Syzygium cumini (L.) skeels: A prominent source of bioactive molecules against cardiometabolic diseases

Frontiers in Pharmacology

Volumn 6, Issue NOV, 2015, Pages

  Chagas, Vinicyus Teles ^a   França, Lucas Martins ^a   Malik, Sonia ^a   Paes, Antonio Marcus de Andrade ^a  

^a FEDERAL UNIVERSITY OF MARANHÃO   (Brazil)

Author keywords

Black plum; Complementary and alternative medicine; Ethnopharmacology; Jamun; Medicinal plants; Metabolic syndrome; Myrtaceae; Phenolic compounds

Indexed keywords

ALPHA CADINOL; ANTHOCYANIN; CAFFEIC ACID; CHLOROGENIC ACID; CINEOLE; CORILAGIN; CYANIDIN; DELPHINIDIN; ELLAGIC ACID; ELLAGITANNIN; EUCARVONE; FERULIC ACID; FLAVONOID; GALLIC ACID; MALVIDIN CHLORIDE; MUUROLOL; MYRICETIN; MYRTENOL; NILOCETIN; PEONIDIN; PETUNIDIN; PHENOL DERIVATIVE; PINENE; PLANT MEDICINAL PRODUCT; QUERCETIN; RUTOSIDE; SYZYGIUM CUMINI EXTRACT; TANNIN DERIVATIVE; TERPENE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTHRITIS; DRUG INDUSTRY; DRUG MECHANISM; DRUG TARGETING; HEART DISEASE; HEART PROTECTION; HERBAL MEDICINE; HUMAN; MEDICINAL PLANT; METABOLIC DISORDER; NONHUMAN; PAW EDEMA; SHORT SURVEY; SYZYGIUM CUMINI;

EID: 84949763939     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2015.00259     Document Type: Short Survey

References (76)

