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Volumn 122, Issue 20, 2013, Pages 3521-3532

Inhibiting Glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia

(21)  Willems, Lise a,b,c   Jacque, Nathalie b   Jacquel, Arnaud d   Neveux, Nathalie a   Maciel, Thiago Trovati e   Lambert, Mireille b   Schmitt, Alain f   Poulain, Laury b   Green, Alexa S b   Uzunov, Madalina a   Kosmider, Olivier b,c,h   Radford Weiss, Isabelle g   Moura, Ivan Cruz e   Auberger, Patrick d   Ifrah, Norbert h   Bardet, Valerie a,b,c   Chapuis, Nicolas a,b,c   Lacombe, Catherine a,b,c   Mayeux, Patrick b,c   Tamburini, Jerome a,b,c   more..

b CNRS   (France)
e INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; GLUTAMATE AMMONIA LIGASE; GLUTAMINASE; GLUTAMINE;

EID: 84888271341     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-03-493163     Document Type: Article
Times cited : (239)

References (49)
  • 1
    • 0035498939 scopus 로고    scopus 로고
    • Hierarchical phosphorylation of the translation inhibitor 4E-BP1
    • Gingras AC, Raught B, Gygi SP, et al. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev. 2001;15(21):2852-2864.
    • (2001) Genes Dev. , vol.15 , Issue.21 , pp. 2852-2864
    • Gingras, A.C.1    Raught, B.2    Gygi, S.P.3
  • 2
    • 38049187096 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: Rationale for therapeutic inhibition of both pathways
    • Tamburini J, Chapuis N, Bardet V, et al. Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways. Blood. 2008;111(1):379-382.
    • (2008) Blood , vol.111 , Issue.1 , pp. 379-382
    • Tamburini, J.1    Chapuis, N.2    Bardet, V.3
  • 4
    • 84861833364 scopus 로고    scopus 로고
    • Mtorc1 is essential for leukemia propagation but not stem cell self-renewal
    • Hoshii T, Tadokoro Y, Naka K, et al. mTORC1 is essential for leukemia propagation but not stem cell self-renewal. J Clin Invest. 2012;122(6):2114- 2129.
    • (2012) J Clin Invest. , vol.122 , Issue.6 , pp. 2114-2129
    • Hoshii, T.1    Tadokoro, Y.2    Naka, K.3
  • 5
    • 28844480101 scopus 로고    scopus 로고
    • Mtor regulates cell survival after etoposide treatment in primary AML cells
    • Xu Q, Thompson JE, Carroll M. mTOR regulates cell survival after etoposide treatment in primary AML cells. Blood. 2005;106(13):4261-4268.
    • (2005) Blood , vol.106 , Issue.13 , pp. 4261-4268
    • Xu, Q.1    Thompson, J.E.2    Carroll, M.3
  • 6
    • 70349576526 scopus 로고    scopus 로고
    • Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia
    • Tamburini J, Green AS, Bardet V, et al. Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia. Blood. 2009;114(8):1618-1627.
    • (2009) Blood , vol.114 , Issue.8 , pp. 1618-1627
    • Tamburini, J.1    Green, A.S.2    Bardet, V.3
  • 7
    • 84862012594 scopus 로고    scopus 로고
    • The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia
    • Willems L, Chapuis N, Puissant A, et al. The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia. Leukemia. 2012;26(6):1195-1202.
    • (2012) Leukemia. , vol.26 , Issue.6 , pp. 1195-1202
    • Willems, L.1    Chapuis, N.2    Puissant, A.3
  • 8
    • 78349273297 scopus 로고    scopus 로고
    • Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia
    • Chapuis N, Tamburini J, Green AS, et al. Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia. Clin Cancer Res. 2010;16(22):5424-5435.
    • (2010) Clin Cancer Res. , vol.16 , Issue.22 , pp. 5424-5435
    • Chapuis, N.1    Tamburini, J.2    Green, A.S.3
  • 9
    • 84859778293 scopus 로고    scopus 로고
    • Mtor signaling in growth control and disease
    • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012;149(2):274-293.
    • (2012) Cell , vol.149 , Issue.2 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 10
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem. 1998;273(23):14484-14494.
