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Volumn 54, Issue 1, 2016, Pages 18-24

Salvia miltiorrhiza: A source for anti-Alzheimers disease drugs

Author keywords

Anti amyloid ; anti apoptosis; anti inflammation; antioxidant; multitarget; neurogenesis; neuroprotection

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; AMYLOID BETA PROTEIN ANTIBODY; CHOLINESTERASE INHIBITOR; CRYPTOTANSHINONE; DIHYDROTANSHINONE; DONEPEZIL; GALANTAMINE; NEW DRUG; PLANT MEDICINAL PRODUCT; RIVASTIGMINE; SALVIA MILTIORRHIZA EXTRACT; SALVIANIC BORNEOL ESTER; SALVIANOLIC ACID A; SALVIANOLIC ACID B; TACRINE; TANSHINONE I; TANSHINONE IIA; UNCLASSIFIED DRUG; NEUROPROTECTIVE AGENT; PLANT EXTRACT;

EID: 84949784723     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2015.1027408     Document Type: Review
Times cited : (104)

References (77)
  • 1
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimers disease
    • Akiyama H, Barger S, Barnum S, et al. (2000). Inflammation and Alzheimers disease. Neurobiol Aging 21: 383-421
    • (2000) Neurobiol Aging , vol.21 , pp. 383-421
    • Akiyama, H.1    Barger, S.2    Barnum, S.3
  • 2
    • 84883465132 scopus 로고    scopus 로고
    • Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC derived human neurons
    • Almeida S, Gascon E, Tran H, et al. (2013). Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC derived human neurons. Acta Neuropathol 126: 385-99
    • (2013) Acta Neuropathol , vol.126 , pp. 385-399
    • Almeida, S.1    Gascon, E.2    Tran, H.3
  • 3
    • 38749108906 scopus 로고    scopus 로고
    • Salvianolic acid B promotes survival of transplanted mesenchymal stem cells in spinal cord-injured rats
    • Bi XB, Deng YB, Gan DH, Wang YZ. (2008). Salvianolic acid B promotes survival of transplanted mesenchymal stem cells in spinal cord-injured rats. Acta Pharmacol Sin 29: 169-76
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 169-176
    • Bi, X.B.1    Deng, Y.B.2    Gan, D.H.3    Wang, Y.Z.4
  • 4
    • 67649865357 scopus 로고    scopus 로고
    • Alzheimers disease: New approaches to drug discovery
    • Bolognesi ML, Matera R, Minarini A, et al. (2009). Alzheimers disease: New approaches to drug discovery. Curr Opin Chem Biol 13: 303-8
    • (2009) Curr Opin Chem Biol , vol.13 , pp. 303-308
    • Bolognesi, M.L.1    Matera, R.2    Minarini, A.3
  • 5
    • 0036905921 scopus 로고    scopus 로고
    • Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: Implications for neurodegeneration in Alzheimers disease brain: A review
    • Butterfield DA. (2002). Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: Implications for neurodegeneration in Alzheimers disease brain: A review. Free Radic Res 36: 1307-13
    • (2002) Free Radic Res , vol.36 , pp. 1307-1313
    • Butterfield, D.A.1
  • 6
    • 34547102265 scopus 로고    scopus 로고
    • Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimers disease and mild cognitive impairment
    • Butterfield DA, Reed T, Newman SF, Sultana R. (2007). Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimers disease and mild cognitive impairment. Free Radic Biol Med 43: 658-77
    • (2007) Free Radic Biol Med , vol.43 , pp. 658-677
    • Butterfield, D.A.1    Reed, T.2    Newman, S.F.3    Sultana, R.4
  • 7
    • 77958126450 scopus 로고    scopus 로고
    • Cellular stress responses, the hormesis paradigm, and vitagenes: Novel targets for therapeutic intervention in neurodegenerative disorders
    • Calabrese V, Cornelius C, Dinkova-Kostova AT, et al. (2010). Cellular stress responses, the hormesis paradigm, and vitagenes: Novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal 13: 1763-811
    • (2010) Antioxid Redox Signal , vol.13 , pp. 1763-1811
    • Calabrese, V.1    Cornelius, C.2    Dinkova-Kostova, A.T.3
  • 8
    • 84880813975 scopus 로고    scopus 로고
    • Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza Bunge, as a multifunctional agent for the treatment of Alzheimers disease
    • Cao YY, Wang L, Ge H, et al. (2013). Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza Bunge, as a multifunctional agent for the treatment of Alzheimers disease. Mol Divers 17: 515-24
    • (2013) Mol Divers , vol.17 , pp. 515-524
    • Cao, Y.Y.1    Wang, L.2    Ge, H.3
  • 9
    • 31544454713 scopus 로고    scopus 로고
    • Separation and identification of water-soluble salvianolic acids from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography and ESI-MS analysis
    • Chen J, Wang F, Lee FS, et al. (2006). Separation and identification of water-soluble salvianolic acids from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography and ESI-MS analysis. Talanta 69: 172-9
    • (2006) Talanta , vol.69 , pp. 172-179
    • Chen, J.1    Wang, F.2    Lee, F.S.3
  • 10
    • 3242681877 scopus 로고    scopus 로고
    • Effect of different drug dosage to activate blood circulation and to nourish qi on cardiac function and structure of congestive heart failure rats after acute myocardial infarction
    • Chen JX, Wang SR, Zhao MJ, et al. (2003). Effect of different drug dosage to activate blood circulation and to nourish qi on cardiac function and structure of congestive heart failure rats after acute myocardial infarction. Zhongguo Zhong Yao Za Zhi 28: 446-9
    • (2003) Zhongguo Zhong Yao Za Zhi , vol.28 , pp. 446-449
    • Chen, J.X.1    Wang, S.R.2    Zhao, M.J.3
  • 11
    • 33847684809 scopus 로고    scopus 로고
    • Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells
    • Chen TH, Hsu YT, Chen CH, et al. (2007). Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells. Mitochondrion 7: 101-5
    • (2007) Mitochondrion , vol.7 , pp. 101-105
    • Chen, T.H.1    Hsu, Y.T.2    Chen, C.H.3
  • 12
    • 84863034624 scopus 로고    scopus 로고
    • Neuroprotective capabilities of Tanshinone IIA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats
    • Chen Y, Wu X, Yu S, et al. (2012). Neuroprotective capabilities of Tanshinone IIA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats. Biol Pharm Bull 35: 164-70
    • (2012) Biol Pharm Bull , vol.35 , pp. 164-170
    • Chen, Y.1    Wu, X.2    Yu, S.3
  • 13
    • 13744259982 scopus 로고    scopus 로고
    • Molecular mechanisms of inhibitory activities of tanshinones on lipopolysaccharide-induced nitric oxide generation in RAW 264.7 cells
    • Choi HS, Cho DI, Choi HK, et al. (2004). Molecular mechanisms of inhibitory activities of tanshinones on lipopolysaccharide-induced nitric oxide generation in RAW 264.7 cells. Arch Pharm Res 27: 1233-7
    • (2004) Arch Pharm Res , vol.27 , pp. 1233-1237
    • Choi, H.S.1    Cho, D.I.2    Choi, H.K.3
  • 14
    • 84877114390 scopus 로고    scopus 로고
    • Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish
    • Chong CM, Zhou ZY, Razmovski-Naumovski V, et al. (2013). Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish. Neurosci Lett 543: 121-5
    • (2013) Neurosci Lett , vol.543 , pp. 121-125
    • Chong, C.M.1    Zhou, Z.Y.2    Razmovski-Naumovski, V.3
  • 15
    • 0020686674 scopus 로고
    • Alzheimers disease: A disorder of cortical cholinergic innervation
    • Coyle JT, Price DL, DeLong MR. (1983). Alzheimers disease: A disorder of cortical cholinergic innervation. Science 219: 1184-90
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    DeLong, M.R.3
  • 16
    • 3042857903 scopus 로고    scopus 로고
    • Alzheimers disease
    • Cummings JL. (2004). Alzheimers disease. N Engl J Med 351: 56-67
    • (2004) N Engl J Med , vol.351 , pp. 56-67
    • Cummings, J.L.1
  • 17
    • 38349160407 scopus 로고    scopus 로고
    • Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects against Abeta-induced cytotoxicty
