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Volumn 86, Issue 9, 2013, Pages 1301-1310

Nicorandil ameliorates mitochondrial dysfunction in doxorubicin-induced heart failure in rats: Possible mechanism of cardioprotection

Author keywords

Cardiotoxicity; Doxorubicin; Mitochondria; Nicorandil

Indexed keywords

ADENINE NUCLEOTIDE; CASPASE 3; CREATINE KINASE; CREATINE PHOSPHATE; CYTOCHROME C; DOXORUBICIN; NICORANDIL; PROTEIN BAX; PROTEIN BCL 2;

EID: 84886720225     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.07.005     Document Type: Article
Times cited : (51)

References (66)
  • 2
    • 0037024402 scopus 로고    scopus 로고
    • Early decline in left ventricular ejection fraction predicts doxorubicin cardiotoxicity in lymphoma patients
    • T. Nousiainen, E. Jantunen, E. Vanninen, and J. Hartikainen Early decline in left ventricular ejection fraction predicts doxorubicin cardiotoxicity in lymphoma patients Br J Cancer 86 2002 1697 1700
    • (2002) Br J Cancer , vol.86 , pp. 1697-1700
    • Nousiainen, T.1    Jantunen, E.2    Vanninen, E.3    Hartikainen, J.4
  • 3
    • 67349234999 scopus 로고    scopus 로고
    • Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
    • E.D. Danz, J. Skramsted, N. Henry, J.A. Bennett, and R.S. Keller Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway Free Radic Biol Med 46 2009 1589 1597
    • (2009) Free Radic Biol Med , vol.46 , pp. 1589-1597
    • Danz, E.D.1    Skramsted, J.2    Henry, N.3    Bennett, J.A.4    Keller, R.S.5
  • 4
    • 0027207013 scopus 로고
    • In-vivo and in-vitro mitochondrial membrane damages induced in mice by adriamycin and derivatives
    • M. Praet, and J.M. Ruysschaert In-vivo and in-vitro mitochondrial membrane damages induced in mice by adriamycin and derivatives Biochim Biophys Acta 1149 1993 79 85
    • (1993) Biochim Biophys Acta , vol.1149 , pp. 79-85
    • Praet, M.1    Ruysschaert, J.M.2
  • 5
    • 0033091198 scopus 로고    scopus 로고
    • Structural and functional impairment of mitochondria in adriamycin induced cardiomyopathy in mice: Suppression of cytochrome c oxidase II gene expression
    • L.C. Papadopoulou, G. Theophilidis, G.N. Thomopoulos, and A.S. Tsiftsoglou Structural and functional impairment of mitochondria in adriamycin induced cardiomyopathy in mice: suppression of cytochrome c oxidase II gene expression Biochem Pharmacol 57 1999 481 489
    • (1999) Biochem Pharmacol , vol.57 , pp. 481-489
    • Papadopoulou, L.C.1    Theophilidis, G.2    Thomopoulos, G.N.3    Tsiftsoglou, A.S.4
  • 6
    • 33846861106 scopus 로고    scopus 로고
    • Relationship between oxidative stress, lipid peroxidation, and ultrastructural damage in patients with coronary artery disease undergoing cardioplegic arrest/reperfusion
    • J. Milei, P. Forcada, C.G. Fraga, D.R. Grana, G. Iannelli, and M. Chiariello Relationship between oxidative stress, lipid peroxidation, and ultrastructural damage in patients with coronary artery disease undergoing cardioplegic arrest/reperfusion Cardiovasc Res 73 2007 710 719
    • (2007) Cardiovasc Res , vol.73 , pp. 710-719
    • Milei, J.1    Forcada, P.2    Fraga, C.G.3    Grana, D.R.4    Iannelli, G.5    Chiariello, M.6
  • 7
    • 0035479423 scopus 로고    scopus 로고
    • Nuclear magnetic resonance study of doxorubicin binding to cardiolipin containing magnetically oriented phospholipid bilayers
    • M.A. Parker, V. King, and K.P. Howard Nuclear magnetic resonance study of doxorubicin binding to cardiolipin containing magnetically oriented phospholipid bilayers Biochim Biophys Acta 1514 2001 206 216
    • (2001) Biochim Biophys Acta , vol.1514 , pp. 206-216