    • (1998) J Biol Chem. , vol.273 , Issue.23 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.P.3    Kozlowski, M.T.4    Belham, C.5    Avruch, J.6
  • 13
    • 45849105156 scopus 로고    scopus 로고
    • The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    • Sancak Y, Peterson TR, Shaul YD, et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008;320(5882):1496-1501.
    • (2008) Science. , vol.320 , Issue.5882 , pp. 1496-1501
    • Sancak, Y.1    Peterson, T.R.2    Shaul, Y.D.3
  • 14
    • 23044474905 scopus 로고    scopus 로고
    • Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
    • Fuchs BC, Bode BP. Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime? Semin Cancer Biol. 2005;15(4):254-266.
    • (2005) Semin Cancer Biol. , vol.15 , Issue.4 , pp. 254-266
    • Fuchs, B.C.1    Bode, B.P.2
  • 15
    • 59049087460 scopus 로고    scopus 로고
    • Bidirectional transport of amino acids regulates mTOR and autophagy
    • Nicklin P, Bergman P, Zhang B, et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009;136(3):521-534.
    • (2009) Cell , vol.136 , Issue.3 , pp. 521-534
    • Nicklin, P.1    Bergman, P.2    Zhang, B.3
  • 16
    • 59449092185 scopus 로고    scopus 로고
    • Singlevector inducible lentiviral RNAi system for oncology target validation
    • Wiederschain D, Wee S, Chen L, et al. Singlevector inducible lentiviral RNAi system for oncology target validation. Cell Cycle. 2009;8(3):498-504.
    • (2009) Cell Cycle. , vol.8 , Issue.3 , pp. 498-504
    • Wiederschain, D.1    Wee, S.2    Chen, L.3
  • 17
    • 77951046942 scopus 로고    scopus 로고
    • Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia
    • Callens C, Coulon S, Naudin J, et al. Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010;207(4):731-750.
    • (2010) J Exp Med. , vol.207 , Issue.4 , pp. 731-750
    • Callens, C.1    Coulon, S.2    Naudin, J.3
  • 18
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010;141(2):290-303.
    • (2010) Cell , vol.141 , Issue.2 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 19
    • 77956402268 scopus 로고    scopus 로고
    • Targeting autophagy to fight hematopoietic malignancies
    • Puissant A, Robert G, Auberger P. Targeting autophagy to fight hematopoietic malignancies. Cell Cycle. 2010;9(17):3470-3478.
    • (2010) Cell Cycle. , vol.9 , Issue.17 , pp. 3470-3478
    • Puissant, A.1    Robert, G.2    Auberger, P.3
  • 20
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine AJ, Puzio-Kuter AM. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science. 2010;330(6009):1340-1344.
    • (2010) Science. , vol.330 , Issue.6009 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 21
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
    • Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell. 2012;21(3):297-308.
    • (2012) Cancer Cell. , vol.21 , Issue.3 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 22
    • 77956674635 scopus 로고    scopus 로고
    • Evidence for an alternative glycolytic pathway in rapidly proliferating cells
    • Vander Heiden MG, Locasale JW, Swanson KD, et al. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science. 2010;329(5998):1492-1499.
    • (2010) Science. , vol.329 , Issue.5998 , pp. 1492-1499
    • Van Der Heiden, M.G.1    Locasale, J.W.2    Swanson, K.D.3
  • 23
    • 77955281020 scopus 로고    scopus 로고
    • Glutamine addiction: A new therapeutic target in cancer
    • Wise DR, Thompson CB. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci. 2010;35(8):427-433.
    • (2010) Trends Biochem Sci. , vol.35 , Issue.8 , pp. 427-433
    • Wise, D.R.1    Thompson, C.B.2
  • 24
    • 33750916736 scopus 로고    scopus 로고
    • Characterization of several amino acid transports and glutamine metabolism in MOLT4 human T4 leukemia cells
    • Ochiai H, Higa K, Hishiyama N, Hisamatsu S, Fujise H. Characterization of several amino acid transports and glutamine metabolism in MOLT4 human T4 leukemia cells. Clin Lab Haematol. 2006;28(6):399-404.
