Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer

Biochemical Pharmacology

Volumn 90, Issue 1, 2014, Pages 25-33

  Granados Principal, Sergio ^a   El Azem, Nuri ^a   Pamplona, Reinald ^b   Ramirez Tortosa, Cesar ^c   Pulido Moran, Mario ^a   Vera Ramirez, Laura ^d   Quiles, Jose L ^a   Sanchez Rovira, Pedro ^c   Naudí, Alba ^b   Portero Otin, Manuel ^b   Perez Lopez, Patricia ^a   Ramirez Tortosa, McArmen ^a  

^a Biomedical Research Center   (Spain)

^b UNIVERSITY OF LLEIDA   (Spain)

^c Hospital of Jaen   (Spain)

^d PTS Granada   (Spain)

Author keywords

Apoptosis inducing factor; Chemo toxicity; Electron transport chain; Hydroxytyrosol; Oxidative stress; Protein damage

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALANINE AMINOTRANSFERASE; APOPTOSIS INDUCING FACTOR; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; DOXORUBICIN; FLAVOPROTEIN; HYDROXYTYROSOL; IRON SULFUR PROTEIN; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BREAST CANCER; CARDIOTOXICITY; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; ENZYME ACTIVITY; FATTY ACID ANALYSIS; FEMALE; HEART DISEASE; HEART MITOCHONDRION; HEART PROTECTION; HISTOPATHOLOGY; IMMUNOBLOTTING; LACTATE DEHYDROGENASE BLOOD LEVEL; MASS FRAGMENTOGRAPHY; MITOCHONDRION SWELLING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TREATMENT DURATION;

APOPTOSIS-INDUCING FACTOR; CHEMO TOXICITY; ELECTRON TRANSPORT CHAIN; HYDROXYTYROSOL; OXIDATIVE STRESS; PROTEIN DAMAGE;

ANIMALS; ANTIOXIDANTS; APOPTOSIS INDUCING FACTOR; DOXORUBICIN; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; ELECTRON TRANSPORT COMPLEX III; ELECTRON TRANSPORT COMPLEX IV; FATTY ACIDS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEART DISEASES; IMMUNOBLOTTING; MAMMARY NEOPLASMS, ANIMAL; MICROSCOPY, ELECTRON; MITOCHONDRIA, HEART; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHENYLETHYL ALCOHOL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84901827990     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.04.001     Document Type: Article

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