Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 2, 2015, Pages 312-322.e7

  Castanhinha, Susana ^a   Sherburn, Rebekah ^b   Walker, Simone ^b   Gupta, Atul ^c   Bossley, Cara J ^c   Buckley, James ^b   Ullmann, Nicola ^a   Grychtol, Ruth ^b   Campbell, Gaynor ^b   Maglione, Marco ^a   Koo, Sergio ^a   Fleming, Louise ^a,b   Gregory, Lisa ^b   Snelgrove, Robert J ^b   Bush, Andrew ^a,b   Lloyd, Clare M ^b   Saglani, Sejal ^a,b  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

fungal sensitization; IL 33; innate immunity; pediatric; Severe asthma; steroid resistance

Indexed keywords

BUDESONIDE; GELATINASE B; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 33; ANTIASTHMATIC AGENT; ANTIIDIOTYPIC ANTIBODY; IL1RL1 PROTEIN, MOUSE; IL33 PROTEIN, HUMAN; IL33 PROTEIN, MOUSE; INTERLEUKIN DERIVATIVE; INTERLEUKIN RECEPTOR; MONOCLONAL ANTIBODY; OMALIZUMAB;

ALTERNARIA ALTERNATA; ANIMAL EXPERIMENT; ARTICLE; ASPERGILLUS FUMIGATUS; ASTHMA; CHILD; CLADOSPORIUM HERBARUM; CLINICAL ASSESSMENT; CLINICAL FEATURE; DERMATOPHAGOIDES; FEMALE; HUMAN; IMMUNOPATHOLOGY; LONG TERM EXPOSURE; LUNG LAVAGE; LUNG PARENCHYMA; LYMPHOID CELL; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; ONSET AGE; PRICK TEST; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; SEVERE ASTHMA WITH FUNGAL SENSITIZATION; STEROID THERAPY; ADOLESCENT; ALTERNARIA; ANIMAL; CHEMISTRY; CLADOSPORIUM; CLINICAL TRIAL; COMPLICATION; DEFICIENCY; DISEASE MODEL; GENETICS; IMMUNOLOGY; MYCOSES; NEWBORN; PATHOLOGY; PYROGLYPHIDAE; SEVERITY OF ILLNESS INDEX; SKIN TEST; TH2 CELL;

ADOLESCENT; ALTERNARIA; ANIMALS; ANIMALS, NEWBORN; ANTI-ASTHMATIC AGENTS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL, HUMANIZED; ASPERGILLUS FUMIGATUS; ASTHMA; BUDESONIDE; CHILD; CLADOSPORIUM; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-13; INTERLEUKIN-33; INTERLEUKINS; MALE; MICE; MYCOSES; OMALIZUMAB; PYROGLYPHIDAE; RECEPTORS, INTERLEUKIN; SEVERITY OF ILLNESS INDEX; SKIN TESTS; TH2 CELLS;

EID: 84937869139     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.01.016     Document Type: Article

References (36)

1. C.J. Bossley, L. Fleming, A. Gupta, N. Regamey, J. Frith, T. Oates, and et al. Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines J Allergy Clin Immunol 129 2012 974 982
2. M. Zureik, C. Neukirch, B. Leynaert, R. Liard, J. Bousquet, and F. Neukirch Sensitisation to airborne moulds and severity of asthma: cross sectional study from European Community respiratory health survey BMJ 325 2002 411 414
3. J.F. Gent, J.M. Kezik, M.E. Hill, E. Tsai, D.W. Li, and B.P. Leaderer Household mold and dust allergens: exposure, sensitization and childhood asthma morbidity Environ Res 118 2012 86 93
4. A.G. Vicencio, M.T. Santiago, K. Tsirilakis, A. Stone, S. Worgall, E.A. Foley, and et al. Fungal sensitization in childhood persistent asthma is associated with disease severity Pediatr Pulmonol 49 2014 8 14
5. J. Blatter, E. Forno, J. Brehm, E. Acosta-Perez, M. Alvarez, A. Colon-Semidey, and et al. Fungal exposure, atopy, and asthma exacerbations in Puerto Rican children Ann Am Thorac Soc 11 2014 925 932
6. P.V. Targonski, V.W. Persky, and V. Ramekrishnan Effect of environmental molds on risk of death from asthma during the pollen season J Allergy Clin Immunol 95 1995 955 961
7. M.T. O'Hollaren, J.W. Yunginger, K.P. Offord, M.J. Somers, E.J. O'Connell, D.J. Ballard, and et al. Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma N Engl J Med 324 1991 359 363
8. D.W. Denning, B.R. O'Driscoll, C.M. Hogaboam, P. Bowyer, and R.M. Niven The link between fungi and severe asthma: a summary of the evidence Eur Respir J 27 2006 615 626
9. R. Agarwal Severe asthma with fungal sensitization Curr Allergy Asthma Rep 11 2011 403 413
10. P.N. Black, A.A. Udy, and S.M. Brodie Sensitivity to fungal allergens is a risk factor for life-threatening asthma Allergy 55 2000 501 504
11. D.W. Denning, C. Pashley, D. Hartl, A. Wardlaw, C. