Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways

Apoptosis

Volumn 19, Issue 4, 2014, Pages 567-580

  Song, Lina ^a,b   Yang, Hui ^a,b   Wang, Hong Xia ^a,b   Tian, Cui ^a,b   Liu, Yu ^a,b   Zeng, Xiang Jun ^a,b   Gao, Erhe ^c   Kang, Yu Ming ^d   Du, Jie ^a,b   Li, Hui Hua ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF HEART   (China)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

12 15 Lipoxygenase; Baicalein; Cardiac injury; Ischemia reperfusion; Signaling pathway

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; BAICALEIN; CASPASE 3; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE 1; SYNAPTOTAGMIN I; 12-15-LIPOXYGENASE; FLAVANONE DERIVATIVE; LIPOXYGENASE INHIBITOR;

ACUTE HEART INFARCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CARDITIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART CELL CULTURE; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MOUSE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SIMULATION; UPREGULATION; ACUTE DISEASE; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; HEART MUSCLE; INFLAMMATION; METABOLISM; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY;

ACUTE DISEASE; ANIMALS; APOPTOSIS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; CELLS, CULTURED; FLAVANONES; INFLAMMATION; LIPOXYGENASE INHIBITORS; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATIVE STRESS; RATS; SIGNAL TRANSDUCTION;

EID: 84896402759     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0946-z     Document Type: Article

References (39)

