Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

Science Translational Medicine

Volumn 7, Issue 284, 2015, Pages 284ra58-

  Yarova, Polina L ^a   Stewart, Alecia L ^b   Sathish, Venkatachalem ^b   Britt, Rodney D ^b   Thompson, Michael A ^b   Lowe, Alexander P P ^c   Freeman, Michelle ^b   Aravamudan, Bharathi ^b   Kita, Hirohito ^b   Brennan, Sarah C ^a   Schepelmann, Martin ^a   Davies, Thomas ^a   Yung, Sun ^a   Cholisoh, Zakky ^c   Kidd, Emma J ^c   Ford, William R ^c   Broadley, Kenneth J ^c   Rietdorf, Katja ^d   Chang, Wenhan ^e   Bin Khayat, Mohd E ^f   Ward, Donald T ^f   Corrigan, Christopher J ^g   Ward, Jeremy P T ^g   Kemp, Paul J ^a   Pabelick, Christina M ^b   Prakash, Y S ^b   Riccardi, Daniela ^a   more..

^a CARDIFF UNIVERSITY   (United Kingdom)

^b MAYO CLINIC   (United States)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d OPEN UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIASTHMATIC AGENT; CALCILYTIC; CALCIUM ION; CALCIUM SENSING RECEPTOR; CALHEX 231; CYCLIC AMP; MITOGEN ACTIVATED PROTEIN KINASE P38; NPS 2143; NPS 89636; POLYCATION; UNCLASSIFIED DRUG; ALLERGEN; CATION;

AIRWAY SMOOTH MUSCLE CELL; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHOCONSTRICTION; CALCIUM MOBILIZATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; ANIMAL; ANTAGONISTS AND INHIBITORS; ASTHMA; BAGG ALBINO MOUSE; BIOPSY; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHUS; BRONCHUS HYPERREACTIVITY; CHEMISTRY; HEK293 CELL LINE; HOMEOSTASIS; HYPERSENSITIVITY; INFLAMMATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION;

ALLERGENS; ANIMALS; ASTHMA; BIOPSY; BRONCHI; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTION; CATIONS; HEK293 CELLS; HOMEOSTASIS; HUMANS; HYPERSENSITIVITY; INFLAMMATION; MALE; MICE; MICE, INBRED BALB C; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RECEPTORS, CALCIUM-SENSING;

EID: 85016649721     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aaa0282     Document Type: Article

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