메뉴 건너뛰기




Volumn 20, Issue 2, 2016, Pages 225-243

The Metabolic Syndrome and Its Influence on Nonalcoholic Steatohepatitis

Author keywords

Hepatocellular carcinoma; Metabolic syndrome; NAFLD; Nonalcoholic steatohepatitis; Risk factors

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPOCYTOKINE; ADIPONECTIN; ALPHA TOCOPHEROL; EZETIMIBE; FATTY ACID; FENOFIBRATE; FIBRIC ACID DERIVATIVE; GEMFIBROZIL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; I KAPPA B KINASE BETA; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; METFORMIN; PIOGLITAZONE; ROSIGLITAZONE; STRESS ACTIVATED PROTEIN KINASE; TELMISARTAN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VALSARTAN;

EID: 84949894917     PISSN: 10893261     EISSN: 15578224     Source Type: Journal    
DOI: 10.1016/j.cld.2015.10.002     Document Type: Review
Times cited : (95)

References (138)
  • 1
    • 21544462572 scopus 로고    scopus 로고
    • Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence
    • Ford E.S. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care 2005, 28(7):1769-1778.
    • (2005) Diabetes Care , vol.28 , Issue.7 , pp. 1769-1778
    • Ford, E.S.1
  • 2
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • Reaven G.M. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988, 37(12):1595-1607.
    • (1988) Diabetes , vol.37 , Issue.12 , pp. 1595-1607
    • Reaven, G.M.1
  • 3
    • 0030642245 scopus 로고    scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease. 1988
    • [discussion: 64, 66]
    • Reaven G.M. Banting lecture 1988. Role of insulin resistance in human disease. 1988. Nutrition 1997, 13(1):65. [discussion: 64, 66].
    • (1997) Nutrition , vol.13 , Issue.1 , pp. 65
    • Reaven, G.M.1
  • 4
    • 33747474408 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and metabolic syndrome
    • Machado M., Cortez-Pinto H. Non-alcoholic steatohepatitis and metabolic syndrome. Curr Opin Clin Nutr Metab Care 2006, 9(5):637-642.
    • (2006) Curr Opin Clin Nutr Metab Care , vol.9 , Issue.5 , pp. 637-642
    • Machado, M.1    Cortez-Pinto, H.2
  • 5
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
    • Chalasani N., Younossi Z., Levine J.E., et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012, 55(6):2005-2023.
    • (2012) Hepatology , vol.55 , Issue.6 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Levine, J.E.3
  • 6
    • 84901463537 scopus 로고    scopus 로고
    • Obesity and non-alcoholic fatty liver disease: disparate associations among Asian populations
    • Wong R.J., Ahmed A. Obesity and non-alcoholic fatty liver disease: disparate associations among Asian populations. World J Hepatol 2014, 6(5):263-273.
    • (2014) World J Hepatol , vol.6 , Issue.5 , pp. 263-273
    • Wong, R.J.1    Ahmed, A.2
  • 7
    • 29244444549 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis and the metabolic syndrome
    • Neuschwander-Tetri B.A. Nonalcoholic steatohepatitis and the metabolic syndrome. Am J Med Sci 2005, 330(6):326-335.
    • (2005) Am J Med Sci , vol.330 , Issue.6 , pp. 326-335
    • Neuschwander-Tetri, B.A.1
  • 8
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner D.E., Brunt E.M., Van Natta M., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 41(6):1313-1321.
    • (2005) Hepatology , vol.41 , Issue.6 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 9
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • Marchesini G., Bugianesi E., Forlani G., et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003, 37(4):917-923.
    • (2003) Hepatology , vol.37 , Issue.4 , pp. 917-923
    • Marchesini, G.1    Bugianesi, E.2    Forlani, G.3
  • 10
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; World heart federation; International atherosclerosis society; and International association for the study of obesity
    • Alberti K.G., Eckel R.H., Grundy S.M., et al. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; World heart federation; International atherosclerosis society; and International association for the study of obesity. Circulation 2009, 120(16):1640-1645.
    • (2009) Circulation , vol.120 , Issue.16 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3
  • 11
    • 79952231349 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings
    • Brunt E.M., Kleiner D.E., Wilson L.A., NASH Clinical Research Network (CRN), et al. Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology 2011, 53(3):810-820.
    • (2011) Hepatology , vol.53 , Issue.3 , pp. 810-820
    • Brunt, E.M.1    Kleiner, D.E.2    Wilson, L.A.3
  • 12
    • 84883311618 scopus 로고    scopus 로고
    • Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999-2010
    • Beltrán-Sánchez H., Harhay M.O., Harhay M.M., et al. Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999-2010. J Am Coll Cardiol 2013, 62(8):697-703.
    • (2013) J Am Coll Cardiol , vol.62 , Issue.8 , pp. 697-703
    • Beltrán-Sánchez, H.1    Harhay, M.O.2    Harhay, M.M.3
  • 13
    • 77955839370 scopus 로고    scopus 로고
    • Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US
    • Ford E.S., Li C., Zhao G. Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US. J Diabetes 2010, 2(3):180-193.
    • (2010) J Diabetes , vol.2 , Issue.3 , pp. 180-193
    • Ford, E.S.1    Li, C.2    Zhao, G.3
  • 14
    • 84875625146 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: results of a US national survey in three ethnic groups
    • Smits M.M., Ioannou G.N., Boyko E.J., et al. Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: results of a US national survey in three ethnic groups. J Gastroenterol Hepatol 2013, 28(4):664-670.
    • (2013) J Gastroenterol Hepatol , vol.28 , Issue.4 , pp. 664-670
    • Smits, M.M.1    Ioannou, G.N.2    Boyko, E.J.3
  • 15
    • 2542420070 scopus 로고    scopus 로고
    • The metabolic syndrome: prevalence in worldwide populations
    • Cameron A.J., Shaw J.E., Zimmet P.Z. The metabolic syndrome: prevalence in worldwide populations. Endocrinol Metab Clin North Am 2004, 33(2):351-375.
    • (2004) Endocrinol Metab Clin North Am , vol.33 , Issue.2 , pp. 351-375
    • Cameron, A.J.1    Shaw, J.E.2    Zimmet, P.Z.3
  • 16
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • Vernon G., Baranova A., Younossi Z.M. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011, 34(3):274-285.
    • (2011) Aliment Pharmacol Ther , vol.34 , Issue.3 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 17
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: from steatosis to cirrhosis
    • Farrell G.C., Larter C.Z. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006, 43(2 Suppl 1):S99-S112.
    • (2006) Hepatology , vol.43 , Issue.2 , pp. S99-S112
    • Farrell, G.C.1    Larter, C.Z.2
  • 18
    • 4344628555 scopus 로고    scopus 로고
    • The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
    • McCullough A.J. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 2004, 8:521-533.