    • Parker, M.A.1    King, V.2    Howard, K.P.3
  • 9
    • 0033920540 scopus 로고    scopus 로고
    • Effect of Adriamycin on the boundary lipid structure of cytochrome c oxidase: Pico-second time-resolved fluorescence depolarization studies
    • T.K. Das, and S. Mazumdar Effect of Adriamycin on the boundary lipid structure of cytochrome c oxidase: pico-second time-resolved fluorescence depolarization studies Biophys Chem 86 2000 15 28
    • (2000) Biophys Chem , vol.86 , pp. 15-28
    • Das, T.K.1    Mazumdar, S.2
  • 10
    • 0034913884 scopus 로고    scopus 로고
    • Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes
    • G.W. Wang, J.B. Klein, and Y.J. Kang Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes J Pharmacol Exp Ther 298 2001 461 468
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 461-468
    • Wang, G.W.1    Klein, J.B.2    Kang, Y.J.3
  • 11
    • 54149115155 scopus 로고    scopus 로고
    • Ginkgo biloba extract 761 reduces doxorubicin-induced apoptotic damage in rat hearts and neonatal cardiomyocytes
    • T.J. Liu, Y.C. Yeh, C.T. Ting, W.L. Lee, L.C. Wang, and H.W. Lee Ginkgo biloba extract 761 reduces doxorubicin-induced apoptotic damage in rat hearts and neonatal cardiomyocytes Cardiovasc Res 80 2008 227 235
    • (2008) Cardiovasc Res , vol.80 , pp. 227-235
    • Liu, T.J.1    Yeh, Y.C.2    Ting, C.T.3    Lee, W.L.4    Wang, L.C.5    Lee, H.W.6
  • 12
    • 0032925283 scopus 로고    scopus 로고
    • Myocardial distribution and biotransformation in vitro and in vivo of nicorandil in rats, with special reference to mitochondria
    • K. Sakai, Y. Tsuchiya, S. Kitajima, and H. Hamada Myocardial distribution and biotransformation in vitro and in vivo of nicorandil in rats, with special reference to mitochondria J Cardiovasc Pharmacol 33 1999 163 168
    • (1999) J Cardiovasc Pharmacol , vol.33 , pp. 163-168
    • Sakai, K.1    Tsuchiya, Y.2    Kitajima, S.3    Hamada, H.4
  • 13
    • 33645079928 scopus 로고    scopus 로고
    • Nicorandil regulates Bcl-2 family proteins and protects cardiac myocytes against hypoxia-induced apoptosis
    • S. Nishikawa, T. Tatsumi, J. Shiraishi, S. Matsunaga, M. Takeda, and A. Mano Nicorandil regulates Bcl-2 family proteins and protects cardiac myocytes against hypoxia-induced apoptosis J Mol Cell Cardiol 40 2006 510 519
    • (2006) J Mol Cell Cardiol , vol.40 , pp. 510-519
    • Nishikawa, S.1    Tatsumi, T.2    Shiraishi, J.3    Matsunaga, S.4    Takeda, M.5    Mano, A.6
  • 14
    • 0037151626 scopus 로고    scopus 로고
    • Antiapoptotic effect of nicorandil mediated by mitochondrial atp-sensitive potassium channels in cultured cardiac myocytes
    • M. Akao, Y. Teshima, and E. Marbán Antiapoptotic effect of nicorandil mediated by mitochondrial atp-sensitive potassium channels in cultured cardiac myocytes J Am Coll Cardiol 40 2002 803 810
    • (2002) J Am Coll Cardiol , vol.40 , pp. 803-810
    • Akao, M.1    Teshima, Y.2    Marbán, E.3
  • 15
    • 79959296571 scopus 로고    scopus 로고
    • Pharmacological preconditioning with nicorandil and pioglitazone attenuates myocardial ischemia/reperfusion injury in rats
    • L.A. Ahmed, H.A. Salem, A.S. Attia, and A.M. Agha Pharmacological preconditioning with nicorandil and pioglitazone attenuates myocardial ischemia/reperfusion injury in rats Eur J Pharmacol 663 2011 51 58
    • (2011) Eur J Pharmacol , vol.663 , pp. 51-58
    • Ahmed, L.A.1    Salem, H.A.2    Attia, A.S.3    Agha, A.M.4
  • 18
    • 0002276871 scopus 로고
    • Oxygen proton and phosphate fluxes and stoichiometries
    • G.C. Brown, C.E. Cooper, IRL Press Oxford
