Mechanism of neem limonoids-induced cell death in cancer: Role of oxidative phosphorylation

Free Radical Biology and Medicine

Volumn 90, Issue , 2016, Pages 261-271

  Yadav, Neelu ^a   Kumar, Sandeep ^a   Kumar, Rahul ^a   Srivastava, Pragya ^a   Sun, Leimin ^a,b   Rapali, Peter ^a   Marlowe, Timothy ^a   Schneider, Andrea ^a   Inigo, Joseph R ^a   O'Malley, Jordan ^a   Londonkar, Ramesh ^a   Gogada, Raghu ^a   Chaudhary, Ajay K ^a   Yadava, Nagendra ^c   Chandra, Dhyan ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b ZHEJIANG UNIVERSITY   (China)

^c Pioneer Valley Life Sciences Institute   (United States)

Author keywords

Apoptosis; Mitochondrial DNA; Necroptosis; Neem; Oxidative phosphorylation complex; ROS

Indexed keywords

CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; LIMONOID; MITOCHONDRIAL DNA; NEEM OIL; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE (UBIQUINONE); CARRIER PROTEIN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNM1L PROTEIN, HUMAN; GUANOSINE TRIPHOSPHATASE; MICROTUBULE ASSOCIATED PROTEIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOCHONDRIAL PROTEIN; PROTEIN P53; TP53 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AZADIRACHTA INDICA; BIOMASS; CANCER CELL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; NONHUMAN; OUTER MEMBRANE; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; UPREGULATION; CHEMISTRY; DRUG EFFECTS; HCT 116 CELL LINE; METABOLISM; NEOPLASMS; PATHOLOGY; PHYSIOLOGY;

APOPTOSIS; AZADIRACHTA; CASPASES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX I; GTP PHOSPHOHYDROLASES; HCT116 CELLS; HUMANS; LIMONINS; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; NEOPLASMS; OXIDATIVE PHOSPHORYLATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84949033763     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.11.028     Document Type: Article

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