    • Durairajan SS, Yuan Q, Xie L, et al. (2008). Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects against Abeta-induced cytotoxicty. Neurochem Int 52: 741-50
    • (2008) Neurochem Int , vol.52 , pp. 741-750
    • Durairajan, S.S.1    Yuan, Q.2    Xie, L.3
  • 18
  • 19
    • 61349154148 scopus 로고    scopus 로고
    • The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS
    • Fan GW, Gao XM, Wang H, et al. (2009). The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS. J Steroid Biochem Mol Biol 113: 275-80
    • (2009) J Steroid Biochem Mol Biol , vol.113 , pp. 275-280
    • Fan, G.W.1    Gao, X.M.2    Wang, H.3
  • 21
    • 77954302479 scopus 로고    scopus 로고
    • Effects of salvianolic acid B on proliferation, neurite outgrowth and differentiation of neural stem cells derived from the cerebral cortex of embryonic mice
    • Guo G, Li B, Wang Y, et al. (2010). Effects of salvianolic acid B on proliferation, neurite outgrowth and differentiation of neural stem cells derived from the cerebral cortex of embryonic mice. Sci China Life Sci 53: 653-62
    • (2010) Sci China Life Sci , vol.53 , pp. 653-662
    • Guo, G.1    Li, B.2    Wang, Y.3
  • 22
    • 1442264828 scopus 로고    scopus 로고
    • Take five - BACE and the gamma-secretase quartet conduct Alzheimers amyloid beta-peptide generation
    • Haass C. (2004). Take five-BACE and the gamma-secretase quartet conduct Alzheimers amyloid beta-peptide generation. EMBO J 23: 483-8
    • (2004) EMBO J , vol.23 , pp. 483-488
    • Haass, C.1
  • 23
    • 80053064706 scopus 로고    scopus 로고
    • Salvianic borneol ester reduces beta-amyloid oligomers and prevents cytotoxicity
    • Han M, Liu Y, Zhang B, et al. (2011). Salvianic borneol ester reduces beta-amyloid oligomers and prevents cytotoxicity. Pharm Biol 49: 1008-13
    • (2011) Pharm Biol , vol.49 , pp. 1008-1013
    • Han, M.1    Liu, Y.2    Zhang, B.3
  • 24
    • 47849119964 scopus 로고    scopus 로고
    • Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimers disease: A systematic review and meta-analysis
    • Hansen RA, Gartlehner G, Webb AP, et al. (2008). Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimers disease: A systematic review and meta-analysis. Clin Interv Aging 3: 211-25
    • (2008) Clin Interv Aging , vol.3 , pp. 211-225
    • Hansen, R.A.1    Gartlehner, G.2    Webb, A.P.3
  • 25
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimers disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. (2002). The amyloid hypothesis of Alzheimers disease: Progress and problems on the road to therapeutics. Science 297: 353-6
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 26
    • 0037162725 scopus 로고    scopus 로고
    • New Alzheimers treatments that may ease the mind
    • New therapies
    • Helmuth L. New therapies. (2002). New Alzheimers treatments that may ease the mind. Science 297: 1260-2
    • (2002) Science , vol.297 , pp. 1260-1262
    • Helmuth, L.1
  • 27
    • 79958046643 scopus 로고    scopus 로고
    • Effects of Salvia miltorrhiza in neural differentiation of rat mesenchymal stem cells with optimized protocol
    • Hu L, Yu J, Li F, et al. (2011). Effects of Salvia miltorrhiza in neural differentiation of rat mesenchymal stem cells with optimized protocol. J Ethnopharmacol 136: 334-40
    • (2011) J Ethnopharmacol , vol.136 , pp. 334-340
    • Hu, L.1    Yu, J.2    Li, F.3
  • 28
    • 38049127210 scopus 로고    scopus 로고
    • Apolipoprotein e genotype and alpha-tocopherol modulate amyloid precursor protein metabolism and cell cycle regulation
    • Huebbe P, Schaffer S, Jofre-Monseny L, et al. (2007). Apolipoprotein E genotype and alpha-tocopherol modulate amyloid precursor protein metabolism and cell cycle regulation. Mol Nutr Food Res 51: 1510-17
    • (2007) Mol Nutr Food Res , vol.51 , pp. 1510-1517
    • Huebbe, P.1    Schaffer, S.2    Jofre-Monseny, L.3
  • 29
    • 38749148124 scopus 로고    scopus 로고