1. Alberti, K. G., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., et al. (2009). Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; american heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation 120, 1640-1645. doi: 10.1161/CIRCULATIONAHA.109.192644
2. Anandharajan, R., Jaiganesh, S., Shankernarayanan, N., Viswakarma, R., and Balakrishnan, A. (2006). In vitro glucose uptake activity of Aegles marmelos and Syzygium cumini by activation of Glut-4, PI3 kinase and PPAR γ in L6 myotubes. Phytomedicine 13, 434-441. doi: 10.1016/j.phymed.2005.03.008
3. Aqil, F., Gupta, A., Munagala, R., Jeyabalan, J., Kausar, H., Sharma, R. J., et al. (2012). Antioxidant and antiproliferative activities of anthocyanin/ellagitannin-enriched extracts from Syzygium cumini L. (Jamun, the Indian Blackberry). Nutr. Cancer 64, 428-438. doi: 10.1080/01635581.2012.657766
4. Arun, R., Prakash, M. V., Abraham, S. K., and Premkumar, K. (2011). Role of Syzygium cumini seed extract in the chemoprevention of in vivo genomic damage and oxidative stress. J. Ethnopharmacol. 134, 329-333. doi: 10.1016/j.jep.2010.12.014
5. Ayyanar, M., and Subash-Babu, P. (2012). Syzygium cumini (L.) Skeels: a review of its phytochemical constituents and traditional uses. Asian Pac. J. Trop. Biomed. 2, 240-246. doi: 10.1016/S2221-1691(12)60050-51
6. Baliga, M. S., Bhat, H. P., Baliga, B. R. V., Wilson, R., and Palatty, P. L. (2011). Phytochemistry, traditional uses and pharmacology of Eugenia jambolana Lam.(black plum): a review. Food Res. Int. 44, 1776-1789. doi: 10.1016/j.foodres.2011.02.007
7. Baliga, M. S., Fernandes, S., Thilakchand, K. R., D'souza, P., and Rao, S. (2013). Scientific validation of the antidiabetic effects of Syzygium jambolanum DC (black plum), a traditional medicinal plant of India. J. Altern. Complement. Med. 19, 191-197. doi: 10.1089/acm.2011.0752
8. Bardy, G., Virsolvy, A., Quignard, J., Ravier, M., Bertrand, G., Dalle, S., et al. (2013). Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells. Br. J. Pharmacol. 169, 1102-1113. doi: 10.1111/bph.12194
9. Bhatia, I., and Bajaj, K. (1975). Chemical constituents of the seeds and bark of Syzygium cumini. Planta Med. 28, 346-352. doi: 10.1055/s-0028-1097868
10. Bilal, R., Zakaria, M., Usman, A., and Zia, A. (2011). Comparison of simvastatin with Eugenia jambolana fruit pulp in their effects on Alanine Transferase, Aspartate Aminotransferase and Creatinine Phosphokinase levels of hyperlipidaemic rats. J. Pak. Med. Assoc. 61, 1190.
11. Birari, R. B., and Bhutani, K. K. (2007). Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discov. Today 12, 879-889. doi: 10.1016/j.drudis.2007.07.024
12. Brito, F. A., Lima, L. A., Ramos, M. F., Nakamura, M. J., Cavalher-Machado, S. C., Siani, A. C., et al. (2007). Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels. Braz. J. Med. Biol. Res. 40, 105-115. doi: 10.1590/S0100-879X2007000100014
13. Chaturvedi, A., Kumar, M. M., Bhawani, G., Chaturvedi, H., Kumar, M., and Goel, R. (2007). Effect of ethanolic extract of Eugenia jambolana seeds on gastric ulceration and secretion in rats. Indian J. Physiol. Pharmacol. 51, 131-140.
14. Corrêa, M. P., and Penna, L. D. A. (1974). Dicionário das Plantas úteis do Brasil e das Exóticas Cultivadas, Vol. 5. Rio de Janeiro: Instituto Brasiliero de Desenvolvimento Florestal, 687.
15. De Bona, K. S., Bellé, L. P., Sari, M. H., Thomé, G., Schetinger, M. R., Morsch, V. M., et al. (2010). Syzygium cumini extract decrease adenosine deaminase, 5' nucleotidase activities and oxidative damage in platelets of diabetic patients. Cell Physiol. Biochem. 26, 729-738. doi: 10.1159/000322340
16. Eshwarappa, R. S. B., Iyer, R. S., Subbaramaiah, S. R., Richard, S. A., and Dhananjaya, B. L. (2014). Antioxidant activity of Syzygium cumini leaf gall extracts. BioImpacts 4, 101-107. doi: 10.5681/bi.2014.018
17. Esmaeili, M. A., Zohari, F., and Sadeghi, H. (2009). Antioxidant and protective effects of major flavonoids from Teucrium polium on beta-cell destruction in a model of streptozotocin-induced diabetes. Planta Med. 75, 1418-1420. doi: 10.1055/s-0029-1185704
