The enigmatic processing and secretion of interleukin-33

Cellular and Molecular Immunology

Volumn 7, Issue 4, 2010, Pages 260-262

  Zhao, Weihua ^a   Hu, Zhiqing ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Caspase 1; Interleukin 1 family; Interleukin 33; Intracrine; Necrocrine

Indexed keywords

INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 33; MESSENGER RNA; PROTEIN ST2; UNCLASSIFIED DRUG; IL33 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE;

AUTOIMMUNE DISEASE; BASOPHIL; CELL ACTIVATION; CELL DEATH; CELL INTERACTION; CHROMATIN; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EOSINOPHIL; HUMAN; IMMUNOREGULATION; INFECTION; INFLAMMATION; MAST CELL; NONHUMAN; PARACRINE SIGNALING; PATHOGENESIS; PHENOTYPE; POLARIZATION; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PROCESSING; RECEPTOR BINDING; REVIEW; RNA TRANSLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH2 CELL; ANIMAL; IMMUNOLOGY; METABOLISM; SECRETION;

ANIMALS; HUMANS; INTERLEUKINS; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 77957288759     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2010.3     Document Type: Review

References (64)

1. Baekkevold ES, RoussignéM, Yamanaka T, Johansen FE, Jahnsen FL, Amalric F et al. Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. Am J Pathol 2003; 163: 69-79. (Pubitemid 36759592)
2. Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005; 23: 479-490. (Pubitemid 41587888)
3. Boraschi D, Tagliabue A. The interleukin-1 receptor family. Vitam Horm 2006; 74: 229-254.
4. ÓNeill LA. The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. Immunol Rev 2008; 226: 10-18.
5. Kakkar R, Lee RT. The IL-33/ST2 pathway: therapeutic target and novel biomarker. Nat Rev Drug Discov 2008; 7: 827-840.
6. Löhning M, Stroehmann A, Coyle AJ, Grogan JL, Lin S, Gutierrez-Ramos JC et al. T1/ ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci USA 1998; 95: 6930-6935. (Pubitemid 28278084)
7. Meisel C, Bonhagen K, Löhning M, Coyle AJ, Gutierrez-Ramos JC, Radbruch A et al. Regulation and function of T1/ST2 expression on CD41 T cells: induction of type 2 cytokine production by T1/ST2 cross-linking. J Immunol 2001; 166: 3143-3150. (Pubitemid 33117311)
8. Gachter T, Werenskiold AK, Klemenz R. Transcription of the interleukin-1 receptorrelated T1 gene is initiated at different promoters in mast cells and fibroblasts. J Biol Chem 1996; 271: 124-129. (Pubitemid 26026567)
9. Moritz DR, Rodewald HR, Gheyselinck J, Klemenz R. The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors. J Immunol 1998; 161: 4866-4874. (Pubitemid 28492065)
10. Carriere V, Roussel L, Ortega N, Lacorre DA, Americh L, Aguilar L et al. IL-33, the IL-1- like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci USA 2007; 104: 282-287. (Pubitemid 46068023)
11. Arend WP, Palmer G, Gabay C. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev 2008; 223: 20-38. (Pubitemid 351986169)
12. Guo L, Wei G, Zhu J, Liao W, Leonard WJ, Zhao K et al. IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci USA 2009; 106: 13463-13468.
13. Komai-Koma M, Xu D, Li Y, McKenzie AN, McInnes IB, Liew FY. IL-33 is a chemoattractant for human Th2 cells. Eur J Immunol 2007; 37: 2779-2786. (Pubitemid 47578297)
14. Smithgall MD, Comeau MR, Yoon BR, Kaufman D, Armitage R, Smith DE. IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells. Int Immunol 2008; 20: 1019-1030.
15. Allakhverdi Z, Smith DE, Comeau MR, Delespesse G. Cutting edge: the ST2 ligand IL- potently activates and drives maturation of human mast cells. J Immunol 2007; 179: 2051-2054.
16. Moulin D, DonzéO, Talabot-Ayer D, Mézin F, Palmer G, Gabay C. Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells. Cytokine 2007; 40: 216-225. (Pubitemid 350213434)
17. Ho LH, Ohno T, Oboki K, Kajiwara N, Suto H, Iikura M et al. IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals. J Leukoc Biol 2007; 82: 1481-1490. (Pubitemid 350276960)
