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Volumn 10, Issue 23, 2011, Pages 4128-4137

Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis

Author keywords

Apaf 1; Caspase; Curcumin; Cytochrome c; Mitochondria; p21

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BIM PROTEIN; CASPASE; CASPASE 3; CASPASE 8; CURCUMIN; CYTOCHROME C; PROTEIN BAK; PROTEIN BAX; PROTEIN BID; PROTEIN P21;

EID: 82855181502     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.23.18292     Document Type: Article
Times cited : (70)

References (55)
  • 1
    • 0034717046 scopus 로고    scopus 로고
    • L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis
    • PMID:10747850; DOI:10.1074/jbc.C000105200
    • Anto RJ, Maliekal TT, Karunagaran D. L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis. J Biol Chem 2000; 275:15601-4; PMID:10747850; DOI:10.1074/jbc.C000105200.
    • (2000) J Biol Chem , vol.275 , pp. 15601-15604
    • Anto, R.J.1    Maliekal, T.T.2    Karunagaran, D.3
  • 2
    • 4644364745 scopus 로고    scopus 로고
    • Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2
    • PMID:15367704
    • Syng-Ai C, Kumari AL, Khar A. Effect of curcumin on normal and tumor cells: role of glutathione and bcl-2. Mol Cancer Ther 2004; 3:1101-8; PMID:15367704.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1101-1108
    • Syng-Ai, C.1    Kumari, A.L.2    Khar, A.3
  • 3
    • 70350225860 scopus 로고    scopus 로고
    • Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics
    • PMID:19660870; DOI:10.1016/j.ctrv.2009.07.001
    • Sarkar FH, Li Y. Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics. Cancer Treat Rev 2009; 35:597-607; PMID:19660870; DOI:10.1016/j.ctrv.2009.07.001.
    • (2009) Cancer Treat Rev , vol.35 , pp. 597-607
    • Sarkar, F.H.1    Li, Y.2
  • 4
    • 16844371915 scopus 로고    scopus 로고
    • Induction of apoptosis by curcumin and its implications for cancer therapy
    • PMID:15810876; DOI:10.2174/1568009053202081
    • Karunagaran D, Rashmi R, Kumar TR. Induction of apoptosis by curcumin and its implications for cancer therapy. Curr Cancer Drug Targets 2005; 5:117-29; PMID:15810876; DOI:10.2174/1568009053202081.
    • (2005) Curr Cancer Drug Targets , vol.5 , pp. 117-129
    • Karunagaran, D.1    Rashmi, R.2    Kumar, T.R.3
  • 5
    • 79955804832 scopus 로고    scopus 로고
    • Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia
    • Phila PMID:21372035; DOI:10.1158/1940-6207.CAPR-10-0098
    • Carroll RE, Benya RV, Turgeon DK, Vareed S, Neuman M, Rodriguez L, et al. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res (Phila) 2011; 4:354-64; PMID:21372035; DOI:10.1158/1940-6207.CAPR-10-0098.
    • (2011) Cancer Prev Res , vol.4 , pp. 354-364
    • Carroll, R.E.1    Benya, R.V.2    Turgeon, D.K.3    Vareed, S.4    Neuman, M.5    Rodriguez, L.6
  • 6
    • 84934444244 scopus 로고    scopus 로고
    • Clinical studies with curcumin
    • PMID:17569225; DOI:10.1007/978-0-387-46401- 5-21
    • Hsu CH, Cheng AL. Clinical studies with curcumin. Adv Exp Med Biol 2007; 595:471-80; PMID:17569225; DOI:10.1007/978-0-387-46401- 5-21.
    • (2007) Adv Exp Med Biol , vol.595 , pp. 471-480
    • Hsu, C.H.1    Cheng, A.L.2
  • 7
    • 0037305821 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) downregulates the constitutive activation of nuclear factor kappaB and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis
    • PMID:12393461; DOI:10.1182/blood-2002-05-1320
    • Bharti AC, Donato N, Singh S, Aggarwal BB. Curcumin (diferuloylmethane) downregulates the constitutive activation of nuclear factor kappaB and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 2003; 101:1053-62; PMID:12393461; DOI:10.1182/blood-2002-05-1320.
