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Volumn 22, Issue 1, 2016, Pages 46-52

Airway inflammation in asthma: Key players beyond the Th2 pathway

Author keywords

Endothelial cells; Epithelial cells; IL 4; Innate lymphoid cell type 2; Phosphodiesterase

Indexed keywords

CYCLIC AMP; DEOXYRIBOZYME; GLUCOCORTICOID; INTERLEUKIN 25; INTERLEUKIN 33; INTERLEUKIN 4; NOTCH RECEPTOR; PHOSPHODIESTERASE; THYMIC STROMAL LYMPHOPOIETIN; TRANSCRIPTION FACTOR GATA 3; CYTOKINE;

EID: 84948579893     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/MCP.0000000000000224     Document Type: Review
Times cited : (57)

References (76)
  • 1
    • 77649198441 scopus 로고    scopus 로고
    • Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma
    • Oh CK, Geba GP, Molfino N. Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma. Eur Respir Rev 2010; 19:46-54.
    • (2011) Eur Respir Rev , vol.19 , pp. 46-54
    • Oh, C.K.1    Geba, G.P.2    Molfino, N.3
  • 2
    • 84902352161 scopus 로고    scopus 로고
    • The cell biology of asthma
    • Erle DJ, Sheppard D. The cell biology of asthma. J Cell Biol 2014; 205:621-631.
    • (2014) J Cell Biol , vol.205 , pp. 621-631
    • Erle, D.J.1    Sheppard, D.2
  • 4
    • 84928228562 scopus 로고    scopus 로고
    • IgE-Activated basophils regulate eosinophil tissue entry by modulating endothelial function
    • Cheng LE, Sullivan BM, Retana LE, et al. IgE-Activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med 2015; 212:513-524.
    • (2015) J Exp Med , vol.212 , pp. 513-524
    • Cheng, L.E.1    Sullivan, B.M.2    Retana, L.E.3
  • 5
    • 84898801869 scopus 로고    scopus 로고
    • Potential non-T cells source of interleukin-4 in food allergy
    • Caubet JC, Masilamani M, Rivers NA, et al. Potential non-T cells source of interleukin-4 in food allergy. Pediatr Allergy Immunol 2014; 25:243-249.
    • (2014) Pediatr Allergy Immunol , vol.25 , pp. 243-249
    • Caubet, J.C.1    Masilamani, M.2    Rivers, N.A.3
  • 6
    • 77951677789 scopus 로고    scopus 로고
    • Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy
    • e1078
    • Sicherer SH, Wood RA, Stablein D, et al. Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy. J Allergy Clin Immunol 2010; 125:1077-1083; e1078.
    • (2011) J Allergy Clin Immunol , vol.125 , pp. 1077-1083
    • Sicherer, S.H.1    Wood, R.A.2    Stablein, D.3
  • 7
    • 84887436574 scopus 로고    scopus 로고
    • GATA-1 regulates the generation and function of basophils
    • Nei Y, Obata-Ninomiya K, Tsutsui H, et al. GATA-1 regulates the generation and function of basophils. Proc Natl Acad Sci U S A 2013; 110:18620-18625.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 18620-18625
    • Nei, Y.1    Obata-Ninomiya, K.2    Tsutsui, H.3
  • 8
    • 0028850516 scopus 로고
    • Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product
    • Moqbel R, Ying S, Barkans J, et al. Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product. J Immunol 1995; 155:4939-4947.
    • (1995) J Immunol , vol.155 , pp. 4939-4947
    • Moqbel, R.1    Ying, S.2    Barkans, J.3
  • 9
    • 0030136550 scopus 로고    scopus 로고
    • Immunolocalization of interleukin-4 in eosinophils in the bronchial mucosa of atopic asthmatics
    • Moller GM, de Jong TA, van der Kwast TH, et al. Immunolocalization of interleukin-4 in eosinophils in the bronchial mucosa of atopic asthmatics. Am J Respir Cell Mol Biol 1996; 14:439-443.
    • (1996) Am J Respir Cell Mol Biol , vol.14 , pp. 439-443
    • Moller, G.M.1    De Jong, T.A.2    Van Der Kwast, T.H.3
  • 10
    • 84863805992 scopus 로고    scopus 로고
    • Pathogenesis and classification of eosinophil disorders: A review of recent developments in the field
    • Valent P, Gleich GJ, Reiter A, et al. Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field. Expert Rev Hematol 2012; 5:157-176.