    • P.C. Hinkle Oxygen proton and phosphate fluxes and stoichiometries G.C. Brown, C.E. Cooper, Bioenergetics: a practical approach 1995 IRL Press Oxford 1 16
    • (1995) Bioenergetics: A Practical Approach , pp. 1-16
    • Hinkle, P.C.1
  • 19
    • 77951290337 scopus 로고    scopus 로고
    • Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson's disease
    • K. Banerjee, M. Sinha, C.L.L. Pham, S. Jana, D. Chanda, and R. Cappai Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson's disease FEBS Lett 584 2010 1571 1576
    • (2010) FEBS Lett , vol.584 , pp. 1571-1576
    • Banerjee, K.1    Sinha, M.2    Pham, C.L.L.3    Jana, S.4    Chanda, D.5    Cappai, R.6
  • 20
    • 56049107269 scopus 로고    scopus 로고
    • + ATPase activity and associated peroxidative damage in rat brain synaptosomes
    • + ATPase activity and associated peroxidative damage in rat brain synaptosomes Biogerontology 9 2008 421 428
    • (2008) Biogerontology , vol.9 , pp. 421-428
    • Bagh, M.B.1    Maiti, A.K.2    Roy, A.3    Chakrabarti, S.4
  • 21
    • 0014077032 scopus 로고
    • An improved procedure for serum creatine phosphokinase determination
    • S.B. Rosalki An improved procedure for serum creatine phosphokinase determination Lab Clin Med 69 1967 696 705
    • (1967) Lab Clin Med , vol.69 , pp. 696-705
    • Rosalki, S.B.1
  • 22
    • 73649194769 scopus 로고
    • Improved method for the determination of blood glutathione
    • E. Beutler, O. Duron, and B.M. Kelly Improved method for the determination of blood glutathione J Lab Clin Med 61 1963 882 888
    • (1963) J Lab Clin Med , vol.61 , pp. 882-888
    • Beutler, E.1    Duron, O.2    Kelly, B.M.3
  • 23
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • J.A. Buege, and S.D. Aust Microsomal lipid peroxidation Methods Enzymol 52 1978 302 310
    • (1978) Methods Enzymol , vol.52 , pp. 302-310
    • Buege, J.A.1    Aust, S.D.2
  • 25
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
    • D.E. Paglia, and W.N. Valentine Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase J Lab Clin Med 70 1967 158 169
    • (1967) J Lab Clin Med , vol.70 , pp. 158-169
    • Paglia, D.E.1    Valentine, W.N.2
  • 26
    • 0021318441 scopus 로고
    • Catalase in vitro
    • H. Abei Catalase in vitro Methods Enzymol 105 1984 121 126
    • (1984) Methods Enzymol , vol.105 , pp. 121-126
    • Abei, H.1
  • 27
    • 0027454113 scopus 로고
    • Simultaneous determination of creatine compounds and adenine nucleotides in myocardial tissue by high-performance liquid chromatography
    • T. Teerlink, M. Hennekes, J. Bussemaker, and J. Groeneveld Simultaneous determination of creatine compounds and adenine nucleotides in myocardial tissue by high-performance liquid chromatography Anal Biochem 214 1993 278 283
    • (1993) Anal Biochem , vol.214 , pp. 278-283
    • Teerlink, T.1    Hennekes, M.2    Bussemaker, J.3    Groeneveld, J.4
  • 28
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 29
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • M.W. Pfaffl A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res 29 2001 e45
    • (2001) Nucleic Acids Res , vol.29 , pp. 45
    • Pfaffl, M.W.1
  • 30
    • 0018097581 scopus 로고
    • Effect of propranolol on mitochondrial morphology during acute myocardial ischemia
    • R.A. Kloner, M.C. Fishbein, E. Braunwald, and P.R. Maroko Effect of propranolol on mitochondrial morphology during acute myocardial ischemia Am J Cardiol 41 1978 880 886
    • (1978) Am J Cardiol , vol.41 , pp. 880-886
    • Kloner, R.A.1    Fishbein, M.C.2    Braunwald, E.3    Maroko, P.R.4