    • Multipotent natural agents to combat Alzheimers disease. Functional spectrum and structural features
    • Ji HF, Zhang HY. (2008). Multipotent natural agents to combat Alzheimers disease. Functional spectrum and structural features. Acta Pharmacol Sin 29: 143-51
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 143-151
    • Ji, H.F.1    Zhang, H.Y.2
  • 30
    • 84877676755 scopus 로고    scopus 로고
    • PF2401-SF, standardized fraction of Salvia miltiorrhiza shows anti-inflammatory activity in macrophages and acute arthritis in vivo
    • Jiang WY, Jeon BH, Kim YC, et al. (2013). PF2401-SF, standardized fraction of Salvia miltiorrhiza shows anti-inflammatory activity in macrophages and acute arthritis in vivo. Int Immunopharmacol 16: 160-4
    • (2013) Int Immunopharmacol , vol.16 , pp. 160-164
    • Jiang, W.Y.1    Jeon, B.H.2    Kim, Y.C.3
  • 31
    • 33748981088 scopus 로고    scopus 로고
    • Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression
    • Jin DZ, Yin LL, Ji XQ, Zhu XZ. (2006). Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression. Eur J Pharmacol 549: 166-72
    • (2006) Eur J Pharmacol , vol.549 , pp. 166-172
    • Jin, D.Z.1    Yin, L.L.2    Ji, X.Q.3    Zhu, X.Z.4
  • 32
    • 84861535775 scopus 로고    scopus 로고
    • Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities
    • Joe Y, Zheng M, Kim HJ, et al. (2012). Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities. J Pharmacol Exp Ther 341: 850-8
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 850-858
    • Joe, Y.1    Zheng, M.2    Kim, H.J.3
  • 33
    • 66549104205 scopus 로고    scopus 로고
    • Bridging physiology and pathology in AD
    • Kim D, Tsai LH. (2009). Bridging physiology and pathology in AD. Cell 137: 997-1000
    • (2009) Cell , vol.137 , pp. 997-1000
    • Kim, D.1    Tsai, L.H.2
  • 34
    • 35348901335 scopus 로고    scopus 로고
    • Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice
    • Kim DH, Jeon SJ, Jung JW, et al. (2007). Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice. Eur J Pharmacol 574: 140-7
    • (2007) Eur J Pharmacol , vol.574 , pp. 140-147
    • Kim, D.H.1    Jeon, S.J.2    Jung, J.W.3
  • 35
    • 80053586194 scopus 로고    scopus 로고
    • Cognitive dysfunctions induced by a cholinergic blockade and Abeta 25-35 peptide are attenuated by salvianolic acid B
    • Kim DH, Park SJ, Kim JM, et al. (2011). Cognitive dysfunctions induced by a cholinergic blockade and Abeta 25-35 peptide are attenuated by salvianolic acid B. Neuropharmacology 61: 1432-40
    • (2011) Neuropharmacology , vol.61 , pp. 1432-1440
    • Kim, D.H.1    Park, S.J.2    Kim, J.M.3
  • 36
    • 0034682414 scopus 로고    scopus 로고
    • Neurotoxicity induces cleavage of p35 to p25 by calpain
    • Lee MS, Kwon YT, Li M, et al. (2000). Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405: 360-4
    • (2000) Nature , vol.405 , pp. 360-364
    • Lee, M.S.1    Kwon, Y.T.2    Li, M.3
  • 37
    • 84855998738 scopus 로고    scopus 로고
    • Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages
    • Lee SE, Jeong SI, Yang H, et al. (2012). Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages. J Ethnopharmacol 139: 541-8
    • (2012) J Ethnopharmacol , vol.139 , pp. 541-548
    • Lee, S.E.1    Jeong, S.I.2    Yang, H.3
  • 38
    • 84875065361 scopus 로고    scopus 로고
    • Neuroprotective effects of salvianolic acid B on an Aβ 25-35 peptide-induced mouse model of Alzheimers disease
    • Lee YW, Kim DH, Jeon SJ, et al. (2013). Neuroprotective effects of salvianolic acid B on an Aβ 25-35 peptide-induced mouse model of Alzheimers disease. Eur J Pharmacol 704: 70-7
    • (2013) Eur J Pharmacol , vol.704 , pp. 70-77
    • Lee, Y.W.1    Kim, D.H.2    Jeon, S.J.3
  • 39
    • 0037686253 scopus 로고    scopus 로고
    • Neural stem cells in aging and disease
