6-gingerol ameliorated doxorubicin-induced cardiotoxicity: Role of nuclear factor kappa B and protein glycation

Cancer Chemotherapy and Pharmacology

Volumn 70, Issue 6, 2012, Pages 833-841

  El Bakly, Wesam M ^a   Louka, Manal L ^a   El Halawany, Ali M ^b   Schaalan, Mona F ^c  

^a AIN SHAMS UNIVERSITY   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c Egypt   (Egypt)

Author keywords

6 gingerol; Caspase 3; Doxorubicin (DOX) cardiotoxicity; Nuclear factor kappa B (NF B); sRAGE (receptor for advanced glycation endproducts)

Indexed keywords

(6) GINGEROL; ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; CASPASE 3; DOXORUBICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CARDIOTOXICITY; CELL NUCLEUS; CONTROLLED STUDY; CORRELATION ANALYSIS; HEART PROTECTION; HISTOPATHOLOGY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CASPASE 3; CATECHOLS; CREATINE KINASE, MB FORM; DOXORUBICIN; FATTY ALCOHOLS; HEART; HEART DISEASES; IMMUNOHISTOCHEMISTRY; INFUSIONS, PARENTERAL; MALE; MYOCARDIUM; NF-KAPPA B; OXIDATIVE STRESS; RATS; RATS, INBRED STRAINS; RECEPTORS, IMMUNOLOGIC;

EID: 84871186031     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-012-1975-y     Document Type: Article

References (43)

