Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages

Journal of Ethnopharmacology

Volumn 139, Issue 2, 2012, Pages 541-548

  Lee, Seung Eun ^a   Jeong, Seong Il ^a   Yang, Hana ^a   Jeong, Se Hee ^b   Jang, Young Pyo ^b   Park, Cheung Seog ^a   Kim, Jinju ^b   Park, Yong Seek ^a  

^a Kyung Hee University Hospital   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

HO 1; Macrophages; Nrf2; Oxidative stress; Salvia miltiorrhiza (Danshen)

Indexed keywords

HEME OXYGENASE 1; HYDROGEN PEROXIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; SALVIA MILTIORRHIZA EXTRACT; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; MACROPHAGE; MOLECULAR MECHANICS; OXIDATIVE STRESS; PROTEIN EXPRESSION; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; UPREGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIOXIDANTS; CELL LINE; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENZYME INDUCTION; HEME OXYGENASE-1; MACROPHAGES; MAP KINASE KINASE 1; MASS SPECTROMETRY; MEMBRANE PROTEINS; MICE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHENANTHROLINES; PHOSPHATIDYLINOSITOL 3-KINASE; PLANT ROOTS; PLANTS, MEDICINAL; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, MESSENGER; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

SALVIA MILTIORRHIZA;

EID: 84855998738     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.11.046     Document Type: Article

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