1. Armstrong SC (2004) Protein kinase activation and myocardial ischemia/reperfusion injury. Cardiovasc Res 61:427-436
2. Eefting F, Rensing B, Wigman J et al (2004) Role of apoptosis in reperfusion injury. Cardiovasc Res 61:414-426
3. Frangogiannis NG, Smith CW, Entman ML (2002) The inflammatory response in myocardial infarction. Cardiovasc Res 53:31-47
4. Kayama Y, Minamino T, Toko H et al (2009) Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure. J Exp Med 206:1565-1574
5. Yigitkanli K, Pekcec A, Karatas H et al (2013) Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Ann Neurol 73:129-135
6. Guadall A, Orriols M, Alcudia JF, Cachofeiro V, Martinez-Gonzalez J, Rodriguez C (2011) Hypoxia-induced ROS signaling is required for LOX up-regulation in endothelial cells. Front Biosci (Elite Ed) 3:955-967
7. van Leyen K, Kim HY, Lee SR, Jin G, Arai K, Lo EH (2006) Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke 37:3014-3018
8. Natarajan R, Nadler JL (2004) Lipid inflammatory mediators in diabetic vascular disease. Arterioscler Thromb Vasc Biol 24:1542-1548
9. Reilly KB, Srinivasan S, Hatley ME et al (2004) 12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo. J Biol Chem 279:9440-9450
10. Taylor AM, Hanchett R, Natarajan R et al (2005) The effects of leukocyte-type 12/15-lipoxygenase on Id3-mediated vascular smooth muscle cell growth. Arterioscler Thromb Vasc Biol 25:2069-2074
11. Woo AY, Cheng CH, Waye MM (2005) Baicalein protects rat cardiomyocytes from hypoxia/reoxygenation damage via a prooxidant mechanism. Cardiovasc Res 65:244-253
12. Sexton A, McDonald M, Cayla C, Thiemermann C, Ahluwalia A (2007) 12-Lipoxygenase-derived eicosanoids protect against myocardial ischemia/reperfusion injury via activation of neuronal TRPV1. FASEB J 21:2695-2703
13. Tsutsumi YM, Patel HH, Huang D, Roth DM (2006) Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice. Am J Physiol Heart Circ Physiol 291:H979-H983
14. Zhang Y, Zeng Y, Wang M et al (2011) Cardiac-specific overexpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury. Basic Res Cardiol 106:371-383
15. Gao E, Lei YH, Shang X et al (2010) A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ Res 107:1445-1453
16. Ha T, Hua F, Li Y et al (2006) Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo. Am J Physiol Heart Circ Physiol 290:985-994
17. Li HH, Kedar V, Zhang C et al (2004) Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. J Clin Investig 114:1058-1071
18. Li HH, Willis MS, Lockyer P et al (2007) Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins. J Clin Investig 117:3211-3223
19. Xu CW, Zhang TP, Wang HX, Yang H, Li HH (2013) CHIP enhances angiogenesis and restores cardiac function after infarction in transgenic mice. Cell Physiol Biochem 31:199-208
20. Yang K, Zhang TP, Tian C, Jia LX, Du J, Li HH (2012) Carboxyl terminus of heat shock protein 70-interacting protein inhibits angiotensin II-induced cardiac remodeling. Am J Hypertens 25:994-1001
21. Sakamoto M, Minamino T, Toko H et al (2006) Upregulation of heat shock transcription factor 1 plays a critical role in adaptive cardiac hypertrophy. Circ Res 99:1411-1418
22. Sano M, Minamino T, Toko H et al (2007) p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446:444-448
23. +/calmodulin- dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy. Circulation 122:891-899
24. Natarajan R, Yang DC, Lanting L, Nadler JL (2002) Key role of P38 mitogen-activated protein kinase and the lipoxygenase pathway in angiotensin II actions in H295R adrenocortical cells. Endocrine 18:295-301
25. Jin G, Arai K, Murata Y et al (2008) Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Stroke 39:2538-2543
26. Pidgeon GP, Tang K, Cai YL, Piasentin E, Honn KV (2003) Overexpression of platelet-type 12-lipoxygenase promotes tumor cell survival by enhancing alpha(v)beta(3) and alpha(v)beta(5) integrin expression. Cancer Res 63:4258-4267
27. Logue SE, Gustafsson AB, Samali A, Gottlieb RA (2005) Ischemia/reperfusion injury at the intersection with cell death. J Mol Cell Cardiol 38:21-33
28. Lopez-Neblina F, Toledo AH, Toledo-Pereyra LH (2005) Molecular biology of apoptosis in ischemia and reperfusion. J Investig Surg 18:335-350
29. Wen Y, Gu J, Vandenhoff GE, Liu X, Nadler JL (2008) Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages. Am J Physiol Heart Circ Physiol 294:H1933-H1938
30. Bowden RA, Ding ZM, Donnachie EM et al (2002) Role of alpha4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium. Circ Res 90:562-569
31. Feng Y, Zhao H, Xu X et al (2008) Innate immune adaptor MyD88 mediates neutrophil recruitment and myocardial injury after ischemia-reperfusion in mice. Am J Physiol Heart Circ Physiol 295:H1311-H1318
32. Gu J, Liu Y, Wen Y, Natarajan R, Lanting L, Nadler JL (2001) Evidence that increased 12-lipoxygenase activity induces apoptosis in fibroblasts. J Cell Physiol 186:357-365
33. Gu J, Wen Y, Mison A, Nadler JL (2003) 12-lipoxygenase pathway increases aldosterone production, 3′,5′-cyclic adenosine monophosphate response element-binding protein phosphorylation, and p38 mitogen-activated protein kinase activation in H295R human adrenocortical cells. Endocrinology 144:534-543
34. Li H, Gao F, Ma L et al (2012) Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta. J Cell Mol Med 16:1606-1617
35. Kuhn H, Romisch I, Belkner J (2005) The role of lipoxygenase-isoforms in atherogenesis. Mol Nutr Food Res 49:1014-1029
36. Heusch G, Boengler K, Schulz R (2008) Cardioprotection: nitric oxide, protein kinases, and mitochondria. Circulation 118:1915-1919
37. Zhang T, Yang D, Fan Y, Xie P, Li H (2009) Epigallocatechin-3-gallate enhances ischemia/reperfusion-induced apoptosis in human umbilical vein endothelial cells via AKT and MAPK pathways. Apoptosis 14:1245-1254
38. Baines CP, Molkentin JD (2005) STRESS signaling pathways that modulate cardiac myocyte apoptosis. J Mol Cell Cardiol 38:47-62
39. Wen Y, Gu J, Liu Y, Wang PH, Sun Y, Nadler JL (2001) Overexpression of 12-lipoxygenase causes cardiac fibroblast cell growth. Circ Res 88:70-76