  • 31
    • 0027441050 scopus 로고
    • Hyperthermic potentiation of cisplatin on solid Ehrlich carcinoma
    • A.M. Osman, M.M. Sayed-Ahmed, M.T. Khayyal, and M.M. El-Merzabani Hyperthermic potentiation of cisplatin on solid Ehrlich carcinoma Tumori 79 1993 268 272
    • (1993) Tumori , vol.79 , pp. 268-272
    • Osman, A.M.1    Sayed-Ahmed, M.M.2    Khayyal, M.T.3    El-Merzabani, M.M.4
  • 32
    • 84880701913 scopus 로고    scopus 로고
    • Cardioprotective effects of nicorandil, a mitochondrial potassium channel opener against doxorubicin-induced cardiotoxicity in rats
    • [Epub ahead of print]
    • I.T. Abdel-Raheem, A. Taye, and M.M. Abouzied Cardioprotective effects of nicorandil, a mitochondrial potassium channel opener against doxorubicin-induced cardiotoxicity in rats Basic Clin Pharmacol Toxicol 2013 [Epub ahead of print]
    • (2013) Basic Clin Pharmacol Toxicol
    • Abdel-Raheem, I.T.1    Taye, A.2    Abouzied, M.M.3
  • 33
    • 33747814448 scopus 로고    scopus 로고
    • Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin
    • M. Tokarska-Schlattner, T. Wallimann, and U. Schlattner Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin C R Biol 329 2006 657 668
    • (2006) C R Biol , vol.329 , pp. 657-668
    • Tokarska-Schlattner, M.1    Wallimann, T.2    Schlattner, U.3
  • 34
    • 0032973059 scopus 로고    scopus 로고
    • Clinical and preclinical modulation of chemotherapy-induced toxicity in patients with cancer
    • K. Hoekman, W.J.F. Van der Vijgh, and J.B. Vermorken Clinical and preclinical modulation of chemotherapy-induced toxicity in patients with cancer Drugs 57 1999 133 156
    • (1999) Drugs , vol.57 , pp. 133-156
    • Hoekman, K.1    Van Der Vijgh, W.J.F.2    Vermorken, J.B.3
  • 35
    • 0034016426 scopus 로고    scopus 로고
    • Comparison of the protective effects of amifostine and dexrazoxane against the toxicity of doxorubicin in spontaneously hypertensive rats
    • E.H. Herman, J. Zhang, D.P. Chadwick, and V. Ferrans Comparison of the protective effects of amifostine and dexrazoxane against the toxicity of doxorubicin in spontaneously hypertensive rats Cancer Chemother Pharmacol 45 2000 329 334
    • (2000) Cancer Chemother Pharmacol , vol.45 , pp. 329-334
    • Herman, E.H.1    Zhang, J.2    Chadwick, D.P.3    Ferrans, V.4
  • 36
    • 0028023717 scopus 로고
    • Cardiotoxicity of doxorubicin: Effects of drugs inhibiting the release of vasoactive substances
    • F. Rossi, W. Filipelli, S. Russo, A. Filippelli, and L. Berrino Cardiotoxicity of doxorubicin: effects of drugs inhibiting the release of vasoactive substances Pharmacol Toxicol 75 1994 99 107
    • (1994) Pharmacol Toxicol , vol.75 , pp. 99-107
    • Rossi, F.1    Filipelli, W.2    Russo, S.3    Filippelli, A.4    Berrino, L.5
  • 37
    • 0028356959 scopus 로고
    • Antioxidant changes in hypertrophied and failing guinea pig hearts
    • A.K. Dhalla, and P.K. Singal Antioxidant changes in hypertrophied and failing guinea pig hearts Am J Physiol 266 1994 1280 1285
    • (1994) Am J Physiol , vol.266 , pp. 1280-1285
    • Dhalla, A.K.1    Singal, P.K.2
  • 38
    • 0034048933 scopus 로고    scopus 로고
    • Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels
    • T. Sato, N. Sasaki, B. O'Rourke, and E. Marbán Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels J Am Coll Cardiol 35 2000 514 518
    • (2000) J Am Coll Cardiol , vol.35 , pp. 514-518
    • Sato, T.1    Sasaki, N.2    O'Rourke, B.3    Marbán, E.4
  • 39
    • 80051555577 scopus 로고    scopus 로고
    • Nicorandil preserves myocardial function following brain death in rats by mitochondrial adenosine triphosphate-sensitive potassium channel-dependent mechanism
