Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα

PLoS Biology

Volumn 13, Issue 11, 2015, Pages

  Akimoto, Madoka ^a   McNicholl, Eric Tyler ^a   Ramkissoon, Avinash ^a   Moleschi, Kody ^a   Taylor, Susan S ^b   Melacini, Giuseppe ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IALPHA; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; HYBRID PROTEIN; PEPTIDE FRAGMENT; PRKACA PROTEIN, MOUSE;

ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE; PROTEIN DOMAIN; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; BOVINE; CHEMISTRY; ENERGY TRANSFER; GENE DELETION; GENETICS; METABOLISM; MOLECULAR MODEL; MOUSE; MUTATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; TANDEM REPEAT;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CATTLE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNITS; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIALPHA SUBUNIT; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENERGY TRANSFER; ENZYME ACTIVATION; GENE DELETION; MICE; MODELS, MOLECULAR; MUTATION; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; RECOMBINANT FUSION PROTEINS; TANDEM REPEAT SEQUENCES;

EID: 84949440484     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1002305     Document Type: Article

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