18. Gordon, A., Jungfer, E., Da Silva, B. A., Maia, J. G., and Marx, F. (2011). Phenolic constituents and antioxidant capacity of four underutilized fruits from the Amazon region. J. Agric. Food Chem. 59, 7688-7699. doi: 10.1021/jf201039r
19. Ha, D. T., Tuan, D. T., Thu, N. B., Nhiem, N. X., Ngoc, T. M., Yim, N., et al. (2009). Palbinone and triterpenes from moutan cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells. Bioorg. Med. Chem. Lett. 19, 5556-5559. doi: 10.1016/j.bmcl.2009.08.048
20. Haraguchi, H., Kanada, M., Fukuda, A., Naruse, K., Okamura, N., and Yagi, A. (1998). An inhibitor of aldose reductase and sorbitol accumulation from Anthocepharus chinensis. Planta Med. 64, 68-69.
21. Havsteen, B. H. (2002). The biochemistry and medical significance of the flavonoids. Pharmacol. Ther. 96, 67-202. doi: 10.1016/S0163-7258(02)00298-X
22. Helmstadter, A. (2008). Syzygium cumini (L.) SKEELS (Myrtaceae) against diabetes-125 years of research. Pharmazie 63, 91-101.
23. Herrera, M. D., Zarzuelo, A., Jiménez, J., Marhuenda, E., and Duarte, J. (1996). Effects of flavonoids on rat aortic smooth muscle contractility: structure-activity relationships. Gen. Pharmacol. 27, 273-277. doi: 10.1016/0306-3623(95)02010-1
24. Hotamisligil, G. S. (2006). Inflammation and metabolic disorders. Nature 444, 860-867. doi: 10.1038/nature05485
25. Hou, X., Liu, Y., Niu, L., Cui, L., and Zhang, M. (2014). Enhancement of voltage-gated K+ channels and depression of voltage-gated Ca2+ channels are involved in quercetin-induced vasorelaxation in rat coronary artery. Planta Med. 80, 465-472. doi: 10.1055/s-0034-1368320
26. Jain, A., Sharma, S., Goyal, M., Dubey, S., Jain, S., Sahu, J., et al. (2011). Anti-inflammatory activity of Syzygium cumini leaves. Int. J. Phytomed. 2, 124-126. doi: 10.3109/13880209.2013.768675
27. Jung, U. J., Lee, M.-K., Park, Y. B., Jeon, S.-M., and Choi, M.-S. (2006). Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice. J. Pharmacol. Exp. Ther. 318, 476-483. doi: 10.1124/jpet.106.105163
28. Kamalakkannan, N., and Prince, P. S. M. (2006). Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic Clin. Pharmacol. Toxicol. 98, 97-103. doi: 10.1111/j.1742-7843.2006.pto_241.x
29. Karthic, K., Kirthiram, K. S., Sadasivam, S., and Thayumanavan, B. (2008). Identification of alpha amylase inhibitors from Syzygium cumini linn seeds. Indian J. Exp. Biol. 46, 677-680.
30. Kohli, K., and Singh, R. (1993). A clinical trial of jambu (Eugenia jambolana) in non-insulin dependant diabetes mellitus. J. Res. Ayurveda Siddha 13, 89-97.
31. Kumar, A., Ilavarasan, R., Jayachandran, T., Deecaraman, M., Aravindan, P., Padmanabhan, N., et al. (2008a). Anti-diabetic activity of Syzygium cumini and its isolated compound against streptozotocin-induced diabetic rats. J. Med. Plants Res. 2, 246-249.
32. Kumar, E., Mastan, S., Reddy, K. R., Reddy, G. A., Raghunandan, N., and Chaitanya, G. (2008b). Anti-arthritic property of the methanolic extract of Syzygium cumini seeds. Int. J. Integr. Biol. 4, 55-61.
33. Lim, S. S., Vos, T., Flaxman, A. D., Danaei, G., Shibuya, K., Adair-Rohani, H., et al. (2012). A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2224-2260. doi: 10.1016/S0140-6736(12)61766-8
34. Liu, I.-M., Tzeng, T.-F., Liou, S.-S., and Lan, T.-W. (2007). Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats. Life Sci. 81, 1479-1488. doi: 10.1016/j.lfs.2007.08.045
35. Maciel, M. C., Farias, J. C., Maluf, M. J., Gomes, E. A., Pereira, P. V., Aragão-Filho, W. C., et al. (2008). Syzygium jambolanum treatment improves survival in lethal sepsis induced in mice. BMC Complement Altern. Med. 8:57. doi: 10.1186/1472-6882-8-57
36. Mahmoud, Ii Marzouk, M. S., Moharram, F. A., El-Gindi, M. R., and Hassan, A. M. (2001). Acylated flavonol glycosides from Eugenia jambolana leaves. Phytochemistry 58, 1239-1244. doi: 10.1016/S0031-9422(01)00365-X
37. Mastan, S., Chaitanya, G., Bhavya Latha, T., Srikanth, A., Sumalatha, G., and Eswar Kumar, K. (2009). Cardioprotective effect of methanolic extract of Syzygium cumini seeds on isoproterenol-induced myocardial infarction in rats. Der Pharm. Lett. 1, 143-149.