    • Limke TL, Rao MS. (2002). Neural stem cells in aging and disease. J Cell Mol Med 6: 475-96
    • (2002) J Cell Mol Med , vol.6 , pp. 475-496
    • Limke, T.L.1    Rao, M.S.2
  • 40
    • 33746891189 scopus 로고    scopus 로고
    • Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents Abeta(25-35)-induced reduction in BPRP in PC12 cells
    • Lin YH, Liu AH, Wu H, et al. (2006). Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents Abeta(25-35)-induced reduction in BPRP in PC12 cells. Biochem Biophys Res Commun 348: 593-9
    • (2006) Biochem Biophys Res Commun , vol.348 , pp. 593-599
    • Lin, Y.H.1    Liu, A.H.2    Wu, H.3
  • 41
    • 34447556001 scopus 로고    scopus 로고
    • Protection of PC12 cells from hydrogen peroxide-induced cytotoxicity by salvianolic acid B, a new compound isolated from Radix Salviae miltiorrhizae
    • Liu CS, Chen NH, Zhang JT. (2007). Protection of PC12 cells from hydrogen peroxide-induced cytotoxicity by salvianolic acid B, a new compound isolated from Radix Salviae miltiorrhizae. Phytomedicine 14: 492-7
    • (2007) Phytomedicine , vol.14 , pp. 492-497
    • Liu, C.S.1    Chen, N.H.2    Zhang, J.T.3
  • 42
    • 0035827136 scopus 로고    scopus 로고
    • Protection of Salvia miltiorrhiza against aflatoxin-B1-induced hepatocarcinogenesis in Fischer 344 rats dual mechanisms involved
    • Liu J, Yang CF, Wasser S, et al. (2001). Protection of Salvia miltiorrhiza against aflatoxin-B1-induced hepatocarcinogenesis in Fischer 344 rats dual mechanisms involved. Life Sci 69: 309-26
    • (2001) Life Sci , vol.69 , pp. 309-326
    • Liu, J.1    Yang, C.F.2    Wasser, S.3
  • 43
    • 77958100063 scopus 로고    scopus 로고
    • The neuroprotective effects of tanshinone IIA on beta-amyloid-induced toxicity in rat cortical neurons
    • Liu T, Jin H, Sun QR, et al. (2010). The neuroprotective effects of tanshinone IIA on beta-amyloid-induced toxicity in rat cortical neurons. Neuropharmacology 59: 595-604
    • (2010) Neuropharmacology , vol.59 , pp. 595-604
    • Liu, T.1    Jin, H.2    Sun, Q.R.3
  • 44
    • 0032786202 scopus 로고    scopus 로고
    • Effects of ligustrazine, tanshinone II A, ubiquinone, and idebenone on mouse water maze performance
    • Liu XJ, Wu WT. (1999). Effects of ligustrazine, tanshinone II A, ubiquinone, and idebenone on mouse water maze performance. Zhongguo Yao Li Xue Bao 20: 987-90
    • (1999) Zhongguo Yao Li Xue Bao , vol.20 , pp. 987-990
    • Liu, X.J.1    Wu, W.T.2
  • 45
    • 0030779677 scopus 로고    scopus 로고
    • Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
    • Mattson MP. (1997). Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev 77: 81-132
    • (1997) Physiol Rev , vol.77 , pp. 81-132
    • Mattson, M.P.1
  • 46
    • 77955717406 scopus 로고    scopus 로고
    • Cryptotanshinione upregulates alpha-secretase by activation PI3K pathway in cortical neurons
    • Mei Z, Situ B, Tan X, et al. (2010). Cryptotanshinione upregulates alpha-secretase by activation PI3K pathway in cortical neurons. Brain Res 1348: 165-73
    • (2010) Brain Res , vol.1348 , pp. 165-173
    • Mei, Z.1    Situ, B.2    Tan, X.3
  • 47
    • 84858974983 scopus 로고    scopus 로고
    • Cryptotanshinione inhibits beta-amyloid aggregation and protects damage from beta-amyloid in SH-SY5Y cells
    • Mei Z, Yan P, Situ B, et al. (2012). Cryptotanshinione inhibits beta-amyloid aggregation and protects damage from beta-amyloid in SH-SY5Y cells. Neurochem Res 37: 622-8
    • (2012) Neurochem Res , vol.37 , pp. 622-628
    • Mei, Z.1    Yan, P.2    Situ, B.3
  • 48
    • 60249088016 scopus 로고    scopus 로고
    • Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro
    • Mei Z, Zhang F, Tao L, et al. (2009). Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro. Neurosci Lett 452: 90-5
    • (2009) Neurosci Lett , vol.452 , pp. 90-95
    • Mei, Z.1    Zhang, F.2    Tao, L.3
  • 49
