Analysis of insulin allostery in solution and solid state with FTIR

Journal of Pharmaceutical Sciences

Volumn 98, Issue 9, 2009, Pages 3265-3277

  Maltesen, Morten Jonas ^a,b   Bjerregaard, Simon ^b   Hovgaard, Lars ^b   Havelund, Svend ^b   Van De Weert, Marco ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Allostery; Fourier transform infrared (FTIR) spectroscopy; Insulin; Lyophilisation; Principal component analysis (PCA); Protein structure; Proteins

Indexed keywords

HUMAN INSULIN; LIGAND; PHENOL;

ALLOSTERISM; ALPHA HELIX; ANALYTIC METHOD; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; DISSOCIATION CONSTANT; DRUG CONFORMATION; FREEZE DRYING; HYDROPHOBICITY; INFRARED SPECTROSCOPY; MOLECULAR STABILITY; PRINCIPAL COMPONENT ANALYSIS; SOLID STATE;

EID: 68949144641     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21736     Document Type: Article

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