38. Mohamed, A. A., Ali, S. I., and El-Baz, F. K. (2013). Antioxidant and antibacterial activities of crude extracts and essential oils of Syzygium cumini leaves. PLoS ONE 8:e60269. doi: 10.1371/journal.pone.0060269
39. Muruganandan, S., Pant, S., Srinivasan, K., Chandra, S., Tandan, S. K., Lal, J., et al. (2002). Inhibitory role of Syzygium cumini on autacoid-induced inflammation in rats. Indian J. Physiol. Pharmacol. 46, 482-486.
40. Patel, S. S., Shah, R. S., and Goyal, R. K. (2009). Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats. Indian J. Exp. Biol. 47, 564-570.
41. Prabhakar, P. K., and Doble, M. (2008). A target based therapeutic approach towards diabetes mellitus using medicinal plants. Curr. Diabetes Rev. 4, 291-308. doi: 10.2174/157339908786241124
42. Raffaelli, F., Borroni, F., Alidori, A., Tirabassi, G., Faloia, E., Rabini, R. A., et al. (2014). Effects of in vitro supplementation with Syzygium cumini (L.) on platelets from subjects affected by diabetes mellitus. Platelets 26, 720-725. doi: 10.3109/09537104.2014.980797
43. Ramya, S., Neethirajan, K., and Jayakumararaj, R. (2012). Profile of bioactive compounds in Syzygium cumini-a review. J. Pharm. Res. 5, 4548-4553.
44. Ravi, K., Rajasekaran, S., and Subramanian, S. (2003). Hypoglycemic effect of Eugenia jambolana seed kernels on streptozotocin-induced diabetes in rats. Pharm. Biol. 41, 598-603. doi: 10.1080/13880200390501929
45. Ravi, K., Rajasekaran, S., and Subramanian, S. (2005). Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats. Food Chem. Toxicol. 43, 1433-1439. doi: 10.1016/j.fct.2005.04.004
46. Rekha, N., Balaji, R., and Deecaraman, M. (2008). Effect of aqueous extract of Syzygium cumini Pulp on antioxidant defense system in streptozotocin induced diabetic rats. Iran. J. Pharmacol. Ther. 7, 137-145.
47. Reynertson, K. A., Yang, H., Jiang, B., Basile, M. J., and Kennelly, E. J. (2008). Quantitative analysis of antiradical phenolic constituents from fourteen edible Myrtaceae fruits. Food Chem. 109, 883-890. doi: 10.1016/j.foodchem.2008.01.021
48. Ribeiro, R. M. (2007). Estudo da Atividade Hipotensora das Folhas de Syzygium Jambolanum DC (Jambolão). Mestrado Dissertação (Mestrado em Saúde e Ambiente), Universidade Federal do Maranhão, São Luís.
49. Ribeiro, R. M., Pinheiro Neto, V. F., Ribeiro, K. S., Vieira, D. A., Abreu, I. C., Silva Sdo, N., et al. (2014). Antihypertensive effect of Syzygium cumini in spontaneously hypertensive rats. Evid Based Complement. Alternat. Med. 2014:605452. doi: 10.1155/2014/605452
50. Ruan, Z. P., Zhang, L. L., and Lin, Y. M. (2008). Evaluation of the antioxidant activity of Syzygium cumini leaves. Molecules 13, 2545-2556. doi: 10.3390/molecules13102545
51. Schossler, D. R. C., Mazzanti, C. M., Luz, S. C. A. D., Filappi, A., Prestes, D., Silveira, A. F. D., et al. (2004). Syzygium cumini and the regeneration of insulin positive cells from the pancreatic duct. Braz. J. Vet. Res. Anim. Sci. 41, 236-239. doi: 10.1590/S1413-95962004000400003
52. Seo, Y. S., Kang, O. H., Kim, S. B., Mun, S. H., Kang, D. H., Yang, D. W., et al. (2015). Quercetin prevents adipogenesis by regulation of transcriptional factors and lipases in OP9 cells. Int. J. Mol. Med. 35, 1779-1785. doi: 10.3892/ijmm.2015.2185
53. Shafi, P. M., Rosamma, M. K., Jamil, K., and Reddy, P. S. (2002). Antibacterial activity of Syzygium cumini and Syzygium travancoricum leaf essential oils. Fitoterapia 73, 414-416. doi: 10.1016/S0367-326X(02)00131-4
54. Sharma, A. K., Bharti, S., Kumar, R., Krishnamurthy, B., Bhatia, J., Kumari, S., et al. (2011). Syzygium cumini ameliorates insulin resistance and β-cell dysfunction via modulation of PPAR, dyslipidemia, oxidative stress, and TNF-α in type 2 diabetic rats. J. Pharmacol. Sci. 119, 205-213. doi: 10.1254/jphs.11184FP
55. Sharma, A. K., Bharti, S., Kumar, R., Krishnamurthy, B., Bhatia, J., Kumari, S., et al. (2012). Syzygium cumini ameliorates insulin resistance and beta-cell dysfunction via modulation of PPAR, dyslipidemia, oxidative stress, and TNF-alpha in type 2 diabetic rats. J. Pharmacol. Sci. 119, 205-213. doi: 10.1254/jphs.11184FP
