메뉴 건너뛰기




Volumn 17, Issue 11, 2015, Pages 4802-4815

Dynamic exometabolome analysis reveals active metabolic pathways in non-replicating mycobacteria

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; GLYOXYLIC ACID DERIVATIVE; OXYGEN;

EID: 84949205916     PISSN: 14622912     EISSN: 14622920     Source Type: Journal    
DOI: 10.1111/1462-2920.13056     Document Type: Article
Times cited : (30)

References (42)
  • 1
    • 0038699591 scopus 로고    scopus 로고
    • High-throughput classification of yeast mutants for functional genomics using metabolic footprinting
    • Allen, J., Davey, H.M., Broadhurst, D., Heald, J.K., Rowland, J.J., Oliver, S.G., and Kell, D.B. (2003) High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nat Biotechnol 21: 692-696.
    • (2003) Nat Biotechnol , vol.21 , pp. 692-696
    • Allen, J.1    Davey, H.M.2    Broadhurst, D.3    Heald, J.K.4    Rowland, J.J.5    Oliver, S.G.6    Kell, D.B.7
  • 2
    • 84878239366 scopus 로고    scopus 로고
    • Metabolite profiling to characterize disease-related bacteria: gluconate excretion by Pseudomonas aeruginosa mutants and clinical isolates from cystic fibrosis patients
    • Behrends, V., Bell, T.J., Liebeke, M., Cordes-Blauert, A., Ashraf, S.N., Nair, C., etal. (2013) Metabolite profiling to characterize disease-related bacteria: gluconate excretion by Pseudomonas aeruginosa mutants and clinical isolates from cystic fibrosis patients. J Biol Chem 288: 15098-15109.
    • (2013) J Biol Chem , vol.288 , pp. 15098-15109
    • Behrends, V.1    Bell, T.J.2    Liebeke, M.3    Cordes-Blauert, A.4    Ashraf, S.N.5    Nair, C.6
  • 3
    • 84860583271 scopus 로고    scopus 로고
    • Regulation of proline metabolism in mycobacteria and its role in carbon metabolism under hypoxia
    • Berney, M., Weimar, M.R., Heikal, A., and Cook, G.M. (2012) Regulation of proline metabolism in mycobacteria and its role in carbon metabolism under hypoxia. Mol Microbiol 84: 664-681.
    • (2012) Mol Microbiol , vol.84 , pp. 664-681
    • Berney, M.1    Weimar, M.R.2    Heikal, A.3    Cook, G.M.4
  • 4
    • 47549099578 scopus 로고    scopus 로고
    • Using atom mapping rules for an improved detection of relevant routes in weighted metabolic networks
    • Blum, T., and Kohlbacher, O. (2008) Using atom mapping rules for an improved detection of relevant routes in weighted metabolic networks. J Comput Biol 15: 565-576.
    • (2008) J Comput Biol , vol.15 , pp. 565-576
    • Blum, T.1    Kohlbacher, O.2
  • 5
    • 11144250804 scopus 로고    scopus 로고
    • Tuberculosis - metabolism and respiration in the absence of growth
    • Boshoff, H.I.M., and Barry, C.E. (2005) Tuberculosis - metabolism and respiration in the absence of growth. Nat Rev Microbiol 3: 70-80.
    • (2005) Nat Rev Microbiol , vol.3 , pp. 70-80
    • Boshoff, H.I.M.1    Barry, C.E.2
  • 6
    • 0000935874 scopus 로고
    • Kinetics of utilization of organic compounds in the growth of mycobacterium tuberculosis
    • Bowles, J.A., and Segal, W. (1965) Kinetics of utilization of organic compounds in the growth of mycobacterium tuberculosis. J Bacteriol 90: 157-163.
    • (1965) J Bacteriol , vol.90 , pp. 157-163
    • Bowles, J.A.1    Segal, W.2
  • 8
    • 77952985821 scopus 로고    scopus 로고
    • Ultrahigh performance liquid chromatography-tandem mass spectrometry method for fast and robust quantification of anionic and aromatic metabolites
    • Buescher, J.M., Moco, S., Sauer, U., and Zamboni, N. (2010) Ultrahigh performance liquid chromatography-tandem mass spectrometry method for fast and robust quantification of anionic and aromatic metabolites. Anal Chem 82: 4403-4412.
    • (2010) Anal Chem , vol.82 , pp. 4403-4412
    • Buescher, J.M.1    Moco, S.2    Sauer, U.3    Zamboni, N.4
  • 9
    • 77957946456 scopus 로고    scopus 로고
    • Letting sleeping dos lie: does dormancy play a role in tuberculosis?