    • (2003) Blood , vol.101 , pp. 1053-1062
    • Bharti, A.C.1    Donato, N.2    Singh, S.3    Aggarwal, B.B.4
  • 8
    • 0031000902 scopus 로고    scopus 로고
    • Modulation of apoptosis by sulindac, curcumin, phenylethyl-3- methylcaffeate and 6-phenylhexyl isothiocyanate: Apoptotic index as a biomarker in colon cancer chemoprevention and promotion
    • PMID:9102217
    • Samaha HS, Kelloff GJ, Steele V, Rao CV, Reddy BS. Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res 1997; 57:1301-5; PMID:9102217.
    • (1997) Cancer Res , vol.57 , pp. 1301-1305
    • Samaha, H.S.1    Kelloff, G.J.2    Steele, V.3    Rao, C.V.4    Reddy, B.S.5
  • 9
    • 77956231201 scopus 로고    scopus 로고
    • Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells
    • PMID:20472336; DOI:10.1016/j.canlet.2010.04.018
    • Watson JL, Hill R, Yaffe PB, Greenshields A, Walsh M, Lee PW, et al. Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells. Cancer Lett 2010; 297:1-8; PMID:20472336; DOI:10.1016/j.canlet.2010.04.018.
    • (2010) Cancer Lett , vol.297 , pp. 1-8
    • Watson, J.L.1    Hill, R.2    Yaffe, P.B.3    Greenshields, A.4    Walsh, M.5    Lee, P.W.6
  • 10
    • 40949089329 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species affect sensitivity to curcumin-induced apoptosis
    • PMID:18206126; DOI:10.1016/j.freeradbiomed.2007.12.034
    • Hail N Jr. Mitochondrial reactive oxygen species affect sensitivity to curcumin-induced apoptosis. Free Radic Biol Med 2008; 44:1382-93; PMID:18206126; DOI:10.1016/j.freeradbiomed.2007.12.034.
    • (2008) Free Radic Biol Med , vol.44 , pp. 1382-1393
    • Hail Jr., N.1
  • 11
    • 21244498576 scopus 로고    scopus 로고
    • Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner
    • PMID:15738001; DOI:10.1074/jbc.M410670200
    • Choudhuri T, Pal S, Das T, Sa G. Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner. J Biol Chem 2005; 280:20059-68; PMID:15738001; DOI:10.1074/jbc.M410670200.
    • (2005) J Biol Chem , vol.280 , pp. 20059-20068
    • Choudhuri, T.1    Pal, S.2    Das, T.3    Sa, G.4
  • 12
    • 0031716184 scopus 로고    scopus 로고
    • Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells
    • PMID:9764849; DOI:10.1046/ j.1523-747.1998.00352.x
    • Jee SH, Shen SC, Tseng CR, Chiu HC, Kuo ML. Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells. J Invest Dermatol 1998; 111:656-61; PMID:9764849; DOI:10.1046/ j.1523-747.1998.00352.x.
    • (1998) J Invest Dermatol , vol.111 , pp. 656-661
    • Jee, S.H.1    Shen, S.C.2    Tseng, C.R.3    Chiu, H.C.4    Kuo, M.L.5
  • 13
    • 74249083465 scopus 로고    scopus 로고
    • Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling
    • PMID:19676105
    • Watson JL, Greenshields A, Hill R, Hilchie A, Lee PW, Giacomantonio CA, et al. Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling. Mol Carcinog 2010; 49:13-24; PMID:19676105.
    • (2010) Mol Carcinog , vol.49 , pp. 13-24
    • Watson, J.L.1    Greenshields, A.2    Hill, R.3    Hilchie, A.4    Lee, P.W.5    Giacomantonio, C.A.6
  • 14
    • 0037070201 scopus 로고    scopus 로고
    • Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction
    • PMID:11852106; DOI:10.1016/ S0014-5793(02)02292-5
    • Choudhuri T, Pal S, Agwarwal ML, Das T, Sa G. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett 2002; 512:334-40; PMID:11852106; DOI:10.1016/ S0014-5793(02)02292-5.
    • (2002) FEBS Lett , vol.512 , pp. 334-340
    • Choudhuri, T.1    Pal, S.2    Agwarwal, M.L.3    Das, T.4    Sa, G.5
  • 15
    • 34447306902 scopus 로고    scopus 로고
    • Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa
    • PMID:17277231; DOI:10.1093/carcin/bgm024
    • Shankar S, Srivastava RK. Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa. Carcinogenesis 2007; 28:1277-86; PMID:17277231; DOI:10.1093/carcin/bgm024.