    • (2004) Clin Liver Dis , vol.8 , pp. 521-533
    • McCullough, A.J.1
  • 19
    • 62349096544 scopus 로고    scopus 로고
    • Prevalence of non-alcoholic fatty liver disease in urban south Indians in relation to different grades of glucose intolerance and metabolic syndrome
    • Mohan V., Farooq S., Deepa M., et al. Prevalence of non-alcoholic fatty liver disease in urban south Indians in relation to different grades of glucose intolerance and metabolic syndrome. Diabetes Res Clin Pract 2009, 84(1):84-91.
    • (2009) Diabetes Res Clin Pract , vol.84 , Issue.1 , pp. 84-91
    • Mohan, V.1    Farooq, S.2    Deepa, M.3
  • 20
    • 65549113744 scopus 로고    scopus 로고
    • The roles of obesity and gender on the relationship between metabolic risk factors and non-alcoholic fatty liver disease in Koreans
    • Lee K., Sung J.A., Kim J.S., et al. The roles of obesity and gender on the relationship between metabolic risk factors and non-alcoholic fatty liver disease in Koreans. Diabetes Metab Res Rev 2009, 25(2):150-155.
    • (2009) Diabetes Metab Res Rev , vol.25 , Issue.2 , pp. 150-155
    • Lee, K.1    Sung, J.A.2    Kim, J.S.3
  • 21
    • 0034866715 scopus 로고    scopus 로고
    • Correlation between fatty liver and coronary risk factors: a population study of elderly men and women in Nagasaki, Japan
    • Akahoshi M., Amasaki Y., Soda M., et al. Correlation between fatty liver and coronary risk factors: a population study of elderly men and women in Nagasaki, Japan. Hypertens Res 2001, 24(4):337-343.
    • (2001) Hypertens Res , vol.24 , Issue.4 , pp. 337-343
    • Akahoshi, M.1    Amasaki, Y.2    Soda, M.3
  • 22
    • 84928696497 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and metabolic syndrome-position paper of the Indian National Association for the Study of the Liver, Endocrine Society of India, Indian College of Cardiology and Indian Society of Gastroenterology
    • Duseja A., Singh S.P., Saraswat V.A., et al. Non-alcoholic fatty liver disease and metabolic syndrome-position paper of the Indian National Association for the Study of the Liver, Endocrine Society of India, Indian College of Cardiology and Indian Society of Gastroenterology. J Clin Exp Hepatol 2015, 5(1):51-68.
    • (2015) J Clin Exp Hepatol , vol.5 , Issue.1 , pp. 51-68
    • Duseja, A.1    Singh, S.P.2    Saraswat, V.A.3
  • 23
    • 33645304589 scopus 로고    scopus 로고
    • Insulin resistance, the insulin resistance syndrome, and cardiovascular disease
    • Reaven G.M. Insulin resistance, the insulin resistance syndrome, and cardiovascular disease. Panminerva Med 2005, 47(4):201-210.
    • (2005) Panminerva Med , vol.47 , Issue.4 , pp. 201-210
    • Reaven, G.M.1
  • 24
    • 0029862540 scopus 로고    scopus 로고
    • Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM
    • Abate N., Garg A., Peshock R.M., et al. Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM. Diabetes 1996, 45(12):1684-1693.
    • (1996) Diabetes , vol.45 , Issue.12 , pp. 1684-1693
    • Abate, N.1    Garg, A.2    Peshock, R.M.3
  • 25
    • 80051774002 scopus 로고    scopus 로고
    • The metabolic syndrome-from insulin resistance to obesity and diabetes
    • Gallagher E.J., Leroith D., Karnieli E. The metabolic syndrome-from insulin resistance to obesity and diabetes. Med Clin North Am 2011, 95(5):855-873.
    • (2011) Med Clin North Am , vol.95 , Issue.5 , pp. 855-873
    • Gallagher, E.J.1    Leroith, D.2    Karnieli, E.3
  • 26
    • 20944450486 scopus 로고    scopus 로고
    • Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms
    • Bugianesi E., Gastaldelli A., Vanni E., et al. Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia 2005, 48(4):634-642.
    • (2005) Diabetologia , vol.48 , Issue.4 , pp. 634-642
    • Bugianesi, E.1    Gastaldelli, A.2    Vanni, E.3
  • 27
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • Yamaguchi K., Yang L., McCall S., et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007, 45(6):1366-1374.
    • (2007) Hepatology , vol.45 , Issue.6 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3
  • 28
    • 3042824524 scopus 로고    scopus 로고
    • Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
    • Feldstein A.E., Werneburg N.W., Canbay A., et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004, 40(1):185-194.
    • (2004) Hepatology , vol.40 , Issue.1 , pp. 185-194
    • Feldstein, A.E.1    Werneburg, N.W.2    Canbay, A.3
  • 29
    • 18844389970 scopus 로고    scopus 로고
    • NASH: a mitochondrial disease
    • Pessayre D., Fromenty B. NASH: a mitochondrial disease. J Hepatol 2005, 42(6):928-940.
    • (2005) J Hepatol , vol.42 , Issue.6 , pp. 928-940
    • Pessayre, D.1    Fromenty, B.2
  • 30
    • 80055026523 scopus 로고    scopus 로고
    • Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition
    • Charlton M., Krishnan A., Viker K., et al. Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. Am J Physiol Gastrointest Liver Physiol 2011, 301(5):G825-G834.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301 , Issue.5 , pp. G825-G834
    • Charlton, M.1    Krishnan, A.2    Viker, K.3
  • 31
    • 77956634470 scopus 로고    scopus 로고
    • High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
    • Kohli R., Kirby M., Xanthakos S.A., et al. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology 2010, 52(3):934-944.
    • (2010) Hepatology , vol.52 , Issue.3 , pp. 934-944
    • Kohli, R.1    Kirby, M.2    Xanthakos, S.A.3
  • 32
    • 57349137214 scopus 로고    scopus 로고
    • Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent
    • Tetri L.H., Basaranoglu M., Brunt E.M., et al. Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol 2008, 295(5):G987-G995.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295 , Issue.5 , pp. G987-G995
    • Tetri, L.H.1    Basaranoglu, M.2    Brunt, E.M.3
  • 33
    • 84866736015 scopus 로고    scopus 로고
    • Dietary trans-fatty acid induced NASH is normalized following loss of trans-fatty acids from hepatic lipid pools
    • Neuschwander-Tetri B.A., Ford D.A., Acharya S., et al. Dietary trans-fatty acid induced NASH is normalized following loss of trans-fatty acids from hepatic lipid pools. Lipids 2012, 47(10):941-950.
    • (2012) Lipids , vol.47 , Issue.10 , pp. 941-950
    • Neuschwander-Tetri, B.A.1    Ford, D.A.2    Acharya, S.3
  • 34
    • 84927696639 scopus 로고    scopus 로고
    • Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis
    • Mells J.E., Fu P.P., Kumar P., et al. Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis. J Nutr Biochem 2015, 26(3):285-292.
    • (2015) J Nutr Biochem , vol.26 , Issue.3 , pp. 285-292
    • Mells, J.E.1    Fu, P.P.2    Kumar, P.3
  • 35
    • 0037382071 scopus 로고    scopus 로고
    • Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
    • Musso G., Gambino R., De Michieli F., et al. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology 2003, 37(4):909-916.