1. Ayla S, Seckin I, Tanriverdi G et al (2011) Doxorubicin induced nephrotoxicity: protective effect of nicotinamide. Int J Cell Biol 2011:1-9
2. Fadillioǧlu E, Erdoǧan H, Söǧüt S, Kuku I (2003) Protective effects of erdosteine against doxorubicin-induced cardiomyopathy in rats. J Appl Toxicol 23:71-74
3. Fan GC, Zhou X, Wang X et al (2008) Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity. Circ Res 103: 1270-1279
4. Simoncikova P, Ravingerova T, Barancik M (2008) The effect of chronic doxorubicin treatment on mitogen - activated protein kinases and heat stress proteins in rat hearts. Physiol Res 57(2):S97-S102
5. Aiken MJ, Suhag V, Garcia CA et al (2009) Doxorubicin-induced cardiac toxicity and cardiac rest gated blood pool imaging. Clin Nucl Med 34(11):762-767
6. Li T, Danelisen I, Bello-Klein A, Singal PK (2000) Effects of probucol on changes of antioxidant enzymes in AIC in rats. Cardiovasc Res 46:523-530
7. Ferreira ALA, Matsubara LS, Matsubara BB (2008) Anthracycline- induced cardiotoxicity. Cardiovasc Hematol Agents Med Chem 6:278-281
8. Hudson BI, Bucciarelli LG, Wendt T et al (2003) Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders. Arch Biochem Biophys 419(1):80-88
9. Moriyamaa T, Kemib M, Okumurab C, Yoshiharac K, Horiea T (2010) Involvement of advanced glycation end-products, pentosidine and Ne-(carboxymethyl) lysine, in doxorubicin induced cardiomyopathy in rats. J Toxicol 268:89-97
10. Arozal W, Watanabe K, Veeraveedu PT, Ma M, Nafrialdi N (2011) Telmisartan inhibits the progression of cardiomyopathy in daunorubicin treated rats: the role of advanced glycation end products. Med J Indones 20:255-262
11. Schmidt AM, Yan SD, Wautier JL, Stern D (1999) Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ Res 84(5):489-497
12. Bruynzeel AME, Abou El Hassan MA, Schalkwijk C et al (2007) Anti-inflammatory agents and monoHER protect against DOXinduced cardiotoxicity and accumulation of CML in mice. BJC 96:937-943
13. Chen F, Castranova V, Shi X, Demers LM (1999) New insights into the role of NF-jB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 45:7-17
14. Aoki M, Nata T, Morishita R et al (2001) Endothelial apoptosis induced by oxidative stress through activation of NF-jB: antiapoptotic effect of antioxidant agents on endothelial cells. Hypertension 38:48-55
15. Joyce D, Bouzahzah B, Fu M et al (1999) Integration of Racdependent regulation of cyclin D1 transcription through a NF-jB dependent pathway. J Biol Chem 274:25245-25249
16. Injac R, Perse M, Cerne M et al (2009) Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer. Biomaterials 30:1184-1196
17. Kolarovic J, Popovic M, Zlinská J, Trivic S, Vojnovic M (2010) Antioxidant activities of celery and parsley juices in rats treated with doxorubicin. Molecules 15:6193-6204
18. Seo HB, Lee SC, Kwon TD, Kang JY, Song YJ, Ryu S (2011) The effect of ginger extract ingestion and swimming exercise on insulin resistance and skeletal muscle antioxidant capacity and apoptosis in hyperglycemic rats fed a high-fructose diet. JENB 15(1):41-48
19. Surh Y (1999) Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat Res 428:305-327
20. Tjendraputra E, Tran VH, Liu-Brennan D, Roufogalis BD, Duke CC (2001) Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorg Chem 29:156-163.
21. It is cited in Aggarwal BB, Shishodia S (2004) Suppression of the NF-jB activation pathway by spice-derived phytochemicals. Ann NY Acad Sci 1030:434-441
22. Oyagbemi AA, Saba AB, Azeez OI (2010) Molecular targets of 6-gingerol: its potential roles in cancer chemoprevention. Bio- Factors 36:169-178
23. Abdel-Aleem S, El-Merzabani MM, Ahmed MS, Taylor DA, Lowe JE (1997) Acute and chronic effects of adriamycin on fatty acid oxidation in isolated cardiac myocytes. J Mol Cell Cardiol 29:789-797
24. Escoubas P, Lajide L, Mizutani J (1995) Termite antifeedant activity in Aframomum activity. Phytochemistry 40:1097-1099
25. Mansour MA, Bakheet SA, Aleisa AM et al (2008) Protective effect of 6-gingerol against cardiotoxicity induced by doxorubicin. Open Pharmacol J 2:20-23
26. Goraca A, Piechota A, Huk-kolega H (2009) Effect of alpha - lipoic acid on LPS-induced oxidative stress in the heart. J Physiol Pharmacol 60(1):61-68
27. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
28. Petit T (2004) Anthracycline-induced cardiotoxicity. Bull Cancer 91(3):159-165
29. Zhang FY, Du GJ, Zhang L, Zhang CL, Lu WL, Liang W (2009) Naringenin enhances the anti-tumor effect of Doxorubicin through selectively inhibiting the activity of multidrug resistance associated proteins but not P-glycoprotein. Pharm Res 26:914-925
30. Xiao J, Sun GB, Sun B et al (2012) Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. Toxicology 292:53-62
31. Deatley SM, Aksenov MY, Aksenova MV, Jordan B, Carney JM, Butterfield DA (1999) Adriamycin-induced changes of creatine kinase activity in vivo and in cardiomyocyte culture. Toxicology 134:51-62
32. Mair J, Apple F (1997) Progress in myocardial damage detection: new biochemical markers for clinicians. Crit Rev Clin Lab Sci 34:1-66
33. Herman EH, Zhang J, Rifai N et al (2001) The use of serum levels of cardiac troponin T to compare the protective activity of dexrazoxane against doxorubicin-and mitoxantrone-induced cardiotoxicity. Cancer Chemother Pharmacol 48:297-304
34. Saad SY, Najjar TA, Al-Rikabi AC (2001) The preventive role of desferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats. Pharmacol Res 43:211-218
35. El-Demerdash E, Ali AA, Ahmed MS, Osman AM (2003) New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity. Cancer Chemother Pharmacol 52:411-416
36. Sakr SA, Mahran HA, Lamfon HA (2011) Protective effect of ginger (Zingiber officinale) on adriamycin-induced hepatotoxicity in albino rats. J Med Plant Res 5(1):133-140
37. Lander HM, Tauras JM, Ogiste JS, Hori O, Moss RA, Schmidt AM (1997) Activation of the receptor for advanced glycation end products triggers a p21ras-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J Biol Chem 272:17810-17814
38. Li N, Karin M (1999) Is NF-kappa B the sensor of oxidative stress? FASEB J 13:1137-1143
39. Wang S, Kotamraju S, Konorev E, Kalivendi S, Joseph J, Kalyanaraman B (2002) Activation of NF-jB during doxorubicininduced apoptosis in endothelial cells and myocytes is proapoptotic: the role of hydrogen peroxide. Biochemical J 367: 729-740
40. Liu J, Mao W, Ding B, Liang CS (2008) ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes. Am J Physiol 295: 1956-1965
41. Tam XH, Shiu SW, Leng L, Bucala R, Betteridge DJ, Tan KC (2011) Enhanced expression of receptor for advanced glycation end-products is associated with low circulating soluble isoforms of the receptor in type 2 diabetes. Clin Sci 120:81-89
42. Pereira MM, Haniadka R, Chacko PP, Palatty PL, Baliga MS (2011) Zingiber officinale Roscoe (ginger) as an adjuvant in cancer treatment: a review. J BUON 16(3):414-424
43. Ryan JL, Heckler C, Dakhil SR et al (2009) Ginger for chemotherapy- related nausea in cancer patients: a URCC CCOP randomized, double-blind, placebo-controlled clinical trial of 644 cancer patients. J Clin Oncol 27:15s