Nanoparticle-induced tight-junction opening for the transport of an anti-angiogenic sulfated polysaccharide across Caco-2 cell monolayers

Acta Biomaterialia

Volumn 9, Issue 7, 2013, Pages 7449-7459

  Yu, Shu Huei ^a   Tang, Deh Wei ^a   Hsieh, Hao Ying ^a   Wu, Wen Shin ^b,d   Lin, Bo Xian ^a   Chuang, Er Yuan ^c   Sung, Hsing Wen ^c   Mi, Fwu Long ^b,d  

^a VANUNG UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Chitosan; Fucoidan; Nanoparticles; Oral delivery

Indexed keywords

BARIUM COMPOUNDS; CELL CULTURE; CHITOSAN; CHLORINE COMPOUNDS; ENDOTHELIAL CELLS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; MACROMOLECULES;

ANGIOGENESIS; BASIC FIBROBLAST GROWTH FACTOR; CACO-2 CELLS; CELL MONOLAYERS; FUCOIDANS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; ORAL DELIVERY; POSITIVE SURFACE CHARGE; SULFATED POLYSACCHARIDES; TIGHT JUNCTIONS;

NANOPARTICLES;

ANGIOGENESIS INHIBITOR; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; CHITOSAN; FIBROBLAST GROWTH FACTOR 2; FUCOIDIN; NANOCARRIER; POLYANION; POLYCATION; PROTEIN ZO1;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL STRAIN CACO 2; CONFOCAL LASER MICROSCOPY; DRUG TRANSPORT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INFRARED SPECTROSCOPY; MACROMOLECULE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SURFACE CHARGE; SYNTHESIS; TIGHT JUNCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

EID: 84878340773     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.04.009     Document Type: Article

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