    • (2012) Expert Rev Hematol , vol.5 , pp. 157-176
    • Valent, P.1    Gleich, G.J.2    Reiter, A.3
  • 11
    • 84882778526 scopus 로고    scopus 로고
    • Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production
    • Doherty TA, Khorram N, Lund S, et al. Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. J Allergy Clin Immunol 2013; 132:205-213.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 205-213
    • Doherty, T.A.1    Khorram, N.2    Lund, S.3
  • 12
    • 84867773093 scopus 로고    scopus 로고
    • The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells
    • Mjosberg J, Bernink J, Golebski K, et al. The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity 2012; 37:649-659.
    • (2012) Immunity , vol.37 , pp. 649-659
    • Mjosberg, J.1    Bernink, J.2    Golebski, K.3
  • 13
    • 0035096259 scopus 로고    scopus 로고
    • Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways
    • Braunstahl GJ, Overbeek SE, Kleinjan A, et al. Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways. J Allergy Clin Immunol 2001; 107:469-476.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 469-476
    • Braunstahl, G.J.1    Overbeek, S.E.2    Kleinjan, A.3
  • 14
    • 0033784393 scopus 로고    scopus 로고
    • Basophil and eosinophil accumulation and mast cell degranulation in the nasal mucosa of patients with hay fever after local allergen provocation
    • KleinJan A, McEuen AR, Dijkstra MD, et al. Basophil and eosinophil accumulation and mast cell degranulation in the nasal mucosa of patients with hay fever after local allergen provocation. J Allergy Clin Immunol 2000; 106:677-686.
    • (2000) J Allergy Clin Immunol , vol.106 , pp. 677-686
    • KleinJan, A.1    McEuen, A.R.2    Dijkstra, M.D.3
  • 15
    • 84899622336 scopus 로고    scopus 로고
    • Interleukin-4 and interleukin-13 cause barrier dysfunction in human airway epithelial cells
    • Saatian B, Rezaee F, Desando S, et al. Interleukin-4 and interleukin-13 cause barrier dysfunction in human airway epithelial cells. Tissue Barriers 2013; 1:e24333-1-e24333-5.
    • (2013) Tissue Barriers , vol.1 , pp. e243331-e243335
    • Saatian, B.1    Rezaee, F.2    Desando, S.3
  • 16
    • 58849099058 scopus 로고    scopus 로고
    • The different faces of Notch in T-helper-cell differentiation
    • Amsen D, Antov A, Flavell RA. The different faces of Notch in T-helper-cell differentiation. Nat Rev Immunol 2009; 9:116-124.
    • (2009) Nat Rev Immunol , vol.9 , pp. 116-124
    • Amsen, D.1    Antov, A.2    Flavell, R.A.3
  • 17
    • 84908226945 scopus 로고    scopus 로고
    • Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses
    • Fasnacht N, Huang HY, Koch U, et al. Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses. J Exp Med 2014; 211:2265-2279.
    • (2014) J Exp Med , vol.211 , pp. 2265-2279
    • Fasnacht, N.1    Huang, H.Y.2    Koch, U.3
  • 18
    • 84875446770 scopus 로고    scopus 로고
    • Delta-like ligand 4 identifies a previously uncharacterized population of inflammatory dendritic cells that plays important roles in eliciting allogeneic T cell responses in mice
    • Mochizuki K, Xie F, He S, et al. Delta-like ligand 4 identifies a previously uncharacterized population of inflammatory dendritic cells that plays important roles in eliciting allogeneic T cell responses in mice. J Immunol 2013; 190:3772-3782.
    • (2013) J Immunol , vol.190 , pp. 3772-3782
    • Mochizuki, K.1    Xie, F.2    He, S.3
  • 19
    • 82255164211 scopus 로고    scopus 로고
    • Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responses
    • Pletinckx K, Stijlemans B, Pavlovic V, et al. Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responses. Eur J Immunol 2011; 41:3479-3494.