18. Iikura M, Suto H, Kajiwara N, Oboki K, Ohno T, Okayama Y et al. IL-33 can promote survival, adhesion and cytokine production in human mast cells. Lab Invest 2007; 87: 971-978. (Pubitemid 47429189)
19. Xu D, Jiang HR, Kewin P, Li Y, Mu R, Fraser AR et al. IL-33 exacerbates antigeninduced arthritis by activating mast cells. Proc Natl Acad Sci USA 2008; 105: 10913-10918.
20. Silver MR, Margulis A, Wood N, Goldman SJ, Kasaian M, Chaudhary D. IL-33 synergizes with IgE-dependent and IgE-independent agents to promote mast cell and basophil activation. Inflamm Res 2010; 59: 207-218.
21. Suzukawa M, Iikura M, Koketsu R, Nagase H, Tamura C, Komiya A et al. An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor. J Immunol 2008; 181: 5981-5989.
22. Schneider E, Petit-Bertron AF, Bricard R, Levasseur M, Ramadan A, Girard JP et al. IL- activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production. J Immunol 2009; 183: 3591-3597.
23. Kroeger KM, Sullivan BM, Locksley RM. IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. J Leukoc Biol 2009; 86: 769-778.
24. Pecaric-Petkovic T, Didichenko SA, Kaempfer S, Spiegl N, Dahinden CA. Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. Blood 2009; 113: 1526-1534.
25. Suzukawa M, Koketsu R, Iikura M, Nakae S, Matsumoto K, NagaseHet al. Interleukin-enhances adhesion, CD11b expression and survival in human eosinophils. Lab Invest 2008; 88: 1245-1253.
26. Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H. A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J Allergy Clin Immunol 2008; 121: 1484-1490. (Pubitemid 351787349)
27. Bourgeois E, Van LP, Samson M, Diem S, Barra A, Roga S et al. The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production. Eur J Immunol 2009; 39: 1046-1055.
28. Nakajima H, Takatsu K. Role of cytokines in allergic airway inflammation. Int Arch Allergy Immunol 2007; 142: 265-273. (Pubitemid 46425806)
29. Hayakawa H, Hayakawa M, Kume A, Tominaga S. Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J Biol Chem 2007; 282: 26369-26380. (Pubitemid 47443815)
30. Aoki S, Hayakawa M, Ozaki H, Takezako N, Obata H, Ibaraki N et al. ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells. Mol Cell Biochem 2010; 335: 75-81.
31. Kondo Y, Yoshimoto T, Yasuda K, Futatsugi-Yumikura S, Morimoto M, HayashiN et al. Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int Immunol 2008; 20: 791-800. (Pubitemid 351791523)
32. Pushparaj PN, Tay HK, H́ng SC, Pitman N, Xu D, McKenzie A et al. The cytokine interleukin-33 mediates anaphylactic shock. Proc Natl Acad Sci USA 2009; 106: 9773-9778.
33. Smith DE. IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma. Clin Exp Allergy 2010; 40: 200-208.
34. Haraldsen G, Balogh J, Pollheimer J, Sponheim J, Küchler AM. Interleukin-33 - cytokine of dual function or novel alarmin? Trends Immunol 2009; 30: 227-233.
35. Préfontaine D, Lajoie-Kadoch S, Foley S, Audusseau S, Olivenstein R, Halayko AJ et al. Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. J Immunol 2009; 183: 5094-5103.
36. Kearley J, Buckland KF, Mathie SA, Lloyd CM. Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway.Am J Respir Crit Care Med 2009; 179: 772-781.
37. Manetti M, Ibba-Manneschi L, Liakouli V, Guiducci S, Milia AF, Benelli G et al. The IL- 1-like cytokine IL-33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis. Ann Rheum Dis 2010; in press.
38. Miller AM, Xu D, Asquith DL, Denby L, Li Y, Sattar N et al. IL-33 reduces the development of atherosclerosis. J Exp Med 2008; 205: 339-346. (Pubitemid 351281600)
39. Dinarello CA. An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor. Immunity 2005; 23: 461-462. (Pubitemid 41587885)
40. Li H, Willingham SB, Ting JP, Re F. Cutting edge: inflammasome activation by alum and aluḿs adjuvant effect are mediated by NLRP3. J Immunol 2008; 181: 17-21.