    • (2003) Hepatology , vol.37 , Issue.4 , pp. 909-916
    • Musso, G.1    Gambino, R.2    De Michieli, F.3
  • 36
    • 77950202777 scopus 로고    scopus 로고
    • Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease
    • Petersen K.F., Dufour S., Hariri A., et al. Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. N Engl J Med 2010, 362(12):1082-1089.
    • (2010) N Engl J Med , vol.362 , Issue.12 , pp. 1082-1089
    • Petersen, K.F.1    Dufour, S.2    Hariri, A.3
  • 37
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S., Kozlitina J., Xing C., et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008, 40(12):1461-1465.
    • (2008) Nat Genet , vol.40 , Issue.12 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 38
    • 80053408094 scopus 로고    scopus 로고
    • Fatty acids, obesity, and insulin resistance: time for a reevaluation
    • Karpe F., Dickmann J.R., Frayn K.N. Fatty acids, obesity, and insulin resistance: time for a reevaluation. Diabetes 2011, 60(10):2441-2449.
    • (2011) Diabetes , vol.60 , Issue.10 , pp. 2441-2449
    • Karpe, F.1    Dickmann, J.R.2    Frayn, K.N.3
  • 39
    • 0035405847 scopus 로고    scopus 로고
    • Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects
    • Boden G., Lebed B., Schatz M., et al. Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 2001, 50(7):1612-1617.
    • (2001) Diabetes , vol.50 , Issue.7 , pp. 1612-1617
    • Boden, G.1    Lebed, B.2    Schatz, M.3
  • 40
    • 0027218865 scopus 로고
    • Interaction between glucose and free fatty acid metabolism in human skeletal muscle
    • Kelley D.E., Mokan M., Simoneau J.A., et al. Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 1993, 92(1):91-98.
    • (1993) J Clin Invest , vol.92 , Issue.1 , pp. 91-98
    • Kelley, D.E.1    Mokan, M.2    Simoneau, J.A.3
  • 41
    • 84867413099 scopus 로고    scopus 로고
    • Obesity, type 2 diabetes, and cancer: the insulin and IGF connection
    • LeRoith D., Cohen D.H. Obesity, type 2 diabetes, and cancer: the insulin and IGF connection. Endocr Relat Cancer 2012, 19(5):F27-F45.
    • (2012) Endocr Relat Cancer , vol.19 , Issue.5 , pp. F27-F45
    • LeRoith, D.1    Cohen, D.H.2
  • 42
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly K.L., Smith C.I., Schwarzenberg S.J., et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005, 115(5):1343-1351.
    • (2005) J Clin Invest , vol.115 , Issue.5 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3
  • 43
    • 0037080024 scopus 로고    scopus 로고
    • Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
    • Zarember K.A., Godowski P.J. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 2002, 168(2):554-561.
    • (2002) J Immunol , vol.168 , Issue.2 , pp. 554-561
    • Zarember, K.A.1    Godowski, P.J.2
  • 44
    • 84862059730 scopus 로고    scopus 로고
    • Increased toll-like receptor activity in patients with metabolic syndrome
    • Jialal I., Huet B.A., Kaur H., et al. Increased toll-like receptor activity in patients with metabolic syndrome. Diabetes Care 2012, 35(4):900-904.
    • (2012) Diabetes Care , vol.35 , Issue.4 , pp. 900-904
    • Jialal, I.1    Huet, B.A.2    Kaur, H.3
  • 45
    • 84863115343 scopus 로고    scopus 로고
    • Role and function of macrophages in the metabolic syndrome
    • Bhargava P., Lee C.H. Role and function of macrophages in the metabolic syndrome. Biochem J 2012, 442(2):253-262.
    • (2012) Biochem J , vol.442 , Issue.2 , pp. 253-262
    • Bhargava, P.1    Lee, C.H.2
  • 46
    • 34547602916 scopus 로고    scopus 로고
    • Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    • Tsukumo D.M., Carvalho-Filho M.A., Carvalheira J.B., et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 2007, 56(8):1986-1998.
    • (2007) Diabetes , vol.56 , Issue.8 , pp. 1986-1998
    • Tsukumo, D.M.1    Carvalho-Filho, M.A.2    Carvalheira, J.B.3
  • 47
    • 77953891627 scopus 로고    scopus 로고
    • Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice
    • Miura K., Kodama Y., Inokuchi S., et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 2010, 139(1):323-334.
    • (2010) Gastroenterology , vol.139 , Issue.1 , pp. 323-334
    • Miura, K.1    Kodama, Y.2    Inokuchi, S.3
  • 48
    • 79952230506 scopus 로고    scopus 로고
    • Role of toll-like receptors and their downstream molecules in the development of nonalcoholic fatty liver disease
    • Miura K., Seki E., Ohnishi H., et al. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic fatty liver disease. Gastroenterol Res Pract 2010, 2010:362847.
    • (2010) Gastroenterol Res Pract , vol.2010 , pp. 362847
    • Miura, K.1    Seki, E.2    Ohnishi, H.3
  • 49
    • 84859164281 scopus 로고    scopus 로고
    • Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation
    • Roth C.L., Elfers C.T., Figlewicz D.P., et al. Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation. Hepatology 2012, 55(4):1103-1111.
    • (2012) Hepatology , vol.55 , Issue.4 , pp. 1103-1111
    • Roth, C.L.1    Elfers, C.T.2    Figlewicz, D.P.3
  • 50
    • 44949163013 scopus 로고    scopus 로고
    • Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms
    • Buettner C., Muse E.D., Cheng A., et al. Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat Med 2008, 14(6):667-675.
    • (2008) Nat Med , vol.14 , Issue.6 , pp. 667-675
    • Buettner, C.1    Muse, E.D.2    Cheng, A.3
  • 51
    • 0030898516 scopus 로고    scopus 로고
    • Direct antidiabetic effect of leptin through triglyceride depletion of tissues
    • Shimabukuro M., Koyama K., Chen G., et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci U S A 1997, 94(9):4637-4641.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.9 , pp. 4637-4641
    • Shimabukuro, M.1    Koyama, K.2    Chen, G.3
  • 52
    • 49749107875 scopus 로고    scopus 로고
    • Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: new therapeutic approaches
    • Kalra S.P. Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: new therapeutic approaches. Nutrition 2008, 24(9):820-826.
    • (2008) Nutrition , vol.24 , Issue.9 , pp. 820-826
    • Kalra, S.P.1
  • 53
    • 17844401180 scopus 로고    scopus 로고
    • Molecular and anatomical determinants of central leptin resistance
    • Münzberg H., Myers M.G. Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 2005, 8(5):566-570.
    • (2005) Nat Neurosci , vol.8 , Issue.5 , pp. 566-570
    • Münzberg, H.1    Myers, M.G.2
  • 54
    • 55749105417 scopus 로고    scopus 로고
    • Adipokines and insulin resistance
    • Rabe K., Lehrke M., Parhofer K.G., et al. Adipokines and insulin resistance. Mol Med 2008, 14(11-12):741-751.
