Neuroprotective capabilities of tanshinone IIA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 2, 2012, Pages 164-170

  Chen, Yanlin ^a   Wu, Xuemei ^a   Yu, Shanshan ^a   Fauzee, Nilufer Jasmine Selimah ^a   Wu, Jingxian ^a   Li, Lan ^a   Zhao, Jing ^a   Zhao, Yong ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cerebral; Ischemia; Reperfusion; Tanshinone IIA

Indexed keywords

CASPASE 3; PROTEIN BCL 2; TANSHINONE IIA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; TREATMENT RESPONSE; WATER CONTENT;

ANIMALS; APOPTOSIS; CASPASE 3; DITERPENES, ABIETANE; DNA FRAGMENTATION; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84863034624     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.35.164     Document Type: Article

References (31)

1. Yu SJ, Kim JR, Lee CK, Han JE, Lee JH, Kim HS, Hong JH, Kang SG. Gastrodia elata blume and an active component, p-hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expressions. Biol. Pharm. Bull., 28, 1016-1020 (2005).
2. Feigin VL, Lawes CM, Bennett DA, Anderson CS. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol., 2, 43-53 (2003).
3. Appelboom G, Strozyk D, Meyers PM, Higashida RT. Current recommendations for endovascular interventions in the treatment of ischemic stroke. Curr. Atheroscler. Rep., 12, 244-250 (2010).
4. Li M, Zhang XJ, Cui LL, Yang R, Wang LN, Liu LL, Du W. The neuroprotection of oxymatrine in cerebral ischemia/reperfusion is related to nuclear factor erythroid 2-related factor 2 (nrf2)-mediated antioxidant response: role of nrf2 and hemeoxygenase-1 expression. Biol. Pharm. Bull., 34, 595-601 (2011).
5. Qi J, Hong ZY, Xin H, Zhu YZ. Neuroprotective effects of leonurine on ischemia/reperfusion-induced mitochondrial dysfunctions in rat cerebral cortex. Biol. Pharm. Bull., 33, 1958-1964 (2010).
6. Zhao J, Yu SS, Zheng WP, Feng G, Luo GB, Wang LL, Zhao Y. Curcumin improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats. Neurochem. Res., 35, 374-379 (2010).
7. Yang JP, Liu HJ, Yang H, Feng PY. Therapeutic time window for the neuroprotective effects of NGF when administered after focal cerebral ischemia. Neurol. Sci., 32, 433-441 (2011).
8. Li Q, Zhang R, Guo YL, Mei YW. Effect of neuregulin on apoptosis and expressions of STAT3 and GFAP in rats following cerebral ischemic reperfusion. J. Mol. Neurosci., 37, 67-73 (2009).
9. Zhang HF, Hu XM, Wang LX, Xu SQ, Zeng FD. Protective effects of scutellarin against cerebral ischemia in rats: evidence for inhibition of the apoptosis-inducing factor pathway. Planta Med., 75, 121-126 (2009).
10. Xu W, Yang J, Wu LM. Cardioprotective effects of tanshinone IIA on myocardial ischemia injury in rats. Pharmazie, 64, 332-336 (2009).
11. Yang R, Liu A, Ma X, Li L, Su D, Liu J. Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation. J. Cardiovasc. Pharmacol., 51, 396-401 (2008).
12. Lam BY, Lo AC, Sun X, Luo HW, Chung SK, Sucher NJ. Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice. Phytomedicine, 10, 286-291 (2003).
13. Dong K, Xu W, Yang J, Qiao H, Wu L. Neuroprotective effects of Tanshinone IIA on permanent focal cerebral ischemia in mice. Phytother. Res., 23, 608-613 (2009).
14. Adams JD, Wang R, Yang J, Lien EJ. Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions. Chin. Med., 1, 3 (2006).
15. Liu LL, Zhang XL, Wang LN, Yang R, Cui LL, Li M, Du W, Wang S. The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke. Brain Res. Bull., 82, 228-233 (2010).
16. Kim HH, Kim JH, Kwak HB, Huang H, Han SH, Ha H, Lee SW, Woo ER, Lee ZH. Inhibition of osteoclast differentiation and bone resorption by tanshinone IIA isolated from Salvia miltiorrhiza Bunge. Biochem. Pharmacol., 67, 1647-1656 (2004).
17. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke, 20, 84-91 (1989).
18. Yu SS, Zhao J, Zheng WP, Zhao Y. Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats. Brain Res., 1308, 167-175 (2010).
19. Zhu C, Wang X, Cheng X, Qiu L, Xu F, Simbruner G, Blomgren K. Post-ischemic hypothermia-induced tissue protection and diminished apoptosis after neonatal cerebral hypoxia-ischemia. Brain Res., 996, 67-75 (2004).
20. Hoffman GE, Merchenthaler I, Zup SL. Neuroprotection by ovarian hormones in animal models of neurological disease. Endocrine, 29, 217-231 (2006).
21. Wang LN, Zhang XJ, Liu LL, Cui LL, Yang R, Li M, Du W. Tanshinone IIA down-regulates HMGB1, RAGE, TLR4, NFkappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. Brain Res., 1321, 143-151 (2010).
22. Tang C, Xue HL, Bai CL, Fu R, Wu AH. The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats. Phytomedicine, 17, 1145-1149 (2010).
23. Yu SS, Zhao J, Lei SP, Lin XM, Wang LL, Zhao Y. 4-Hydroxybenzyl alcohol ameliorates cerebral injury in rats by antioxidant action. Neurochem. Res., 36, 339-346 (2011).
24. Harada S, Hamabe W, Kamiya K, Satake T, Yamamoto J, Tokuyama S. Preventive effect of Morinda citrifolia fruit juice on neuronal damage induced by focal ischemia. Biol. Pharm. Bull., 32, 405-409 (2009).
25. Zhao J, Zhao Y, Zheng WP, Lu YY, Feng G, Yu SS. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res., 1229, 224-232 (2008).
26. Khatibi NH, Ma Q, Rolland W, Ostrowski R, Fathali N, Martin R, Applegate R, Stier G, Tang J, Zhang JH. Isoflurane Posttreatment Reduces Brain Injury after an Intracerebral Hemorrhagic Stroke in Mice. Anesth. Analg., 113, 343-348 (2011).
27. Chen D, Tang J, Khatibi NH, Zhu M, Li Y, Wang C, Jiang R, Tu L, Wang S. Treatment with Z-ligustilide, a component of Angelica sinensis, reduces brain injury after a subarachnoid hemorrhage in rats. J. Pharmacol. Exp. Ther., 337, 663-672 (2011).
28. Cavallucci V, D'Amelio M. Matter of life and death: the pharmacological approaches targeting apoptosis in brain diseases. Curr. Pharm. Des., 17, 215-229 (2011).
29. Nizamutdinova IT, Jin YC, Kim JS, Yean MH, Kang SS, Kim YS, Lee JH, Seo HG, Kim HJ, Chang KC. Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats. Planta Med., 74, 14-18 (2008).
30. Liu Y, Wang L, Li X, Lv C, Feng D, Luo Z. Tanshinone IIA improves impaired nerve functions in experimental diabetic rats. Biochem. Biophys. Res. Commun., 399, 49-54 (2010).
31. Zhang WJ, Feng J, Zhou R, Ye LY, Liu HL, Peng L, Lou JN, Li CH. Tanshinone IIA protects the human blood-brain barrier model from leukocyte-associated hypoxia-reoxygenation injury. Eur. J. Pharmacol., 648, 146-152 (2010).