    • (2006) Clin Lab Haematol. , vol.28 , Issue.6 , pp. 399-404
    • Ochiai, H.1    Higa, K.2    Hishiyama, N.3    Hisamatsu, S.4    Fujise, H.5
  • 25
    • 34248140159 scopus 로고    scopus 로고
    • Acidosissensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells
    • Evans K, Nasim Z, Brown J, et al. Acidosissensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells. J Am Soc Nephrol. 2007;18(5):1426-1436.
    • (2007) J Am Soc Nephrol. , vol.18 , Issue.5 , pp. 1426-1436
    • Evans, K.1    Nasim, Z.2    Brown, J.3
  • 27
    • 0015074696 scopus 로고
    • L-asparaginase: Clinical, biochemical, pharmacological, and immunological studies
    • Capizzi RL, Bertino JR, Skeel RT, et al. L-asparaginase: clinical, biochemical, pharmacological, and immunological studies. Ann Intern Med. 1971;74(6):893-901.
    • (1971) Ann Intern Med. , vol.74 , Issue.6 , pp. 893-901
    • Capizzi, R.L.1    Bertino, J.R.2    Skeel, R.T.3
  • 28
    • 0021032126 scopus 로고
    • Influence of intensive asparaginase in the treatment of childhood non-T-cell acute lymphoblastic leukemia
    • Sallan SE, Hitchcock-Bryan S, Gelber R, Cassady JR, Frei E III, Nathan DG. Influence of intensive asparaginase in the treatment of childhood non-T-cell acute lymphoblastic leukemia. Cancer Res. 1983;43(11):5601-5607.
    • (1983) Cancer Res. , vol.43 , Issue.11 , pp. 5601-5607
    • Sallan, S.E.1    Hitchcock-Bryan, S.2    Gelber, R.3    Cassady, J.R.4    Frei III, E.5    Nathan, D.G.6
  • 29
    • 30444437486 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia
    • Pui C-H, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med. 2006;354(2):166-178.
    • (2006) N Engl J Med. , vol.354 , Issue.2 , pp. 166-178
    • Pui, C.-H.1    Evans, W.E.2
  • 30
    • 0014445065 scopus 로고
    • Amino acid levels following L-asparagine amidohydrolase (EC. 3.5.1.1) therapy
    • Miller HK, Salser JS, Balis ME. Amino acid levels following L-asparagine amidohydrolase (EC. 3.5.1.1) therapy. Cancer Res. 1969;29(1):183-187.
    • (1969) Cancer Res. , vol.29 , Issue.1 , pp. 183-187
    • Miller, H.K.1    Salser, J.S.2    Balis, M.E.3
  • 31
    • 0032145202 scopus 로고    scopus 로고
    • Use of L-asparaginase in childhood ALL
    • Müller HJ, Boos J. Use of L-asparaginase in childhood ALL. Crit Rev Oncol Hematol. 1998;28(2):97-113.
    • (1998) Crit Rev Oncol Hematol. , vol.28 , Issue.2 , pp. 97-113
    • Müller, H.J.1    Boos, J.2
  • 32
    • 0037085747 scopus 로고    scopus 로고
    • A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: A Children's Cancer Group study
    • Avramis VI, Sencer S, Periclou AP, et al. A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study. Blood. 2002;99(6):1986-1994.
    • (2002) Blood , vol.99 , Issue.6 , pp. 1986-1994
    • Avramis, V.I.1    Sencer, S.2    Periclou, A.P.3
  • 33
    • 34547811078 scopus 로고    scopus 로고
    • Pharmacoanalytical assays of Erwinia asparaginase (erwinase) and pharmacokinetic results in high-risk acute lymphoblastic leukemia (HR ALL) patients: Simulations of erwinase population PK-PD models
    • Avramis VI, Martin-Aragon S, Avramis EV, Asselin BL. Pharmacoanalytical assays of Erwinia asparaginase (erwinase) and pharmacokinetic results in high-risk acute lymphoblastic leukemia (HR ALL) patients: simulations of erwinase population PK-PD models. Anticancer Res. 2007;27(4 C):2561-2572.