    • (2008) Mol Med , vol.14 , Issue.11-12 , pp. 741-751
    • Rabe, K.1    Lehrke, M.2    Parhofer, K.G.3
  • 55
    • 0036329894 scopus 로고    scopus 로고
    • Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity?
    • Chiturri S., Farrell G., Frost L., et al. Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity?. Hepatology 2002, 36(2):403-409.
    • (2002) Hepatology , vol.36 , Issue.2 , pp. 403-409
    • Chiturri, S.1    Farrell, G.2    Frost, L.3
  • 56
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T., Kamon J., Waki H., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001, 7(8):941-946.
    • (2001) Nat Med , vol.7 , Issue.8 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 57
    • 0036303146 scopus 로고    scopus 로고
    • Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome
    • Kondo H., Shimomura I., Matsukawa Y., et al. Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes 2002, 51(7):2325-2328.
    • (2002) Diabetes , vol.51 , Issue.7 , pp. 2325-2328
    • Kondo, H.1    Shimomura, I.2    Matsukawa, Y.3
  • 58
    • 33644636469 scopus 로고    scopus 로고
    • Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis
    • Musso G., Gambino R., Biroli G., et al. Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2005, 100(11):2438-2446.
    • (2005) Am J Gastroenterol , vol.100 , Issue.11 , pp. 2438-2446
    • Musso, G.1    Gambino, R.2    Biroli, G.3
  • 59
    • 30944469306 scopus 로고    scopus 로고
    • Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease
    • Musso G., Gambino R., Durazzo M., et al. Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease. Hepatology 2005, 42(5):1175-1183.
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 1175-1183
    • Musso, G.1    Gambino, R.2    Durazzo, M.3
  • 60
    • 10844220730 scopus 로고    scopus 로고
    • Adiponectin and its receptors in non-alcoholic steatohepatitis
    • Kaser S., Moschen A., Cayon A., et al. Adiponectin and its receptors in non-alcoholic steatohepatitis. Gut 2005, 54(1):117-121.
    • (2005) Gut , vol.54 , Issue.1 , pp. 117-121
    • Kaser, S.1    Moschen, A.2    Cayon, A.3
  • 61
    • 84903171544 scopus 로고    scopus 로고
    • Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis
    • Handa P., Maliken B., Nelson J.E., et al. Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis. Hepatology 2014, 60(1):133-145.
    • (2014) Hepatology , vol.60 , Issue.1 , pp. 133-145
    • Handa, P.1    Maliken, B.2    Nelson, J.E.3
  • 62
    • 84865553250 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis versus steatosis: adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism
    • Musso G., Cassader M., De Michieli F., et al. Nonalcoholic steatohepatitis versus steatosis: adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism. Hepatology 2012, 56(3):933-942.
    • (2012) Hepatology , vol.56 , Issue.3 , pp. 933-942
    • Musso, G.1    Cassader, M.2    De Michieli, F.3
  • 63
    • 0034676629 scopus 로고    scopus 로고
    • Cytokines in alcoholic and nonalcoholic steatohepatitis
    • Tilg H., Diehl A.M. Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 2000, 343(20):1467-1476.
    • (2000) N Engl J Med , vol.343 , Issue.20 , pp. 1467-1476
    • Tilg, H.1    Diehl, A.M.2
  • 64
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • Li Z., Yang S., Lin H., et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003, 37(2):343-350.
    • (2003) Hepatology , vol.37 , Issue.2 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3
  • 65
    • 37449020075 scopus 로고    scopus 로고
    • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
    • Koves T.R., Ussher J.R., Noland R.C., et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008, 7(1):45-56.
    • (2008) Cell Metab , vol.7 , Issue.1 , pp. 45-56
    • Koves, T.R.1    Ussher, J.R.2    Noland, R.C.3
  • 66
    • 32844458032 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it
    • Begricke K., Igoudjil A., Pessayre D., et al. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion 2006, 6(1):1-28.
    • (2006) Mitochondrion , vol.6 , Issue.1 , pp. 1-28
    • Begricke, K.1    Igoudjil, A.2    Pessayre, D.3
  • 67
    • 84930675030 scopus 로고    scopus 로고
    • Metabolic syndrome and nonalcoholic fatty liver disease: is insulin resistance the link?
    • [Epub ahead of print]
    • Asrih M., Jornayvaz F.R. Metabolic syndrome and nonalcoholic fatty liver disease: is insulin resistance the link?. Mol Cell Endocrinol 2015, [Epub ahead of print].
    • (2015) Mol Cell Endocrinol
    • Asrih, M.1    Jornayvaz, F.R.2
  • 68
    • 78449244718 scopus 로고    scopus 로고
    • Insulin resistance in obesity as the underlying cause for the metabolic syndrome
    • Gallagher E.J., Leroith D., Karnieli E. Insulin resistance in obesity as the underlying cause for the metabolic syndrome. Mt Sinai J Med 2010, 77(5):511-523.
    • (2010) Mt Sinai J Med , vol.77 , Issue.5 , pp. 511-523
    • Gallagher, E.J.1    Leroith, D.2    Karnieli, E.3
  • 69
    • 39749147110 scopus 로고    scopus 로고
    • Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes
    • Muoio D.M., Newgard C.B. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 2008, 9(3):193-205.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , Issue.3 , pp. 193-205
    • Muoio, D.M.1    Newgard, C.B.2
  • 70
    • 0034096785 scopus 로고    scopus 로고
    • Adverse endothelial function and the insulin resistance syndrome
    • Tooke J.E., Hannemann M.M. Adverse endothelial function and the insulin resistance syndrome. J Intern Med 2000, 247(4):425-431.
    • (2000) J Intern Med , vol.247 , Issue.4 , pp. 425-431
    • Tooke, J.E.1    Hannemann, M.M.2
  • 71
    • 0016659653 scopus 로고
    • The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man
    • DeFronzo R.A., Cooke C.R., Andres R., et al. The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. J Clin Invest 1975, 55(4):845-855.
    • (1975) J Clin Invest , vol.55 , Issue.4 , pp. 845-855
    • DeFronzo, R.A.1    Cooke, C.R.2    Andres, R.3
  • 72
    • 0942301243 scopus 로고    scopus 로고
    • Metabolic syndrome and renal sodium handling in three ethnic groups living in England
    • Barbato A., Cappuccio F.P., Folkerd E.J., et al. Metabolic syndrome and renal sodium handling in three ethnic groups living in England. Diabetologia 2004, 47(1):40-46.
    • (2004) Diabetologia , vol.47 , Issue.1 , pp. 40-46
    • Barbato, A.1    Cappuccio, F.P.2    Folkerd, E.J.3
  • 73
    • 0035650575 scopus 로고    scopus 로고
    • Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation
    • Massiera F., Bloch-Faure M., Ceiler D., et al. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J 2001, 15(14):2727-2729.
    • (2001) FASEB J , vol.15 , Issue.14 , pp. 2727-2729
    • Massiera, F.1    Bloch-Faure, M.2    Ceiler, D.3
  • 74
    • 11244349747 scopus 로고    scopus 로고
    • Obesity-associated hypertension: new insights into mechanisms
    • Rahmouni K., Correia M.L., Haynes W.G., et al. Obesity-associated hypertension: new insights into mechanisms. Hypertension 2005, 45(1):9-14.