    • (2011) Eur J Immunol , vol.41 , pp. 3479-3494
    • Pletinckx, K.1    Stijlemans, B.2    Pavlovic, V.3
  • 20
    • 84969541566 scopus 로고    scopus 로고
    • Kinetics of TH2 biomarkers in sputum of asthmatics following inhaled allergen
    • Zuiker RGJA, Ruddy MK, Morelli N, et al. Kinetics of TH2 biomarkers in sputum of asthmatics following inhaled allergen. Eur Clin Respir Journal 2015; 2:28319.
    • (2015) Eur Clin Respir Journal , vol.2 , pp. 28319
    • Rgja, Z.1    Ruddy, M.K.2    Morelli, N.3
  • 21
    • 84883218243 scopus 로고    scopus 로고
    • IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma
    • e613
    • Saglani S, Lui S, Ullmann N, et al. IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma. J Allergy Clin Immunol 2013; 132:676-685; e613.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 676-685
    • Saglani, S.1    Lui, S.2    Ullmann, N.3
  • 22
    • 84920593779 scopus 로고    scopus 로고
    • Biological clustering supports both Dutch and British hypotheses of asthma and chronic obstructive pulmonary disease
    • Ghebre MA, Bafadhel M, Desai D, et al. Biological clustering supports both Dutch and British hypotheses of asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol 2015; 135:63-72.
    • (2015) J Allergy Clin Immunol , vol.135 , pp. 63-72
    • Ghebre, M.A.1    Bafadhel, M.2    Desai, D.3
  • 23
    • 0033769933 scopus 로고    scopus 로고
    • Preventive treatment of intranasal fluticasone propionate reduces cytokine mRNA expressing cells before and during a single nasal allergen provocation
    • Kleinjan A, Holm AF, Dijkstra MD, et al. Preventive treatment of intranasal fluticasone propionate reduces cytokine mRNA expressing cells before and during a single nasal allergen provocation. Clin Exp Allergy 2000; 30:1476-1485.
    • (2000) Clin Exp Allergy , vol.30 , pp. 1476-1485
    • Kleinjan, A.1    Holm, A.F.2    Dijkstra, M.D.3
  • 25
    • 80054906310 scopus 로고    scopus 로고
    • T(H)17 cells in asthma and inflammation
    • Aujla SJ, Alcorn JF. T(H)17 cells in asthma and inflammation. Biochim Biophys Acta 2011; 1810:1066-1079.
    • (2011) Biochim Biophys Acta , vol.1810 , pp. 1066-1079
    • Aujla, S.J.1    Alcorn, J.F.2
  • 26
    • 77954558988 scopus 로고    scopus 로고
    • Alarming dendritic cells for allergic sensitization
    • Willart MA, Hammad H. Alarming dendritic cells for allergic sensitization. Allergol Int 2010; 59:95-103.
    • (2011) Allergol Int , vol.59 , pp. 95-103
    • Willart, M.A.1    Hammad, H.2
  • 27
    • 84866130874 scopus 로고    scopus 로고
    • Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33
    • Willart MA, Deswarte K, Pouliot P, et al. Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J Exp Med 2012; 209:1505-1517.
    • (2012) J Exp Med , vol.209 , pp. 1505-1517
    • Willart, M.A.1    Deswarte, K.2    Pouliot, P.3
  • 28
    • 84901759301 scopus 로고    scopus 로고
    • Effects of an anti-TSLP antibody on allergen-induced asthmatic responses
    • Gauvreau GM, OByrne PM, Boulet LP, et al. Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med 2014; 370:2102-2110.
    • (2014) N Engl J Med , vol.370 , pp. 2102-2110
    • Gauvreau, G.M.1    OByrne, P.M.2    Boulet, L.P.3
  • 29
    • 84908459245 scopus 로고    scopus 로고
    • Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma
    • Cheng D, Xue Z, Yi L, et al. Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma. Am J Respir Crit Care Med 2014; 190:639-648.
    • (2014) Am J Respir Crit Care Med , vol.190 , pp. 639-648
    • Cheng, D.1    Xue, Z.2    Yi, L.3
  • 30
    • 84908374296 scopus 로고    scopus 로고
    • Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation
    • Beale J, Jayaraman A, Jackson DJ, et al. Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation. Sci Transl Med 2014; 6:256ra134.
    • (2014) Sci Transl Med , vol.6 , pp. 256ra134
    • Beale, J.1    Jayaraman, A.2    Jackson, D.J.3
  • 31
    • 84908374072 scopus 로고    scopus 로고
    • IL-25: The missing link between allergy viral infection, and asthma?