    • (2007) Anticancer Res. , vol.27 , Issue.4 C , pp. 2561-2572
    • Avramis, V.I.1    Martin-Aragon, S.2    Avramis, E.V.3    Asselin, B.L.4
  • 35
    • 33845195466 scopus 로고    scopus 로고
    • Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase
    • Reinert RB, Oberle LM, Wek SA, et al. Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase. J Biol Chem. 2006;281(42):31222-31233.
    • (2006) J Biol Chem. , vol.281 , Issue.42 , pp. 31222-31233
    • Reinert, R.B.1    Oberle, L.M.2    Wek, S.A.3
  • 36
    • 0014733901 scopus 로고
    • Clinical results of treatment with E. Coli L-asparaginase in adults with leukemia, lymphoma, and solid tumors
    • Clarkson B, Krakoff I, Burchenal J, et al. Clinical results of treatment with E. coli L-asparaginase in adults with leukemia, lymphoma, and solid tumors. Cancer. 1970;25(2):279-305.
    • (1970) Cancer. , vol.25 , Issue.2 , pp. 279-305
    • Clarkson, B.1    Krakoff, I.2    Burchenal, J.3
  • 37
    • 0014851427 scopus 로고
    • Biochemical and pharmacological studies with asparaginase in man
    • Ohnuma T, Holland JF, Freeman A, Sinks LF. Biochemical and pharmacological studies with asparaginase in man. Cancer Res. 1970;30(9):2297-2305.
    • (1970) Cancer Res. , vol.30 , Issue.9 , pp. 2297-2305
    • Ohnuma, T.1    Holland, J.F.2    Freeman, A.3    Sinks, L.F.4
  • 38
    • 0023867205 scopus 로고
    • Synergy between high-dose cytarabine and asparaginase in the treatment of adults with refractory and relapsed acute myelogenous leukemia: A Cancer and Leukemia Group B Study
    • Capizzi RL, Davis R, Powell B, et al. Synergy between high-dose cytarabine and asparaginase in the treatment of adults with refractory and relapsed acute myelogenous leukemia: a Cancer and Leukemia Group B Study. J Clin Oncol. 1988;6(3):499-508.
    • (1988) J Clin Oncol. , vol.6 , Issue.3 , pp. 499-508
    • Capizzi, R.L.1    Davis, R.2    Powell, B.3
  • 39
    • 28544450141 scopus 로고    scopus 로고
    • Treatment of childhood acute myeloblastic leukemia: Dose intensification improves outcome and maintenance therapy is of no benefit: Multicenter studies of the French LAME (Leucémie Aiguë Myéloblastique Enfant) Cooperative Group
    • Perel Y, Auvrignon A, Leblanc T, et al. Treatment of childhood acute myeloblastic leukemia: dose intensification improves outcome and maintenance therapy is of no benefit: multicenter studies of the French LAME (Leucémie Aiguë Myéloblastique Enfant) Cooperative Group. Leukemia. 2005;19(12):2082-2089.
    • (2005) Leukemia. , vol.19 , Issue.12 , pp. 2082-2089
    • Perel, Y.1    Auvrignon, A.2    Leblanc, T.3
  • 40
    • 0034667607 scopus 로고    scopus 로고
    • Cellular drug resistance profiles in childhood acute myeloid leukemia: Differences between FAB types and comparison with acute lymphoblastic leukemia
    • Zwaan CM, Kaspers GJ, Pieters R, et al. Cellular drug resistance profiles in childhood acute myeloid leukemia: differences between FAB types and comparison with acute lymphoblastic leukemia. Blood. 2000;96(8):2879-2886.
    • (2000) Blood , vol.96 , Issue.8 , pp. 2879-2886
    • Zwaan, C.M.1    Kaspers, G.J.2    Pieters, R.3
  • 41
    • 0035203378 scopus 로고    scopus 로고
    • Clinical relevance of in vitro chemoresistance in childhood acute myeloid leukemia
    • Yamada S, Hongo T, Okada S, Watanabe C, Fujii Y, Ohzeki T. Clinical relevance of in vitro chemoresistance in childhood acute myeloid leukemia. Leukemia. 2001;15(12):1892-1897.