    • M. Iwasaki, Y. Hayashi, H. Yamanaka, T. Kamibayashi, and T. Mashimo Nicorandil preserves myocardial function following brain death in rats by mitochondrial adenosine triphosphate-sensitive potassium channel-dependent mechanism Eur J Cardiothorac Surg 40 2011 710 714
    • (2011) Eur J Cardiothorac Surg , vol.40 , pp. 710-714
    • Iwasaki, M.1    Hayashi, Y.2    Yamanaka, H.3    Kamibayashi, T.4    Mashimo, T.5
  • 40
    • 0025051505 scopus 로고
    • Doxorubicin cardiotoxicity: Analysis of prevailing hypotheses
    • R.D. Olson, and P.S. Mushlin Doxorubicin cardiotoxicity: analysis of prevailing hypotheses FASEB J 4 1990 3076 3086
    • (1990) FASEB J , vol.4 , pp. 3076-3086
    • Olson, R.D.1    Mushlin, P.S.2
  • 41
    • 33845904691 scopus 로고    scopus 로고
    • Glutathione-related enzyme activity in liver and kidney of rats exposed to cadmium and ethanol
    • M. Jurczuk, J. Moniuszko-Jakoniuk, and J. Rogalska Glutathione-related enzyme activity in liver and kidney of rats exposed to cadmium and ethanol Polish J Environ Stud 15 2006 861 868
    • (2006) Polish J Environ Stud , vol.15 , pp. 861-868
    • Jurczuk, M.1    Moniuszko-Jakoniuk, J.2    Rogalska, J.3
  • 42
    • 0043237846 scopus 로고    scopus 로고
    • Doxorubicin-induced cardiac mitochondrionopathy
    • K.B. Wallace Doxorubicin-induced cardiac mitochondrionopathy Pharmacol Toxicol 93 2003 105 115
    • (2003) Pharmacol Toxicol , vol.93 , pp. 105-115
    • Wallace, K.B.1
  • 43
    • 0034711165 scopus 로고    scopus 로고
    • Adriamycin-induced early changes in myocardial antioxidant enzymes and their modulation by probucol
    • T. Li, and P.K. Singal Adriamycin-induced early changes in myocardial antioxidant enzymes and their modulation by probucol Circulation 102 2000 2105 2110
    • (2000) Circulation , vol.102 , pp. 2105-2110
    • Li, T.1    Singal, P.K.2
  • 44
    • 0001893875 scopus 로고
    • Effect of unsaturated fatty acids and their peroxides on enzymes
    • E.D. Wills Effect of unsaturated fatty acids and their peroxides on enzymes Biochem Pharmacol 7 1961 7 16
    • (1961) Biochem Pharmacol , vol.7 , pp. 7-16
    • Wills, E.D.1
  • 45
    • 0014541624 scopus 로고
    • Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde
    • K.S. Choi, and A.L. Tappel Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde Biochemistry 8 1969 2827 2832
    • (1969) Biochemistry , vol.8 , pp. 2827-2832
    • Choi, K.S.1    Tappel, A.L.2
  • 47
    • 0026047662 scopus 로고
    • The aging process: Major risk factor for disease and death
    • D. Harman The aging process: major risk factor for disease and death Proc Nat Acad Sci U S A 88 1991 5360 5363
    • (1991) Proc Nat Acad Sci U S A , vol.88 , pp. 5360-5363
    • Harman, D.1
  • 48
    • 2642586567 scopus 로고    scopus 로고
    • Protection against acute adriamycin-induced cardiotoxicity by garlic: Role of endogenous antioxidants and inhibition of TNF-α expression
    • S. Mukherjee, S.K. Banerjee, M. Maulik, A.K. Dinda, K.K. Talwar, and S.K. Maulik Protection against acute adriamycin-induced cardiotoxicity by garlic: role of endogenous antioxidants and inhibition of TNF-α expression BMC Pharmacol 3 2003 16
    • (2003) BMC Pharmacol , vol.3 , pp. 16
    • Mukherjee, S.1    Banerjee, S.K.2    Maulik, M.3    Dinda, A.K.4    Talwar, K.K.5    Maulik, S.K.6
  • 49
    • 0038639298 scopus 로고    scopus 로고
    • Mitochondrial KATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: A study in an intact anesthetized rabbit model
