Using markov state models to develop a mechanistic understanding of protein kinase a regulatory subunit RIα activation in response to cAMP binding

Journal of Biological Chemistry

Volumn 289, Issue 43, 2014, Pages 30040-30051

  Boras, Britton W ^a   Kornev, Alexandr ^b   Taylor, Susan S ^b,c   McCulloch, Andrew D ^a,d  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b Department of Chemistry and Biochemistry ^*  (United States)

^c San Diego   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; NUCLEOTIDES; PROTEINS;

ALLOSTERIC MECHANISMS; CONFORMATIONAL SELECTION; CYCLIC NUCLEOTIDE BINDING DOMAIN; MARKOV STATE MODELS; MECHANISTIC MODELING; PROTEIN KINASE A; REGULATORY SUBUNITS; SUBUNIT DIMERS;

CHEMICAL ACTIVATION;

CYCLIC AMP DEPENDENT PROTEIN KINASE; HOLOENZYME; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IALPHA; KEMPTIDE; MUTANT PROTEIN; OLIGOPEPTIDE;

ACCURACY; ALGORITHM; ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME BINDING; MATHEMATICAL ANALYSIS; PROBABILITY; THERMODYNAMICS; VALIDITY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; MARKOV CHAIN; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; REPRODUCIBILITY;

CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIALPHA SUBUNIT; ENZYME ACTIVATION; MARKOV CHAINS; MODELS, MOLECULAR; MUTANT PROTEINS; OLIGOPEPTIDES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; REPRODUCIBILITY OF RESULTS;

EID: 84908192391     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.568907     Document Type: Article

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