Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells

European Review for Medical and Pharmacological Sciences

Volumn 17, Issue 9, 2013, Pages 1185-1190

  Ocak, Z ^a   Acar, M ^b   Gunduz, E ^b   Gunduz, M ^b   Demircan, K ^b   Uyeturk, U ^a   Ozlu T ^a  

^a ABANT IZZET BAYSAL UNIVERSITY   (Turkey)

^b FATIH UNIVERSITY   (Turkey)

Author keywords

ADAMTS8; ADAMTS9; Breast cancer; Hypericin

Indexed keywords

ADAMTS 8 PROTEIN; ADAMTS 9 PROTEIN; COMPLEMENTARY DNA; HYPERICIN; METALLOPROTEINASE; RNA; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG CYTOTOXICITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPERICUM PERFORATUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADAM PROTEINS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; COLORING AGENTS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPERICUM; PERYLENE; REAL-TIME POLYMERASE CHAIN REACTION; RNA, NEOPLASM; TETRAZOLIUM SALTS;

EID: 84878526002     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. KOO BH, COE D, DIXON LJ, SOMERVILLE RPT, NELSON CM, WANG LW, YOUNG ME, LINDNER DJ, APTE SS. ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. Am J Pathol 2010; 176: 1494-1504.
2. UYSAL S, UNAL ZN, ERDO AN S, AKYOL S, RAMAZAN YI ITO LU M, HIROHATA S, I IK B, DEMIRCAN K. Augmentation of ADAMTS9 gene expression by IL-1a is reversed by NFEB and MAPK inhibitors, but not PI3 kinase inhibitors. Cell Biochem Funct 2012 Nov 23. doi: 10.1002/cbf.2932. [Epub ahead of print].
3. WAGSATER D, BJORK H, ZHU C, BJORKEGREN J, VALEN G, HAMSTEN A, ERIKSSON P. ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. Atherosclerosis 2008; 196: 514-522.
4. LUNG HL, LO PH, XIE D, APTE SS, CHEUNG AK, CHENG Y, LAW EW, CHUA D, ZENG YX, TSAO SW, STANBRIDGE EJ, LUNG ML. Characterization of a novel epigenetically- silenced, growthsuppressive gene, ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma. Int J Cancer 2008; 123: 401-408.
5. DEMIRCAN K, GUNDUZ E, GUNDUZ M, BEDER LB, HIROHATA S, NAGATSUKA H, CENGIZ B, CILEK MZ, YAMANAKA N, SHIMIZU K, NINOMIYA Y. Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer. Head Neck 2009; 31: 793-801.
6. LO PH, LUNG HL, CHEUNG AK, APTE SS, CHAN KW, KWONG FM, KO JM, CHENG Y, LAW S, SRIVASTAVA G, ZABAROVSKY ER, TSAO SW, TANG JC, STANBRIDGE EJ, LUNG ML. Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis. Cancer Res 2010; 70: 5567-5576.
7. VAZQUEZ F, HASTINGS G, ORTEGA MA, LANE TF, OIKEMUS S, LOMBARDO M, IRUELA-ARISPE ML. METH-1, A HUMAN ORTHOLOG OF ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. J Biol Chem 1999; 274: 23349-22357.
8. PORTER S, SPAN PN, SWEEP FC, TJAN-HEIJNEN VC, PENNINGTON CJ, PEDERSEN TX, JOHNSEN M, LUND LR, RØMER J, EDWARDS DR. ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. Int J Cancer 2006; 118: 1241-1247.
9. AEBI S, DAVIDSON T, GRUBER G, CARDOSO F; ESMO GUIDELINES WORKING GROUP. Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2011; 6: 12-24.
10. CUI XH, MURTHY HN, JIN YX, YIM YH, KIM JY, PAEK KY. Production of adventitious root biomass and secondary metabolites of Hypericum perforatum L. in a balloon type airlift reactor. Bioresour Technol 2011; 102: 10072-10079.
11. PORTER S, SCOTT SD, SASSOON EM, WILLIAMS MR, JONES JL, GIRLING AC, BALL RY, EDWARDS DR. Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma. Clin Cancer Res 2004; 10: 2429-2440.
12. PORTER S, CLARK IM, KEVORKIAN L, EDWARDS DR: The ADAMTS metalloproteinases. Biochem J 2005; 386: 15-27.
13. DEMIRCAN K, HIROHATA S, NISHIDA K, HATIPOGLU OF, OOHASHI T, YONEZAWA T, APTE SS, NINOMIYA Y. ADAMTS-9 is synergistically induced by interleukin- 1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes. Arthritis Rheum 2005; 52: 1451-1460.
14. POTACKA J. The chemistry, pharmacology and toxicology of the biologicallyactive constituens of the herb Hypericum perforatum L. J Appl Biomed 2003; 1: 61-73.
15. CRNOLATAC I, HUYGENS A, VAN AERSCHOT A, BUSSON R, ROZENSKI J, DE WITTE PA. Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives. Bioorg Med Chem 2005; 13: 6347-6353.
16. MISKOVSKY P, SUREAU F, CHINSKY L, TURPIN PY. Subcellular distribution of hypericin in human cancer cells. Photochem Photobiol 1995; 62: 546-549.
17. GUEDES RC, ERIKSSON LA. Theoretical study of hypericin. J Photochem Photobiol Chem 2005; 172: 293-299.
18. CRISCIONE VD, WEINSTOCK MA.Incidence of cutaneous T-cell lymphoma in the United States, 1973-2002. Arch Dermatol 2007; 143: 854-859.
19. GIGINEISHVILI D, SHENGELIA N, SHALASHVILI G, ROHRMANN S, TSISKARIDZE A, SHAKARISHVILI R. Primary brain tumour epidemiology in Georgia: first-year results of a population-based study. J Neurooncol 2013; 112: 241-246.