Apolipoprotein E genotype and alpha-tocopherol modulate amyloid precursor protein metabolism and cell cycle regulation

Molecular Nutrition and Food Research

Volumn 51, Issue 12, 2007, Pages 1510-1517

  Huebbe, Patricia ^a   Schaffer, Sebastian ^b   Jofre Monseny, Laia ^a   Boesch Saadatmandi, Christine ^a   Minihane, Anne Marie ^c   Müller, Walter E ^b   Eckert, Gunter P ^b   Rimbach, Gerald ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY OF READING   (United Kingdom)

Author keywords

Alpha tocopherol; Amyloid precursor protein; Apolipoprotein E genotype; Cell cycle; Mice

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; CELL CYCLE PROTEIN; MESSENGER RNA; SECRETASE;

ALZHEIMER DISEASE; ANIMAL; ARTICLE; BRAIN CORTEX; CELL CYCLE; CHEMISTRY; DIET; DRUG EFFECT; FEMALE; GENE EXPRESSION; GENETICS; GENOTYPE; HIPPOCAMPUS; MEMBRANE FLUIDITY; METABOLISM; MOUSE; PHYSIOLOGY; SYNAPTOSOME; TRANSGENIC MOUSE;

ALPHA-TOCOPHEROL; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; CELL CYCLE; CELL CYCLE PROTEINS; CEREBRAL CORTEX; DIET; FEMALE; GENE EXPRESSION; GENOTYPE; HIPPOCAMPUS; MEMBRANE FLUIDITY; MICE; MICE, TRANSGENIC; RNA, MESSENGER; SYNAPTOSOMES;

MUS; MUS MUSCULUS;

EID: 38049127210     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200700194     Document Type: Article

References (36)

