Antioxidant and antiproliferative activities of anthocyanin/ellagitannin- enriched extracts from Syzygium cumini L. (Jamun, the Indian Blackberry)

Nutrition and Cancer

Volumn 64, Issue 3, 2012, Pages 428-438

  Aqil, Farrukh ^a   Gupta, Akash ^a   Munagala, Radha ^a   Jeyabalan, Jeyaprakash ^a   Kausar, Hina ^a   Sharma, Ram Jee ^b   Singh, Inder Pal ^b   Gupta, Ramesh C ^c  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^c University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANTHOCYANIN; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CYANIDIN 3 GLUCOSIDE; DELPHINIDIN; ELLAGIC ACID; ELLAGITANNIN; MALVIDIN CHLORIDE; OXYGEN RADICAL; POLACRILIN; POLYPHENOL DERIVATIVE; SYZYGIUM CUMINI EXTRACT; TROLOX C;

ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CHEMOPROPHYLAXIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; LUNG NON SMALL CELL CANCER; PLANT SEED; POWDER; SYZYGIUM CUMINI;

ANTHOCYANINS; ANTIOXIDANTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EUGENIA; FRUIT; HUMANS; HYDROLYZABLE TANNINS; PLANT EXTRACTS; SEEDS;

RUBUS; SYZYGIUM CUMINI;

EID: 84859736882     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2012.657766     Document Type: Article

References (41)

