Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 8, 2015, Pages 2497-2502

  Li, Suzhao ^a   Neff, C Preston ^a   Barber, Kristina ^a   Hong, Jaewoo ^b   Luo, Yuchun ^a   Azam, Tania ^a   Palmer, Brent E ^a   Fujita, Mayumi ^a   Garlanda, Cecilia ^c   Mantovani, Alberto ^c   Kim, Soohyun ^b   Dinarello, Charles Anthony ^a,d  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Konkuk University   (South Korea)

^c HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Endotoxemia; Immunity; Inflammasome

Indexed keywords

INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR TYPE 8; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 37; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; NEUTRALIZING ANTIBODY; RECOMBINANT CYTOKINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; IL37 PROTEIN, HUMAN; IMMOBILIZED PROTEIN; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE P38; RECOMBINANT PROTEIN; TIR8 PROTEIN, HUMAN; TIR8 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD; BONE MARROW DERIVED DENDRITIC CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; LIGAND BINDING; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENDOTOXEMIA; ENZYME ACTIVATION; ENZYMOLOGY; EXTRACELLULAR SPACE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS;

MUS;

ANIMALS; CELL DIFFERENTIATION; ENDOTOXEMIA; ENZYME ACTIVATION; EXTRACELLULAR SPACE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMOBILIZED PROTEINS; IMMUNITY, INNATE; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NEUTRALIZATION TESTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-1; RECOMBINANT PROTEINS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84923676031     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424626112     Document Type: Article

References (29)

1. Dinarello CA, Bufler P (2013) Interleukin-37. Semin Immunol 25(6):466-468.
2. Nold MF, et al. (2010) IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol 11(11):1014-1022.
3. McNamee EN, et al. (2011) Interleukin 37 expression protects mice from colitis. Proc Natl Acad Sci USA 108(40):16711-16716.
4. Ballak DB, et al. (2014) IL-37 protects against obesity-induced inflammation and insulin resistance. Nat Commun 5:4711.
5. Yousif NG, et al. (2011) Expression of IL-37 in mouse protects the myocardium against ischemic injury via modulation of NF-κB activation. Circulation 124(Suppl 21):A8603.
6. Luo Y, et al. (2014) Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells. Proc Natl Acad Sci USA 111(42):15178-15183.
7. Sharma S, et al. (2008) The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines. J Immunol 180(8):5477-5482.
8. Bulau AM, et al. (2014) Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. Proc Natl Acad Sci USA 111(7):2650-2655.
9. Riva F, et al. (2012) TIR8/SIGIRR is an interleukin-1 receptor/Toll like receptor family member with regulatory functions in inflammation and immunity. Front Immunol 3:322.
10. Sakai N, et al. (2012) Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells. J Gastroenterol Hepatol 27(10):1609-1616.
11. Moretti S, et al. (2014) IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis. PLoS Pathog 10(11):e1004462.
12. Pan G, et al. (2001) IL-1H, an interleukin 1-related protein that binds IL-18 receptor/ IL-1Rrp. Cytokine 13(1):1-7.
13. Kumar S, et al. (2002) Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. Cytokine 18(2):61-71.
14. Bufler P, et al. (2002) A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Proc Natl Acad Sci USA 99(21):13723- 13728.
15. Wald D, et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 4(9):920-927.
16. Garlanda C, et al. (2004) Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc Natl Acad Sci USA 101(10):3522-3526.
17. Polentarutti N, et al. (2003) Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. Eur Cytokine Netw 14(4): 211-218.
18. Bulek K, et al. (2009) The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response. J Immunol 182(5):2601-2609.
19. Garlanda C, Riva F, Bonavita E, Gentile S, Mantovani A (2013) Decoys and regulatory "receptors" of the IL-1/Toll-like receptor superfamily. Front Immunol 4:180.
20. Garlanda C, et al. (2007) Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family. Cancer Res 67(13):6017-6021.
21. Kim B, et al. (2013) The interleukin-1alpha precursor is biologically active and is likely a key alarmin in the IL-1 family of cytokines. Front Immunol 4:391.
22. Schmit A, et al. (2002) Dose-effect of interleukin-10 and its immunoregulatory role in Crohn's disease. Eur Cytokine Netw 13(3):298-305.
23. Yang Y, et al. (2014) IL-37 inhibits IL-18-induced tubular epithelial cell expression of pro-inflammatory cytokines and renal ischemia-reperfusion injury. Kidney Int.
24. Boraschi D, Tagliabue A (2013) The interleukin-1 receptor family. Semin Immunol 25(6):394-407.
25. Nold-Petry CA, et al. (2009) Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling. J Biol Chem 284(38):25900-25911.
26. Lewis EC, Dinarello CA (2006) Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor. Proc Natl Acad Sci USA 103(45):16852-16857.
27. Garlanda C, Anders HJ, Mantovani A (2009) TIR8/SIGIRR: An IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization. Trends Immunol 30(9):439-446.
28. Nold-Petry C, et al. (2015) IL-37 requires IL-18Rα and IL-1R8 to carry out its multifaceted anti-inflammatory program on innate signal transduction. Nat Immunol, in press.
29. Leoni F, et al. (2005) The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med 11(1-12):1-15.