    • Chao, M.C., and Rubin, E.J. (2010) Letting sleeping dos lie: does dormancy play a role in tuberculosis? Annu Rev Microbiol 64: 293-311.
    • (2010) Annu Rev Microbiol , vol.64 , pp. 293-311
    • Chao, M.C.1    Rubin, E.J.2
  • 10
    • 30344456708 scopus 로고    scopus 로고
    • Inferring meaningful pathways in weighted metabolic networks
    • Croes, D., Couche, F., Wodak, S.J., and van Helden, J. (2006) Inferring meaningful pathways in weighted metabolic networks. J Mol Biol 356: 222-236.
    • (2006) J Mol Biol , vol.356 , pp. 222-236
    • Croes, D.1    Couche, F.2    Wodak, S.J.3    van Helden, J.4
  • 11
    • 0028176507 scopus 로고
    • Transport of C4-dicarboxylates by anaerobically grown Escherichia coli. Energetics and mechanism of exchange, uptake and efflux
    • Engel, P., Kramer, R., and Unden, G. (1994) Transport of C4-dicarboxylates by anaerobically grown Escherichia coli. Energetics and mechanism of exchange, uptake and efflux. Eur J Biochem 222: 605-614.
    • (1994) Eur J Biochem , vol.222 , pp. 605-614
    • Engel, P.1    Kramer, R.2    Unden, G.3
  • 12
    • 84876253419 scopus 로고    scopus 로고
    • Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis
    • Eoh, H., and Rhee, K.Y. (2013) Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis. PNAS 110: 6554-6559.
    • (2013) PNAS , vol.110 , pp. 6554-6559
    • Eoh, H.1    Rhee, K.Y.2
  • 13
    • 84860689683 scopus 로고    scopus 로고
    • Understanding latent tuberculosis: the key to improved diagnostic and novel treatment strategies
    • Esmail, H., Barry, C.E., III, and Wilkinson, R.J. (2012) Understanding latent tuberculosis: the key to improved diagnostic and novel treatment strategies. Drug Discov Today 17: 514-521.
    • (2012) Drug Discov Today , vol.17 , pp. 514-521
    • Esmail, H.1    Barry, C.E.2    Wilkinson, R.J.3
  • 14
    • 80052785690 scopus 로고    scopus 로고
    • High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry
    • Fuhrer, T., Heer, D., Begemann, B., and Zamboni, N. (2011) High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry. Anal Chem 83: 7074-7080.
    • (2011) Anal Chem , vol.83 , pp. 7074-7080
    • Fuhrer, T.1    Heer, D.2    Begemann, B.3    Zamboni, N.4
  • 15
    • 84859429244 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis: success through dormancy
    • Gengenbacher, M., and Kaufmann, S.H.E. (2012) Mycobacterium tuberculosis: success through dormancy. FEMS Microbiol Rev 36: 514-532.
    • (2012) FEMS Microbiol Rev , vol.36 , pp. 514-532
    • Gengenbacher, M.1    Kaufmann, S.H.E.2
  • 16
    • 76849095708 scopus 로고    scopus 로고
    • Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability
    • Gengenbacher, M., Rao, S.P.S., Pethe, K., and Dick, T. (2010) Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability. Microbiology 156: 81-87.
    • (2010) Microbiology , vol.156 , pp. 81-87
    • Gengenbacher, M.1    Rao, S.P.S.2    Pethe, K.3    Dick, T.4
  • 18
    • 84895761851 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection
    • Gouzy, A., Larrouy-Maumus, G., Bottai, D., Levillain, F., Dumas, A., Wallach, J.B., etal. (2014) Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection. PLoS Pathog 10: e1003928.
    • (2014) PLoS Pathog , vol.10 , pp. e1003928
    • Gouzy, A.1    Larrouy-Maumus, G.2    Bottai, D.3    Levillain, F.4    Dumas, A.5    Wallach, J.B.6
  • 19
    • 0036399823 scopus 로고    scopus 로고
    • How host-microbial interactions shape the nutrient environment of the mammalian intestine
    • Hooper, L.V., Midtvedt, T., and Gordon, J.I. (2002) How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu. Rev. Nutr. 22: 283-307.