    • (2005) Hypertension , vol.45 , Issue.1 , pp. 9-14
    • Rahmouni, K.1    Correia, M.L.2    Haynes, W.G.3
  • 75
    • 0037399286 scopus 로고    scopus 로고
    • The metabolic syndrome: targeting dyslipidaemia to reduce coronary risk
    • Ginsberg H.N., Stalenhoef A.F. The metabolic syndrome: targeting dyslipidaemia to reduce coronary risk. J Cardiovasc Risk 2003, 10(2):121-128.
    • (2003) J Cardiovasc Risk , vol.10 , Issue.2 , pp. 121-128
    • Ginsberg, H.N.1    Stalenhoef, A.F.2
  • 76
    • 0028839110 scopus 로고
    • Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans
    • Lewis G.F., Uffelman K.D., Szeto L.W., et al. Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J Clin Invest 1995, 95(1):158-166.
    • (1995) J Clin Invest , vol.95 , Issue.1 , pp. 158-166
    • Lewis, G.F.1    Uffelman, K.D.2    Szeto, L.W.3
  • 77
    • 70849136098 scopus 로고    scopus 로고
    • Pathogenesis and pathophysiology of the cardiometabolic syndrome
    • Kirk E.P., Klein S. Pathogenesis and pathophysiology of the cardiometabolic syndrome. J Clin Hypertens (Greenwich) 2009, 11(12):761-765.
    • (2009) J Clin Hypertens (Greenwich) , vol.11 , Issue.12 , pp. 761-765
    • Kirk, E.P.1    Klein, S.2
  • 78
    • 0022868323 scopus 로고
    • Role of triglyceride-rich lipoproteins and hepatic lipase in determining the particle size and composition of high density lipoproteins
    • Hopkins G.J., Barter P.J. Role of triglyceride-rich lipoproteins and hepatic lipase in determining the particle size and composition of high density lipoproteins. J Lipid Res 1986, 27(12):1265-1277.
    • (1986) J Lipid Res , vol.27 , Issue.12 , pp. 1265-1277
    • Hopkins, G.J.1    Barter, P.J.2
  • 79
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
    • Tilg H., Moschen A.R. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 2010, 52(5):1836-1846.
    • (2010) Hepatology , vol.52 , Issue.5 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 81
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: human gut microbes associated with obesity
    • Ley R.E., Turnbaugh P.J., Klein S., et al. Microbial ecology: human gut microbes associated with obesity. Nature 2006, 444(7122):1022-1023.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3
  • 82
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • Vrieze A., Van Nood E., Holleman F., et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 2012, 143(4):913-916.
    • (2012) Gastroenterology , vol.143 , Issue.4 , pp. 913-916
    • Vrieze, A.1    Van Nood, E.2    Holleman, F.3
  • 83
    • 84879830881 scopus 로고    scopus 로고
    • Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet
    • Mattace Raso G., Simeoli R., Russo R., et al. Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet. PLoS One 2013, 8(7):e68626.
    • (2013) PLoS One , vol.8 , Issue.7
    • Mattace Raso, G.1    Simeoli, R.2    Russo, R.3
  • 84
    • 0033329864 scopus 로고    scopus 로고
    • 1999 Liver pathology and the metabolic syndrome X in severe obesity
    • Marceau P., Biron S., Hould F.S. 1999 Liver pathology and the metabolic syndrome X in severe obesity. J Clin Endocrinol Metab 1999, 84(5):1513-1517.
    • (1999) J Clin Endocrinol Metab , vol.84 , Issue.5 , pp. 1513-1517
    • Marceau, P.1    Biron, S.2    Hould, F.S.3
  • 85
    • 0035431018 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    • Marchesini G., Brizi M., Bianchi G., et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001, 50(8):1844-1850.
    • (2001) Diabetes , vol.50 , Issue.8 , pp. 1844-1850
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3
  • 86
    • 33644699492 scopus 로고    scopus 로고
    • Bright liver and alanine aminotransferase are associated with metabolic syndrome in adults
    • Shen Y.H., Yang W.S., Lee L.T., et al. Bright liver and alanine aminotransferase are associated with metabolic syndrome in adults. Obes Res 2005, 13(7):1238-1245.
    • (2005) Obes Res , vol.13 , Issue.7 , pp. 1238-1245
    • Shen, Y.H.1    Yang, W.S.2    Lee, L.T.3
  • 87
    • 21344449292 scopus 로고    scopus 로고
    • Prevalence of and risk factors for nonalcoholic fatty liver disease: the dionysos nutrition and liver study
    • Bedogni G., Miglioli L., Masutti F., et al. Prevalence of and risk factors for nonalcoholic fatty liver disease: the dionysos nutrition and liver study. Hepatology 2005, 42(1):44-52.
    • (2005) Hepatology , vol.42 , Issue.1 , pp. 44-52
    • Bedogni, G.1    Miglioli, L.2    Masutti, F.3
  • 88
    • 84916234057 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis associated with metabolic syndrome: relationship to insulin resistance and liver histology
    • Jung K.Y., Cho S.Y., Kim H.J., et al. Nonalcoholic steatohepatitis associated with metabolic syndrome: relationship to insulin resistance and liver histology. J Clin Gastroenterol 2014, 48(10):883-888.
    • (2014) J Clin Gastroenterol , vol.48 , Issue.10 , pp. 883-888
    • Jung, K.Y.1    Cho, S.Y.2    Kim, H.J.3
  • 89
    • 77956339546 scopus 로고    scopus 로고
    • Association between metabolic syndrome and liver histology among children with nonalcoholic Fatty liver disease
    • Patton H.M., Yates K., Unalp-Arida A., et al. Association between metabolic syndrome and liver histology among children with nonalcoholic Fatty liver disease. Am J Gastroenterol 2010, 105(9):2093-2102.
    • (2010) Am J Gastroenterol , vol.105 , Issue.9 , pp. 2093-2102
    • Patton, H.M.1    Yates, K.2    Unalp-Arida, A.3
  • 90
    • 39449100352 scopus 로고    scopus 로고
    • Metabolic syndrome and liver histology in paediatric non-alcoholic steatohepatitis
    • Manco M., Marcellini M., Devito R., et al. Metabolic syndrome and liver histology in paediatric non-alcoholic steatohepatitis. Int J Obes (Lond) 2008, 32(2):381-387.
    • (2008) Int J Obes (Lond) , vol.32 , Issue.2 , pp. 381-387
    • Manco, M.1    Marcellini, M.2    Devito, R.3
  • 91
    • 65549088089 scopus 로고    scopus 로고
    • Liver histology according to the presence of metabolic syndrome in nonalcoholic fatty liver disease cases
    • Uslusoy H.S., Nak S.G., Gülten M., et al. Liver histology according to the presence of metabolic syndrome in nonalcoholic fatty liver disease cases. World J Gastroenterol 2009, 15(9):1093-1098.