    • (2007) Carcinogenesis , vol.28 , pp. 1277-1286
    • Shankar, S.1    Srivastava, R.K.2
  • 17
    • 3943071150 scopus 로고    scopus 로고
    • Cytochrome C-mediated apoptosis
    • PMID:15189137; DOI:10.1146/annurev.biochem. 73.011303.073706
    • Jiang X, Wang X. Cytochrome C-mediated apoptosis. Annu Rev Biochem 2004; 73:87-106; PMID:15189137; DOI:10.1146/annurev.biochem. 73.011303.073706.
    • (2004) Annu Rev Biochem , vol.73 , pp. 87-106
    • Jiang, X.1    Wang, X.2
  • 18
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • PMID:9721089; DOI:10.1126/science. 281.5381.1305
    • Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998; 281:1305- 8; PMID:9721089; DOI:10.1126/science. 281.5381.1305.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 19
    • 43049152912 scopus 로고    scopus 로고
    • TNFalpha induces two distinct caspase 8 activation pathways
    • PMID:18485876; DOI:10.1016/j.cell.2008.03.036
    • Wang L, Du F, Wang X. TNFalpha induces two distinct caspase 8 activation pathways. Cell 2008; 133:693-703; PMID:18485876; DOI:10.1016/j.cell.2008.03.036.
    • (2008) Cell , vol.133 , pp. 693-703
    • Wang, L.1    Du, F.2    Wang, X.3
  • 20
    • 0036195104 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) induces apoptosis through activation of caspase 8, BID cleavage and cytochrome c release: Its suppression by ectopic expression of Bcl-2 and Bcl-xl
    • PMID:11756235; DOI:10.1093/carcin/23.1.143
    • Anto RJ, Mukhopadhyay A, Denning K, Aggarwal BB. Curcumin (diferuloylmethane) induces apoptosis through activation of caspase 8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 2002; 23:143-50; PMID:11756235; DOI:10.1093/carcin/23.1.143.
    • (2002) Carcinogenesis , vol.23 , pp. 143-150
    • Anto, R.J.1    Mukhopadhyay, A.2    Denning, K.3    Aggarwal, B.B.4
  • 21
    • 0035842333 scopus 로고    scopus 로고
    • Curcumin induces apoptosis in human melanoma cells through a Fas receptor/ caspase 8 pathway independent of p53
    • PMID:11716543; DOI:10.1006/ excr.2001.5381
    • Bush JA, Cheung KJ Jr, Li G. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/ caspase 8 pathway independent of p53. Exp Cell Res 2001; 271:305-14; PMID:11716543; DOI:10.1006/ excr.2001.5381.
    • (2001) Exp Cell Res , vol.271 , pp. 305-314
    • Bush, J.A.1    Cheung Jr., K.J.2    Li, G.3
  • 22
    • 84863011324 scopus 로고    scopus 로고
    • Curcumin Induces Small Cell Lung Cancer NCI-H446 Cell Apoptosis via the Reactive Oxygen Species-Mediated Mitochondrial Pathway and Not the Cell Death Receptor Pathway
    • In Press; PMID:21711158; DOI:10.1089/ dna.2011.1300
    • Yang CL, Ma YG, Xue YX, Liu YY, Xie H, Qiu GR. Curcumin Induces Small Cell Lung Cancer NCI-H446 Cell Apoptosis via the Reactive Oxygen Species-Mediated Mitochondrial Pathway and Not the Cell Death Receptor Pathway. DNA Cell Biol 2011; In Press; PMID:21711158; DOI:10.1089/ dna.2011.1300.
    • (2011) DNA Cell Biol
    • Yang, C.L.1    Ma, Y.G.2    Xue, Y.X.3    Liu, Y.Y.4    Xie, H.5    Qiu, G.R.6
  • 23
    • 1642564603 scopus 로고    scopus 로고
    • Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway
    • PMID:14701837; DOI:10.1074/jbc. M310369200
    • Jana NR, Dikshit P, Goswami A, Nukina N. Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. J Biol Chem 2004; 279:11680-5; PMID:14701837; DOI:10.1074/jbc. M310369200.
