Cryptotanshinione inhibits β-amyloid aggregation and protects damage from β-amyloid in SH-SY5Y cells

Neurochemical Research

Volumn 37, Issue 3, 2012, Pages 622-628

  Mei, Zhengrong ^a   Yan, Pengke ^a   Situ, Bing ^a   Mou, Yonggao ^b   Liu, Peiqing ^b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

A ; Aggregation; Apoptosis; Cryptotanshinone

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMYLOID BETA PROTEIN[1-42]; CRYPTOTANSHINONE; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE;

ALZHEIMER DISEASE; AMYLOIDOSIS; APOPTOSIS; ARTICLE; BRAIN DAMAGE; CELL DAMAGE; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN SYNTHESIS INHIBITION; TRANSMISSION ELECTRON MICROSCOPY;

AMYLOID BETA-PEPTIDES; CELL LINE, TUMOR; FLOW CYTOMETRY; HUMANS; L-LACTATE DEHYDROGENASE; MICROSCOPY, ELECTRON, TRANSMISSION; PHENANTHRENES;

SALVIA;

EID: 84858974983     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-011-0652-6     Document Type: Article

References (34)

1. Hu X, Crick SL, Bu G, Frieden C, Pappu RV, Lee JM (2009) Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc Natl Acad Sci USA 106:20324-20329
2. Aderinwale OG, Ernst HW, Mousa SA (2010) Current therapies and new strategies for the management of Alzheimer's disease. Am J Alzheimers Dis Other Demen 25(5):414-424
3. Bitan G, Kirkitadze MD, Lomakin A, Vollers SS, Benedek GB, Teplow DB (2003) Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proc Natl Acad Sci USA 100:330-335 (Pubitemid 36078074)
4. Allaman I, Gavillet M, Bélanger M, Laroche T, Viertl D, Lashuel HA, Magistretti PJ (2010) Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability. J Neurosci 30(9):3326-3338
5. Uttara B, Singh AV, Zamboni P, Mahajan RT (2009) Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 7:65-74
6. Yamin G, Ruchala P, Teplow DB (2009) A peptide hairpin inhibitor of amyloid beta-protein oligomerization and fibrillogenesis. Biochemistry 48:11329-11331
7. Riviere C, Delaunay JC, Immel F, Cullin C, Monti JP (2009) The polyphenol piceid destabilizes preformed amyloid fibrils and oligomers in vitro: hypothesis on possible molecular mechanisms. Neurochem Res 34:1120-1128
8. McLaurin J, Cecal R, Kierstead ME, Tian X, Phinney AL, Manea M, French JE, Lambermon MH, Darabie AA, Brown ME, Janus C, Chishti MA, Horne P, Westaway D, Fraser PE, Mount HT, Przybylski M, St George-Hyslop P (2002) Therapeutically effective antibodies against amyloid-beta peptide target amyloidbeta residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nat Med 8:1263-1269 (Pubitemid 35373558)
9. Nishida Y, Ito S, Ohtsuki S, Yamamoto N, Takahashi T, Iwata N, Jishage K, Yamada H, Sasaguri H, Yokota S, Piao W, Tomimitsu H, Saido TC, Yanagisawa K, Terasaki T, Mizusawa H, Yokota T (2009) Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease. J Biol Chem 284: 33400-33408
10. Thomas T, Nadackal TG, Thomas K (2001) Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation. Neuroreport 12:3263-3267 (Pubitemid 33014359)
11. Jin YC, Kim CW, Kim YM, Nizamutdinova IT, Ha YM, Kim HJ, Seo HG, Son KH, Jeon SJ, Kang SS, Kim YS, Kam SC, Lee JH, Chang KC (2009) Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-alpha-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo. Eur J Pharmacol 614:91-97
12. Yin HQ, Choi YJ, Kim YC, Sohn DH, Ryu SY, Lee BH (2009) Salvia miltiorrhiza Bunge and its active component cryptotanshinone protects primary cultured rat hepatocytes from acute ethanol-induced cytotoxicity and fatty infiltration. Food Chem Toxicol 47:98-103
13. Wong KK, Ho MT, Lin HQ, Lau KF, Rudd JA, Chung RC, Fung KP, Shaw PC, Wan DC (2010) Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task. Planta Med 76:228-234
14. Adams JD, Wang R, Yang J, Lien EJ (2006) Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions. Chin Med 1:3