    • (2009) World J Gastroenterol , vol.15 , Issue.9 , pp. 1093-1098
    • Uslusoy, H.S.1    Nak, S.G.2    Gülten, M.3
  • 92
    • 39749173966 scopus 로고    scopus 로고
    • Metabolic syndrome is related to nonalcoholic steatohepatitis in severely obese subjects
    • Huang H.L., Lin W.Y., Lee L.T., et al. Metabolic syndrome is related to nonalcoholic steatohepatitis in severely obese subjects. Obes Surg 2007, 17(11):1457-1463.
    • (2007) Obes Surg , vol.17 , Issue.11 , pp. 1457-1463
    • Huang, H.L.1    Lin, W.Y.2    Lee, L.T.3
  • 93
    • 16244368502 scopus 로고    scopus 로고
    • Predictors of nonalcoholic steatohepatitis and advanced fibrosis in morbidly obese patients
    • Ong J.P., Elariny H., Collantes R., et al. Predictors of nonalcoholic steatohepatitis and advanced fibrosis in morbidly obese patients. Obes Surg 2005, 15(3):310-315.
    • (2005) Obes Surg , vol.15 , Issue.3 , pp. 310-315
    • Ong, J.P.1    Elariny, H.2    Collantes, R.3
  • 94
    • 35448950015 scopus 로고    scopus 로고
    • Laparoscopic bariatric surgery: what else are we uncovering? Liver pathology and preoperative indicators of advanced liver disease in morbidly obese patients
    • Kroh M., Liu R., Chand B. Laparoscopic bariatric surgery: what else are we uncovering? Liver pathology and preoperative indicators of advanced liver disease in morbidly obese patients. Surg Endosc 2007, 21(11):1957-1960.
    • (2007) Surg Endosc , vol.21 , Issue.11 , pp. 1957-1960
    • Kroh, M.1    Liu, R.2    Chand, B.3
  • 95
    • 78449286054 scopus 로고    scopus 로고
    • A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients
    • Anty R., Iannelli A., Patouraux S., et al. A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients. Aliment Pharmacol Ther 2010, 32(11-12):1315-1322.
    • (2010) Aliment Pharmacol Ther , vol.32 , Issue.11-12 , pp. 1315-1322
    • Anty, R.1    Iannelli, A.2    Patouraux, S.3
  • 96
    • 84878175866 scopus 로고    scopus 로고
    • Association between metabolic syndrome and the development of non-alcoholic fatty liver disease
    • Wang Y., Li Y.Y., Nie Y.Q., et al. Association between metabolic syndrome and the development of non-alcoholic fatty liver disease. Exp Ther Med 2013, 6(1):77-84.
    • (2013) Exp Ther Med , vol.6 , Issue.1 , pp. 77-84
    • Wang, Y.1    Li, Y.Y.2    Nie, Y.Q.3
  • 97
    • 0033767987 scopus 로고    scopus 로고
    • Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity
    • García-Monzón C., Martín-Pérez E., Iacono O.L., et al. Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity. J Hepatol 2000, 33(5):716-724.
    • (2000) J Hepatol , vol.33 , Issue.5 , pp. 716-724
    • García-Monzón, C.1    Martín-Pérez, E.2    Iacono, O.L.3
  • 98
    • 0034950652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    • Dixon J.B., Bhathal P.S., O'Brien P.E. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001, 121(1):91-100.
    • (2001) Gastroenterology , vol.121 , Issue.1 , pp. 91-100
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 99
    • 77951924601 scopus 로고    scopus 로고
    • Predictors of nonalcoholic steatohepatitis in patients with elevated alanine aminotransferase activity
    • Puljiz Z., Stimac D., Kovac D., et al. Predictors of nonalcoholic steatohepatitis in patients with elevated alanine aminotransferase activity. Coll Antropol 2010, 34(Suppl 1):33-37.
    • (2010) Coll Antropol , vol.34 , pp. 33-37
    • Puljiz, Z.1    Stimac, D.2    Kovac, D.3
  • 100
    • 77953232280 scopus 로고    scopus 로고
    • A noninvasive clinical scoring model predicts risk of nonalcoholic steatohepatitis in morbidly obese patients
    • Ulitsky A., Ananthakrishnan A.N., Komorowski R., et al. A noninvasive clinical scoring model predicts risk of nonalcoholic steatohepatitis in morbidly obese patients. Obes Surg 2010, 20(6):685-691.
    • (2010) Obes Surg , vol.20 , Issue.6 , pp. 685-691
    • Ulitsky, A.1    Ananthakrishnan, A.N.2    Komorowski, R.3
  • 101
    • 46249084411 scopus 로고    scopus 로고
    • A clinical scoring system for predicting nonalcoholic steatohepatitis in morbidly obese patients
    • Campos G.M., Bambha K., Vittinghoff E., et al. A clinical scoring system for predicting nonalcoholic steatohepatitis in morbidly obese patients. Hepatology 2008, 47(6):1916-1923.
    • (2008) Hepatology , vol.47 , Issue.6 , pp. 1916-1923
    • Campos, G.M.1    Bambha, K.2    Vittinghoff, E.3
  • 102
    • 29744468433 scopus 로고    scopus 로고
    • Abnormal glucose tolerance is a predictor of steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease
    • Haukeland J.W., Konopski Z., Linnestad P., et al. Abnormal glucose tolerance is a predictor of steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease. Scand J Gastroenterol 2005, 40(12):1469-1477.
    • (2005) Scand J Gastroenterol , vol.40 , Issue.12 , pp. 1469-1477
    • Haukeland, J.W.1    Konopski, Z.2    Linnestad, P.3
  • 103
    • 43449103130 scopus 로고    scopus 로고
    • Presence of the metabolic syndrome in obese adolescents predicts impaired glucose tolerance and nonalcoholic fatty liver disease
    • Love-Osborne K.A., Nadeau K.J., Sheeder J., et al. Presence of the metabolic syndrome in obese adolescents predicts impaired glucose tolerance and nonalcoholic fatty liver disease. J Adolesc Health 2008, 42(6):543-548.
    • (2008) J Adolesc Health , vol.42 , Issue.6 , pp. 543-548
    • Love-Osborne, K.A.1    Nadeau, K.J.2    Sheeder, J.3
  • 104
    • 84883763886 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease independently predicts prediabetes during a 7-year prospective follow-up
    • Zelber-Sagi S., Lotan R., Shibolet O., et al. Non-alcoholic fatty liver disease independently predicts prediabetes during a 7-year prospective follow-up. Liver Int 2013, 33(9):1406-1412.
    • (2013) Liver Int , vol.33 , Issue.9 , pp. 1406-1412
    • Zelber-Sagi, S.1    Lotan, R.2    Shibolet, O.3
  • 105
    • 84871643501 scopus 로고    scopus 로고
    • Influence of non-alcoholic fatty liver disease on the development of diabetes mellitus
    • Kasturiratne A., Weerasinghe S., Dassanayake A.S., et al. Influence of non-alcoholic fatty liver disease on the development of diabetes mellitus. J Gastroenterol Hepatol 2013, 28(1):142-147.
