Effect of osmotic pressure in the solvent extraction phase on BSA release profile from PLGA microspheres

Pharmaceutical Development and Technology

Volumn 7, Issue 4, 2002, Pages 391-399

  Jiang, Ge ^a   Thanoo, B C ^b   DeLuca, Patrick P ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Oakwood Laboratories LLC   (United States)

Author keywords

BSA; Microsphere; Osmotic pressure; Release; Solvent extraction

Indexed keywords

BOVINE SERUM ALBUMIN; METHYL CHLORIDE; MICROSPHERE; ORGANIC SOLVENT; POLYGLACTIN; SODIUM CHLORIDE; SUCROSE; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; POLYMER; SOLVENT;

AQUEOUS SOLUTION; ARTICLE; EMULSION; EVAPORATION; MORPHOLOGY; OSMOTIC PRESSURE; PARTICLE SIZE; PHASE SEPARATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN STABILITY; SOLVENT EXTRACTION; SURFACE PROPERTY; SUSTAINED RELEASE PREPARATION; ANIMAL; CATTLE; CHEMISTRY;

ANIMALS; CATTLE; LACTIC ACID; MICROSPHERES; OSMOTIC PRESSURE; POLYGLYCOLIC ACID; POLYMERS; SERUM ALBUMIN, BOVINE; SOLVENTS;

EID: 1842865844     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-120015040     Document Type: Article

References (31)

