Protein formulation and lyophilization cycle design: Prevention of damage due to freeze-concentration induced phase separation

Biotechnology and Bioengineering

Volumn 63, Issue 2, 1999, Pages 166-174

  Heller, Martin C ^a   Carpenter, John F ^b   Randolph, Theodore W ^a  

^a UCB 450   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Cooling rate; Lyophilization; Phase separation; Protein stability; Spray freeze drying

Indexed keywords

ANNEALING; COMPOSITION EFFECTS; CRYSTALLIZATION; DRYING; FOURIER TRANSFORM INFRARED SPECTROSCOPY; FREEZING; NITROGEN; PHASE SEPARATION; REACTION KINETICS; SPRAYING; THERMODYNAMIC STABILITY;

LYOPHILIZATION; MANNITOL; SPRAY-FREEZE DRYING;

HEMOGLOBIN;

HEMOGLOBIN;

ARTICLE; COOLING; FREEZE DRYING; HEMOGLOBIN DETERMINATION; PROTEIN ANALYSIS; PROTEIN DEFECT; THERMODYNAMICS;

CALORIMETRY, DIFFERENTIAL SCANNING; CRYOPROTECTIVE AGENTS; DRUG STABILITY; FREEZE DRYING; HEMOGLOBINS; HUMANS; MICROSCOPY, ELECTRON, SCANNING; POLYETHYLENE GLYCOLS; PROTEIN DENATURATION; PROTEIN FOLDING; RECOMBINANT PROTEINS;

EID: 0033586786     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19990420)63:2<166::AID-BIT5>3.0.CO;2-H     Document Type: Article

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