    • (2013) J Gastroenterol Hepatol , vol.28 , Issue.1 , pp. 142-147
    • Kasturiratne, A.1    Weerasinghe, S.2    Dassanayake, A.S.3
  • 106
    • 34249711303 scopus 로고    scopus 로고
    • Metabolic syndrome and NASH
    • Marchesini G., Marzochhi R. Metabolic syndrome and NASH. Clin Liver Dis 2007, 11(1):105-117.
    • (2007) Clin Liver Dis , vol.11 , Issue.1 , pp. 105-117
    • Marchesini, G.1    Marzochhi, R.2
  • 107
    • 84878330831 scopus 로고    scopus 로고
    • Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease: a randomized trial
    • Eckard C., Cole R., Lockwood J., et al. Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease: a randomized trial. Therap Adv Gastroenterol 2013, 6(4):249-259.
    • (2013) Therap Adv Gastroenterol , vol.6 , Issue.4 , pp. 249-259
    • Eckard, C.1    Cole, R.2    Lockwood, J.3
  • 108
    • 84890770825 scopus 로고    scopus 로고
    • Lifestyle intervention in non-alcoholic fatty liver disease in Chengyang District, Qingdao, China
    • Sun W.H., Song M.Q., Jiang C.Q., et al. Lifestyle intervention in non-alcoholic fatty liver disease in Chengyang District, Qingdao, China. World J Hepatol 2012, 4(7):224-230.
    • (2012) World J Hepatol , vol.4 , Issue.7 , pp. 224-230
    • Sun, W.H.1    Song, M.Q.2    Jiang, C.Q.3
  • 109
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    • Promrat K., Kleiner D.E., Neimeier H.M., et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010, 51(1):121-129.
    • (2010) Hepatology , vol.51 , Issue.1 , pp. 121-129
    • Promrat, K.1    Kleiner, D.E.2    Neimeier, H.M.3
  • 110
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • Sanyal A.J., Chalasani N., Kowdley K.V., et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010, 362(18):1675-1685.
    • (2010) N Engl J Med , vol.362 , Issue.18 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3
  • 111
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R., Harrison S.A., Brown K., et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006, 355(22):2297-2307.
    • (2006) N Engl J Med , vol.355 , Issue.22 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3
  • 112
    • 53049101877 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
    • Aithal G.P., Thomas J.A., Kaye P.V., et al. Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology 2008, 135(4):1176-1184.
    • (2008) Gastroenterology , vol.135 , Issue.4 , pp. 1176-1184
    • Aithal, G.P.1    Thomas, J.A.2    Kaye, P.V.3
  • 113
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    • Neuschwander-Tetri B.A., Brunt E.M., Wehmeier K.R., et al. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. Hepatology 2003, 38(4):1008-1017.
    • (2003) Hepatology , vol.38 , Issue.4 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3
  • 114
    • 80055031101 scopus 로고    scopus 로고
    • Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: a 12-month randomized, prospective, open- label trial
    • Torres D., Jones F., Shaw J., et al. Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: a 12-month randomized, prospective, open- label trial. Hepatology 2011, 54(5):1631-1639.
    • (2011) Hepatology , vol.54 , Issue.5 , pp. 1631-1639
    • Torres, D.1    Jones, F.2    Shaw, J.3
  • 115
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials
    • Musso G., Cassader M., Rosina F., et al. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials. Diabetologia 2012, 55(4):885-904.
    • (2012) Diabetologia , vol.55 , Issue.4 , pp. 885-904
    • Musso, G.1    Cassader, M.2    Rosina, F.3
  • 116
    • 78249262957 scopus 로고    scopus 로고
    • Meta-analysis: insulin sensitizers for the treatment of non-alcoholic steatohepatitis
    • Rakoski M.O., Singal A.G., Rogers M.A., et al. Meta-analysis: insulin sensitizers for the treatment of non-alcoholic steatohepatitis. Aliment Pharmacol Ther 2010, 32(10):1211-1221.
    • (2010) Aliment Pharmacol Ther , vol.32 , Issue.10 , pp. 1211-1221
    • Rakoski, M.O.1    Singal, A.G.2    Rogers, M.A.3
  • 117
    • 33947247615 scopus 로고    scopus 로고
    • Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years
    • Furuya C.K., de Oliveira C.P., de Mello E.S., et al. Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years. J Gastroenterol Hepatol 2007, 22(4):510-514.
    • (2007) J Gastroenterol Hepatol , vol.22 , Issue.4 , pp. 510-514
    • Furuya, C.K.1    de Oliveira, C.P.2    de Mello, E.S.3
  • 118
    • 67650951419 scopus 로고    scopus 로고
    • Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease
    • Mathurin P., Hollebecque A., Arnalsteen L., et al. Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease. Gastroenterology 2009, 137(2):532-540.
    • (2009) Gastroenterology , vol.137 , Issue.2 , pp. 532-540
    • Mathurin, P.1    Hollebecque, A.2    Arnalsteen, L.3
  • 119
    • 57149101692 scopus 로고    scopus 로고
    • Effect of bariatric surgery on nonalcoholic fatty liver disease: systematic review and meta-analysis
    • Mummadi R.R., Kasturi K.S., Chennareddygari S., et al. Effect of bariatric surgery on nonalcoholic fatty liver disease: systematic review and meta-analysis. Clin Gastroenterol Hepatol 2008, 6(12):1396-1402.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , Issue.12 , pp. 1396-1402
    • Mummadi, R.R.1    Kasturi, K.S.2    Chennareddygari, S.3
  • 120
    • 71949106750 scopus 로고    scopus 로고
    • Clinical trial: a nutritional supplement Viusid, in combination with diet and exercise, in patients with nonalcoholic fatty liver disease
    • Vilar Gomez E., Rodriguez de Miranda A., Gra Oramas B., et al. Clinical trial: a nutritional supplement Viusid, in combination with diet and exercise, in patients with nonalcoholic fatty liver disease. Aliment Pharmacol Ther 2009, 30(10):999-1009.
    • (2009) Aliment Pharmacol Ther , vol.30 , Issue.10 , pp. 999-1009
    • Vilar Gomez, E.1    Rodriguez de Miranda, A.2    Gra Oramas, B.3
  • 121
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis
    • Harrison S.A., Torgerson S., Hayashi P., et al. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2003, 98(11):2485-2490.
    • (2003) Am J Gastroenterol , vol.98 , Issue.11 , pp. 2485-2490
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3
  • 122
    • 33645888317 scopus 로고    scopus 로고
    • An assessment of statin safety by hepatologists
    • Cohen D.E., Anania F.A., Chalasani N., National Lipid Association Statin Safety Task Force Liver Expert Panel An assessment of statin safety by hepatologists. Am J Cardiol 2006, 97(8A):77C-81C.
