Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 21, 2015, Pages 6625-6630

  Mazhab Jafari, Mohammad T ^a,d   Marshall, Christopher B ^a   Smith, Matthew J ^a   Gasmi Seabrook, Geneviève M C ^a   Stathopulos, Peter B ^a,e   Inagaki, Fuyuhiko ^b   Kay, Lewis E ^c,d   Neel, Benjamin G ^a   Ikura, Mitsuhiko ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOKKAIDO UNIVERSITY   (Japan)

^c UNIVERSITY OF TORONTO   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e WESTERN UNIVERSITY   (Canada)

Author keywords

KAS; Lipid bilayer nanodisc; Noonan syndrome; Nuclear magnetic resonance; Oncogenic mutation

Indexed keywords

GUANOSINE TRIPHOSPHATASE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; K-RAS4B PROTEIN, HUMAN; LIPID BILAYER; PROTEIN P21;

ARTICLE; BINDING SITE; CELL MEMBRANE; CONTROLLED STUDY; GENE MUTATION; LIPID BILAYER; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NOONAN SYNDROME; NUCLEAR MAGNETIC RESONANCE; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN DOMAIN; STATIC ELECTRICITY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR GENETICS; MUTATION; ONCOGENE RAS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

RATTUS;

AMINO ACID SEQUENCE; BINDING SITES; GENES, RAS; HUMANS; LIPID BILAYERS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTO-ONCOGENE PROTEINS P21(RAS); RAL GUANINE NUCLEOTIDE EXCHANGE FACTOR; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; STATIC ELECTRICITY;

EID: 84930221645     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419895112     Document Type: Article

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