Co-encapsulation of lyoprotectants improves the stability of protein-loaded PLGA nanoparticles upon lyophilization

International Journal of Pharmaceutics

Volumn 496, Issue 2, 2015, Pages 850-862

  Fonte, Pedro ^a,b   Araújo, Francisca ^c,d   Seabra, Vítor ^b   Reis, Salette ^a   Van De Weert, Marco ^e   Sarmento, Bruno ^b,c,d  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY INSTITUTE OF HEALTH SCIENCES IUCS   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Co encapsulation; Insulin; Lyophilization; Lyoprotectants; PLGA nanoparticles; Protein stability

Indexed keywords

FRUCTOSE; GLUCOSE; NANOPARTICLE; POLYGLACTIN; RECOMBINANT HUMAN INSULIN; SORBITOL; SUCROSE; TREHALOSE; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; ENCAPSULATION; FOURIER TRANSFORM INFRARED PHOTOACOUSTIC SPECTROSCOPY; FREEZE DRYING; IN VITRO STUDY; LYOPHILISATE; MOISTURE; PARTICLE SIZE; PRIORITY JOURNAL; SURFACE PROPERTY; ZETA POTENTIAL; CHEMISTRY; PROTEIN SECONDARY STRUCTURE; SOLUBILITY; X RAY DIFFRACTION;

CIRCULAR DICHROISM; DRUG STABILITY; FREEZE DRYING; LACTIC ACID; NANOPARTICLES; PARTICLE SIZE; POLYGLYCOLIC ACID; PROTEIN STRUCTURE, SECONDARY; SOLUBILITY; X-RAY DIFFRACTION;

EID: 84949571235     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.10.032     Document Type: Article

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