    • 79961234274 scopus 로고    scopus 로고
    • Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimers disease
    • Mildner A, Schlevogt B, Kierdorf K, et al. (2011). Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimers disease. J Neurosci 31: 11159-71
    • (2011) J Neurosci , vol.31 , pp. 11159-11171
    • Mildner, A.1    Schlevogt, B.2    Kierdorf, K.3
  • 50
    • 33644798952 scopus 로고    scopus 로고
    • Behavioral and histological evaluation of a focal cerebral infarction rat model transplanted with neurons induced from bone marrow stromal cells
    • Mimura T, Dezawa M, Kanno H, Yamamoto I. (2005). Behavioral and histological evaluation of a focal cerebral infarction rat model transplanted with neurons induced from bone marrow stromal cells. J Neuropathol Exp Neurol 64: 1108-17
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 1108-1117
    • Mimura, T.1    Dezawa, M.2    Kanno, H.3    Yamamoto, I.4
  • 51
    • 31544481443 scopus 로고    scopus 로고
    • Neuropathology of Alzheimers disease
    • ix
    • Mott RT, Hulette CM. (2005). Neuropathology of Alzheimers disease. Neuroimaging Clin N Am 15: 755-65, ix
    • (2005) Neuroimaging Clin N Am , vol.15 , pp. 755-765
    • Mott, R.T.1    Hulette, C.M.2
  • 52
    • 84862215711 scopus 로고    scopus 로고
    • The protective effects of tanshinone IIA on beta-amyloid protein (1-42)-induced cytotoxicity via activation of the Bcl-xL pathway in neuron
    • Qian YH, Xiao Q, Xu J. (2012). The protective effects of tanshinone IIA on beta-amyloid protein (1-42)-induced cytotoxicity via activation of the Bcl-xL pathway in neuron. Brain Res Bull 88: 354-8
    • (2012) Brain Res Bull , vol.88 , pp. 354-358
    • Qian, Y.H.1    Xiao, Q.2    Xu, J.3
  • 53
    • 81855204959 scopus 로고    scopus 로고
    • Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA
    • Radak Z, Zhao Z, Goto S, Koltai E. (2011). Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA. Mol Aspects Med 32: 305-15
    • (2011) Mol Aspects Med , vol.32 , pp. 305-315
    • Radak, Z.1    Zhao, Z.2    Goto, S.3    Koltai, E.4
  • 54
    • 84877576513 scopus 로고    scopus 로고
    • Screening and evaluation of traditional Chinese medicine by microarray expression analysis
    • Ren G, Fan X, Liang Q, et al. (2013). Screening and evaluation of traditional Chinese medicine by microarray expression analysis. J Ethnopharmacol 147: 564-9
    • (2013) J Ethnopharmacol , vol.147 , pp. 564-569
    • Ren, G.1    Fan, X.2    Liang, Q.3
  • 55
    • 1842588815 scopus 로고    scopus 로고
    • Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza
    • Ren Y, Houghton PJ, Hider RC, Howes J. (2004). Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza. Planta Med 70: 201-4
    • (2004) Planta Med , vol.70 , pp. 201-204
    • Ren, Y.1    Houghton, P.J.2    Hider, R.C.3    Howes, J.4
  • 56
    • 84863424370 scopus 로고    scopus 로고
    • The protective effects of tanshinone IIA on neurotoxicity induced by beta-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons
    • Shi LL, Yang WN, Chen XL, et al. (2012). The protective effects of tanshinone IIA on neurotoxicity induced by beta-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons. Neurochem Int 61: 227-35
    • (2012) Neurochem Int , vol.61 , pp. 227-235
    • Shi, L.L.1    Yang, W.N.2    Chen, X.L.3
  • 57
    • 84897014787 scopus 로고    scopus 로고
    • Effects of Salvia miltiorrhiza on neural differentiation of induced pluripotent stem cells
    • Shu T, Pang M, Rong L, et al. (2014). Effects of Salvia miltiorrhiza on neural differentiation of induced pluripotent stem cells. J Ethnopharmacol 153: 233-41
    • (2014) J Ethnopharmacol , vol.153 , pp. 233-241
    • Shu, T.1    Pang, M.2    Rong, L.3
  • 58
    • 0028577208 scopus 로고
    • Immunohistochemical evidence for apoptosis in Alzheimers disease