    • (2004) J Biol Chem , vol.279 , pp. 11680-11685
    • Jana, N.R.1    Dikshit, P.2    Goswami, A.3    Nukina, N.4
  • 24
    • 0344053451 scopus 로고    scopus 로고
    • In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
    • PMID:8755496; DOI:10.1073/pnas.93.15.7464
    • Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, et al. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci USA 1996; 93:7464-9; PMID:8755496; DOI:10.1073/pnas.93.15.7464.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7464-7469
    • Fernandes-Alnemri, T.1    Armstrong, R.C.2    Krebs, J.3    Srinivasula, S.M.4    Wang, L.5    Bullrich, F.6
  • 25
    • 0029068871 scopus 로고
    • Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
    • PMID:7596430; DOI:10.1038/376037a0
    • Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 1995; 376:37-43; PMID:7596430; DOI:10.1038/376037a0.
    • (1995) Nature , vol.376 , pp. 37-43
    • Nicholson, D.W.1    Ali, A.2    Thornberry, N.A.3    Vaillancourt, J.P.4    Ding, C.K.5    Gallant, M.6
  • 26
    • 0037184954 scopus 로고    scopus 로고
    • Early mitochondrial activation and cytochrome c upregulation during apoptosis
    • PMID:12407106; DOI:10.1074/jbc.M207622200
    • Chandra D, Liu JW, Tang DG. Early mitochondrial activation and cytochrome c upregulation during apoptosis. J Biol Chem 2002; 277:50842-54; PMID:12407106; DOI:10.1074/jbc.M207622200.
    • (2002) J Biol Chem , vol.277 , pp. 50842-50854
    • Chandra, D.1    Liu, J.W.2    Tang, D.G.3
  • 27
    • 80051700801 scopus 로고    scopus 로고
    • Resveratrol Induces p53-independent, X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Bax Protein Oligomerization on Mitochondria to Initiate Cytochrome c Release and Caspase Activation
    • PMID:21712378; DOI:10.1074/jbc.M110.202440
    • Gogada R, Prabhu V, Amadori M, Scott R, Hashmi S, Chandra D. Resveratrol Induces p53-independent, X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Bax Protein Oligomerization on Mitochondria to Initiate Cytochrome c Release and Caspase Activation. J Biol Chem 2011; 286:28749-60; PMID:21712378; DOI:10.1074/jbc.M110.202440.
    • (2011) J Biol Chem , vol.286 , pp. 28749-28760
    • Gogada, R.1    Prabhu, V.2    Amadori, M.3    Scott, R.4    Hashmi, S.5    Chandra, D.6
  • 28
    • 33745957572 scopus 로고    scopus 로고
    • Pro-apoptotic multidomain Bcl-2/Bax-family proteins: Mechanisms, physiological roles and therapeutic opportunities
    • PMID:16729025; DOI:10.1038/sj.cdd.4401975
    • Reed JC. Pro-apoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles and therapeutic opportunities. Cell Death Differ 2006; 13:1378- 86; PMID:16729025; DOI:10.1038/sj.cdd.4401975.
    • (2006) Cell Death Differ , vol.13 , pp. 1378-1386
    • Reed, J.C.1
  • 29
    • 79952694861 scopus 로고    scopus 로고
    • BH3-only proteins: Orchestrators of apoptosis
    • PMID:21146563; DOI:10.1016/j.bbamcr.2010.11.024
    • Shamas-Din A, Brahmbhatt H, Leber B, Andrews DW. BH3-only proteins: Orchestrators of apoptosis. Biochim Biophys Acta 2011; 1813:508-20; PMID:21146563; DOI:10.1016/j.bbamcr.2010.11.024.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 508-520
    • Shamas-Din, A.1    Brahmbhatt, H.2    Leber, B.3    Andrews, D.W.4
  • 30
    • 0033580901 scopus 로고    scopus 로고
    • Caspases induce cytochrome c release from mitochondria by activating cytosolic factors
    • PMID:10364179; DOI:10.1074/jbc.274.25.17484
    • Bossy-Wetzel E, Green DR. Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. J Biol Chem 1999; 274:17484-90; PMID:10364179; DOI:10.1074/jbc.274.25.17484.
    • (1999) J Biol Chem , vol.274 , pp. 17484-17490
    • Bossy-Wetzel, E.1    Green, D.R.2
  • 31
    • 0842278331 scopus 로고    scopus 로고
    • Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    • PMID:14963330; DOI:10.1126/science.1092734
    • Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004; 303:1010-4; PMID:14963330; DOI:10.1126/science.1092734.
