Mechanisms of unconventional secretion of IL-1 family cytokines

Cytokine

Volumn 74, Issue 2, 2015, Pages 213-218

  Monteleone, Mercedes ^a   Stow, Jennifer L ^a   Schroder, Kate ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Caspase 1; Inflammasome; Interleukin 1; Unconventional secretion

Indexed keywords

INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 33; INTERLEUKIN 37; IL1B PROTEIN, HUMAN;

ARTICLE; AUTOPHAGY; CELL DEATH; CELL MEMBRANE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EXOSOME; HUMAN; INNATE IMMUNITY; LYSOSOME; MEMBRANE MICROPARTICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN SECRETION; SIGNAL TRANSDUCTION; ALZHEIMER DISEASE; ANIMAL; ARTHRITIS; GOUT; IMMUNOLOGY; MACROPHAGE; METABOLISM; PATHOLOGY; SECRETION (PROCESS);

ALZHEIMER DISEASE; ANIMALS; ARTHRITIS; CASPASE 1; GOUT; HUMANS; INTERLEUKIN-1BETA; MACROPHAGES;

EID: 84949727038     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2015.03.022     Document Type: Article

References (58)

1. Murray R.Z., Stow J.L. Cytokine secretion in macrophages: SNAREs, rabs, and membrane trafficking. Front Immunol 2014, 5:538.
2. Chen K.W., Schroder K. Antimicrobial functions of inflammasomes. Curr Opin Microbiol 2013, 16:311-318.
3. Masters S.L., Simon A., Aksentijevich I., Kastner D.L. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease. Annu Rev Immunol 2009, 27:621-668.
4. Dinarello C.A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011, 117:3720-3732.
5. Dinarello C.A. Interleukin-18 and the pathogenesis of inflammatory diseases. Semin Nephrol 2007, 27:98-114.
6. Schroder K., Tschopp J. The inflammasomes. Cell 2010, 140:821-832.
7. Keller M., Rüegg A., Werner S., Beer H.-D. Active caspase-1 is a regulator of unconventional protein secretion. Cell 2008, 132:818-831.
8. Rubartelli A., Cozzolino F., Talio M., Sitia R. A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBO J 1990, 9:1503-1510.
9. Martinon F., Burns K., Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002, 10:417-426.
10. Hazuda D.J., Lee J.C., Young P.R. The kinetics of interleukin 1 secretion from activated monocytes. Differences between interleukin 1 alpha and interleukin 1 beta. J Biol Chem 1988, 263:8473-8479.
11. Andrei C., Dazzi C., Lotti L., Torrisi M.R., Chimini G., Rubartelli A. The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles. Mol Biol Cell 1999, 10:1463-1475.
12. MacKenzie A., Wilson H.L., Kiss-Toth E., Dower S.K., North R.A., Surprenant A. Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 2001, 15:825-835.
13. Andrei C., Margiocco P., Poggi A., Lotti L.V., Torrisi M.R., Rubartelli A. Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes. Proc Natl Acad Sci USA 2004, 101:9745-9750.
14. Pizzirani C., Ferrari D., Chiozzi P., Adinolfi E., Sandona D., Savaglio E., et al. Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells. Blood 2007, 109:3856-3864.
15. Brough D., Rothwell N.J. Caspase-1-dependent processing of pro-interlukin-1β is cytosolic and precedes cell death. J Cell Sci 2007, 120:772-781.
16. Man S.M., Hopkins L.J., Nugent E., Cox S., Gluck I.M., Tourlomousis P., et al. Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex. Proc Natl Acad Sci USA 2014, 111:7403-7408.
17. Franklin B.S., Bossaller L., De Nardo D., Ratter J.M., Stutz A., Engels G., et al. The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation. Nat Immunol 2014, 15:727-737.
18. Qu Y., Franchi L., Núñez G., Dubyak G.R. Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J Immunol 2007, 179:1913-1925.
19. Brough D., Le Feuvre R.A., Wheeler R.D., Solovyova N., Hilfiker S., Rothwell N.J., et al. Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages. J Immunol 2003, 170:3029-3036.
20. Öhman T., Teirilä L., Lahesmaa-Korpinen A.-M., Cypryk W., Veckman V., Saijo S., et al. Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages. J Immunol 2014, 192:5952-5962.
21. Qu Y., Ramachandra L., Mohr S., Franchi L., Harding C.V., Nunez G., et al. P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1. J Immunol 2009, 182:5052-5062.
22. Gross O., Yazdi A.S., Thomas C.J., Masin M., Heinz L.X., Guarda G., et al. Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 2012, 36:388-400.
23. Fernandes-Alnemri T., Wu J., Yu J.W., Datta P., Miller B., Jankowski W., et al. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 2007, 14:1590-1604.
24. Harris J., Hartman M., Roche C., Zeng S.G., O'Shea A., Sharp F.A., et al. Autophagy controls IL-1β secretion by targeting pro-IL-1β for degradation. J Biol Chem 2011.
25. Singer I.I., Scott S., Chin J., Bayne E.K., Limjuco G., Weidner J., et al. The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy. J Exp Med 1995, 182:1447-1459.
26. Dupont N., Jiang S., Pilli M., Ornatowski W., Bhattacharya D., Deretic V. Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β. EMBO J 2011, 30:4701-4711.
27. Fink S.L., Cookson B.T. Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol 2006, 8:1812-1825.
28. Liu T., Yamaguchi Y., Shirasaki Y., Shikada K., Yamagishi M., Hoshino K., et al. Single-cell imaging of caspase-1 dynamics reveals an all-or-none inflammasome signaling response. Cell Rep 2014, 8:974-982.