    • (2002) Annu. Rev. Nutr. , vol.22 , pp. 283-307
    • Hooper, L.V.1    Midtvedt, T.2    Gordon, J.I.3
  • 20
    • 0032190355 scopus 로고    scopus 로고
    • Increased alanine dehydrogenase activity during dormancy in Mycobacterium smegmatis
    • Hutter, B., and Dick, T. (1998) Increased alanine dehydrogenase activity during dormancy in Mycobacterium smegmatis. FEMS Microbiol Lett 167: 7-11.
    • (1998) FEMS Microbiol Lett , vol.167 , pp. 7-11
    • Hutter, B.1    Dick, T.2
  • 21
    • 84861420588 scopus 로고    scopus 로고
    • Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
    • Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A.L., etal. (2012) Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336: 1040-1044.
    • (2012) Science , vol.336 , pp. 1040-1044
    • Jain, M.1    Nilsson, R.2    Sharma, S.3    Madhusudhan, N.4    Kitami, T.5    Souza, A.L.6
  • 22
    • 0043282812 scopus 로고    scopus 로고
    • Functional genomics via metabolic footprinting: monitoring metabolite secretion by Escherichia coli tryptophan metabolism mutants using FT-IR and direct injection electrospray mass spectrometry
    • Kaderbhai, N.N., Broadhurst, D.I., Ellis, D.I., Goodacre, R., and Kell, D.B. (2003) Functional genomics via metabolic footprinting: monitoring metabolite secretion by Escherichia coli tryptophan metabolism mutants using FT-IR and direct injection electrospray mass spectrometry. Comp Funct Genomics 4: 376-391.
    • (2003) Comp Funct Genomics , vol.4 , pp. 376-391
    • Kaderbhai, N.N.1    Broadhurst, D.I.2    Ellis, D.I.3    Goodacre, R.4    Kell, D.B.5
  • 23
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: Kyoto encyclopedia of genes and genomes
    • Kanehisa, M. (2000) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28: 27-30.
    • (2000) Nucleic Acids Res , vol.28 , pp. 27-30
    • Kanehisa, M.1
  • 24
    • 0014984409 scopus 로고
    • The uptake of C4-dicarboxylic acids by Escherichia coli
    • Kay, W.W., and Kornberg, H.L. (1971) The uptake of C4-dicarboxylic acids by Escherichia coli. Eur J Biochem 18: 274-281.
    • (1971) Eur J Biochem , vol.18 , pp. 274-281
    • Kay, W.W.1    Kornberg, H.L.2
  • 26
    • 77956823610 scopus 로고
    • Chapter XV evaluation of growth by physical and chemical means
    • Mallette, M.F. (1969) Chapter XV evaluation of growth by physical and chemical means. Methods Microbiol 1: 521-566.
    • (1969) Methods Microbiol , vol.1 , pp. 521-566
    • Mallette, M.F.1
  • 27
    • 77749320898 scopus 로고    scopus 로고
    • What is flux balance analysis?
    • Orth, J.D., Thiele, I., and Palsson, B.Ø. (2010) What is flux balance analysis? Nat Biotechnol 28: 245-248.
    • (2010) Nat Biotechnol , vol.28 , pp. 245-248
    • Orth, J.D.1    Thiele, I.2    Palsson, B.3
  • 28
    • 84865972260 scopus 로고    scopus 로고
    • Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms
    • Paczia, N., Nilgen, A., Lehmann, T., Gätgens, J., Wiechert, W., and Noack, S. (2012) Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms. Microb Cell Fact 11: 122.
    • (2012) Microb Cell Fact , vol.11 , pp. 122
    • Paczia, N.1    Nilgen, A.2    Lehmann, T.3    Gätgens, J.4    Wiechert, W.5    Noack, S.6
  • 30
    • 50149113470 scopus 로고    scopus 로고
    • The proton motive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis
    • Rao, S.P.S., Alonso, S., Rand, L., Dick, T., and Pethe, K. (2008) The proton motive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proc Natl Acad Sci USA 105: 11945-11950.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11945-11950
    • Rao, S.P.S.1    Alonso, S.2    Rand, L.3    Dick, T.4    Pethe, K.5
  • 31
    • 84855977005 scopus 로고    scopus 로고
    • Collisional fragmentation of central carbon metabolites in LC-MS/MS increases precision of 13C metabolic flux analysis
    • Rühl, M., Rupp, B., Nöh, K., Wiechert, W., Sauer, U., and Zamboni, N. (2011) Collisional fragmentation of central carbon metabolites in LC-MS/MS increases precision of 13C metabolic flux analysis. Biotechnol Bioeng 109: 763-771.