    • (2004) Science , vol.303 , pp. 1010-1014
    • Chipuk, J.E.1    Kuwana, T.2    Bouchier-Hayes, L.3    Droin, N.M.4    Newmeyer, D.D.5    Schuler, M.6
  • 32
    • 51049086207 scopus 로고    scopus 로고
    • Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain
    • PMID:18524770; DOI:10.1074/jbc.M710539200
    • Pietsch EC, Perchiniak E, Canutescu AA, Wang G, Dunbrack RL, Murphy ME. Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain. J Biol Chem 2008; 283:21294-304; PMID:18524770; DOI:10.1074/jbc. M710539200.
    • (2008) J Biol Chem , vol.283 , pp. 21294-21304
    • Pietsch, E.C.1    Perchiniak, E.2    Canutescu, A.A.3    Wang, G.4    Dunbrack, R.L.5    Murphy, M.E.6
  • 33
    • 0035884995 scopus 로고    scopus 로고
    • Curcumin inhibits activation of Vgamma9Vdelta2 T cells by phosphoantigens and induces apoptosis involving apoptosis-inducing factor and large scale DNA fragmentation
    • PMID:11544338
    • Cipriani B, Borsellino G, Knowles H, Tramonti D, Cavaliere F, Bernardi G, et al. Curcumin inhibits activation of Vgamma9Vdelta2 T cells by phosphoantigens and induces apoptosis involving apoptosis-inducing factor and large scale DNA fragmentation. J Immunol 2001; 167:3454-62; PMID:11544338.
    • (2001) J Immunol , vol.167 , pp. 3454-3462
    • Cipriani, B.1    Borsellino, G.2    Knowles, H.3    Tramonti, D.4    Cavaliere, F.5    Bernardi, G.6
  • 34
    • 0037028207 scopus 로고    scopus 로고
    • Betacatenin- mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)- induced growth arrest and apoptosis in colon cancer cells
    • PMID:12466962; DOI:10.1038/sj.onc.1205947
    • Jaiswal AS, Marlow BP, Gupta N, Narayan S. Betacatenin- mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)- induced growth arrest and apoptosis in colon cancer cells. Oncogene 2002; 21:8414-27; PMID:12466962; DOI:10.1038/sj.onc.1205947.
    • (2002) Oncogene , vol.21 , pp. 8414-8427
    • Jaiswal, A.S.1    Marlow, B.P.2    Gupta, N.3    Narayan, S.4
  • 35
    • 35848938724 scopus 로고    scopus 로고
    • Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy
    • PMID:17786026
    • Shinojima N, Yokoyama T, Kondo Y, Kondo S. Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy 2007; 3:635-7; PMID:17786026.
    • (2007) Autophagy , vol.3 , pp. 635-637
    • Shinojima, N.1    Yokoyama, T.2    Kondo, Y.3    Kondo, S.4
  • 36
    • 0042710263 scopus 로고    scopus 로고
    • Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells
    • PMID:12533677
    • Deeb D, Xu YX, Jiang H, Gao X, Janakiraman N, Chapman RA, et al. Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells. Mol Cancer Ther 2003; 2:95-103; PMID:12533677.
    • (2003) Mol Cancer Ther , vol.2 , pp. 95-103
    • Deeb, D.1    Xu, Y.X.2    Jiang, H.3    Gao, X.4    Janakiraman, N.5    Chapman, R.A.6
  • 38
    • 77953554440 scopus 로고    scopus 로고
    • Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis
    • PMID:20305378; DOI:10.4161/ cc.9.7.11193
    • Cipriano R, Patton JT, Mayo LD, Jackson MW. Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis. Cell Cycle 2010; 9:1373-9; PMID:20305378; DOI:10.4161/ cc.9.7.11193.
    • (2010) Cell Cycle , vol.9 , pp. 1373-1379
    • Cipriano, R.1    Patton, J.T.2    Mayo, L.D.3    Jackson, M.W.4
  • 39
    • 79957464247 scopus 로고    scopus 로고
    • Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis
    • PMID:21311096
    • Trinh DL, Elwi AN, Kim SW. Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis. Oncotarget 2010; 1:396-404; PMID:21311096.
