and G. Opdenakker, "Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases," Nature Reviews Drug Discovery, vol. 6, no. 6, pp. 480-498, 2007.
62. J. R. Worley, M. D. Baugh, D. A. Hughes et al., "Metalloproteinase expression in PMA-stimulated THP-1 cells: effects of peroxisome proliferator-activated receptor-γ (PPARγ) agonists and 9-cis-retinoic acid,"The Journal of Biological Chemistry, vol. 278, no. 51, pp. 51340-51346, 2003.
63. D. Wagsater, H. Bjork, C. Zhu, et al., "ADAMTS-4 and -8 are inflammatory regulated enzymes expressed inmacrophage-rich areas of human atherosclerotic plaques," Atherosclerosis, vol. 196, no. 2, pp. 514-522, 2008.
64. A.-C. Jonsson-Rylander, T. Nilsson, R. Fritsche-Danielson et al., "Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican," Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 1, pp. 180-185, 2005.
65. J. van Setten, I. Isgum, J. Smolonska et al., "Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease andmyocardial infarction," Atherosclerosis, vol. 228, no. 2, pp. 400-405, 2013.
66. M. P. Reilly, M. Li, J. He et al., "Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies," The Lancet, vol. 377, no. 9763, pp. 383-392, 2011.
67. A. C. Newby, "Proteinases and plaque rupture: unblocking the road to translation," Current Opinion in Lipidology, vol. 25, no. 5, pp. 358-366, 2014.
68. L. You, L. Tan, L. Liu et al., "ADAMTS7 locus confers high crossrace risk for development of coronary atheromatous plaque," Molecular Genetics and Genomics, vol. 242, pp. 351-356, 2015.
69. L. A. Lotta and F. Peyvandi, "Addressing the complexity of cardiovascular disease by design," TheLancet, vol. 377, no. 9763, pp. 356-358, 2011.
70. L. Wang, X. Wang, and W. Kong, "ADAMTS-7, a novel proteolytic culprit in vascular remodeling," Sheng Li Xue Bao, vol. 62, no. 4, pp. 285-294, 2010.
71. R. C. Bauer, J. Tohyama, J. Cui et al., "Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice," Circulation, vol. 131, no. 13, pp. 1202-1213, 2015.
72. L. Zhang, F. Yu, L. Wang et al., "ADAMTS-7 promotes vascular smooth muscle cells proliferation in vitro and in vivo," Science China Life Sciences, vol. 58, no. 7, pp. 674-681, 2015.
73. R. S. Patel and S. Ye, "ADAMTS7: a promising new therapeutic target in coronary heart disease,"ExpertOpinion onTherapeutic Targets, vol. 17, no. 8, pp. 863-867, 2013.
74. R. Riessen, M. Fenchel, H. Chen, D. I. Axel, K. R. Karsch, and J. Lawler, "Cartilage oligomeric matrix protein (thrombospondin-5) is expressed by human vascular smooth muscle cells," Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 21, no. 1, pp. 47-54, 2001.
75. T. Kessler, L. Zhang, Z. Liu et al., "ADAMTS-7 inhibits reendothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1," Circulation, vol. 131, no. 13, pp. 1191-1201, 2015.
76. A. G. Arroyo and V. Andres, "ADAMTS7 in cardiovascular disease: from bedside to bench and back again?" Circulation, vol. 131, no. 13, pp. 1156-1159, 2015.
77. L. Pi, M. Jorgensen, S. H. Oh et al., "A disintegrin and metalloprotease with thrombospondin type I motif 7: a new protease for connective tissue growth factor in hepatic progenitor/oval cell niche,"TheAmerican Journal of Pathology, vol. 185, pp. 1552-1563, 2015.
78. R. Roy, G. Louis, K. R. Loughlin et al., "Tumor-specific urinary matrix metalloproteinase fingerprinting: identification of high molecular weight urinary matrix metalloproteinase species," Clinical Cancer Research, vol. 14, no. 20, pp. 6610-6617, 2008.
79. V. A. Meliopoulos, L. E. Andersen, P. Brooks et al., "MicroRNA regulation of human protease genes essential for influenza virus replication," PLoS ONE, vol. 7, no. 5, Article ID e37169, 2012.
80. P. Zhang, C. Li, P. Zhang, C. Jin, D. Pan, and Y. Bao, "iTRAQbased proteomics reveals novel members involved in pathogen challenge in sea cucumber Apostichopus japonicus," PLoS ONE, vol. 9, no. 6, Article ID e100492, 2014.