56. Sharma, B., Balomajumder, C., and Roy, P. (2008a). Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food Chem. Toxicol. 46, 2376-2383. doi: 10.1016/j.fct.2008.03.020
57. Sharma, B., Viswanath, G., Salunke, R., and Roy, P. (2008b). Effects of flavonoid-rich extract from seeds of Eugenia jambolana (L.) on carbohydrate and lipid metabolism in diabetic mice. Food Chem. 110, 697-705. doi: 10.1016/j.foodchem.2008.02.068
58. Shaw, J. E., Sicree, R. A., and Zimmet, P. Z. (2010). Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 87, 4-14. doi: 10.1016/j.diabres.2009.10.007
59. Silva, S. D. N., Abreu, I. C., Silva, G. F. C., Ribeiro, R. M., Lopes, A. D. S., Cartágenes, M. D. S. D. S., et al. (2012). The toxicity evaluation of Syzygium cumini leaves in rodents. Rev. Bras. Farm. 22, 102-108. doi: 10.1590/S0102-695X2011005000181
60. Srivastava, S., and Chandra, D. (2013). Pharmacological potentials of Syzygium cumini: a review. J. Sci. Food Agric. 93, 2084-2093. doi: 10.1002/jsfa.6111
61. Srivastava, Y., Bhatt, H., Gupta, O., and Gupta, P. (1983). Hypoglycemia induced by Syzygium cumini Linn. seeds in diabetes mellitus. Asian Med. J. 26, 489-492.
62. Stefanello, M. E., Pascoal, A. C., and Salvador, M. J. (2011). Essential oils from neotropical Myrtaceae: chemical diversity and biological properties. Chem. Biodivers. 8, 73-94. doi: 10.1002/cbdv.201000098
63. Subramanian, S. S., and Nair, A. G. R. (1972). Flavonoids of the flowers of Eugenia jambolana. Curr. Sci. 41, 703-704.
64. Tanwar, R. S., Sharma, S. B., Singh, U. R., and Prabhu, K. M. (2011). Antiatherosclerotic potential of active principle isolated from Eugenia jambolana in streptozotocin-induced diabetic rats. Evid. Based Complement. Alternat. Med. 2011:127641. doi: 10.1155/2011/127641
65. Teixeira, C., Fuchs, F., Weinert, L., and Esteves, J. (2006). The efficacy of folk medicines in the management of type 2 diabetes mellitus: results of a randomized controlled trial of Syzygium cumini (L.) Skeels. J. Clin. Pharm. Ther. 31, 1-5. doi: 10.1111/j.1365-2710.2006.00700.x
66. Teixeira, C. C., Rava, C. A., Da Silva, P. M., Melchior, R., Argenta, R., Anselmi, F., et al. (2000). Absence of antihyperglycemic effect of jambolan in experimental and clinical models. J. Ethnopharmacol. 71, 343-347. doi: 10.1016/S0378-8741(00)00185-9
67. Timbola, A. K., Szpoganicz, B., Branco, A., Monache, F. D., and Pizzolatti, M. G. (2002). A new flavonol from leaves of Eugenia jambolana. Fitoterapia 73, 174-176. doi: 10.1016/S0367-326X(02)00009-6
68. Tripathi, P., Tripathi, R., Patel, R. K., and Pancholi, S. S. (2013). Investigation of antimutagenic potential of Foeniculum vulgare essential oil on cyclophosphamide induced genotoxicity and oxidative stress in mice. Drug Chem. Toxicol. 36, 35-41. doi: 10.3109/01480545.2011.648328
69. Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., and Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39, 44-84. doi: 10.1016/j.biocel.2006.07.001
70. Vasudeva, N., Yadav, N., and Sharma, S. K. (2012). Natural products: a safest approach for obesity. Chin. J. Integr. Med. 18, 473-480. doi: 10.1007/s11655-012-1120-0
71. Veigas, J. M., Narayan, M. S., Laxman, P. M., and Neelwarne, B. (2007). Chemical nature, stability and bioefficacies of anthocyanins from fruit peel of Syzygium cumini Skeels. Food Chem. 105, 619-627. doi: 10.1016/j.foodchem.2007.04.022
72. Vernin, G., Vernin, G., Metzger, J., Roque, C., and Pieribattesti, J.-C. (1991). Volatile constituents of the jamrosa aroma Syzygium jambos L. aston from Reunion Island. J. Essent. Oil Res. 3, 83-97. doi: 10.1080/10412905.1991.9697916
73. Warrier, P. K. (1997). Indian Medicinal Plants: A Compendium of 500 Species. Hyderabad: Orient Blackswan.
74. Wein, S., Behm, N., Petersen, R. K., Kristiansen, K., and Wolffram, S. (2010). Quercetin enhances adiponectin secretion by a PPAR-gamma independent mechanism. Eur. J. Pharm. Sci. 41, 16-22. doi: 10.1016/j.ejps.2010.05.004
75. Williamson, E. M., Foundation, D. R., and Limited, D. A. (2002). Major Herbs of Ayurveda. London: Churchill Livingstone.
76. Yanovski, S. Z., and Yanovski, J. A. (2014). Long-term drug treatment for obesity: a systematic and clinical review. JAMA 311, 74-86. doi: 10.1001/jama.2013.281361