    • (2010) Oncotarget , vol.1 , pp. 396-404
    • Trinh, D.L.1    Elwi, A.N.2    Kim, S.W.3
  • 40
    • 69749092037 scopus 로고    scopus 로고
    • Wild-type p53 protects normal cells against apoptosis induced by thiostrepton
    • PMID:19652535; DOI:10.4161/cc.8.17.9414
    • Halasi M, Schraufnagel DP, Gartel AL. Wild-type p53 protects normal cells against apoptosis induced by thiostrepton. Cell Cycle 2009; 8:2850-1; PMID:19652535; DOI:10.4161/cc.8.17.9414.
    • (2009) Cell Cycle , vol.8 , pp. 2850-2851
    • Halasi, M.1    Schraufnagel, D.P.2    Gartel, A.L.3
  • 41
    • 77955763927 scopus 로고    scopus 로고
    • Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence
    • PMID:20703098; DOI:10.4161/cc.9.16.12688
    • Tavana O, Benjamin CL, Puebla-Osorio N, Sang M, Ullrich SE, Ananthaswamy HN, et al. Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence. Cell Cycle 2010; 9:3328-36; PMID:20703098; DOI:10.4161/cc.9.16.12688.
    • (2010) Cell Cycle , vol.9 , pp. 3328-3336
    • Tavana, O.1    Benjamin, C.L.2    Puebla-Osorio, N.3    Sang, M.4    Ullrich, S.E.5    Ananthaswamy, H.N.6
  • 42
    • 77955261430 scopus 로고    scopus 로고
    • Curcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF-7 cells
    • PMID:20646066
    • Banerjee M, Singh P, Panda D. Curcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF-7 cells. FEBS J 2010; 277:3437-48; PMID:20646066.
    • (2010) FEBS J , vol.277 , pp. 3437-3448
    • Banerjee, M.1    Singh, P.2    Panda, D.3
  • 43
    • 40449094048 scopus 로고    scopus 로고
    • Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: Role of early growth response-1 expression
    • PMID:18316600; DOI:10.1158/0008-5472.CAN-07-5222
    • Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression. Cancer Res 2008; 68:1369-77; PMID:18316600; DOI:10.1158/0008-5472.CAN-07-5222.
    • (2008) Cancer Res , vol.68 , pp. 1369-1377
    • Choi, B.H.1    Kim, C.G.2    Bae, Y.S.3    Lim, Y.4    Lee, Y.H.5    Shin, S.Y.6
  • 44
    • 33947270928 scopus 로고    scopus 로고
    • Curcumin, a dietary component, has anticancer, chemosensitization and radiosensitization effects by downregulating the MDM2 oncogene through the PI3K/ mTOR/ETS2 pathway
    • PMID:17332326; DOI:10.1158/0008-5472.CAN- 06-3066
    • Li M, Zhang Z, Hill DL, Wang H, Zhang R. Curcumin, a dietary component, has anticancer, chemosensitization and radiosensitization effects by downregulating the MDM2 oncogene through the PI3K/ mTOR/ETS2 pathway. Cancer Res 2007; 67:1988-96; PMID:17332326; DOI:10.1158/0008-5472.CAN- 06-3066.
    • (2007) Cancer Res , vol.67 , pp. 1988-1996
    • Li, M.1    Zhang, Z.2    Hill, D.L.3    Wang, H.4    Zhang, R.5
  • 45
    • 70350228784 scopus 로고    scopus 로고
    • Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels
    • PMID:19806015; DOI:10.4161/cc.8.20.9565
    • Villeneuve NF, Sun Z, Chen W, Zhang DD. Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels. Cell Cycle 2009; 8:3255-6; PMID:19806015; DOI:10.4161/cc.8.20.9565.
    • (2009) Cell Cycle , vol.8 , pp. 3255-3256
    • Villeneuve, N.F.1    Sun, Z.2    Chen, W.3    Zhang, D.D.4
  • 46
    • 70350217760 scopus 로고    scopus 로고
    • WAF1/CIP1 protein
    • PMID:19770587; DOI:10.4161/cc.8.20.9832
    • WAF1/CIP1 protein. Cell Cycle 2009; 8:3328-39; PMID:19770587; DOI:10.4161/cc.8.20.9832.
    • (2009) Cell Cycle , vol.8 , pp. 3328-3339
    • Hu, J.1    Cai, X.F.2    Yan, G.3
  • 47
    • 0036594890 scopus 로고    scopus 로고
    • The role of the cyclin-dependent kinase inhibitor p21 in apoptosis
    • PMID:12479224
    • Gartel AL, Tyner AL. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 2002; 1:639-49; PMID:12479224.