1. Steer, P, Millgard, J, Sarabi, D M, Basu, S, Vessby, B. 2002. Cardiac and vascular structure and function are related to lipid peroxidation and metabolism. Lipids, 37: 231-236. (Pubitemid 34274046)
2. Cheeseman, K H, and, Slater, T F. 1993. An introduction to free radical biochemistry. Br Med Bull, 49: 481-493. (Pubitemid 23243824)
3. Yu, L, Haley, S, Perret, J, Harris, M, Wilson, J. 2002. Free radical scavenging properties of wheat extracts. J Agric Food Chem, 50: 1619-1624. (Pubitemid 34233235)
4. Naczk, M, and, Shahidi, F. 2006. Phenolics in cereals, fruits and vegetables: occurrence, extraction and analysis. J Pharm Biomed Anal, 41: 1523-1542. (Pubitemid 44247468)
5. Liu, F, and, Ng, T B. 2000. Antioxidative and free radical scavenging activities of selected medicinal herbs. Life Sci, 66: 725-735. (Pubitemid 30077865)
6. Savikin, K, Zdunic, G, Jankovic, T, Tasic, S, Menkovic, N. 2009. Phenolic content and radical scavenging capacity of berries and related jams from certificated area in Serbia. Plant Foods Hum Nutr, 64: 212-217.
7. Ivanova, D, Gerova, D, Chervenkov, T, and, Yankova, T. 2005. Polyphenols and antioxidant capacity of Bulgarian medicinal plants. J Ethnopharmacol, 96: 145-150. (Pubitemid 39575044)
8. Rice-Evans, C A, and, Miller, N J. 1996. Antioxidant activities of flavonoids as bioactive components of food. Biochem Soc Trans, 24: 790-795. (Pubitemid 26306300)
9. Perron, N R, and, Brumaghim, J L. 2009. A review of the antioxidant mechanisms of polyphenol compounds related to iron binding. Cell Biochem Biophys, 53: 75-100.
10. Mazza, G J. 2007. Anthocyanins and heart health. Ann Ist Super Sanita, 43: 369-374.
11. Jayaprakasam, B, Olson, L K, Schutzki, R E, Tai, M H, and, Nair, M G. 2006. Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem, 54: 243-248. (Pubitemid 43119946)
12. Andres-Lacueva, C, Shukitt-Hale, B, Galli, R L, Jauregui, O, Lamuela-Raventos, R M. 2005. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci, 8: 111-120. (Pubitemid 40959652)
13. Aiyer, H S, Srinivasan, C, and, Gupta, R C. 2008. Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats. Nutr Cancer, 60: 227-234. (Pubitemid 351454024)
14. Stoner, G D, Wang, L S, Zikri, N, Chen, T, Hecht, S S. 2007. Cancer prevention with freeze-dried berries and berry components. Semin Cancer Biol, 17: 403-410. (Pubitemid 47376814)
15. Wang, L S, and, Stoner, G D. 2008. Anthocyanins and their role in cancer prevention. Cancer Lett, 269: 281-290.
16. Achrekar, S, Kaklij, G S, Pote, M S, and, Kelkar, S M. 1991. Hypoglycemic activity of Eugenia jambolana and Ficus bengalensis: mechanism of action. In Vivo, 5: 143-147.
17. Chaturvedi, A, Bhawani, G, Agarwal, P K, Goel, S, Singh, A. 2009. Antidiabetic and antiulcer effects of extract of Eugenia jambolana seed in mild diabetic rats: study on gastric mucosal offensive acid-pepsin secretion. Indian J Physiol Pharmacol, 53: 137-146.
18. Veigas, J M, Narayan, M S, Laxman, P M, and, Neelwarne, B. 2007. Chemical nature, stability and bioefficacies of anthocyanins from fruit peel of syzygium cumini Skeels. Food Chem, 105: 619-627. (Pubitemid 47048555)
19. Prince, P S, Menon, V P, and, Pari, L. 1998. J Ethnopharmacol, 61: 1-7.:Hypoglycaemic activity of Syzigium cumini seeds: effect on lipid peroxidation in alloxan diabetic rats.
20. Kaur, C, and, Kapoor, H C. 2005. Antioxidant activity of some fruits in Indian diet. Vol. 696, 593-565. Acta Hort(ISHS)
21. Arun, R, Prakash, M V, Abraham, S K, and, Premkumar, K. 2011. Role of Syzygium cumini seed extract in the chemoprevention of in vivo genomic damage and oxidative stress. J Ethnopharmacol, 134: 329-333.
22. Li, L, Adams, L S, Chen, S, Killian, C, Ahmed, A. 2009. Eugenia jambolana Lam. berry extract inhibits growth and induces apoptosis of human breast cancer but not nontumorigenic breast cells. J Agric Food Chem, 57: 826-831.
23. Benherlal, P S, and, Arumughan, C. 2007. Chemical composition and in vitro antioxidant studies on Syzygium cumini fruit. J Sci Food Agric, 87: 2560-2569. (Pubitemid 350033239)
24. Sharma, M, Li, L, Celver, J, Killian, C, Kovoor, A. 2010. Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling. J Agric Food Chem, 58: 3965-3969.
25. Khknen, M P, Heinmki, J, Ollilainen, V, and, Heinonen, M. 1984. Berry anthocyanins: isolation, identification, and antioxidant activities. J Sci Food Agric, 83: 1403-1411.
26. Seeram, N P, Lee, R, Hardy, M L, and, Heber, D. 2005. Rapid large-scale purification of ellagitannins from pomegranate husk, a by-product of the commercial juice industry. Separ Purific Technol, 41: 49-55.
27. Lee, J, Durst, R W, and, Wrolstad, R E. 2005. Determination of total monomeric anthocyanin pigment content of fruit juices, beverages, natural colorants, and wines by the pH differential method: collaborative study. J AOAC Int, 88: 1269-1278. (Pubitemid 41568360)
28. Guisti, M M, and, Wrolstad, R E. 2001. Characterization and measurement of anthocyanins by UV-visible spectroscopy. In Currents Protocols in Food Analytical Chemistry, Edited by: Wrolstad, R E. 1-13. New York, NY: John Wiley & Sons.
29. Yemm, E W, and, Willis, A J. 1954. The estimation of carbohydrates in plant extracts by anthrone. Biochem J, 57: 508-514.
30. Lister, E, and, Wilson, P. 2001. Measurement of total phenolics and ABTS assay for antioxidant activity. Edited by: Crop Research Institute. Lincoln, New Zealand
31. Ou, B, Hampsch-Woodill, M, and, Prior, R L. 2001. Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem, 49: 4619-4626. (Pubitemid 32988695)
32. Gyamfi, M A, Yonamine, M, and, Aniya, Y. 1999. Free-radical scavenging action of medicinal herbs from Ghana: Thonningia sanguinea on experimentally induced liver injuries. Gen Pharmacol, 32: 661-667. (Pubitemid 29287176)
33. Re, R, Pellegrini, N, Proteggente, A, Pannala, A, Yang, M. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med, 26: 1231-1237. (Pubitemid 29262709)
34. Ak, T, and, Gulcin, I. 2008. Antioxidant and radical scavenging properties of curcumin. Chemico-Biological Interac, 174: 27-37.
35. Oyaizu, M. 1986. Studies on product of browning reaction prepared from glucose amine. Jpn J Nutr, 44: 307-315.
36. Munagala, R, Kausar, H, Munjal, C, and, Gupta, R C. 2011. Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells. Carcinogenesis, 32: 1697-1705.
37. Aiyer, H S, and, Gupta, R C. 2010. Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. Cancer Prev Res (Phila), 3: 727-737.
38. Prior, R L, Cao, G H, Martin, A, Sofic, E, McEwen, J. 1998. Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity, and variety of Vaccinium species. J Agric Food Chem, 46: 2686-2693. (Pubitemid 128488357)
39. Aiyer, H S, Vadhanam, M V, Stoyanova, R, Caprio, G D, Clapper, M L. 2008. Dietary berries and ellagic acid prevent oxidative DNA damage and modulate expression of DNA repair genes. Int J Mol Sci, 9: 327-341. (Pubitemid 351482118)
40. Kehrer, J P. 2000. The Haber-Weiss reaction and mechanisms of toxicity. Toxicology, 149: 43-50. (Pubitemid 30645786)
41. Adams, L S, Zhang, Y, Seeram, N P, Heber, D, and, Chen, S. 2010. Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev Res (Phila), 3: 108-113.