41. Cassel SL, Joly S, Sutterwala FS. The NLRP3 inflammasome: a sensor of immune danger signals. Semin Immunol 2009; 21: 194-198.
42. Lüthi AU, Cullen SP, McNeela EA, Duriez PJ, Afonina IS, Sheridan C et al. Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. Immunity 2009; 31: 84-98.
43. Lamkanfi M, Dixit VM. IL-33 raises alarm. Immunity 2009; 31: 5-7.
44. Cayrol C, Girard JP. The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci USA 2009; 106: 9021-9026.
45. Talabot-Ayer D, Lamacchia C, Gabay C, Palmer G. Interleukin-33 is biologically active independently of caspase-1 cleavage. J Biol Chem 2009; 284: 19420-19426.
46. Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA et al. Caspase-1, caspase- 8, and calpain are dispensable for IL-33 release by macrophages. J Immunol 2009; 183: 7890-7897.
47. Keller M, Rüegg A, Werner S, Beer HD. Active caspase-1 is a regulator of unconventional protein secretion. Cell 2008; 132: 818-831.
48. Creagh EM, Conroy H, Martin SJ. Caspase-activation pathways in apoptosis and immunity. Immunol Rev 2003; 193: 10-21. (Pubitemid 36688035)
49. Hayakawa M, Hayakawa H, Matsuyama Y, Tamemoto H, Okazaki H, Tominaga S. Mature interleukin-33 is produced by calpain-mediated cleavage in vivo. Biochem Biophys Res Commun 2009; 387: 218-222.
50. Maier JA, Voulalas P, Roeder D, Maciag T. Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer. Science 1990; 249: 1570-1574.
51. Maier JA, Statuto M, Ragnotti G. Endogenous interleukin 1 alpha must be transported to the nucleus to exert its activity in human endothelial cells. Mol Cell Biol 1994; 14: 1845-1851. (Pubitemid 24074579)
52. Mosley B, Urdal DL, Prickett KS, Larsen A, Cosman D, Conlon PJ et al. The interleukin-receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. J Biol Chem 1987; 262: 2941-2944.
53. Kobayashi Y, Yamamoto K, Saido T, Kawasaki H, Oppenheim JJ, Matsushima K. Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha. Proc Natl Acad Sci USA 1990; 87: 5548-5552.
54. Carruth LM, Demczuk S, Mizel SB. Involvement of a calpain-like protease in the processing of the murine interleukin 1 alpha precursor. J Biol Chem 1991; 266: 12162-12167. (Pubitemid 21907072)
55. Kavita U, Mizel SB. Differential sensitivity of interleukin-1 alpha and -beta precursor proteins to cleavage by calpain, a calcium-dependent protease. J Biol Chem 1995; 270: 27758-27765.
56. Eigenbrod T, Park JH, Harder J, Iwakura Y, Núñez G. Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells. J Immunol 2008; 181: 8194-8198.
57. Sakurai T, He G, Matsuzawa A, Yu GY, Maeda S, HardimanGet al. Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 2008; 14: 156-165.
58. Sakashita M, Yoshimoto T, Hirota T, Harada M, Okubo K, Osawa Y et al. Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis. Clin Exp Allergy 2008; 38: 1875-1881.
59. Matsuyama Y, Okazaki H, Tamemoto H, Kimura H, Kamata Y, Nagatani K et al. Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis. J Rheumatol 2010; 37: 18-25.
60. Sanada S, Hakuno D, Higgins LJ, Schreiter ER, McKenzie AN, Lee RT. IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system. J Clin Invest 2007; 117: 1538-1549. (Pubitemid 46871338)
61. Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT. Induction of IL-33 expression and activity in central nervous system glia. J Leukoc Biol 2008; 84: 631-643.
62. Küchler AM, Pollheimer J, Balogh J, Sponheim J, Manley L, Sorensen DR, et al. Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation. Am J Pathol 2008; 173: 1229-1242.
63. Moussion C, Ortega N, Girard JP. The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel alarmiń? PLoS One 2008; 3: e3331.
64. Wood IS, Wang B, Trayhurn P. IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes. Biochem Biophys Res Commun 2009; 384: 105-109.