1. Xu, Q., Bernardo, A., Walker, D., Kanegawa, T., Mahley, R. W., et al., Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus, J. Neurosci. 2006, 26, 4985-4994.
2. Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmeehel, D. E., et al., Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families, Science 1993, 261, 921-923.
3. van Duijn, C. M., de Knijff, P., Cruts, M., Wehnert, A., et al., Apolipoprotein E4 allele in a population-based study of early-onset alzheimer's disease, Nat. Genet, 1994, 7, 74-78.
4. Ramassamy, C., Averill, D., Beffert, U., Bastianetto, S., et al., Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype, Free Radic. Biol. Med. 1999, 27, 544-553.
5. Borroni, B., Di Luca, M., Padovani, A., The effect of APOE genotype on clinical phenotype in Alzheimer disease, Neurology 2007, 68, 624; author reply 624.
6. Herrup, K., Neve, R., Ackerman, S. L., Copani, A., Divide and die: cell cycle events as triggers of nerve cell death, J. Neurosci. 2004, 24, 9232-9239.
7. Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., et al., A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study, N. Engl. J. Med. 1997, 336, 1216-1222.
8. Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., et al., Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study, JAMA 2002, 287, 3230-3237.
9. Petersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., etal., Vitamin E and donepezil for the treatment of mild cognitive impairment, N. Engl. J. Med. 2005, 352, 2379-2388.
10. Kang, J. H., Cook, N., Manson, J., Buring, J. E., Grodstein, F., A randomized trial of vitamin E supplementation and cognitive function in women. Arch. Inlern. Med. 2006, 166, 2462-2468.
11. Miyata, M., Smith, J. D., Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides, Nat. Genet. 1996, 14, 55-61.
12. Mahley, R. W., Weisgraber, K. H., Huang, Y., Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease, Proc. Natl. Acad. Sci. USA 2006, 103, 5644-5651.
13. Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset alzheimer disease, Proc. Natl. Acad. Sci. USA 1993, 90, 8098-8102.
14. Strittmatter, W. J., Saunders, A. M., Goedert, M., Weisgraber, K. H., et al., Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease, Proc. Natl. Acad. Sci. USA 1994, 91, 11183-11186.
15. Holtzman, D. M., Bales, K. R., Tenkova, T., Pagan, A. M., et al., Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease, Proc. Natl. Acad. Sci. US. 2000, 97, 2892-2897.
16. Ye, S., Huang, Y., Mullendorff, K., Dong, L., et al., Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target, Proc. Natl. Acad. Sci. USA 2005, 102, 18700-18705.
17. Selkoe, D. J., The molecular pathology of Alzheimer's disease, Neuron 1991, 6, 487-498.
18. Marx, J., Alzheimer's disease. Bad for the heart, bad for the mind? Science 2001, 294, 508-509.
19. Xu, P. T., Li, Y. J., Qin, X. J., Scherzer, C. R., et al., Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease, Neurobiol. Dis. 2006, 21, 256-275.
20. Rota, C., Rimbach, G., Minihane, A. M., Stoecklin, E., Barella, L., Dietary vitamin E modulates differential gene expression in the rat hippocampus: potential implications for its neuroprotectiveproperties, Nutr. Neurosci. 2005, 8, 21-29.
21. Eckert, G. P., Wood, W. G., Müller, W. E., Effects of aging and beta-amyloid on the properties of brain synaptic and mitochondrial membranes, J. Neural Transm. 2001, 108, 1051-1064.
22. Eckert, G. P., Cairns, N. J., Maras, A., Gattaz, W. F., Muller, W. E., Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease, Dement. Geriatr. Cogn. Disord. 2000, 11, 181-186.
23. Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J., Protein measurement with the Polin phenol reagent, J. Biol. Chem. 1951, 193, 265-275.
24. Auerbach, B. J., Parks, J. S., Applebaum-Bowden, D., A rapid and sensitive micro-assay for the enzymatic determination of plasma and lipoprotein cholesterol, J. Lipid Res. 1990, 31, 738-742.
25. Hawi, Z., Sheehan, K., Lynch, A., Evans, I., et al., Late onset alzheimer's disease and apolipoprotein association in the Irish population: relative risk and attributable fraction, Ir. J. Med. Sci. 2003, 172, 74-76.
26. Sing, C. F., Davignon, J., Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation, Am. J. Hum. Genet. 1985, 37, 268-285.
27. Lane, R. M., Farlow, M. R., Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease, J. Lipid Res. 2005, 46, 949-968.
28. Simons, K., Ikonen, E., Functional rafts in cell membranes, Nature 1997, 387, 569-572.
29. Simons, M., Keller, P., De Strooper, B., Beyreuther, K., et al., Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons, Proc. Natl. Acad. Sci. USA 1998, 95, 6460-6464.
30. Ramaswamy, G., Xu, Q., Huang, Y., Weisgraber, K. H., Effect of domain interaction on apolipoprotein E levels in mouse brain, J. Neurosci. 2005, 25, 10658-10663.
31. McShea, A., Harris, P. L., Webster, K. R., Wahl, A. F., Smith, M. A., Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease, Am. J. Pathol. 1997, 150, 1933-1939.
32. Nagy, Z., Esiri, M. M., Cato, A. M., Smith, A. D., Cell cycle markers in the hippocampus in Alzheimer's disease, Acta Neuropathol. (Berl). 1997, 94, 6-15.
33. Arendt, T., Holzer, M., Gärtner, U., Bruckner, M. K., Aberrancies in signal transduction and cell cycle related events in Alzheimer's disease, J. Neural Transm. Suppl. 1998, 54, 147-158.
34. Prives, C., Signaling to p53: breaking the MDM2-p53 circuit, Cell 1998, 95, 5-8.
35. Quelle, D. E., Zindy, F., Ashmun, R. A., Sherr, C. J., Alternative reading frames of the INK4a tumour suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest, Cell 1995, 83, 993-1000.
36. Weber, J. D., Jeffers, J. R., Rehg, J. E., Randle, D. H., et al., p53-independent functions of the p19(ARF) tumour suppressor, Genes Dev. 2000, 14, 2358-2365.