Evaluation and modification of N-trimethyl chitosan chloride nanoparticles as protein carriers

International Journal of Pharmaceutics

Volumn 336, Issue 1, 2007, Pages 166-173

  Chen, Fu ^a   Zhang, Zhi Rong ^a   Huang, Yuan ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

In vitro release; N Trimethyl chitosan chloride; Nanoparticles; Protein delivery

Indexed keywords

N TRIMETHYL CHITOSAN CHLORIDE; NANOPARTICLE; PROTEIN; TRIPOLYPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; DRUG RELEASE; DRUG SYNTHESIS; IN VITRO STUDY; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; ZETA POTENTIAL;

ALGINATES; ANIMALS; CATTLE; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; COLLOIDS; DRUG CARRIERS; ELECTROSTATICS; GLUCURONIC ACID; HEMOGLOBINS; HEXURONIC ACIDS; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; NANOTECHNOLOGY; PARTICLE SIZE; POLYPHOSPHATES; PRECIPITATION; PROTEINS; SERUM ALBUMIN, BOVINE;

EID: 34047253032     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.11.027     Document Type: Article

References (24)

1. Amidi M., Romeijn S.G., Borchard G., Junginger H.E., Hennink W.E., and Jiskoot W. Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system. J. Control. Rel. 111 (2006) 107-116
2. Aral C., and Akbuĝa J. Alternative approach to preparation of chitosan beads. Int. J. Pharm. 168 (1998) 9-15
3. Artursson P., Lindmark T., Davis S.S., and Illum L. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm. Res. 11 (1994) 1358-1361
4. Bernkop-Schurch A., Humenberg C., and Valenta C. Basic Studies on bioadhesive delivery systems for peptide and protein drugs. Int. J. Pharm. 165 (1998) 217-225
5. Bouillot P., Ubrich N., Sommer F., Duc T.M., and Loeffler J.P. Dellacherie E. Protein encapsulation in biodegradable amphiphilic microspheres. Int. J. Pharm. 181 (1999) 159-172
6. Crotts G., Sah H., and Park T.G. Adsorption determines in vitro protein release rate from biodegradable microspheres: quantative analysis of surface area during degradation. J. Control. Rel. 41 (1997) 101-111
7. Domard A., Rinaudo M., and Terrassin C. New method for the quaternisation of chitosan. Int. J. Biol. Macromol. 8 (1986) 105-107
8. Felt O., Buri P., and Gurny R. Chitosan: a unique polysaccharide for drug delivery. Drug Dev. Ind. Pharm. 24 (1998) 979-993
9. González-Rodrŕguez M.L., Holgado M.A., Sánchez-Lafuente C., Rabasco A.M., and Fini A. Alginate/chitosan particulate systems for sodium diclofenac release. Int. J. Pharm. 232 (2002) 225-234
10. Hamman J.H., Stander M., and Kotzé A.F. Effect of the degree of quaternization of N-trimethyl chitosan chloride on absorption enhancement: in vivo evaluation in rat nasal epithelia. Int. J. Pharm. 232 (2002) 235-242
11. Issa M.M., Köping-Höggård M., and Artursson P. Chitosan and the mucosal delivery of biotechnology drugs. Drug Discovery Today 2 (2005) 1-6
12. Kotzé A.F., Luehen H.L., de Leeuw B.J., de Boer A.G., Verhoef J.C., and Junginger H.E. Chitosan for enhanced intestinal permeability: prospects for derivatives soluble in neutral and basic environments. Eur. J. Pharm. Sci. 7 (1999) 145-151
13. Kotzé A.F., Luehen H.L., de Leeuw B.J., de Boer A.G., Verhoef J.C., and Junginger H.E. N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces: in vitro evaluation in intestinal epithelial cells (Caco-2). Pharm. Res. 14 (1997) 1197-1202
14. Lee K.Y., Ha W.S., and Park W.H. Blood compatibility and biodegradability of partially N-acylated chitosan derivatives. Biomaterials 16 (1995) 1211-1216
15. Onishi H., and Machida Y. Biodegradation and distribution of water-soluble chitosan in mice. Biomaterials 20 (1999) 175-182
16. Shu X.Z., and Zhu K.J. A novel approach to prepare tripolyphosphate:chitosan complex beads for controlled release drug delivery. Int. J. Pharm. 201 (2000) 51-58
17. Sieval A.B., Thanou M., Kotzé A.F., Verhoef J.C., Brussee J., and Junginger H.E. Preparation and NMR-characterisation of highly substituted Ntrimethyl chitosan chloride. Carbohydr. Polym. 36 (1998) 157-165
18. Thanou M., Kotzé A.F., Scharringhausen T., Luessen H.L., De Boer A.G., Verhoef J.C., and Junginger H.E. Effect of degree of quaternisation of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers. J. Control. Rel. 64 (2000) 15-25
19. van der Lubben I.M., Kersten G., Fretz M.M., Beuvery C., Verhoef J.C., and Junginger H.E. Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice. Vaccine 28 (2003) 1400-1408
20. van der Lubben I.M., Verhoef J.C., Borchard G., and Junginger H.E. Chitosan for mucosal vaccination. Adv. Drug Deliv. Rev. 52 (2001) 139-144
21. van der Merwe S.M., Verhoef J.C., Verheijden J.H.M., Kotzé A.F., and Junginger H.E. Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs. Eur. J. Pharm. Biopharm. 58 (2004) 225-235
22. van der Merwe S.M., Verhoef J.C., Kotzé A.F., and Junginger H.E. N-Trimethyl chitosan chloride as absorption enhancer in oral peptide drug delivery. Development and characterization of minitablet and granule formulations. Eur. J. Pharm. Biopharm. 57 (2004) 85-91
23. Vandenberg G.W., Drolet C., Scott S.L., and de la Noüe J. Factors affecting protein release from alginate-chitosan coacervate microcapsules during production and gastric/intestinal simulation. J. Control. Rel. 77 (2001) 297-307
24. Xu Y., Du Y., Huang R., and Gao L. Preparation and modification of N-(2- hydroxyl) propyl-3-trimethyl ammonium chitosan chloride nanoparticle as a protein carrier. Biomaterials 24 (2003) 5015-5022