In vitro glucose uptake activity of Aegles marmelos and Syzygium cumini by activation of Glut-4, PI3 kinase and PPARγ in L6 myotubes

Phytomedicine

Volumn 13, Issue 6, 2006, Pages 434-441

  Anandharajan, R ^a   Jaiganesh, S ^a   Shankernarayanan, N P ^b   Viswakarma, R A ^c   Balakrishnan, A ^d  

^a ANNA UNIVERSITY   (India)

^b Leprosy Project   (India)

^c NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^d Piramal Enterprises Limited   (India)

Author keywords

Aegles marmelos; Glucose transport; L6 myotubes; PI3 kinase; PPAR ; Syzygium cumini

Indexed keywords

AEGLE MARMELOS EXTRACT; ANTIDIABETIC AGENT; CYCLOHEXIMIDE; DEOXYGLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; METHANOL EXTRACTION RESIDUE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; ROSIGLITAZONE;

AEGLE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; ENZYME ACTIVATION; GLUCOSE TRANSPORT; MEDICINAL PLANT; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; TRADITIONAL MEDICINE; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AEGLE; ANIMALS; BIOLOGICAL TRANSPORT; EUGENIA; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; MUSCLE FIBERS; PHYTOTHERAPY; PLANT EXTRACTS; PPAR GAMMA; RATS; UP-REGULATION;

SYZYGIUM CUMINI;

EID: 33646584866     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2005.03.008     Document Type: Article

References (24)

1. Anandharajan R., Pathmanathan K., Shankernarayanan N.P., Viswakarma R.A., and Balakrishnan A. Upregulation of Glut-4 and PPARγ by an isoflavone from Pterocarpus marsupium on L6 myotubes: a possible mechanism of action. J. Ethnopharmacol. 97 (2005) 253-260
2. Bailey C.J., and Day C. Traditional plant medicines as treatment for diabetes. Diabetes Care 12 (1989) 553-564
3. Bandyopadhyay G., Standaert M.L., Galloway L., Moscat J., and Farese R.V. Evidence for involvement of protein kinase C (PKC)-ζ and non-involvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubules. Endocrinology 138 (1997) 4721-4731
4. Buhl E.S., Jessen N., Schmitz O., Steen B., Pedersen S.B., Pedersen O., Holman G.D., and Lund S. Chronic treatment with 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside increases insulin-stimulated glucose uptake and GLUT-4 translocation in rat skeletal muscles in a fiber type-specific manner. Diabetes 50 (2001) 12-17
5. Ciaraldi T.P., Huber-Khudsen K., Hickman M., and Olefsky J.M. Regulation of glucose transport in cultured muscle cells by novel hypoglycemic agents. Metabolism 44 (1995) 976-981
6. Desvergne B., and Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrine Rev. 20 (1999) 649-688
7. Fukumoto H., Kayano T., Buse J.B., Edwards Y., Pilch P.F., Bell G.I., and Seino S. Cloning and characterization of the major insulin responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. J. Biol. Chem. 264 (1989) 7776-7779
8. Garvey W.T., Maianu L., and Zhu J.H. Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes. Heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transporters. Diabetes 42 (1993) 1773-1785
9. Hall L.R., Mehlotra R.K., Higgins A.W., Haxhiu M.A., and Pearlman E. An essential role for interleukin-5 and eosinophils in helminth-induced airway hyper-responsiveness. Infect. Immun. 66 (1998) 4425-4430
10. Kausch C., Krützfeldt J., Witke A., Rettig A., Bachmann O., Rett K., Matthaei S., Machicao F., Häring H.-U., and Stumvoll M. Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem. Biophys. Res. Commun. 280 (2001) 664-674
11. Kellerer M., Lammers R., and Haring H.U. Insulin signal transduction; possible mechanism for insulin resistance. Exp. Clin. Endocrinol. Diabetes 107 (1999) 97-106
12. Koivisto U.-M., Martinez-Valdez H., Bilan P.J., Burdett E., Ramlal T., and Klip A. Differential regulation of the GLUT1 and GLUT4 glucose transport systems by glucose and insulin in L6 muscle cells in culture. J. Biol. Chem. 266 (1991) 615-2621
13. Laville M., Auboeuf D., Khalfallah Y., Vega N., Riou J.P., and Vidal H. Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle. J. Clin. Invest. 98 (1996) 43-49
14. Nolan J.J., Ludvik B., Beerdsen P., Joyce M., and Olefsky J.M. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. New Engl. J. Med. 331 (1994) 1188-1193
15. Ntambi J.M., and Young-Cheul K. Adipocyte differentiation and gene expression. J. Nutr. 130 (2000) 3122S-3126S
16. Okada T., Kawano T., Sakakibara T., Hazeki O., and Ui M. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and anti-lipolysis in rat adipocytes-studies with a selective inhibitor wortmannin. J. Biol. Chem. 269 (1994) 3568-3573
17. Petersen K.F., Krssak M., Inzucchi S., Cline G.W., Dufour S., and Shulman G.I. Mechanism of troglitazone action in type 2 diabetes. Diabetes 49 (2000) 827-831
18. Ponnachan P.T., Paulose C.S., and Panikkar K.R. Effect of leaf extract of Aegle marmelos in diabetic rats. Indian J. Exp. Biol. 31 (1993) 345-347
19. Sahni S.K., Turpin L.C., Brown T.L., and Sporn L.A. Involvement of protein kinase C in Rickettsia rickettsii-induced transcriptional activation of the host endothelial cell. Infect. Immun. 67 (1999) 6418-6423
20. Shimaya A., Kurosaki E., Shioduka K., Nakano R., Shibasaki M., and Shikama H. YM268 increases the glucose uptake, cell differentiation, and mRNA expression of glucose transporter in 3T3-L1 adipocytes. Hormone Metab. Res. 30 (1998) 543-548
21. Teixeira C.C., Pinto L.P., Kessler F.H., and Fuchs F.D. The effect of Syzygium cumini (L) skeels on post-prandial blood glucose levels in non-diabetic rats and rats with streptozotocin-induced diabetes mellitus. J. Ethanopharmacol. 56 (1997) 209-213
22. Tsakiridis T., McDowell H.E., Walker T., Downes C.P., Hundal H.S., Vranic M., and Klip A. Multiple roles of phosphatidlyionosital 3-kinase in regulation of glucose transport, aminoacid transport and glucose transporters in L6 skeletal muscle cells. Endocrinology 136 (1995) 4315-4322
23. Yonemitsu S., Nishimura H., Shintani M., Inoue R., Yamamoto Y., Masuzaki H., Ogawa Y., Hosoda K., Inoue G., Hayashi T., and Nakao K. Troglitazone induces GLUT4 translocation in L6 myotubes. Diabetes 50 (2001) 1093-1101
24. Ziel F.H., Venkatesan N., and Davidson M.B. Glucose transport is rate limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic rats. Diabetes 37 (1988) 885-890