    • Andreakos E, Papadopoulos NG. IL-25: the missing link between allergy, viral infection, and asthma? Sci Transl Med 2014; 6:256fs38.
    • (2014) Sci Transl Med , vol.6 , pp. 256fs38
    • Andreakos, E.1    Papadopoulos, N.G.2
  • 32
    • 84937869139 scopus 로고    scopus 로고
    • Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33
    • Castanhinha S, Sherburn R, Walker S, et al. Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33. J Allergy Clin Immunol 2015; 136:312-322.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 312-322
    • Castanhinha, S.1    Sherburn, R.2    Walker, S.3
  • 33
    • 84905968184 scopus 로고    scopus 로고
    • Alternaria-derived serine protease activity drives IL-33-mediated asthma exacerbations
    • e586
    • Snelgrove RJ, Gregory LG, Peiro T, et al. Alternaria-derived serine protease activity drives IL-33-mediated asthma exacerbations. J Allergy Clin Immunol 2014; 134:583-592; e586.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 583-592
    • Snelgrove, R.J.1    Gregory, L.G.2    Peiro, T.3
  • 34
    • 84860343753 scopus 로고    scopus 로고
    • Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma
    • Klein Wolterink RG, Kleinjan A, van Nimwegen M, et al. Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma. Eur J Immunol 2012; 42:1106-1116.
    • (2012) Eur J Immunol , vol.42 , pp. 1106-1116
    • Klein Wolterink, R.G.1    Kleinjan, A.2    Van Nimwegen, M.3
  • 35
    • 84880331836 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin promotes asthmatic airway remodelling in human lung fibroblast cells through STAT3 signalling pathway
    • Wu J, Liu F, Zhao J, et al. Thymic stromal lymphopoietin promotes asthmatic airway remodelling in human lung fibroblast cells through STAT3 signalling pathway. Cell Biochem Funct 2013; 31:496-503.
    • (2013) Cell Biochem Funct , vol.31 , pp. 496-503
    • Wu, J.1    Liu, F.2    Zhao, J.3
  • 36
    • 84937697152 scopus 로고    scopus 로고
    • An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory T cell numbers
    • Morita H, Arae K, Unno H, et al. An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory T cell numbers. Immunity 2015; 43:175-186.
    • (2015) Immunity , vol.43 , pp. 175-186
    • Morita, H.1    Arae, K.2    Unno, H.3
  • 37
    • 84937618997 scopus 로고    scopus 로고
    • Interleukin-33 and interferon-gamma counter-regulate group 2 innate lymphoid cell activation during immune perturbation
    • Molofsky AB, VanGool F, Liang HE, et al. Interleukin-33 and interferon-gamma counter-regulate group 2 innate lymphoid cell activation during immune perturbation. Immunity 2015; 43:161-174.
    • (2015) Immunity , vol.43 , pp. 161-174
    • Molofsky, A.B.1    VanGool, F.2    Liang, H.E.3
  • 38
    • 84871373164 scopus 로고    scopus 로고
    • IL-25 drives remodelling in allergic airways disease induced by house dust mite
    • Gregory LG, Jones CP, Walker SA, et al. IL-25 drives remodelling in allergic airways disease induced by house dust mite. Thorax 2013; 68:82-90.
    • (2013) Thorax , vol.68 , pp. 82-90
    • Gregory, L.G.1    Jones, C.P.2    Walker, S.A.3
  • 39
    • 84857134135 scopus 로고    scopus 로고
    • IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
    • Lefrancais E, Roga S, Gautier V, et al. IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. Proc Natl Acad Sci U S A 2012; 109:1673-1678.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 1673-1678
    • Lefrancais, E.1    Roga, S.2    Gautier, V.3
  • 40
    • 84908541933 scopus 로고    scopus 로고
    • Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells
    • Lefrancais E, Duval A, Mirey E, et al. Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells. Proc Natl Acad Sci U S A 2014; 111:15502-15507.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 15502-15507
    • Lefrancais, E.1    Duval, A.2    Mirey, E.3
  • 41
    • 84941174746 scopus 로고    scopus 로고
    • Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with T2-driven asthma
    • Homburg U, Renz H, Timmer W, et al. Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with T2-driven asthma. J Allergy Clin Immunol 2015; 136:797-800.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 797-800
    • Homburg, U.1    Renz, H.2    Timmer, W.3
  • 42
    • 84929774279 scopus 로고    scopus 로고
    • Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme
    • Krug N, Hohlfeld JM, Kirsten AM, et al. Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N Engl J Med 2015; 372:1987-1995.