    • (2002) Mol Cancer Ther , vol.1 , pp. 639-649
    • Gartel, A.L.1    Tyner, A.L.2
  • 49
    • 37549050536 scopus 로고    scopus 로고
    • Linkage of curcumin-induced cell cycle arrest and apoptosis by cyclin-dependent kinase inhibitor p21(WAF1/ CIP1)
    • PMID:18156803; DOI:10.4161/cc.6.23.4951
    • Srivastava RK, Chen Q, Siddiqui I, Sarva K, Shankar S. Linkage of curcumin-induced cell cycle arrest and apoptosis by cyclin-dependent kinase inhibitor p21(WAF1/ CIP1). Cell Cycle 2007; 6:2953-61; PMID:18156803; DOI:10.4161/cc.6.23.4951.
    • (2007) Cell Cycle , vol.6 , pp. 2953-2961
    • Srivastava, R.K.1    Chen, Q.2    Siddiqui, I.3    Sarva, K.4    Shankar, S.5
  • 50
    • 33745246534 scopus 로고    scopus 로고
    • Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome
    • PMID:16814719; DOI:10.1016/j.cell.2006.05.026
    • Chandra D, Bratton SB, Person MD, Tian Y, Martin AG, Ayres M, et al. Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome. Cell 2006; 125:1333-46; PMID:16814719; DOI:10.1016/j.cell.2006.05.026.
    • (2006) Cell , vol.125 , pp. 1333-1346
    • Chandra, D.1    Bratton, S.B.2    Person, M.D.3    Tian, Y.4    Martin, A.G.5    Ayres, M.6
  • 51
    • 0034602188 scopus 로고    scopus 로고
    • Role of BAX in the apoptotic response to anticancer agents
    • PMID:11062132; DOI:10.1126/science.290.5493.989
    • Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B. Role of BAX in the apoptotic response to anticancer agents. Science 2000; 290:989-92; PMID:11062132; DOI:10.1126/science.290.5493.989.
    • (2000) Science , vol.290 , pp. 989-992
    • Zhang, L.1    Yu, J.2    Park, B.H.3    Kinzler, K.W.4    Vogelstein, B.5
  • 52
    • 0032553485 scopus 로고    scopus 로고
    • Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    • PMID:9822382; DOI:10.1126/science. 282.5393.1497
    • Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998; 282:1497-501; PMID:9822382; DOI:10.1126/science. 282.5393.1497.
    • (1998) Science , vol.282 , pp. 1497-1501
    • Bunz, F.1    Dutriaux, A.2    Lengauer, C.3    Waldman, T.4    Zhou, S.5    Brown, J.P.6
  • 53
    • 79551525707 scopus 로고    scopus 로고
    • Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation
    • PMID:21297999; DOI:10.1371/journal.pone.0016379
    • Zhang H, Gogada R, Yadav N, Lella RK, Badeaux M, Ayres M, et al. Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation. PLoS ONE 2011; 6:16379; PMID:21297999; DOI:10.1371/journal. pone.0016379.
    • (2011) PLoS ONE , vol.6 , pp. 16379
    • Zhang, H.1    Gogada, R.2    Yadav, N.3    Lella, R.K.4    Badeaux, M.5    Ayres, M.6
  • 54
    • 35748929414 scopus 로고    scopus 로고
    • Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: Evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase 3
    • PMID:17823127; DOI:10.1074/jbc.M702777200
    • Chandra D, Choy G, Tang DG. Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase 3. J Biol Chem 2007; 282:31289-301; PMID:17823127; DOI:10.1074/jbc. M702777200.
    • (2007) J Biol Chem , vol.282 , pp. 31289-31301
    • Chandra, D.1    Choy, G.2    Tang, D.G.3
  • 55
    • 21444443226 scopus 로고    scopus 로고
    • Bax-dependent regulation of Bak by voltage-dependent anion channel 2
    • PMID:15757910; DOI:10.1074/jbc.M501391200
    • Chandra D, Choy G, Daniel PT, Tang DG. Bax-dependent regulation of Bak by voltage-dependent anion channel 2. J Biol Chem 2005; 280:19051-61; PMID:15757910; DOI:10.1074/jbc.M501391200.
    • (2005) J Biol Chem , vol.280 , pp. 19051-19061
    • Chandra, D.1    Choy, G.2    Daniel, P.T.3    Tang, D.G.4


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