    • (2001) Leukemia. , vol.15 , Issue.12 , pp. 1892-1897
    • Yamada, S.1    Hongo, T.2    Okada, S.3    Watanabe, C.4    Fujii, Y.5    Ohzeki, T.6
  • 42
    • 10744219546 scopus 로고    scopus 로고
    • In vitro efficacy of l-asparaginase in childhood acute myeloid leukaemia
    • Okada S, Hongo T, Yamada S, et al. In vitro efficacy of l-asparaginase in childhood acute myeloid leukaemia. Br J Haematol. 2003;123(5):802-809.
    • (2003) Br J Haematol. , vol.123 , Issue.5 , pp. 802-809
    • Okada, S.1    Hongo, T.2    Yamada, S.3
  • 43
    • 0030966193 scopus 로고    scopus 로고
    • Amino acid control of asparagine synthetase: Relation to asparaginase resistance in human leukemia cells
    • Hutson RG, Kitoh T, Moraga Amador DA, Cosic S, Schuster SM, Kilberg MS. Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells. Am J Physiol. 1997;272(5 Pt 1):C1691-C1699.
    • (1997) Am J Physiol. , vol.272 , Issue.5 PART 1
    • Hutson, R.G.1    Kitoh, T.2    Moraga Amador, D.A.3    Cosic, S.4    Schuster, S.M.5    Kilberg, M.S.6
  • 44
    • 33744497255 scopus 로고    scopus 로고
    • Up-regulation of asparagine synthetase expression is not linked to the clinical response L-asparaginase in pediatric acute lymphoblastic leukemia
    • Appel IM, den Boer ML, Meijerink JPP, Veerman AJ, Reniers NC, Pieters R. Up-regulation of asparagine synthetase expression is not linked to the clinical response L-asparaginase in pediatric acute lymphoblastic leukemia. Blood. 2006;107(11):4244-4249.
    • (2006) Blood , vol.107 , Issue.11 , pp. 4244-4249
    • Appel, I.M.1    Den Boer, M.L.2    Meijerink, J.P.P.3    Veerman, A.J.4    Reniers, N.C.5    Pieters, R.6
  • 45
    • 0035881515 scopus 로고    scopus 로고
    • Multiple adaptive mechanisms affect asparagine synthetase substrate availability in asparaginase-resistant MOLT-4 human leukaemia cells
    • Aslanian AM, Kilberg MS. Multiple adaptive mechanisms affect asparagine synthetase substrate availability in asparaginase-resistant MOLT-4 human leukaemia cells. Biochem J. 2001;358(Pt 1):59-67.
    • (2001) Biochem J. , vol.358 , Issue.PART 1 , pp. 59-67
    • Aslanian, A.M.1    Kilberg, M.S.2
  • 46
    • 22544474183 scopus 로고    scopus 로고
    • Inhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells
    • Rotoli BM, Uggeri J, Dall'Asta V, et al. Inhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells. Cell Physiol Biochem. 2005;15(6):281-292.
    • (2005) Cell Physiol Biochem. , vol.15 , Issue.6 , pp. 281-292
    • Rotoli, B.M.1    Uggeri, J.2    Dall'Asta, V.3
  • 47
    • 80052854761 scopus 로고    scopus 로고
    • L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of b-catenin-mutated human hepatocellular carcinoma cells
    • Tardito S, Chiu M, Uggeri J, et al. L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of b-catenin-mutated human hepatocellular carcinoma cells. Curr Cancer Drug Targets. 2011;11(8):929-943.
    • (2011) Curr Cancer Drug Targets. , vol.11 , Issue.8 , pp. 929-943
    • Tardito, S.1    Chiu, M.2    Uggeri, J.3
  • 48
    • 84874049564 scopus 로고    scopus 로고
    • Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363
    • Lamoureux F, Thomas C, Crafter C, et al. Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363. Clin Cancer Res. 2013;19(4):833-844.
    • (2013) Clin Cancer Res. , vol.19 , Issue.4 , pp. 833-844
    • Lamoureux, F.1    Thomas, C.2    Crafter, C.3
  • 49
    • 82555175924 scopus 로고    scopus 로고
    • Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells
    • Han W, Sun J, Feng L, et al. Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells. PLoS ONE. 2011;6(12):e28491.
    • (2011) PLoS ONE. , vol.6 , Issue.12
    • Han, W.1    Sun, J.2    Feng, L.3


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