    • (2015) N Engl J Med , vol.372 , pp. 1987-1995
    • Krug, N.1    Hohlfeld, J.M.2    Kirsten, A.M.3
  • 43
    • 64049085018 scopus 로고    scopus 로고
    • Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation
    • Charles N, Watford WT, Ramos HL, et al. Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity 2009; 30:533-543.
    • (2009) Immunity , vol.30 , pp. 533-543
    • Charles, N.1    Watford, W.T.2    Ramos, H.L.3
  • 44
    • 34250217913 scopus 로고    scopus 로고
    • Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3
    • Taghon T, Yui MA, Rothenberg EV. Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3. Nat Immunol 2007; 8:845-855.
    • (2007) Nat Immunol , vol.8 , pp. 845-855
    • Taghon, T.1    Yui, M.A.2    Rothenberg, E.V.3
  • 45
    • 33845946641 scopus 로고    scopus 로고
    • Essential role of GATA transcriptional factors in the activation of mast cells
    • Masuda A, Hashimoto K, Yokoi T, et al. Essential role of GATA transcriptional factors in the activation of mast cells. J Immunol 2007; 178:360-368.
    • (2007) J Immunol , vol.178 , pp. 360-368
    • Masuda, A.1    Hashimoto, K.2    Yokoi, T.3
  • 46
    • 3042795013 scopus 로고    scopus 로고
    • Expression of alpha-tryptase and beta-tryptase by human basophils
    • Jogie-Brahim S, Min HK, Fukuoka Y, et al. Expression of alpha-tryptase and beta-tryptase by human basophils. J Allergy Clin Immunol 2004; 113:1086-1092.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 1086-1092
    • Jogie-Brahim, S.1    Min, H.K.2    Fukuoka, Y.3
  • 47
    • 65549123032 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
    • Himes BE, Hunninghake GM, Baurley JW, et al. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet 2009; 84:581-593.
    • (2009) Am J Hum Genet , vol.84 , pp. 581-593
    • Himes, B.E.1    Hunninghake, G.M.2    Baurley, J.W.3
  • 48
    • 73349143302 scopus 로고    scopus 로고
    • Genome-wide association study identifies five loci associated with lung function
    • Repapi E, Sayers I, Wain LV, et al. Genome-wide association study identifies five loci associated with lung function. Nat Genet 2010; 42:36-44.
    • (2011) Nat Genet , vol.42 , pp. 36-44
    • Repapi, E.1    Sayers, I.2    Wain, L.V.3
  • 49
    • 0033561637 scopus 로고    scopus 로고
    • IL-3 and IL-4 activate cyclic nucleotide phosphodiesterases 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells
    • Ahmad F, Gao G, Wang LM, et al. IL-3 and IL-4 activate cyclic nucleotide phosphodiesterases 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells. J Immunol 1999; 162:4864-4875.
    • (1999) J Immunol , vol.162 , pp. 4864-4875
    • Ahmad, F.1    Gao, G.2    Wang, L.M.3
  • 50
    • 84922309110 scopus 로고    scopus 로고
    • Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma
    • Lee J, Kim TH, Murray F, et al. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proc Natl Acad Sci U S A 2015; 112:1529-1534.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 1529-1534
    • Lee, J.1    Kim, T.H.2    Murray, F.3
  • 51
    • 69149098943 scopus 로고    scopus 로고
    • Roflumilast in moderateto-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: Two randomised clinical trials
    • Fabbri LM, Calverley PMA, Izquierdo-Alonso JL, et al. Roflumilast in moderateto-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials. Lancet 2009; 374:695-703.
    • (2009) Lancet , vol.374 , pp. 695-703
    • Fabbri, L.M.1    Pma, C.2    Izquierdo-Alonso, J.L.3
  • 52
    • 84887115924 scopus 로고    scopus 로고
    • Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: Findings from four clinical trials
    • Franciosi LG, Diamant Z, Banner KH, et al. Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials. Lancet Respir Med 2013; 1:714-727.
