Increased alanine dehydrogenase activity during dormancy in Mycobacterium smegmatis

FEMS Microbiology Letters

Volumn 167, Issue 1, 1998, Pages 7-11

  Hutter, Bernd ^a   Dick, Thomas ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

Anaerobiosis; Dormancy; Mycobacterium smegmatis

Indexed keywords

ALANINE DEHYDROGENASE;

ANAEROBIC GROWTH; ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PRIORITY JOURNAL;

ADAPTATION, PHYSIOLOGICAL; AEROBIOSIS; ALANINE DEHYDROGENASE; AMINO ACID OXIDOREDUCTASES; ANAEROBIOSIS; ANTITUBERCULAR AGENTS; DRUG RESISTANCE, MICROBIAL; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MYCOBACTERIUM INFECTIONS, ATYPICAL; MYCOBACTERIUM SMEGMATIS; NAD; OXIDATION-REDUCTION; PROLINE OXIDASE;

EID: 0032190355     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(98)00360-7     Document Type: Article

References (20)

1. Parrish, N.M., Dick, J.D. and Bishai, W.R. (1998) Mechanisms of latency in Mycobacterium tuberculosis. Trends Microbiol. 6, 107-112.
2. Wayne, L.G. (1994) Dormancy of Mycobacterium tuberculosis and latency of disease. Eur. J. Clin. Microbiol. Infect. Dis. 13, 908-914.
3. Wayne, L.G. and Hayes, L.G. (1996) An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect. Immun. 64, 2062-2069.
4. Wayne, L.G. and Salkin, D. (1956) The bacteriology of resected tuberculous pulmonary lesions. J. Am. Rev. Respir. Dis. 74, 376-387.
5. Dick, T., Lee, B.H. and Murugasu-Oei, B. (1998) Oxygen depletion induced dormancy in Mycobacterium smegmatis. FEMS Microbiol. Lett. 163, 159-164.
6. DeMaio, J., Zhang, Y., Ko, C., Young, D.B. and Bishai, W.R. (1996) A stationary-phase stress-response sigma factor from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 93, 2790-2794.
7. Yuan, Y., Crane, D.D. and Barry, C.E. III (1996) Stationary phase-associated protein expression in Mycobacterium tuberculosis: Function of the mycobacterial alpha-crystallin homolog. J. Bacteriol. 178, 4484-4492.
8. Cunningham, A.F. and Spreadbury, C.L. (1998) Mycobacterial stationary phase induced by low oxygen tension: cell wall thickening and localization of the 16-kilodalton alpha-crystallin homolog. J. Bacteriol. 180, 801-808.
9. Hu, Y.M., Butcher, P.D., Sole, K., Mitchison, D.A. and Coates, A.R.M. (1998) Protein synthesis is shut down in dormant Mycobacterium tuberculosis. FEMS Microbiol. Lett. 158, 139-145.
10. Andersen, A.B., Andersen, P. and Ljungqvist, L. (1992) Structure and function of a 40 000-molecular-weight protein antigen of Mycobacterium tuberculosis. Infect. Immun. 60, 2317-2323.
11. Hutter, B. and Singh, M. (1998) Host vector system for high level expression and purification of recombinant, enzymatically active alanine dehydrogenase of Mycobacterium tuberculosis. Gene 212, 21-29.
12. Hutter, B. (1996) Die L-Alanin Dehydrogenase aus M. tuberculosis und anderen Mycobakterien: Charakterisierung und klinische Relevanz der Gene und ihrer Produkte. PhD Thesis, University Braunschweig, Germany.
13. Goldman, D.S. (1959) Enzyme systems in mycobacteria. VII. Purification, properties, and mechanism of action of alanine dehydrogenase. Biochim. Biophys. Acta 34, 527-539.
14. Snapper, S.B., Melton, R.E., Mustafa, S., Kieser, T. and Jacobs, W.R. Jr. (1990) Isolation and characterisation of efficient plasmid transformation mutants of Mycobacterium smegmatis. Mol. Microbiol. 4, 1911-1919.
15. Basu, J., Chattopadhyay, R., Kundu, M. and Chakrabarti, P. (1992) Purification and partial characterisation of a penicillin-binding protein from Mycobacterium smegmatis. J. Bacteriol. 174, 4829-4832.
16. Brunhuber, N.M.W. and Blanchard, J.S. (1994) The biochemistry and enzymology of amino acid dehydrogenases. Crit. Rev. Biochem. Mol. Biol. 29, 415-467.
17. Ohshima, T. and Soda, K. (1979) Purification and properties of alanine dehydrogenase from Bacillus sphaericus. Eur. J. Biochem. 100, 29-39.
18. Goldman, D.S. and Wagner, M.J. (1962) Enzyme systems in the mycobacteria. XIII. Glycine dehydrogenase and the glyoxylic cycle. Biochim. Biophys. Acta 65, 297-306.
19. Wayne, L.G. and Lin, K.Y. (1982) Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions. Infect. Immun. 37, 1042-1049.
20. Philipp, W.J., Poulet, S., Eigelmeier, K., Pascopella, L., Balasubramaninan, V., Heym, B., Bergh, S., Bloom, B.R., Jacobs, W.R. Jr. and Cole, S.T. (1996) An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae. Proc. Natl. Acad. Sci. USA 93, 3132-3137.