Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 19, 2009, Pages 5556-5559

  Ha, Do Thi ^a,b   Tuan, Dao Trong ^b   Thu, Nguyen Bich ^b   Nhiem, Nguyen Xuan ^a   Ngoc, Tran Minh ^a   Yim, NamHui ^a   Bae, KiHwan ^a  

^a Chungnam National University   (South Korea)

^b National Institute of Medicinal Materials   (Viet Nam)

Author keywords

AMP activated protein kinase; Glucose uptake; Glycogen synthesis; Moutan Cortex; Palbinone; Type 2 diabetes

Indexed keywords

30 NORHEDERAGENIN; ACETYL COENZYME A CARBOXYLASE; ANTIDIABETIC AGENT; BETULIC ACID; DAUCOSTEROL; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; OLEANOLIC ACID; PALBINONE; SITOSTEROL; TRITERPENE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; URSOLIC ACID;

ARTICLE; DOSE RESPONSE; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INSULIN RESISTANCE; PAEONIA SUFFRUTICOSA;

AMP-ACTIVATED PROTEIN KINASES; CELL LINE, TUMOR; DIABETES MELLITUS, TYPE 2; DRUGS, CHINESE HERBAL; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; PAEONIA; PHOSPHORYLATION; TERPENES; TRITERPENES;

PAEONIA SUFFRUTICOSA; PAEONIACEAE;

EID: 70049110010     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.048     Document Type: Article

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