Immunolocalization of Interleukin-4 in Eosinophils in the Bronchial Mucosa of Atopic Asthmatics

American Journal of Respiratory Cell and Molecular Biology

Volumn 14, Issue 5, 1996, Pages 439-443

  Möller, Gertrude M ^a   De Jong, Ton A W ^b   Van Der Kwast, Theo H ^b   Overbeek, Shelley E ^b   Wierenga Wolf, Annet F ^b   Thepen, Theo ^b   Hoogsteden, Henk C ^b  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; INTERLEUKIN 4;

ARTICLE; ASTHMA; BIOPSY; BRONCHUS; CELL GRANULE; COMPARATIVE STUDY; EOSINOPHIL; HUMAN; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; MUCOSA; PATHOLOGY; REFERENCE VALUE; ULTRASTRUCTURE;

ALLERGENS; ASTHMA; BIOPSY; BRONCHI; CYTOPLASMIC GRANULES; EOSINOPHILS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-4; MICROSCOPY, IMMUNOELECTRON; MUCOUS MEMBRANE; REFERENCE VALUES;

EID: 0030136550     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.14.5.8624248     Document Type: Article

References (33)

1. Bousquet, J., P. Chanez, J. Y. Lacoste, G. Barneon, N. Ghavanian, I. Enander, P. Venge, S. Ahlstedt, J. Simony-Lafontaine, P. Godard, and F. B. Michel. 1990. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323:1033-1039.
2. Djukanovic, R., J. W. Wilson, K. M. Britten, S. J. Wilson, A. F. Walls, W. R. Roche, P. H. Howarth, and S. T. Holgate. 1990. Quantification of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. Am. Rev. Respir. Dis. 142:863-871.
3. Djukanovic, R., W. R. Roche, J. W. Wilson, C. R. W. Beasley, O. P. Twentyman, P. H. Howarth, and S. T. Holgate. 1990. Mucosal inflammation in asthma. Am. Rev. Respir. Dis. 142:434-457.
4. Del Prete, G. F., E. Maggi, P. Parrondi, I. Chretien, A. Tiri, D. Macchia, M. Ricci, J. Banchereau, J. E. de Vries, and S. Romagnani. 1988. IL-4 is an essential co-factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J. Immunol. 140:4193-4198.
5. 2-like helper effectors. J. Immunol. 145: 3796-3806.
6. Schleimer, R. P., S. A. Sterbinsky, J. Kaiser, C. A. Bickel, D. A. Klunk, K. Tomioka, W. Newman, F. W. Luscinskas, M. A. Gimbrone, B. W. McIntyre, and B. S. Bochner. 1992. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-I. J. Immunol. 148:1086-1092.
7. Clutterbuck, E. J., E. M. A. Hirst, and C. J. Sanderson. 1989. Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GM-CSF. Blood 73:1504-1513.
8. Wang, J. M., A. Rambaldi, A. Biondi, Z. G. Chen, C. J. Sanderson, and A. Mantovani. 1989. Recombinant interleukin 5 is a selective eosinophil chemoattractant. Eur. J. Immunol. 19:701-705.
9. Lopez, A. F., C. J. Sanderson, J. R. Gamble, H. R. Campbell, I. G. Young, and M. A. Vadas. 1988. Recombinant human interleukin-5 is a selective activator of human eosinophil function. J. Exp. Med. 167: 219-224.
10. Walker, C., E. Bode, L. Boer, T. T. Hansel, K. Blaser, and J. C. Virchow. 1992. Allergic and non allergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 146:109-115.
11. H2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298-304.
12. Wilson, S. J., P. Bradding, C. Heusser, S. T. Holgate, and P. H. Howarth. 1995. The subcellular localisation of interleukin 4 and interleukin 5 in the respiratory mucosa using immunoelectron microscopy. Am. J. Respir. Crit. Care Med. 151:A702. (Abstr.)
13. Bradding, P., J. A. Roberts, K. M. Britten, S. Montefort, R. Djukanovic, R. Mueller, C. H. Heusser, P. H. Howarth, and S. T. Holgate. 1994. Interleukin-4, -5, and -6 and tumor necrosis factor-α in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am. J. Respir. Cell Mol. Biol. 10:471-480.
14. Bradding, P., Y. Okayama, P. H. Howarth, M. K. Church, and S. T. Holgate. 1995. Heterogeneity of human mast cells based on cytokine content. J. Immunol. 155:297-307.
15. Nonaka, M., R. Nonaka, K. Woolley, E. Adelroth, K. Miura, Y. Okhawara, M. Glibetic, K. Nanako, P. O'Byrne, J. Dolovich, and M. Jordana. 1995. Distinct immunohistochemical localization of IL-4 in human inflamed airway tissues. J. Immunol. 155:3234-3244.