    • (2013) Lancet Respir Med , vol.1 , pp. 714-727
    • Franciosi, L.G.1    Diamant, Z.2    Banner, K.H.3
  • 53
    • 84910649015 scopus 로고    scopus 로고
    • Promising future therapies for asthma
    • Stokes JR. Promising future therapies for asthma. Int Immunopharmacol 2014; 23:373-377.
    • (2014) Int Immunopharmacol , vol.23 , pp. 373-377
    • Stokes, J.R.1
  • 54
    • 84900993020 scopus 로고    scopus 로고
    • Emergency treatment of status asthmaticus with enoximone
    • Beute J. Emergency treatment of status asthmaticus with enoximone. Br J Anaesth 2014.
    • (2014) Br J Anaesth
    • Beute, J.1
  • 55
    • 0026557963 scopus 로고
    • Phosphodiesterase inhibition by enoximone in preparations from nonfailing and failing human hearts
    • Bethke T, Eschenhagen T, Klimkiewicz A, et al. Phosphodiesterase inhibition by enoximone in preparations from nonfailing and failing human hearts. Arzneimittelforschung 1992; 42:437-445.
    • (1992) Arzneimittelforschung , vol.42 , pp. 437-445
    • Bethke, T.1    Eschenhagen, T.2    Klimkiewicz, A.3
  • 56
    • 84894049174 scopus 로고    scopus 로고
    • Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases
    • Armani E, Amari G, Rizzi A, et al. Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases. J Med Chem 2014; 57:793-816.
    • (2014) J Med Chem , vol.57 , pp. 793-816
    • Armani, E.1    Amari, G.2    Rizzi, A.3
  • 57
    • 84922041417 scopus 로고    scopus 로고
    • CHF6001 II: A novel phosphodiesterase 4 inhibitor, suitable for topical pulmonary administration-in vivo preclinical pharmacology profile defines a potent anti-inflammatory compound with a wide therapeutic window
    • Villetti G, Carnini C, Battipaglia L, et al. CHF6001 II: a novel phosphodiesterase 4 inhibitor, suitable for topical pulmonary administration-in vivo preclinical pharmacology profile defines a potent anti-inflammatory compound with a wide therapeutic window. J Pharmacol Exp Ther 2015; 352:568-578.
    • (2015) J Pharmacol Exp Ther , vol.352 , pp. 568-578
    • Villetti, G.1    Carnini, C.2    Battipaglia, L.3
  • 58
    • 85016649721 scopus 로고    scopus 로고
    • Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma
    • Yarova PL, Stewart AL, Sathish V, et al. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Sci Transl Med 2015; 7:284ra260.
    • (2015) Sci Transl Med , vol.7 , pp. 284ra260
    • Yarova, P.L.1    Stewart, A.L.2    Sathish, V.3
  • 59
    • 84928379053 scopus 로고    scopus 로고
    • Physiology Calcilytics for asthma relief
    • Penn RB. Physiology. Calcilytics for asthma relief. Science 2015; 348:398-399.
    • (2015) Science , vol.348 , pp. 398-399
    • Penn, R.B.1
  • 60
    • 0031919107 scopus 로고    scopus 로고
    • Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibition of phosphodiesterases 3 and 4
    • Blease K, Burke-Gaffney A, Hellewell PG. Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibition of phosphodiesterases 3 and 4. Br J Pharmacol 1998; 124:229-237.
    • (1998) Br J Pharmacol , vol.124 , pp. 229-237
    • Blease, K.1    Burke-Gaffney, A.2    Hellewell, P.G.3
  • 61
    • 0031723098 scopus 로고    scopus 로고
    • Phosphodiesterase expression in human epithelial cells
    • Wright LC, Seybold J, Robichaud A, et al. Phosphodiesterase expression in human epithelial cells. Am J Physiol 1998; 275:L694-L700.
    • (1998) Am J Physiol , vol.275 , pp. L694-L700
    • Wright, L.C.1    Seybold, J.2    Robichaud, A.3
  • 62
    • 84874356109 scopus 로고    scopus 로고
    • Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway
    • Kobayashi K, Tsubosaka Y, Hori M, et al. Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway. Arterioscler Thromb Vasc Biol 2013; 33:565-571.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 565-571
    • Kobayashi, K.1    Tsubosaka, Y.2    Hori, M.3
  • 63
    • 76649106741 scopus 로고    scopus 로고
    • Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha-And beta-catenins in cyclic AMP-Epac-Rap1 signal-Activated endothelial cells
    • Noda K, Zhang J, Fukuhara S, et al. Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha-And beta-catenins in cyclic AMP-Epac-Rap1 signal-Activated endothelial cells. Mol Biol Cell 2010; 21:584-596.