    • Su JH, Anderson AJ, Cummings BJ, Cotman CW. (1994). Immunohistochemical evidence for apoptosis in Alzheimers disease. Neuroreport 5: 2529-33
    • (1994) Neuroreport , vol.5 , pp. 2529-2533
    • Su, J.H.1    Anderson, A.J.2    Cummings, B.J.3    Cotman, C.W.4
  • 59
    • 47149092572 scopus 로고    scopus 로고
    • Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory
    • Taylor CJ, Ireland DR, Ballagh I, et al. (2008). Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiol Dis 31: 250-60
    • (2008) Neurobiol Dis , vol.31 , pp. 250-260
    • Taylor, C.J.1    Ireland, D.R.2    Ballagh, I.3
  • 60
    • 39049123781 scopus 로고    scopus 로고
    • Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents 6-hydroxydopamine induced apoptosis in SH-SY5Y cells
    • Tian LL, Wang XJ, Sun YN, et al. (2008). Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents 6-hydroxydopamine induced apoptosis in SH-SY5Y cells. Int J Biochem Cell Biol 40: 409-22
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 409-422
    • Tian, L.L.1    Wang, X.J.2    Sun, Y.N.3
  • 61
    • 3042727914 scopus 로고    scopus 로고
    • Nitric oxide pathways in Alzheimers disease and other neurodegenerative dementias
    • Togo T, Katsuse O, Iseki E. (2004). Nitric oxide pathways in Alzheimers disease and other neurodegenerative dementias. Neurol Res 26: 563-6
    • (2004) Neurol Res , vol.26 , pp. 563-566
    • Togo, T.1    Katsuse, O.2    Iseki, E.3
  • 62
    • 0036945860 scopus 로고    scopus 로고
    • Gas6 rescues cortical neurons from amyloid protein-induced apoptosis
    • Yagami T, Ueda K, Asakura K, et al. (2002). Gas6 rescues cortical neurons from amyloid protein-induced apoptosis. Neuropharmacology 43: 1289-96
    • (2002) Neuropharmacology , vol.43 , pp. 1289-1296
    • Yagami, T.1    Ueda, K.2    Asakura, K.3
  • 63
    • 77957333799 scopus 로고    scopus 로고
    • Evaluation of bone marrow-and brain-derived neural stem cells in therapy of central nervous system autoimmunity
    • Yang J, Yan Y, Ciric B, et al. (2010). Evaluation of bone marrow-and brain-derived neural stem cells in therapy of central nervous system autoimmunity. Am J Pathol 177: 1989-2001
    • (2010) Am J Pathol , vol.177 , pp. 1989-2001
    • Yang, J.1    Yan, Y.2    Ciric, B.3
  • 64
    • 84903730922 scopus 로고    scopus 로고
    • Neuroprotection against Aβ25-35-induced apoptosis by Salvia miltiorrhiza extract in SH-SY5Y cells
    • Yu H, Yao L, Zhou H, et al. (2014). Neuroprotection against Aβ25-35-induced apoptosis by Salvia miltiorrhiza extract in SH-SY5Y cells. Neurochem Int 75: 89-95
    • (2014) Neurochem Int , vol.75 , pp. 89-95
    • Yu, H.1    Yao, L.2    Zhou, H.3
  • 65
    • 79952159138 scopus 로고    scopus 로고
    • The role of P-glycoprotein in transport of danshensu across the blood-brain barrier
    • Yu PF, Wang WY, Eerdun G, et al. (2011). The role of P-glycoprotein in transport of danshensu across the blood-brain barrier. Evid Based Complement Alternat Med 2011: 713523
    • (2011) Evid Based Complement Alternat Med , vol.2011 , pp. 713523
    • Yu, P.F.1    Wang, W.Y.2    Eerdun, G.3
  • 66
    • 84879744934 scopus 로고    scopus 로고
    • Tanshinones inhibit amyloid aggregation by amyloid-beta peptide, disaggregate amyloid fibrils, and protect cultured cells
    • Wang Q, Yu X, Patal K, et al. (2013). Tanshinones inhibit amyloid aggregation by amyloid-beta peptide, disaggregate amyloid fibrils, and protect cultured cells. ACS Chem Neurosci 4: 1004-15
    • (2013) ACS Chem Neurosci , vol.4 , pp. 1004-1015
    • Wang, Q.1    Yu, X.2    Patal, K.3
  • 67
    • 33845768814 scopus 로고    scopus 로고
    • New developments in the chemistry and biology of the bioactive constituents of Tanshen
    • Wang X, Morris-Natschke SL, Lee KH. (2007). New developments in the chemistry and biology of the bioactive constituents of Tanshen. Med Res Rev 27: 133-48
    • (2007) Med Res Rev , vol.27 , pp. 133-148