1. Langer, R. New methods of drug delivery. Science 1990, 249, 1527-1553.
2. Schwendeman, S.P.; Cardamone, M.; Brandon, M.R.; Klibanov, A.; Langer, R. Stability of proteins and their delivery from biodegradable microspheres. In Microparticulate Systems for the Delivery of Proteins and Vaccines; Cohen, S., Bernstein, H., Eds.; Marcel Dekker: New York, 1996; 1-50.
3. Kissel, T.; Koneberg, R. Injectable biodegradable microspheres for vaccine delivery. In Microparticulate Systems for the Delivery of Proteins and Vaccines; Cohen, S., Bernstein, H., Eds.; Marcel Dekker: New York, 1996; 51-58.
4. Woo, B.H.; Jiang, G.; Jo, Y.W.; DeLuca, P.P. Preparation and characterization of a composite PLGA and poly (acryloly-hydroxyethyl starch) microsphere system for protein delivery. Pharm. Res. 2001, 18, 1600-1606.
5. Reed, A.M.; Gilding, D.K. Biodegradable polymers for use in surgery - Poly(glycolic)/poly(lactic acid) homo and copolymers. 2. In vitro degradation. Polymer 1981, 22, 494-498.
6. Yamaguchi, K.; Anderson, J.M. In vivo biocompatibility studies of medisorb 65/35 d,l-lactide/glycolide copolymer microspheres. J. Control. Release 1993, 24, 81-93.
7. Huang, Y.Y.; Chung, T.W.; Tzeng, T.W. Drug release from PLA/PEG microparticulates. Int. J. Pharm. 1997, 156, 9-15.
8. Lin, S.Y.; Chen, K.S.; Teng, H.H.; Li, M.J. In vitro degradation and dissolution behaviors of microspheres prepared by low molecular weight polyesters. J. Microencapsul. 2000, 17 (5), 577-586.
9. Zhu, K.J.; Jiang, H.L.; Du, X.Y.; Wang, J.; Xu, W.X.; Liu, S.F. Preparation and characterization of HCG-loaded polylactide or poly(lactide-co-glycolide) microspheres using a modified water-in-oil-in-water (W/O/W) emulsion solvent evaporation technique. J. Microencapsul. 2001, 18, 247-260.
10. Setterstrom, J.A.; Tice, T.R.; Meyers, W.E.; Vincent, J.W. Development of encapsulated antibiotics for topical administration to wound. Second World Congress on Biomaterials 10th Annual Meeting of the Society for Biomaterials, Washington, DC, April 27-May 1, 1984; 4.
11. Kostanski, J.W.; Thanoo, B.C.; DeLuca, P.P. Preparation, characterization, and in vitro evaluation of 1- and 4-month controlled release orntide PLA and PLGA microspheres. Pharm. Dev. Technol. 2000, 5, 585-596.
12. Shively, M.L.; Coonts, B.A.; Renner, W.D.; Southard, J.L.; Bennett, A.T. Physicochemical characterization of a polymeric injectable implant delivery system. J. Control. Release 1995, 33, 237-243.
13. Huang, X.; Brazel, C.S. On the importance and mechanisms of burst release in matrix-controlled drug delivery system. J. Control. Release 2001, 73, 121-136.
14. Shao, P.G.; Bailey, L.C. Stabilization of pH-induced degradation of porcine insulin in biodegradable polyester microspheres. Pharm. Dev. Technol. 1999, 4, 633-642.
15. Conti, B.; Groppo, A.; Genta, I.; Dacarro, C.; Valvo, L.; Cilurzo, F.; Montanari, L. Comparison among different preparation methods of ovalbumin loaded PLGA microspheres. Proc. Int. Symp. Control. Release Bioact. Mater. 2000, 27, 1060-1061.
16. Wong, H.M.; Wang, J.J.; Wang, C.H. In vitro sustained release of human immunoglobulin G from biodegradable microspheres. Ind. Eng. Chem. Res. 2001, 40, 933-948.
17. Lu, W.; Park, T.G. Protein release from poly(lactic-coglycolic acid) microspheres: Protein stability problems. PDA J. Pharm. Sci. Technol. 1995, 49, 13-19.
18. Igartua, M.; Hernandez, R.M.; Esquisabel, A.; Gascon, A.R.; Calvo, M.B.; Pedraz, J.L. Influence of formulation variables on the in-vitro release of albumin from biodegradable microparticulate systems. J. Microencapsul. 1997, 14, 349-356.
19. Uchida, T.; Shiosaki, K.; Nakada, Y.; Fukada, K.; Eda, Y.; Tokiyoshi, S.; Nagareya, N.; Matsuyama, K. Microencapsulation of hepatitis B core antigen for vaccine preparation. Pharm. Res. 1998, 15, 1708-1713.
20. Péan, J.; Venier-Julienne, M.; Boury, F.; Menei, P.; Denizot, B.; Benoit, J. NGF release from poly(DLlactide-co-glycolide) microspheres. Effect of some formulation parameters on encapsulated NGF stability. J. Control. Release 1998, 56, 175-187.
21. Jeyanthi, R.; Thanoo, B.C.; Metha, R.C.; DeLuca, P.P. Effect of solvent removal technique on the matrix characteristics of polylactide/glycolide microspheres for peptide delivery. J. Control. Release 1996, 38, 235-244.
22. Yang, Y.; Chung, T.; Bai, X.; Chan, W. Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double emulsion method. Chem. Eng. Sci. 2000, 55, 2223-2236.
23. Blanco, D.; Alonso, M.J. Protein encapsulation and release from poly (lactide-co-glycolide) microspheres: Effect of protein and polymer properties and of the coencapsulation of surfactants. Eur. J. Pharm. BioPharm. 1998, 45, 285-294.
24. Huang, Y.; Chung, T.; Tzeng, T. A method using biodegradable polylactides/polyethylene glycol for drug release with reduced initial burst. Int. J. Pharm. 1999, 182, 93-100.
25. Shastri, V.R.; Hildgen, P.; Sinisterra, R.D.; Langer, R.S. Pharmaceutical Microparticles Comprising Cyclodextrin Complexes and Polymers. PCT Int. Appl. Patent No. WO 9961062, 1999, 22.
26. Geze, A.; Venier-Julienne, M.C.; Mathieu, D.; Filmon, R.; Phan-Tan-Luu, R.; Benoit, J.P. Development of 5-Iodo-2′-deoxyuridine milling process to reduce initial burst release from PLGA microparticles. Int. J. Pharm. 1999, 178, 257-268.
27. Li, W.; Anderson, K.W.; DeLuca, P.P. Kinetic and thermodynamic modeling of the formation of polymeric microspheres using solvent extraction/evaporation method. J. Control. Release 1995, 37, 187-198.
28. Wijmans, J.G.; Kant, J.; Mulder, M.H.V.; Smolders, C.A. Phase separation phenomena in solutions of polysulfone in mixtures of a solvent and a nonsolvent: Relationship with membrane formation. Polymer 1985, 26, 1539-1545.
29. Li, W.; Anderson, K.W.; Mehta, R.C.; DeLuca, P.P. Prediction of solvent removal profile and effect on properties for peptide-loaded PLGA microspheres prepared by solvent extraction/evaporation method. J. Control. Release 1995, 37, 199-214.
30. Péan, J.M.; Boury, F.; Venier-Julienne, M.C.; Menei, P.; Proust, J.E.; Benoit, J.P. Why does PEG 400 coencapsulation improve NGF stability and release from PLGA biodegradable microspheres? Pharm. Res. 1999, 16, 1294-1299.
31. Uchida, T.; Nagareya, N.; Sakakibara, S.; Konishi, Y.; Nakai, A.; Nishikata, M.; Matsuyama, K.; Yoshida, K. Preparation and characterization of polylactic acid microspheres containing bovine insulin by a W/O/W emulsion solvent evaporation method. Chem. Pharm. Bull. 1997, 45, 1539-1543.