    • (2011) Mol Biol Cell , vol.21 , pp. 584-596
    • Noda, K.1    Zhang, J.2    Fukuhara, S.3
  • 64
    • 33745939122 scopus 로고    scopus 로고
    • The pharmacology of two novel long-Acting phosphodiesterase 3/4 inhibitors, RPL554 [9, 10-dimethoxy-2(2 4, 6-trimethylphenylimino)-3-(n-carbamoyl-2-Aminoethyl)-3, 4, 6, 7-tetrahydro-2H-pyrimido[6, 1-A]isoquinolin-4-one] and RPL565 [6, 7-dihydro-2-(2, 6-diisopropylphenoxy)-9, 10-dimethoxy-4H-pyrimido[6, 1-A]isoquino lin-4-one]
    • Boswell-Smith V, Spina D, Oxford AW, et al. The pharmacology of two novel long-Acting phosphodiesterase 3/4 inhibitors, RPL554 [9, 10-dimethoxy-2(2, 4, 6-trimethylphenylimino)-3-(n-carbamoyl-2-Aminoethyl)-3, 4, 6, 7-tetrahydro-2H-pyrimido[6, 1-A]isoquinolin-4-one] and RPL565 [6, 7-dihydro-2-(2, 6-diisopropylphenoxy)-9, 10-dimethoxy-4H-pyrimido[6, 1-A]isoquino lin-4-one]. J Pharmacol Exp Ther 2006; 318:840-848.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 840-848
    • Boswell-Smith, V.1    Spina, D.2    Oxford, A.W.3
  • 65
    • 0032567981 scopus 로고    scopus 로고
    • Effects of phosphodiesterase inhibitors and salbutamol on microvascular leakage in Guinea-pig trachea
    • Planquois JM, Mottin G, Artola M, et al. Effects of phosphodiesterase inhibitors and salbutamol on microvascular leakage in guinea-pig trachea. Eur J Pharmacol 1998; 344:59-66.
    • (1998) Eur J Pharmacol , vol.344 , pp. 59-66
    • Planquois, J.M.1    Mottin, G.2    Artola, M.3
  • 66
    • 33846537977 scopus 로고    scopus 로고
    • Nitric oxide decreases cell surface expression of aquaporin-5 and membrane water permeability in lung epithelial cells
    • Nagai K, Watanabe M, Seto M, et al. Nitric oxide decreases cell surface expression of aquaporin-5 and membrane water permeability in lung epithelial cells. Biochem Biophys Res Commun 2007; 354:579-584.
    • (2007) Biochem Biophys Res Commun , vol.354 , pp. 579-584
    • Nagai, K.1    Watanabe, M.2    Seto, M.3
  • 67
    • 13544249981 scopus 로고    scopus 로고
    • CAMP has distinct acute and chronic effects on aquaporin-5 in lung epithelial cells
    • Sidhaye V, Hoffert JD, King LS. cAMP has distinct acute and chronic effects on aquaporin-5 in lung epithelial cells. J Biol Chem 2005; 280:3590-3596.
    • (2005) J Biol Chem , vol.280 , pp. 3590-3596
    • Sidhaye, V.1    Hoffert, J.D.2    King, L.S.3
  • 68
    • 78649381203 scopus 로고    scopus 로고
    • Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kgamma) contributes to ventilator-induced lung injury and edema
    • Fanelli V, Puntorieri V, Assenzio B, et al. Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kgamma) contributes to ventilator-induced lung injury and edema. Intensive Care Med 2010; 36:1935-1945.
    • (2011) Intensive Care Med , vol.36 , pp. 1935-1945
    • Fanelli, V.1    Puntorieri, V.2    Assenzio, B.3
  • 69
    • 84860601367 scopus 로고    scopus 로고
    • Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury
    • Mokra D, Drgova A, Pullmann R Sr, Calkovska A. Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury. Pulm Pharmacol Ther 2012; 25:216-222.
