Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas

Oncogene

Volumn 26, Issue 53, 2007, Pages 7490-7498

  Jin, H ^a   Wang, X ^a   Ying, J ^a   Wong, A H Y ^a   Li, H ^a   Lee, K Y ^a   Srivastava, G ^b   Chan, A T C ^a   Yeo, W ^a   Ma, B B Y ^a   Putti, T C ^c   Lung, M L ^d   Shen, Z Y ^e   Xu, L Y ^e   Langford, C ^f   Tao, Q ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^e SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^f WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

ADAMTS18; Carcinoma; Methylation; Promoter; Tumor suppressor gene

Indexed keywords

A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIF 18; BISULFITE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; BRAIN TUMOR; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CARCINOMA; CARCINOMA CELL; COLORECTAL CARCINOMA; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA DETERMINATION; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; EPITHELIUM; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS CARCINOMA; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE INACTIVATION; GENE LOCATION; GENE LOCUS; GENE SILENCING; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; LUNG CARCINOMA; MALE; MICROARRAY ANALYSIS; MUTATIONAL ANALYSIS; NASOPHARYNX CARCINOMA; OVARY CARCINOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CARCINOMA; SQUAMOUS CELL CARCINOMA; STOMACH CARCINOMA; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CARCINOMA;

ADAM PROTEINS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 16; DNA METHYLATION; DOWN-REGULATION; ESOPHAGEAL NEOPLASMS; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HELA CELLS; HUMANS; MALE; NASOPHARYNGEAL NEOPLASMS; NUCLEIC ACID HYBRIDIZATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 34648817483     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210559     Document Type: Article

References (35)

1. Balsara BR, Pei J, De RA, Simon D, Tosolini A, Lu YY et al. (2001). Human hepatocellular carcinoma is characterized by a highly consistent pattern of genomic imbalances, including frequent loss of 16q23.1-24.1. Genes Chromosomes Cancer 30: 245-253.
2. Baylin SB, Herman JG. (2000). DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16: 168-174.
3. Bishop JM. (1996). The discovery of proto-oncogenes. FASEB J 10: 362-364.
4. Busson P, Ganem G, Flores P, Mugneret F, Clausse B, Caillou B et al. (1988). Establishment and characterization of three transplantable EBV-containing nasopharyngeal carcinomas. Int J Cancer 42: 599-606.
5. Cal S, Obaya AJ, Llamazares M, Garabaya C, Quesada V, Lopez-Otin C. (2002). Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. Gene 283: 49-62.
6. Chan SL, Cui Y, van HA, Li H, Srivastava G, Jin H et al. (2007). The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. Lab Invest. doi: 10.1038.
7. Cottrell SE, Laird PW. (2003). Sensitive detection of DNA methylation. Ann NY Acad Sci 983: 120-130.
8. Deng W, Tsao SW, Guan XY, Lucas JN, Si HX, Leung CS et al. (2004). Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines. Oncogene 23: 9090-9101.
9. Dunn JR, Panutsopulos D, Shaw MW, Heighway J, Dormer R, Salmo EN et al. (2004). METH-2 silencing and promoter hypermethylation in NSCLC. Br J Cancer 91: 1149-1154.
10. Gius D, Bradbury CM, Sun L, Awwad RT, Huang L, Smart DD et al. (2005). The epigenome as a molecular marker and target. Cancer 104: 1789-1793.
11. Hanahan D, Weinberg RA. (2000). The hallmarks of cancer. Cell 100: 57-70.
12. Jin H, Sperka T, Herrlich P, Morrison H. (2006). Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase. Nature 442: 576-579.
13. Jones PA, Baylin SB. (2002). The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428.
14. Knudson AG. (2001). Two genetic hits (more or less) to cancer. Nat Rev Cancer 1: 157-162.
15. Lind GE, Kleivi K, Meling GI, Teixeira MR, Thiis-Evensen E, Rognum TO et al. (2006). ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis. Cell Oncol 28: 259-272.
16. Lo KW, Teo PM, Hui AB, To KF, Tsang YS, Chan SY et al. (2000). High resolution allelotype of microdissected primary nasopharyngeal carcinoma. Cancer Res 60: 3348-3353.
17. Lo PH, Leung AC, Kwok CY, Cheung WS, Ko JM, Yang LC et al. (2007). Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9. Oncogene 26: 148-157.
18. Luque A, Carpizo DR, Iruela-Arispe ML. (2003). ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. J Biol Chem 278: 23656-23665.
19. Masui T, Hosotani R, Tsuji S, Miyamoto Y, Yasuda S, Ida J et al. (2001). Expression of METH-1 and METH-2 in pancreatic cancer. Clin Cancer Res 7: 3437-3443.
20. Mori Y, Matsunaga M, Abe T, Fukushige S, Miura K, Sunamura M et al. (1999). Chromosome band 16q24 is frequently deleted in human gastric cancer. Br J Cancer 80: 556-562.
21. Nakata S, Sugio K, Uramoto H, Oyama T, Hanagiri T, Morita M et al. (2006). The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance. Cancer 106: 2190-2199.
22. Paige AJ, Taylor KJ, Taylor C, Hillier SG, Farrington S, Scott D et al. (2001). WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci USA 98: 11417-11422.
23. Pinkel D, Segraves R, Sudar D, Clark S, Poole I, Kowbel D et al. (1998). High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet 20: 207-211.
24. Ponder BA. (2001). Cancer genetics. Nature 411: 336-341.
25. Porter S, Clark IM, Kevorkian L, Edwards DR. (2005). The ADAMTS metalloproteinases. Biochem J 386: 15-27.
26. Porter S, Scott SD, Sassoon EM, Williams MR, Jones JL, Girling AC et al. (2004). Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma. Clin Cancer Res 10: 2429-2440.
27. Qiu GH, Tan LK, Loh KS, Lim CY, Srivastava G, Tsai ST et al. (2004). The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. Oncogene 23: 4793-4806.
28. Riegman PH, Vissers KJ, Alers JC, Geelen E, Hop WC, Tilanus HW et al. (2001). Genomic alterations in malignant transformation of Barrett's esophagus. Cancer Res 61: 3164-3170.
29. Seng TJ, Low JS, Li H, Cui Y, Goh HK, Wong ML et al. (2007). The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation. Oncogene 26: 934-944.
30. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD et al. (2006). The consensus coding sequences of human breast and colorectal cancers. Science 314: 268-274.
31. Tao Q, Huang H, Geiman TM, Lim CY, Fu L, Qiu GH et al. (2002). Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells. Hum Mol Genet 11: 2091-2102.
32. Tao Q, Swinnen LJ, Yang J, Srivastava G, Robertson KD, Ambinder RF. (1999). Methylation status of the Epstein-Barr virus major latent promoter C in iatrogenic B cell lymphoproliferative disease. Application of PCR-based analysis. Am J Pathol 155: 619-625.
33. Ying J, Li H, Seng TJ, Langford C, Srivastava G, Tsao SW et al. (2006). Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation. Oncogene 25: 1070-1080.
34. Ying J, Srivastava G, Hsieh WS, Gao Z, Murray P, Liao SK et al. (2005). The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors. Clin Cancer Res 11: 6442-6449.
35. Zhou L, Jiang W, Ren C, Yin Z, Feng X, Liu W et al. (2005). Frequent hypermethylation of RASSF1A and TSLC1, and high viral load of Epstein-Barr Virus DNA in nasopharyngeal carcinoma and matched tumor-adjacent tissues. Neoplasia 7: 809-815.