    • (2011) Biotechnol Bioeng , vol.109 , pp. 763-771
    • Rühl, M.1    Rupp, B.2    Nöh, K.3    Wiechert, W.4    Sauer, U.5    Zamboni, N.6
  • 32
    • 84949283365 scopus 로고    scopus 로고
    • Carbon flux rerouting during Mycobacterium tuberculosis growth arrestmmi_7399
    • Wiley Online Library.
    • Shi, L., Sohaskey, C., Pfeiffer, C., Datta, P., and Parks, M. (2010) Carbon flux rerouting during Mycobacterium tuberculosis growth arrestmmi_7399. Wiley Online Library.
    • (2010)
    • Shi, L.1    Sohaskey, C.2    Pfeiffer, C.3    Datta, P.4    Parks, M.5
  • 34
    • 69849092281 scopus 로고    scopus 로고
    • Central metabolism in Mycobacterium smegmatis during the transition from O2-rich to O2-poor conditions as studied by isotopomer-assisted metabolite analysis
    • Tang, Y.J., Shui, W., Myers, S., Feng, X., Bertozzi, C., and Keasling, J.D. (2009) Central metabolism in Mycobacterium smegmatis during the transition from O2-rich to O2-poor conditions as studied by isotopomer-assisted metabolite analysis. Biotechnol Lett 31: 1233-1240.
    • (2009) Biotechnol Lett , vol.31 , pp. 1233-1240
    • Tang, Y.J.1    Shui, W.2    Myers, S.3    Feng, X.4    Bertozzi, C.5    Keasling, J.D.6
  • 35
    • 0034468564 scopus 로고    scopus 로고
    • Stoichiometry of energy coupling by proton-translocating ATPases: a history of variability
    • Tomashek, J.J., and Brusilow, W.S. (2000) Stoichiometry of energy coupling by proton-translocating ATPases: a history of variability. J Bioenerg Biomembr 32: 493-500.
    • (2000) J Bioenerg Biomembr , vol.32 , pp. 493-500
    • Tomashek, J.J.1    Brusilow, W.S.2
  • 36
    • 37449003688 scopus 로고    scopus 로고
    • Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis
    • Upton, A.M., and McKinney, J.D. (2007) Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis. Microbiology 153: 3973-3982.
    • (2007) Microbiology , vol.153 , pp. 3973-3982
    • Upton, A.M.1    McKinney, J.D.2
  • 37
    • 80055079575 scopus 로고    scopus 로고
    • Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis
    • Watanabe, S., Zimmermann, M., Goodwin, M.B., Sauer, U., Barry, C.E., and Boshoff, H.I. (2011) Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis. PLoS Pathog 7: e1002287.
    • (2011) PLoS Pathog , vol.7 , pp. e1002287
    • Watanabe, S.1    Zimmermann, M.2    Goodwin, M.B.3    Sauer, U.4    Barry, C.E.5    Boshoff, H.I.6
  • 38
    • 0029976980 scopus 로고    scopus 로고
    • An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence
    • Wayne, L.G., and Hayes, L.G. (1996) An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun 64: 2062-2069.
    • (1996) Infect Immun , vol.64 , pp. 2062-2069
    • Wayne, L.G.1    Hayes, L.G.2
  • 39
    • 0019973896 scopus 로고
    • Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions
    • Wayne, L.G., and Lin, K.Y. (1982) Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions. Infect Immun 37: 1042-1049.
    • (1982) Infect Immun , vol.37 , pp. 1042-1049
    • Wayne, L.G.1    Lin, K.Y.2
  • 40
    • 0034780485 scopus 로고    scopus 로고
    • Nonreplicating persistence of Mycobacterium tuberculosis
    • Wayne, L.G., and Sohaskey, C.D. (2001) Nonreplicating persistence of Mycobacterium tuberculosis. Annu Rev Microbiol 55: 139-163.
    • (2001) Annu Rev Microbiol , vol.55 , pp. 139-163
    • Wayne, L.G.1    Sohaskey, C.D.2
  • 42
    • 84883479917 scopus 로고    scopus 로고
    • Nontargeted profiling of coenzyme A thioesters in biological samples by tandem mass spectrometry
    • Zimmermann, M., Thormann, V., Sauer, U., and Zamboni, N. (2013) Nontargeted profiling of coenzyme A thioesters in biological samples by tandem mass spectrometry. Anal Chem 85: 8284-8290.
    • (2013) Anal Chem , vol.85 , pp. 8284-8290
    • Zimmermann, M.1    Thormann, V.2    Sauer, U.3    Zamboni, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.