    • (2012) Pulm Pharmacol Ther , vol.25 , pp. 216-222
    • Mokra, D.1    Drgova, A.2    Pullmann, R.3    Calkovska, A.4
  • 70
    • 0029979610 scopus 로고    scopus 로고
    • Hyperpermeability of pulmonary endothelial monolayer: Protective role of phosphodiesterase isoenzymes 3 and 4
    • Suttorp N, Ehreiser P, Hippenstiel S, et al. Hyperpermeability of pulmonary endothelial monolayer: protective role of phosphodiesterase isoenzymes 3 and 4. Lung 1996; 174:181-194.
    • (1996) Lung , vol.174 , pp. 181-194
    • Suttorp, N.1    Ehreiser, P.2    Hippenstiel, S.3
  • 71
    • 0037740001 scopus 로고    scopus 로고
    • Synthesis and structure-Activity relationships of cis-tetrahydrophthalazinone/pyridazinone hybrids: A novel series of potent dual PDE3/PDE4 inhibitory agents
    • Van der Mey M, Bommele KM, Boss H, et al. Synthesis and structure-Activity relationships of cis-tetrahydrophthalazinone/pyridazinone hybrids: a novel series of potent dual PDE3/PDE4 inhibitory agents. J Med Chem 2003; 46:2008-2016.
    • (2003) J Med Chem , vol.46 , pp. 2008-2016
    • Van Der Mey, M.1    Bommele, K.M.2    Boss, H.3
  • 72
    • 84941218378 scopus 로고    scopus 로고
    • Obesity, asthma prevalence and IL-4: Roles of inflammatory cytokines, adiponectin and neuropeptide y
    • Lu Y, Van Bever HP, Lim TK, et al. Obesity, Asthma Prevalence and IL-4: Roles of Inflammatory Cytokines, Adiponectin and Neuropeptide Y. Pediatr Allergy Immunol 2015.
    • (2015) Pediatr Allergy Immunol
    • Lu, Y.1    Van Bever, H.P.2    Lim, T.K.3
  • 73
    • 84939231284 scopus 로고    scopus 로고
    • Effect of bariatric surgery on asthma control, lung function and bronchial and systemic inflammation in morbidly obese subjects with asthma
    • van Huisstede A, Rudolphus A, Castro Cabezas M, et al. Effect of bariatric surgery on asthma control, lung function and bronchial and systemic inflammation in morbidly obese subjects with asthma. Thorax 2015; 70:659-667.
    • (2015) Thorax , vol.70 , pp. 659-667
    • Van Huisstede, A.1    Rudolphus, A.2    Castro Cabezas, M.3
  • 74
    • 84922552062 scopus 로고    scopus 로고
    • Obesity increases airway hyperresponsiveness via the TNF-Alpha pathway and treating obesity induces recovery
    • Kim JY, Sohn JH, Lee JH, Park JW. Obesity increases airway hyperresponsiveness via the TNF-Alpha pathway and treating obesity induces recovery. PLoS One 2015; 10:e0116540.
    • (2015) PLoS One , vol.10 , pp. e0116540
    • Kim, J.Y.1    Sohn, J.H.2    Lee, J.H.3    Park, J.W.4
  • 75
    • 84926671737 scopus 로고    scopus 로고
    • Chitinase 3-like-1 regulates both visceral fat accumulation and asthma-like Th2 inflammation
    • Ahangari F, Sood A, Ma B, et al. Chitinase 3-like-1 regulates both visceral fat accumulation and asthma-like Th2 inflammation. Am J Respir Crit Care Med 2015; 191:746-757.
    • (2015) Am J Respir Crit Care Med , vol.191 , pp. 746-757
    • Ahangari, F.1    Sood, A.2    Ma, B.3
  • 76
    • 84922042474 scopus 로고    scopus 로고
    • Bronchial and systemic inflammation in morbidly obese subjects with asthma: A biopsy study
    • van Huisstede A, Rudolphus A, van Schadewijk A, et al. Bronchial and systemic inflammation in morbidly obese subjects with asthma: a biopsy study. Am J Respir Crit Care Med 2014; 190:951-954.
    • (2014) Am J Respir Crit Care Med , vol.190 , pp. 951-954
    • Van Huisstede, A.1    Rudolphus, A.2    Van Schadewijk, A.3


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