29. Shirasaki Y., Yamagishi M., Suzuki N., Izawa K., Nakahara A., Mizuno J., et al. Real-time single-cell imaging of protein secretion. Sci Rep 2014, 4:4736.
30. Verhoef P.A., Kertesy S.B., Estacion M., Schilling W.P., Dubyak G.R. Maitotoxin induces biphasic interleukin-1beta secretion and membrane blebbing in murine macrophages. Mol Pharmacol 2004, 66:909-920.
31. Verhoef P.A., Kertesy S.B., Lundberg K., Kahlenberg J.M., Dubyak G.R. Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor. J Immunol 2005, 175:7623-7634.
32. Pelegrin P., Barroso-Gutierrez C., Surprenant A. P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol 2008, 180:7147-7157.
33. Chen K.W., Gross C.J., Sotomayor F.V., Stacey K.J., Tschopp J., Sweet M.J., et al. The neutrophil NLRC4 inflammasome selectively promotes IL-1beta maturation without pyroptosis during acute Salmonella challenge. Cell Rep 2014, 8:570-582.
34. Hamon Y., Luciani M.F., Becq F., Verrier B., Rubartelli A., Chimini G. Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1. Blood 1997, 90:2911-2915.
35. Zhou X., Engel T., Goepfert C., Erren M., Assmann G., von Eckardstein A. The ATP binding cassette transporter A1 contributes to the secretion of interleukin 1beta from macrophages but not from monocytes. Biochem Biophys Res Commun 2002, 291:598-604.
36. Ikeda Y., Murakami A., Fujimura Y., H Tachibana, Yamada K., Masuda D., et al. Aggregated ursolic acid a natural triterpenoid induces IL-1beta release from murine peritoneal macrophages: role of CD36. J Immunol 2007, 4854-4864.
37. Lamkanfi M., Mueller J.L., Vitari A.C., Misaghi S., Fedorova A., Deshayes K., et al. Glyburide inhibits the cryopyrin/Nalp3 inflammasome. J Cell Biol 2009, 187:61-70.
38. Steringer J.P., Müller H.-M., Nickel W. Unconventional secretion of fibroblast growth factor 2-A novel type of protein translocation across membranes?. J Mol Biol 2014.
39. Cordoba-Rodriguez R., Fang H., Lankford C.S.R., Frucht D.M. Anthrax lethal toxin rapidly activates caspase-1/ICE and induces extracellular release of interleukin (IL)-1beta and IL-18. J Biol Chem 2004, 279:20563-20566.
40. Perregaux D.G., McNiff P., Laliberte R., Conklyn M., Gabel C.A. ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood. J Immunol 2000, 165:4615-4623.
41. Bulau A.M., Nold M.F., Li S., Nold-Petry C.A., Fink M., Mansell A., et al. Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. Proc Natl Acad Sci USA 2014, 111:2650-2655.
42. Nold-Petry C.A., Lo C.Y., Rudloff I., Elgass K.D., Li S., Gantier M.P., et al. IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. Nat Immunol 2015, 16:354-365.
43. Li S., Neff C.P., Barber K., Hong J., Luo Y., Azam T., et al. Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8. Proc Natl Acad Sci USA 2015, 112:2497-2502.
44. England H., Summersgill H.R., Edye M.E., Rothwell N.J., Brough D. Release of interleukin-1α or interleukin-1β depends on mechanism of cell death. J Biol Chem 2014, 289:15942-15950.
45. Lima H., Jacobson L.S., Goldberg M.F., Chandran K., Diaz-Griffero F., Lisanti M.P., et al. Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death. Cell Cycle 2013, 12:1868-1878.
46. Chen C.J., Kono H., Golenbock D., Reed G., Akira S., Rock K.L. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med 2007, 13:851-856.
47. Zhao W., Hu Z. The enigmatic processing and secretion of interleukin-33. Cell Mol Immunol 2010, 7:260-262.
48. Luthi A.U., Cullen S.P., McNeela E.A., Duriez P.J., Afonina I.S., Sheridan C., et al. Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. Immunity 2009, 31:84-98.
49. Talabot-Ayer D., Lamacchia C., Gabay C., Palmer G. Interleukin-33 is biologically active independently of caspase-1 cleavage. J Biol Chem 2009, 284:19420-19426.
50. Ohno T., Oboki K., Kajiwara N., Morii E., Aozasa K., Flavell R.A., et al. Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages. J Immunol 2009, 183:7890-7897.
51. Timms A.E., Crane A.M., Sims A.M., Cordell H.J., Bradbury L.A., Abbott A., et al. The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis. Am J Hum Genet 2004, 75:587-595.
52. Liu N., Li X., Liu C., Zhao Y., Cui B., Ning G. The association of interleukin-1alpha and interleukin-1beta polymorphisms with the risk of Graves' disease in a case-control study and meta-analysis. Hum Immunol 2010, 71:397-401.
53. Dinarello C.A. Anti-inflammatory agents: Present and future. Cell 2010, 140:935-950.
54. So A., De Meulemeester M., Pikhlak A., Yucel A.E., Richard D., Murphy V., et al. Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study. Arthritis Rheum 2010, 62:3064-3076.
55. Rubartelli A. DAMP-mediated activation of NLRP3-inflammasome in brain sterile inflammation: the fine line between healing and neurodegeneration. Front Immunol 2014, 5:99.
56. Fantuzzi G., Reed D.A., Dinarello C.A. IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor. J Clin Invest 1999, 104:761-767.
57. Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M., Gabel C.A., et al. Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity. J Biol Chem 2011, 286:42594-42602.
58. Lin H., Ho A.S., Haley-Vicente D., Zhang J., Bernal-Fussell J., Pace A.M., et al. Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. J Biol Chem 2001, 276:20597-20602.