    • B. Das, and C. Sarkar Mitochondrial KATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model Pharmacol Res 47 2003 447 461
    • (2003) Pharmacol Res , vol.47 , pp. 447-461
    • Das, B.1    Sarkar, C.2
  • 50
    • 0028102570 scopus 로고
    • Antioxidative action of the nitrovasodilator nicorandil: Inhibition of oxidative activation of liver microsomal glutathion-S-transferase and lipid peroxidation
    • A. Naito, Y. Aniya, and M. Sakanashi Antioxidative action of the nitrovasodilator nicorandil: inhibition of oxidative activation of liver microsomal glutathion-S-transferase and lipid peroxidation Jpn J Pharmacol 65 1994 209 213
    • (1994) Jpn J Pharmacol , vol.65 , pp. 209-213
    • Naito, A.1    Aniya, Y.2    Sakanashi, M.3
  • 51
    • 69249219274 scopus 로고    scopus 로고
    • Nicorandil protects ATP-sensitive potassium channels against oxidation-induced dysfunction in cardiomyocytes of aging rats
    • S. Raveaud, J. Verdetti, and G. Faury Nicorandil protects ATP-sensitive potassium channels against oxidation-induced dysfunction in cardiomyocytes of aging rats Biogerontology 10 2009 537 547
    • (2009) Biogerontology , vol.10 , pp. 537-547
    • Raveaud, S.1    Verdetti, J.2    Faury, G.3
  • 52
    • 33749433230 scopus 로고    scopus 로고
    • Mitochondrial uncoupling, with low concentration FCCP induces ROS-dependent cardioprotection independent of KATP channel activation
    • J.P. Brennan, R. Southworth, R.A. Medina, S.M. Davidson, M.R. Duchen, and M.J. Shattock Mitochondrial uncoupling, with low concentration FCCP induces ROS-dependent cardioprotection independent of KATP channel activation Cardiovasc Res 72 2006 313 321
    • (2006) Cardiovasc Res , vol.72 , pp. 313-321
    • Brennan, J.P.1    Southworth, R.2    Medina, R.A.3    Davidson, S.M.4    Duchen, M.R.5    Shattock, M.J.6
  • 53
    • 0242442100 scopus 로고    scopus 로고
    • Time-dependent and tissue-specific accumulation of mtDNA and respiratory chain defects in chronic doxorubicin cardiomyopathy
    • D. Lebrecht, B. Setzer, U.P. Ketelsen, J. Haberstroh, and U.A. Walker Time-dependent and tissue-specific accumulation of mtDNA and respiratory chain defects in chronic doxorubicin cardiomyopathy Circulation 108 2003 2423 2429
    • (2003) Circulation , vol.108 , pp. 2423-2429
    • Lebrecht, D.1    Setzer, B.2    Ketelsen, U.P.3    Haberstroh, J.4    Walker, U.A.5
  • 55
    • 34249326963 scopus 로고    scopus 로고
    • Mechanisms of sepsis-induced cardiac dysfunction
    • A. Rudiger, and M. Singer Mechanisms of sepsis-induced cardiac dysfunction Crit Care Med 35 2007 1599 1608
    • (2007) Crit Care Med , vol.35 , pp. 1599-1608
    • Rudiger, A.1    Singer, M.2
  • 56
    • 0030780773 scopus 로고    scopus 로고
    • Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP sensitive K+ channels. Possible mechanism of cardioprotection
    • K.D. Garlid, P. Paucek, V. Yarov-Yarovoy, H.N. Murray, R.B. Darbenzio, and A.J. D'Alonzo Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP sensitive K+ channels. Possible mechanism of cardioprotection Circ Res 81 1997 1072 1082
    • (1997) Circ Res , vol.81 , pp. 1072-1082
    • Garlid, K.D.1    Paucek, P.2    Yarov-Yarovoy, V.3    Murray, H.N.4    Darbenzio, R.B.5    D'Alonzo, A.J.6
  • 57
    • 0036162268 scopus 로고    scopus 로고
    • Synergistic effect of nicorandil and amlodipine on mitochondrial function during isoproterenol-induced myocardial infarction in rats
    • V. Sathish, V. Vimal, K.K. Ebenezar, and T. Devaki Synergistic effect of nicorandil and amlodipine on mitochondrial function during isoproterenol-induced myocardial infarction in rats J Pharm Pharmacol 54 2002 133 137