    • Wang, X.1    Morris-Natschke, S.L.2    Lee, K.H.3
  • 68
    • 12844287571 scopus 로고    scopus 로고
    • Salvianic acid A protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity
    • Wang XJ, Xu JX. (2005). Salvianic acid A protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. Neurosci Res 51: 129-38
    • (2005) Neurosci Res , vol.51 , pp. 129-138
    • Wang, X.J.1    Xu, J.X.2
  • 69
    • 0028316959 scopus 로고
    • Hepatotoxic effects of tacrine administration in patients with Alzheimers disease
    • Watkins PB, Zimmerman HJ, Knapp MJ, et al. (1994). Hepatotoxic effects of tacrine administration in patients with Alzheimers disease. JAMA 271: 992-8
    • (1994) JAMA , vol.271 , pp. 992-998
    • Watkins, P.B.1    Zimmerman, H.J.2    Knapp, M.J.3
  • 70
    • 0019410162 scopus 로고
    • Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
    • Whitehouse PJ, Price DL, Clark AW, et al. (1981). Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 10: 122-6
    • (1981) Ann Neurol , vol.10 , pp. 122-126
    • Whitehouse, P.J.1    Price, D.L.2    Clark, A.W.3
  • 71
    • 0025752360 scopus 로고
    • Phagocytosis of beta/A4 amyloid fibrils of the neuritic neocortical plaques
    • Wisniewski HM, Barcikowska M, Kida E. (1991). Phagocytosis of beta/A4 amyloid fibrils of the neuritic neocortical plaques. Acta Neuropathol 81: 588-90
    • (1991) Acta Neuropathol , vol.81 , pp. 588-590
    • Wisniewski, H.M.1    Barcikowska, M.2    Kida, E.3
  • 72
    • 77049128277 scopus 로고    scopus 로고
    • Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task
    • Wong KK, Ho MT, Lin HQ, et al. (2010). Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task. Planta Med 76: 228-34
    • (2010) Planta Med , vol.76 , pp. 228-234
    • Wong, K.K.1    Ho, M.T.2    Lin, H.Q.3
  • 73
    • 59449107703 scopus 로고    scopus 로고
    • Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway
    • Zhang F, Zheng W, Pi R, et al. (2009). Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway. Exp Brain Res 193: 109-18
    • (2009) Exp Brain Res , vol.193 , pp. 109-118
    • Zhang, F.1    Zheng, W.2    Pi, R.3
  • 74
    • 84869496447 scopus 로고    scopus 로고
    • Effects of salvianolic acid B on survival, self-renewal and neuronal differentiation of bone marrow derived neural stem cells
    • Zhang N, Kang T, Xia Y, et al. (2012). Effects of salvianolic acid B on survival, self-renewal and neuronal differentiation of bone marrow derived neural stem cells. Eur J Pharmacol 697: 32-9
    • (2012) Eur J Pharmacol , vol.697 , pp. 32-39
    • Zhang, N.1    Kang, T.2    Xia, Y.3
  • 75
    • 68249097262 scopus 로고    scopus 로고
    • Chemical characteristics of Salvia miltiorrhiza (Danshen) collected from different locations in China
    • Zhong GX, Li P, Zeng LJ, et al. (2009). Chemical characteristics of Salvia miltiorrhiza (Danshen) collected from different locations in China. J Agric Food Chem 57: 6879-87
    • (2009) J Agric Food Chem , vol.57 , pp. 6879-6887
    • Zhong, G.X.1    Li, P.2    Zeng, L.J.3
  • 76
    • 27844511101 scopus 로고    scopus 로고
    • Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
    • Zhou L, Zuo Z, Chow MS. (2005). Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol 45: 1345-59
    • (2005) J Clin Pharmacol , vol.45 , pp. 1345-1359
    • Zhou, L.1    Zuo, Z.2    Chow, M.S.3
  • 77
    • 84860211693 scopus 로고    scopus 로고
    • Direct stimulation of adult neural stem/progenitor cells in vitro and neurogenesis in vivo by salvianolic acid B
    • Zhuang P, Zhang Y, Cui G, et al. (2012). Direct stimulation of adult neural stem/progenitor cells in vitro and neurogenesis in vivo by salvianolic acid B. PLoS One 7: e35636
    • (2012) PLoS One , vol.7 , pp. e35636
    • Zhuang, P.1    Zhang, Y.2    Cui, G.3


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