ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques

Atherosclerosis

Volumn 196, Issue 2, 2008, Pages 514-522

  Wågsäter, Dick ^a   Björk, Hanna ^a   Zhu, Chaoyong ^a   Björkegren, Johan ^a   Valen, Guro ^b   Hamsten, Anders ^a   Eriksson, Per ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

ADAMTS; Atherosclerosis; Inflammation; Macrophages; Matrix degrading proteases

Indexed keywords

A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 4 PROTEIN; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 7 PROTEIN; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 8 PROTEIN; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 9 PROTEIN; ADAM PROTEIN; ALPHA INTERFERON; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL WALL; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ADAM PROTEINS; ANIMALS; ATHEROSCLEROSIS; CAROTID ARTERIES; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERFERON TYPE II; MACROPHAGES; MICE; MONOCYTES; PROCOLLAGEN N-ENDOPEPTIDASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 38349140386     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2007.05.018     Document Type: Article

References (42)

1. Wittekind C., and Neid M. Cancer invasion and metastasis. Oncology 69 1 (2005) 14-16
2. Burrage P.S., Mix K.S., and Brinckerhoff C.E. Matrix metalloproteinases: role in arthritis. Front Biosci 11 (2006) 529-543
3. Newby A.C. Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. Physiol Rev 85 (2005) 1-31
4. Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352 (2005) 1685-1695
5. Libby P., Ridker P.M., and Maseri A. Inflammation and atherosclerosis. Circulation 105 (2002) 1135-1143
6. Brauer P.R. MMPs-role in cardiovascular development and disease. Front Biosci 11 (2006) 447-478
7. Whatling C., Bjork H., Gredmark S., Hamsten A., and Eriksson P. Effect of macrophage differentiation and exposure to mildly oxidized LDL on the proteolytic repertoire of THP-1 monocytes. J Lipid Res 45 (2004) 1768-1776
8. Porter S., Clark I.M., Kevorkian L., and Edwards D.R. The ADAMTS metalloproteinases. Biochem J 386 (2005) 15-27
9. Seals D.F., and Courtneidge S.A. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev 17 (2003) 7-30
10. Tang B.L. ADAMTS: a novel family of extracellular matrix proteases. Int J Biochem Cell Biol 33 (2001) 33-44
11. Kuno K., and Matsushima K. ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region. J Biol Chem 273 (1998) 13912-13917
12. Kashiwagi M., Tortorella M., Nagase H., and Brew K. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J Biol Chem 276 (2001) 12501-12504
13. Gao G., Westling J., Thompson V.P., et al. Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation. J Biol Chem 277 (2002) 11034-11041
14. Kramerova I.A., Kawaguchi N., Fessler L.I., et al. Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. Development 127 (2000) 5475-5485
15. Kuno K., Kanada N., Nakashima E., et al. Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J Biol Chem 272 (1997) 556-562
16. Vazquez F., Hastings G., Ortega M.A., et al. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. J Biol Chem 274 (1999) 23349-23357
17. Evanko S.P., Angello J.C., and Wight T.N. Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 19 (1999) 1004-1013
18. Lemire J.M., Braun K.R., Maurel P., et al. Versican/PG-M isoforms in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 19 (1999) 1630-1639
19. Bongrazio M., Baumann C., Zakrzewicz A., Pries A.R., and Gaehtgens P. Evidence for modulation of genes involved in vascular adaptation by prolonged exposure of endothelial cells to shear stress. Cardiovasc Res 47 (2000) 384-393
20. Jonsson-Rylander A.C., Nilsson T., Fritsche-Danielson R., et al. Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican. Arterioscler Thromb Vasc Biol 25 (2005) 180-185
21. Jones G.C., and Riley G.P. ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis. Arthritis Res Ther 7 (2005) 160-169
22. Sandy J.D., Westling J., Kenagy R.D., et al. Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4. J Biol Chem 276 (2001) 13372-13378
23. Tortorella M.D., Arner E.C., Hills R., et al. Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes. J Biol Chem 279 (2004) 17554-17561
24. Ishibashi S., Brown M.S., Goldstein J.L., et al. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92 (1993) 883-893
25. Farese R.V.J., Veniant M.M., Cham C.M., et al. Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. Proc Natl Acad Sci USA 93 (1996) 6393-6398
26. Chen F., Eriksson P., Hansson G.K., et al. Expression of matrix metalloproteinase 9 and its regulators in the unstable coronary atherosclerotic plaque. Int J Mol Med 15 (2005) 57-65
27. Holm S. A simple sequentially rejective multiple test procedure. Scand J Stat 6 (1979) 65-70
28. Worley J.R., Baugh M.D., Hughes D.A., et al. Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. J Biol Chem 278 (2003) 51340-51346
29. Tsuzaki M., Guyton G., Garrett W., et al. IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells. J Orthop Res 21 (2003) 256-264
30. Demircan K., Hirohata S., Nishida K., et al. ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes. Arthritis Rheum 52 (2005) 1451-1460
31. Thirunavukkarasu K., Pei Y., Moore T.L., et al. Regulation of the human ADAMTS-4 promoter by transcription factors and cytokines. Biochem Biophys Res Commun 345 (2006) 197-204
32. Beals C.R., Clipstone N.A., Ho S.N., and Crabtree G.R. Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev 11 (1997) 824-834
33. Sica A., Dorman L., Viggiano V., et al. Interaction of NF-kappaB and NFAT with the interferon-gamma promoter. J Biol Chem 272 (1997) 30412-30420
34. Tsai E.Y., Jain J., Pesavento P.A., Rao A., and Goldfeld A.E. Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp. Mol Cell Biol 16 (1996) 459-467
35. Yao L.Y., Moody C., Schonherr E., Wight T.N., and Sandell L.J. Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry. Matrix Biol 14 (1994) 213-225
36. Theocharis A.D., Tsolakis I., Hjerpe A., and Karamanos N.K. Human abdominal aortic aneurysm is characterized by decreased versican concentration and specific downregulation of versican isoform V(0). Atherosclerosis 154 (2001) 367-376
37. Merrilees M.J., Beaumont B., and Scott L.J. Comparison of deposits of versican, biglycan and decorin in saphenous vein and internal thoracic, radial and coronary arteries: correlation to patency. Coron Artery Dis 12 (2001) 7-16
38. Kenagy R.D., Plaas A.H., and Wight T.N. Versican degradation and vascular disease. Trends Cardiovasc Med 16 (2006) 209-215
39. Bode-Lesniewska B., Dours-Zimmermann M.T., Odermatt B.F., et al. Distribution of the large aggregating proteoglycan versican in adult human tissues. J Histochem Cytochem 44 (1996) 303-312
40. O'Brien K.D., Olin K.L., Alpers C.E., et al. Comparison of apolipoprotein and proteoglycan deposits in human coronary atherosclerotic plaques: colocalization of biglycan with apolipoproteins. Circulation 98 (1998) 519-527
41. Matsuura R., Isaka N., Imanaka-Yoshida K., et al. Deposition of PG-M/versican is a major cause of human coronary restenosis after percutaneous transluminal coronary angioplasty. J Pathol 180 (1996) 311-316
42. Strom A., Ahlqvist E., Franzen A., Heinegard D., and Hultgardh-Nilsson A. Extracellular matrix components in atherosclerotic arteries of Apo E/LDL receptor deficient mice: an immunohistochemical study. Histol Histopathol 19 (2004) 337-347