    • (2002) J Pharm Pharmacol , vol.54 , pp. 133-137
    • Sathish, V.1    Vimal, V.2    Ebenezar, K.K.3    Devaki, T.4
  • 58
    • 0036960328 scopus 로고    scopus 로고
    • Mitochondrial membrane potential in cardiac myocytes
    • L. Skárka, and B. Ostádal Mitochondrial membrane potential in cardiac myocytes Physiol Res 51 2002 425 434
    • (2002) Physiol Res , vol.51 , pp. 425-434
    • Skárka, L.1    Ostádal, B.2
  • 59
    • 0035800885 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis in heart failure progression
    • J.M. Hare Oxidative stress and apoptosis in heart failure progression Circ Res 89 2001 198 200
    • (2001) Circ Res , vol.89 , pp. 198-200
    • Hare, J.M.1
  • 60
    • 0035116301 scopus 로고    scopus 로고
    • Anticancer drugs induce increased mitochondrial cytochrome c expression that precedes cell death
    • J.A. Sánchez-Alcázar, A. Khodjakov, and E. Schneider Anticancer drugs induce increased mitochondrial cytochrome c expression that precedes cell death Cancer Res 61 2001 1038 1044
    • (2001) Cancer Res , vol.61 , pp. 1038-1044
    • Sánchez-Alcázar, J.A.1    Khodjakov, A.2    Schneider, E.3
  • 61
    • 0026501785 scopus 로고
    • Alterations in left ventricular mechanics, energetic and contractile reserve in experimental heart failure
    • M.R. Wolff, P.P. De Tombe, Y. Harasawa, D. Burkhoff, S. Bier, and W.C. Hunter Alterations in left ventricular mechanics, energetic and contractile reserve in experimental heart failure Circ Res 70 1992 516 529
    • (1992) Circ Res , vol.70 , pp. 516-529
    • Wolff, M.R.1    De Tombe, P.P.2    Harasawa, Y.3    Burkhoff, D.4    Bier, S.5    Hunter, W.C.6
  • 62
    • 0036858041 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis in heart dysfunction
    • D. Kumar, H. Lou, and P.K. Singal Oxidative stress and apoptosis in heart dysfunction Herz 27 2002 662 668
    • (2002) Herz , vol.27 , pp. 662-668
    • Kumar, D.1    Lou, H.2    Singal, P.K.3
  • 63
    • 0034141455 scopus 로고    scopus 로고
    • Activation of mitochondrial ATP-dependent potassium channels by nitric oxide
    • N. Sasaki, T. Sato, A. Ohler, B. O'Rourke, and E. Marbán Activation of mitochondrial ATP-dependent potassium channels by nitric oxide Circulation 101 2000 439 445
    • (2000) Circulation , vol.101 , pp. 439-445
    • Sasaki, N.1    Sato, T.2    Ohler, A.3    O'Rourke, B.4    Marbán, E.5
  • 64
    • 0033781027 scopus 로고    scopus 로고
    • The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
    • J.C. Goldstein, N.J. Waterhouse, P. Juin, G.I. Evan, and D.R. Green The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant Nat Cell Biol 2 2000 156 162
    • (2000) Nat Cell Biol , vol.2 , pp. 156-162
    • Goldstein, J.C.1    Waterhouse, N.J.2    Juin, P.3    Evan, G.I.4    Green, D.R.5
  • 65
    • 0035933436 scopus 로고    scopus 로고
    • Mitochondrial ATPsensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells
    • M. Akao, A. Ohler, B. O'Rourke, and E. Marbán Mitochondrial ATPsensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells Circ Res 88 2001 1267 1275
    • (2001) Circ Res , vol.88 , pp. 1267-1275
    • Akao, M.1    Ohler, A.2    O'Rourke, B.3    Marbán, E.4
  • 66
    • 0030662226 scopus 로고    scopus 로고
    • Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms
    • Y.M. Kim, R.V. Talanian, and T.R. Billiar Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms J Biol Chem 272 1997 31138 31148
    • (1997) J Biol Chem , vol.272 , pp. 31138-31148
    • Kim, Y.M.1    Talanian, R.V.2    Billiar, T.R.3


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