Baicalein alleviates doxorubicin-induced cardiotoxicity via suppression of myocardial oxidative stress and apoptosis in mice

Life Sciences

Volumn 144, Issue , 2016, Pages 8-18

  Sahu, Bidya Dhar ^a   Kumar, Jerald Mahesh ^b   Kuncha, Madhusudana ^a   Borkar, Roshan M ^a   Srinivas, R ^a   Sistla, Ramakrishna ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Apoptosis; Baicalein; Doxorubicin induced cardiotoxicity; Nuclear factor E2 related factor 2 (Nrf2); Nuclear factor kappa B (NF B); Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BAICALEIN; CASPASE 3; CREATINE KINASE MB; DOXORUBICIN; HEME OXYGENASE 1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOENZYME; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; TRANSCRIPTION FACTOR NRF2; ANTINEOPLASTIC ANTIBIOTIC; ANTIOXIDANT; BIOLOGICAL MARKER; FLAVANONE DERIVATIVE; I KAPPA B; NITRITE; TRANSCRIPTION FACTOR RELA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CARDIOTOXICITY; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DNA DAMAGE; DRUG MECHANISM; DRUG MEGADOSE; HISTOPATHOLOGY; IN VIVO STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; LOW DRUG DOSE; MALE; MOUSE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CARDIAC MUSCLE; CHEMICALLY INDUCED; DRUG EFFECTS; HEART DISEASES; METABOLISM; ORGAN SIZE; PATHOLOGY;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; APOPTOSIS; BIOMARKERS; CARDIOTOXICITY; DOXORUBICIN; FLAVANONES; HEART DISEASES; I-KAPPA B PROTEINS; MALE; MICE; MICE, INBRED BALB C; MYOCARDIUM; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; ORGAN SIZE; OXIDATIVE STRESS; TRANSCRIPTION FACTOR RELA;

EID: 84948705636     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.11.018     Document Type: Article

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