16. ATS Task Group. 1987. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am. Rev. Respir. Dis. 136:225-231.
17. Andersson, U., and J. Andersson. 1994. Immunolabeling of cytokine-producing cells in tissues and in suspension. In Cytokine Producing Cells. D. Fralelizie and D. Emilie, editors. Inserm. Paris. 1-16.
18. Bjerke, T., M. Gaustadnes, S. Nielsen, C. M. Rheimert, O. Schiotz, N. Rudiger, E. I. Christensen, R. Dahl, and L. K. Poulsen. 1995. Human blood eosinophils express interleukin 4. J. Allergy Clin. Immunol. 95: A801.
19. Ying, S., S. R. Durham, C. J. Corrigan, Q. Hamid, and A. B. Kay. 1995. Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon τ) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects. Am. J. Respir. Cell Mol. Biol. 12:477-487.
20. Moqbel, R., S. Ying, J. Barkans, T. M. Newman, P. Kimmitt, M. Wakelin, C. J. Corrigan, S. R. Durham, and A. B. Kay. 1995. Human eosinophils synthesise interleukin-4 (IL-4). The Immunologist 3:A224. (Abstr.)
21. Gleich, G. J., and C. R. Adolphson. 1986. The eosinophil leukocyte: structure and function. Adv. Immunol. 39:177-253.
22. Egesten, A., J. Alumets, C. von Mecklenburg, M. Palmegren, and I. Olsson. 1986. Localization of eosinophil cationic protein, major basic protein, and eosinophil peroxidase by immuno electron microscopic technique. J. Histochem. Cytochem. 11:1399-1403.
23. Peters, M. S., M. Rodriguez, and G. J. Gleich. 1986. Localization of human eosinophil granule major basic protein, eosinophil cationic protein, and eosinophil-derived neurotoxin by immunoelectron microscopy. Lab. Invest. 54:656-662.
24. Del Pozo, V., B. De Andres, E. Martin, N. Maruri, J. M. Zubeldia, P. Palomino, and C. Lahoz. 1990. Murine eosinophils and IL-1: αIL-1 mRNA detection by in situ hybridization. Production and release of IL-1 from peritoneal eosinophils. J. Immunol. 144:3117-3122.
25. Kita, H., T. Ohnishi, Y. Okubo, D. Weiler, J. S. Abrams, and G. J. Gleich. 1991. Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils. J. Exp. Med. 174:745-748.
26. Desreumaux, P., A. Janin, J. F. Colombel, L. Prin, J. Plumas, D. Emilie, G. Torpier, A. Capron, and M. Capron. 1992. Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease. J. Exp. Med. 175:293-296.
27. Hamid, Q., J. Barkans, Q. Meng, S. Ying, J. S. Abrams, A. B. Kay, and R. Moqbel. 1992. Human eosinophils synthesize and secrete interleukin 6 in vitro. Blood 80:1496-1501.
28. Braun, R. K., M. Franchini, F. Erard, S. Rihs, I. J. De Vries, K. Blaser, T. T. Hansel, and C. Walker. 1993. Human peripheral blood eosinophils produce and release interleukin-8 on stimulation with calcium ionophore. Eur J. Immunol. 23:956-960.
29. Moqbel, R., Q. Hamid, S. Ying, J. Barkans, A. Hartnell, A. Tsicopoulos, A. J. Wardlaw, and A. B. Kay. 1991. Expression of mRNA and immunoreactivity for the granulocyte/macrophage colony-stimulating factor in activated human eosinophils. J. Exp. Med. 174:749-752.
30. Beil, W. J., P. F. Weller, D. M. Tzizik, S. J. Galli, and A. M. Dvorak. 1993. Ultrastructural immunogold localization of tumor necrosis factor-α to the matrix compartment of eosinophil secondary granules in patients with idiopathic hypereosinophilic syndrome. J. Histochem. Cytochem. 41:1611-1615.
31. Costa, J. J., K. Matossian, M. B. Resnick, W. J. Beil, D. T. W. Wong, J. R. Gordon, A. M. Dvorak, P. F. Weiler, and S. J. Galli. 1993. Human eosinophils can express the cytokines tumor necrosis factor-α and macrophage inflammatory protein-1α. J. Clin. Invest. 91:2673-2684.
32. Wong, D. T. W., P. F. Weller, S. J. Galli, A. Elovic, T. H. Rand, G. T. Gallagher, T. Chiang, M. Y. Chou, K. Motossian, J. McBride, and R. Todd. 1990. Human eosinophils express transforming growth factor-α. J. Exp Med. 172:673-681.
33. Ohno, I., R. G. Lea, K. C. Flanders, D. A. Clark, D. Banwatt, J. Dolovich, J. Denburg, C. B. Harley, I. Gauldie, and M. Jordana. 1992. Eosinophils in chronically inflamed human upper airway tissues express transforming growth factor β1 gene (TGF β1). J. Clin. Invest. 89:1662-1668.