15. Yu XY, Lin SG, Chen X, Zhou ZW, Liang J, Duan W, Chowbay B, Wen JY, Chan E, Cao J, Li CG, Zhou SF (2007) Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier. Curr Drug Metab 8:365-378
16. Isaacs AM, Senn DB, Yuan M, Shine JP, Yankner BA (2006) Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium. J Biol Chem 281:27916-27923 (Pubitemid 44414503)
17. Polimeno L, Pesetti B, Lisowsky T, Iannone F, Resta L, Giorgio F, Mallamaci R, Buttiglione M, Santovito D, Vitiello F, Mancini ME, Francavilla A (2009) Protective effect of augmenter of liver regeneration on hydrogen peroxide-induced apoptosis in SHSY5Y human neuroblastoma cells. Free Radic Res 43:865-875
18. Spallarossa P, Garibaldi S, Altieri P, Fabbi P, Manca V, Nasti S, Rossettin P, Ghigliotti G, Ballestrero A, Patrone F, Barsotti A, Brunelli C (2004) Carvedilol prevents doxorubicin-induced free radical release and apoptosis in cardiomyocytes in vitro. J Mol Cell Cardiol 37:837-846 (Pubitemid 39222076)
19. Wolfe MS (2002) Therapeutic strategies for Alzheimer's disease. Nat Rev Drug Discov 1:859-866 (Pubitemid 37361581)
20. Jana M, Palencia CA, Pahan K (2008) Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease. J Immunol 181:7254-7262
21. Faller P (2009) Copper and zinc binding to amyloid-beta: coordination, dynamics, aggregation, reactivity and metal-ion transfer. Chembiochem 10:2837-2845
22. Grossi C, Francese S, Casini A, Rosi MC, Luccarini I, Fiorentini A, Gabbiani C, Messori L, Moneti G, Casamenti F (2009) Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis 17:423-440
23. Choo-Smith LP, Garzon-Rodriguez W, Glabe CG, Surewicz WK (1997) Acceleration of amyloid fibril formation by specific binding of Abeta-(1-40) peptide to ganglioside-containing membrane vesicles. J Biol Chem 272:22987-22990 (Pubitemid 27392420)
24. Iurescia S, Fioretti D, Mangialasche F, Rinaldi M (2010) The pathological cross talk between apolipoprotein E and amyloidbeta peptide in Alzheimer's disease: emerging gene-based therapeutic approaches. J Alzheimers Dis 21(1):35-48
25. McLaurin J, Franklin T, Zhang X, Deng J, Fraser PE (1999) Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth. Eur J Biochem 266:1101-1110 (Pubitemid 30010129)
26. Mei Z, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S, Pi R, Liu P (2009) Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro. Neurosci Lett 452(2): 90-95
27. Skovronsky DM, Doms RW, Lee VM (1998) Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture. J Cell Biol 141:1031-1039 (Pubitemid 28243969)
28. Vaisid T, Kosower NS, Elkind E, Barnoy S (2008) Amyloid beta peptide toxicity in differentiated PC12 cells: calpain-calpastatin, caspase, and membrane damage. J Neurosci Res 86:2314-2325
29. Lloret A, Badia MC, Mora NJ, Ortega A, Pallardo FV, Alonso MD, Atamna H, Vina J (2008) Gender and age-dependent differences in the mitochondrial apoptogenic pathway in Alzheimer's disease. Free Radic Biol Med 44:2019-2025
30. Miranda S, Opazo C, Larrondo LF, Munoz FJ, Ruiz F, Leighton F, Inestrosa NC (2000) The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease. Prog Neurobiol 62:633-648 (Pubitemid 30407138)
31. Boldogh I, Kruzel ML (2008) Colostrinin: an oxidative stress modulator for prevention and treatment of age-related disorders. J Alzheimers Dis 13:303-321 (Pubitemid 352039033)
32. Moon JH, Kim SY, Lee HG, Kim SU, Lee YB (2008) Activation of nicotinic acetylcholine receptor prevents the production of reactive oxygen species in fibrillar beta amyloid peptide (1-42)stimulated microglia. Exp Mol Med 40:11-18 (Pubitemid 351346812)
33. Bras M, Queenan B, Susin SA (2005) Programmed cell death via mitochondria: different modes of dying. Biochemistry (Mosc) 70:231-239 (Pubitemid 40512332)
34. Pelicano H, Feng L, Zhou Y, Carew JS, Hileman EO, Plunkett W, Keating MJ, Huang P (2003) Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem 278:37832-37839 (Pubitemid 37175311)