    • (2006) Am J Cardiol , vol.97 , Issue.8 , pp. 77C-781C
    • Cohen, D.E.1    Anania, F.A.2    Chalasani, N.3
  • 123
    • 33745046866 scopus 로고    scopus 로고
    • Effect of multifactorial treatment on non-alcoholic fatty liver disease in metabolic syndrome: a randomised study
    • Athyros V.G., Mikhailidis D.P., Didangelos T.P., et al. Effect of multifactorial treatment on non-alcoholic fatty liver disease in metabolic syndrome: a randomised study. Curr Med Res Opin 2006, 22(5):873-883.
    • (2006) Curr Med Res Opin , vol.22 , Issue.5 , pp. 873-883
    • Athyros, V.G.1    Mikhailidis, D.P.2    Didangelos, T.P.3
  • 124
    • 84856951127 scopus 로고    scopus 로고
    • Efficacy of pitavastatin for the treatment of non-alcoholic steatohepatitis with dyslipidemia: an open-label, pilot study
    • Hyogo H., Ikegami T., Tokushige K., et al. Efficacy of pitavastatin for the treatment of non-alcoholic steatohepatitis with dyslipidemia: an open-label, pilot study. Hepatol Res 2011, 41(11):1057-1065.
    • (2011) Hepatol Res , vol.41 , Issue.11 , pp. 1057-1065
    • Hyogo, H.1    Ikegami, T.2    Tokushige, K.3
  • 125
    • 38749085998 scopus 로고    scopus 로고
    • A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease
    • Fernandez-Miranda C., Perez-Carreras M., Colina F., et al. A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease. Dig Liver Dis 2008, 40(3):200-205.
    • (2008) Dig Liver Dis , vol.40 , Issue.3 , pp. 200-205
    • Fernandez-Miranda, C.1    Perez-Carreras, M.2    Colina, F.3
  • 126
    • 0032776856 scopus 로고    scopus 로고
    • A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis
    • Basaranoglu M., Acbay O., Sonsuz A. A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis. J Hepatol 1999, 31(2):384.
    • (1999) J Hepatol , vol.31 , Issue.2 , pp. 384
    • Basaranoglu, M.1    Acbay, O.2    Sonsuz, A.3
  • 127
    • 49649110937 scopus 로고    scopus 로고
    • Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
    • Wouters K., van Gorp P.J., Bieghs V., et al. Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology 2008, 48(2):474-486.
    • (2008) Hepatology , vol.48 , Issue.2 , pp. 474-486
    • Wouters, K.1    van Gorp, P.J.2    Bieghs, V.3
  • 128
    • 41149120450 scopus 로고    scopus 로고
    • Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice
    • Zheng S., Hoos L., Cook J., et al. Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice. Eur J Pharmacol 2008, 584(1):118-124.
    • (2008) Eur J Pharmacol , vol.584 , Issue.1 , pp. 118-124
    • Zheng, S.1    Hoos, L.2    Cook, J.3
  • 129
    • 77954366025 scopus 로고    scopus 로고
    • Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: an open-label, pilot study
    • Yoneda M., Fujita K., Nozaki Y., et al. Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: an open-label, pilot study. Hepatol Res 2010, 40(6):566-573.
    • (2010) Hepatol Res , vol.40 , Issue.6 , pp. 566-573
    • Yoneda, M.1    Fujita, K.2    Nozaki, Y.3
  • 130
    • 78651473467 scopus 로고    scopus 로고
    • Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease
    • Park H., Shima T., Yamaguchi K., et al. Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease. J Gastroenterol 2011, 46(1):101-107.
    • (2011) J Gastroenterol , vol.46 , Issue.1 , pp. 101-107
    • Park, H.1    Shima, T.2    Yamaguchi, K.3
  • 131
    • 84898600580 scopus 로고    scopus 로고
    • The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial
    • Takeshita Y., Takamura T., Honda M., et al. The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial. Diabetologia 2014, 57(5):878-890.
    • (2014) Diabetologia , vol.57 , Issue.5 , pp. 878-890
    • Takeshita, Y.1    Takamura, T.2    Honda, M.3
  • 132
    • 40749152772 scopus 로고    scopus 로고
    • The effect of Ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells
    • Zvibel I., Bar-Zohar D., Kloog Y., et al. The effect of Ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells. Dig Dis Sci 2008, 53(4):1048-1053.
    • (2008) Dig Dis Sci , vol.53 , Issue.4 , pp. 1048-1053
    • Zvibel, I.1    Bar-Zohar, D.2    Kloog, Y.3
  • 133
    • 65649112801 scopus 로고    scopus 로고
    • Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis
    • Georgescu E.F., Ionescu R., Niculescu M., et al. Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis. World J Gastroenterol 2009, 15(8):942-954.
    • (2009) World J Gastroenterol , vol.15 , Issue.8 , pp. 942-954
    • Georgescu, E.F.1    Ionescu, R.2    Niculescu, M.3
  • 134
    • 84940232965 scopus 로고    scopus 로고
    • Renin-angiotensin system and fibrosis in non-alcoholic fatty liver disease
    • Goh G.B., Pagadala M.R., Dasarathy J., et al. Renin-angiotensin system and fibrosis in non-alcoholic fatty liver disease. Liver Int 2015, 35(3):979-985.
    • (2015) Liver Int , vol.35 , Issue.3 , pp. 979-985
    • Goh, G.B.1    Pagadala, M.R.2    Dasarathy, J.3
  • 135
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: a population-based cohort study
    • Adams L.A., Lymp J.F., St Sauver J., et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005, 129(1):113-121.
    • (2005) Gastroenterology , vol.129 , Issue.1 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St Sauver, J.3
  • 136
    • 77957196987 scopus 로고    scopus 로고
    • Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease: a population-based study
    • Stepanova M., Rafiq N., Younossi Z.M. Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease: a population-based study. Gut 2010, 59(10):1410-1415.
    • (2010) Gut , vol.59 , Issue.10 , pp. 1410-1415
    • Stepanova, M.1    Rafiq, N.2    Younossi, Z.M.3
  • 137
    • 84874109244 scopus 로고    scopus 로고
    • In patients with non-alcoholic fatty liver disease, metabolically abnormal individuals are at a higher risk for mortality while metabolically normal individuals are not
    • Younossi Z.M., Otgonsuren M., Venkatesan C., et al. In patients with non-alcoholic fatty liver disease, metabolically abnormal individuals are at a higher risk for mortality while metabolically normal individuals are not. Metabolism 2013, 62(3):352-360.
    • (2013) Metabolism , vol.62 , Issue.3 , pp. 352-360
    • Younossi, Z.M.1    Otgonsuren, M.2    Venkatesan, C.3
  • 138
    • 84885304313 scopus 로고    scopus 로고
    • Predictors of all-cause mortality and liver-related mortality in patients with non-alcoholic fatty liver disease (NAFLD)
    • Stepanova M., Rafiq N., Makhlouf H., et al. Predictors of all-cause mortality and liver-related mortality in patients with non-alcoholic fatty liver disease (NAFLD). Dig Dis Sci 2013, 58(10):3017-3023.
    • (2013) Dig Dis Sci , vol.58 , Issue.10 , pp. 3017-3023
    • Stepanova, M.1    Rafiq, N.2    Makhlouf, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.