81. T. Shindo, H. Kurihara, K. Kuno et al., "ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function," Journal of Clinical Investigation, vol. 105, no. 10, pp. 1345-1352, 2000.
82. V. M. Freitas, J. B. do Amaral, T. A. Silva et al., "Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion, " Molecular Cancer, vol. 12, article 2, 2013.
83. A. Nakamura, Y. Sakai, C. Ohata, and T. Komurasaki, "Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction," Experimental and Toxicologic Pathology, vol. 59, no. 1, pp. 1-7, 2007.
84. L. Mittaz, S. Ricardo, G. Martinez et al., "Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis," Nephrology Dialysis Transplantation, vol. 20, no. 2, pp. 419-423, 2005.
85. F. Vazquez, G. Hastings, M.-A. Ortega et al., "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity," The Journal of Biological Chemistry, vol. 274, no. 33, pp. 23349-23357, 1999.
86. D. Toms, S. Xu, B. Pan, D. Wu, and J. Li, "Progesterone receptor expression in granulosa cells is suppressed by microRNA-378-3p," Molecular and Cellular Endocrinology, vol. 399, pp. 95-102, 2015.
87. L. Q. Hong-Brown, C. R. Brown, M. Navaratnarajah, and C. H. Lang, "Adamts1 mediates ethanol-induced alterations in collagen and elastin via a FoxO1-sestrin3-ampk signaling cascade in myocytes," Journal of Cellular Biochemistry, vol. 116, no. 1, pp. 91-101, 2015.
88. D. Toms, S. Xu, B. Pan, D. Wu, and J. Li, "Progesterone receptor expression in granulosa cells is suppressed by microRNA-378-3p," Molecular and Cellular Endocrinology, vol. 399, pp. 95-102, 2015.
89. L. Q. Hong-Brown, C. R. Brown, M. Navaratnarajah, and C. H. Lang, "Adamts1 mediates ethanol-induced alterations in collagen and elastin via a FoxO1-sestrin3-ampk signaling cascade in myocytes," Journal of Cellular Biochemistry, vol. 116, no. 1, pp. 91-101, 2015.
90. A. Colige, A. L. Sieron, S.-W. Li et al., "Human ehlers-danlos syndrome type VII C and bovine dermatosparaxis are caused bymutations in the procollagen I N-proteinase gene," American Journal of Human Genetics, vol. 65, no. 2, pp. 308-317, 1999.
91. J. Dubail, F. Kesteloot, C. Deroanne et al., "ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity," Cellular and Molecular Life Sciences, vol. 67, no. 24, pp. 4213-4232, 2010.
92. G. Matullo, S. Guarrera, M. Betti et al., "Genetic variants associated with increased risk ofmalignant pleuralmesothelioma: a genome-wide association study," PLoSONE, vol. 8, no. 4, Article ID e61253, 2013.
93. H. Takahashi, K. Yuge, S. Matsubara et al., "Differential expression of ADAM (a disintegrin and metalloproteinase) genes between human first trimester villous and extravillous trophoblast cells," Journal of Nippon Medical School, vol. 81, no. 3, pp. 122-129, 2014.
94. C. Kawahara, T. Forster, K. Chapman, A. Carr, and J. Loughlin, "Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q," Annals of the Rheumatic Diseases, vol. 64, no. 3, pp. 474-476, 2005.
95. M. Jeltsch, S. K. Jha, D. Tvorogov et al., "CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation," Circulation, vol. 129, no. 19, pp. 1962-1971, 2014.
96. P. Verma and K. Dalal, "ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis," Journal of Cellular Biochemistry, vol. 112, no. 12, pp. 3507-3514, 2011.
97. M. K. Majumdar, R. Askew, S. Schelling et al., "Doubleknockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis," Arthritis and Rheumatism, vol. 56, no. 11, pp. 3670-3674, 2007.
98. S. S. Glasson, R. Askew, B. Sheppard et al., "Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice," Arthritis and Rheumatism, vol. 50, no. 8, pp. 2547-2558, 2004.
99. A. N. Corps, G. C. Jones, R. L. Harrall, V. A. Curry, B. L. Hazleman, and G. P. Riley, "The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendonderived cells," Matrix Biology, vol. 27, no. 5, pp. 393-401, 2008.
100. M. Nakada, H. Miyamori, D. Kita et al., "Human glioblastomas overexpress ADAMTS-5 that degrades brevican," Acta Neuropathologica, vol. 110, no. 3, pp. 239-246, 2005.
101. A. Didangelos, U. Mayr, C. Monaco, and M. Mayr, "Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis," The Journal of Biological Chemistry, vol. 287, no. 23, pp. 19341-19345, 2012.
102. P. Tababat-Khani, L. M. Berglund, C.-D. Agardh, M. F. Gomez, and E. Agardh, "Photocoagulation of human retinal pigment epithelial cells in vitro: evaluation of necrosis, apoptosis, cell migration, cell proliferation and expression of tissue repairing and cytoprotective genes," PLoS ONE, vol. 8, no. 8, Article ID e70465, 2013.
103. Y.-X. Gao, C.-A. Yu, J.-H. Lu et al., "ADAMTS-7 expression increases in the early stage of angiotensin II-induced renal injury in elderly mice," Kidney and Blood Pressure Research, vol. 38, no. 1, pp. 121-131, 2013.
104. J. R. Dunn, J. E. Reed, D. G. du Plessis et al., "Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours," British Journal of Cancer, vol. 94, no. 8, pp. 1186-1193, 2006.
105. S. Moriguchi-Goto, A. Yamashita, N. Tamura et al., "ADAMTS-13 attenuates thrombus formation on type I collagen surface and disrupted plaques under flow conditions," Atherosclerosis, vol. 203, no. 2, pp. 409-416, 2009.
106. L. A. Collins-Racie, C. R. Flannery, W. Zeng et al., "ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage," Matrix Biology, vol. 23, no. 4, pp. 219-230, 2004.
107. Z. Ocak, M. Acar, E. Gunduz et al., "Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells," European Review forMedical and Pharmacological Sciences, vol. 17, no. 9, pp. 1185-1190, 2013.
108. K. Demircan, S. Hirohata, K. Nishida et al., "ADAMTS-9 is synergistically induced by interleukin-1β and tumor necrosis factor α in OUMS-27 chondrosarcoma cells and in human chondrocytes," Arthritis and Rheumatism, vol. 52, no. 5, pp. 1451-1460, 2005.
109. J. Dubail, N. Aramaki-Hattori, H. L. Bader et al., "A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression," Genesis, vol. 52, no. 7, pp. 702-712, 2014.
110. G. Sengle, K. Tsutsui, D. R. Keene et al., "Microenvironmental regulation by fibrillin-1," PLoS Genetics, vol. 8, no. 1, Article ID e1002425, 2012.
111. T. Fontanil, S. Rua, M. Llamazares et al., "Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumorsuppressive effects in breast cancer cells," Oncotarget, vol. 5, no. 5, pp. 1253-1264, 2014.
112. A. Moncada-Pazos, A. J. Obaya, M. Llamazares et al., "ADAMTS-12 metalloprotease is necessary for normal inflammatory response,"The Journal of Biological Chemistry, vol. 287, no. 47, pp. 39554-39563, 2012.
113. M. El Hour, A. Moncada-Pazos, S. Blacher et al., "Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis," Oncogene, vol. 29, no. 20, pp. 3025-3032, 2010.
114. P. Johnston, A. J. Chojnowski, R. K. Davidson, G. P. Riley, S. T. Donell, and I. M. Clark, "A complete expression profile of matrix-degrading metalloproteinases in Dupuytrens disease," Journal of Hand Surgery, vol. 32, no. 3, pp. 343-351, 2007.
115. J. Rodriguez-Lopez, M. Pombo-Suarez, J. Loughlin et al., "Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes," Osteoarthritis and Cartilage, vol. 17, no. 3, pp. 321-327, 2009.
116. T. Poonpet, S. Honsawek, N. Tammachote, S. Kanitnate, and R. Tammachote, "ADAMTS14 gene polymorphism associated with knee osteoarthritis in Thai women," Genetics and Molecular Research, vol. 12, no. 4, pp. 5301-5309, 2013.
117. L. El Khoury, M. Posthumus, M. Collins, C. J. Handley, J. Cook, and S. M. Raleigh, "Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study," Journal of Science and Medicine in Sport, vol. 16, no. 6, pp. 493-498, 2013.
118. R. Goertsches, M. Comabella, A. Navarro, H. Perkal, and X. Montalban, "Genetic association between polymorphisms in the ADAMTS14 gene and multiple sclerosis," Journal of Neuroimmunology, vol. 164, no. 1-2, pp. 140-147, 2005.
119. C. N. Molokwu, O. O. Adeniji, S. Chandrasekharan, F. C. Hamdy, and D. J. Buttle, "Androgen regulates ADAMTS15 gene expression in prostate cancer cells," Cancer Investigation, vol. 28, no. 7, pp. 698-710, 2010.
120. M. C. Peluffo, M. J. Murphy, S. T. Baughman, R. L. Stouffer, and J. D. Hennebold, "Systematic analysis of protease gene expression in the rhesus macaque ovulatory follicle: metalloproteinase involvement in follicle rupture," Endocrinology, vol. 152, no. 10, pp. 3963-3974, 2011.
121. N. Stupka, C. Kintakas, J. D. White et al., "Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion,"The Journal of Biological Chemistry, vol. 288, no. 3, pp. 1907-1917, 2013.
122. K. Demircan, V. Topcu, T. Takigawa et al., "ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury," BioMed Research International, vol. 2014, Article ID 693746, 8 pages, 2014.
123. S. Gao, C. De Geyter, K. Kossowska, and H. Zhang, "FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles," Molecular Human Reproduction, vol. 13, no. 7, pp. 465-471, 2007.
124. J.-A. Pyun, S. Kim, and K. Kwack, "Interaction between thyroglobulin and ADAMTS16 in premature ovarian failure," Clinical and Experimental ReproductiveMedicine, vol. 41, no. 3, pp. 120-124, 2014.
125. J.-A. Pyun, S. Kim, D. H. Cha, and K. Kwack, "Epistasis between polymorphisms in TSHB and ADAMTS16 is associated with premature ovarian failure," Menopause, vol. 21, no. 8, pp. 890-895, 2014.
126. J. Morales, L. Al-Sharif, D. S. Khalil et al., "Homozygousmutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature," The American Journal ofHuman Genetics, vol. 85, no. 5, pp. 558-568, 2009.
127. H. A. van Duyvenvoorde, J. C. Lui, S. G. Kant et al., "Copy number variants in patients with short stature," European Journal of Human Genetics, vol. 22, no. 5, pp. 602-609, 2014.
128. A. Arning, M. Hiersche, A. Witten et al., "A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke," Blood, vol. 120, no. 26, pp. 5231-5236, 2012.
129. M. A. Aldahmesh, A. O. Khan, J. Y. Mohamed et al., "Identification of ADAMTS18 as a gene mutated in Knobloch syndrome," Journal of Medical Genetics, vol. 48, no. 9, pp. 597-601, 2011.
130. H. Jin, X. Wang, J. Ying et al., "Epigenetic identification of ADAMTS18 as a novel 16q23. 1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas," Oncogene, vol. 26, no. 53, pp. 7490-7498, 2007.
131. I. Peluso, I. Conte, F. Testa et al., "The ADAMTS18 gene is responsible for autosomal recessive early onset severe retinal dystrophy," Orphanet Journal of Rare Diseases, vol. 8, article 16, 2013.
132. Z. Li, M. A. Nardi, Y.-S. Li et al., "C-terminal ADAMTS-18 fragment induces oxidative platelet fragmentation, dissolves platelet aggregates, and protects against carotid artery occlusion and cerebral stroke," Blood, vol. 113, no. 24, pp. 6051-6060, 2009.
133. J. Wei, C.-J. Liu, and Z. Li, "Adamts-18: ametalloproteinase with multiple functions," Frontiers in Bioscience, vol. 19, no. 8, pp. 1456-1467, 2014.
134. E. A. H. Knauff, L. Franke, M. A. van Es et al., "Genomewide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene," Human Reproduction, vol. 24, no. 9, pp. 2372-2378, 2009.
135. S. Cal, A. J. Obaya, M. Llamazares, C. Garabaya, V. Quesada, and C. Lopez-Otin, "Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains," Gene, vol. 283, no. 1-2, pp. 49-62, 2002.
136. J.-A. Pyun, S. Kim, D. H. Cha, and K. Kwack, "Epistasis between IGF2R and ADAMTS19 polymorphisms associates with premature ovarian failure," Human Reproduction, vol. 28, no. 11, pp. 3146-3154, 2013.
137. J.-A. Pyun, S. Kim, and K. Kwack, "Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure," Menopause, vol. 22, no. 2, pp. 212-216, 2015.
138. D. L. Silver, L. Hou, R. Somerville, M. E. Young, S. S. Apte, and W. J. Pavan, "The secretedmetalloprotease ADAMTS20 is required for melanoblast survival," PLoS Genetics, vol. 4, no. 2, Article ID e1000003, 2008.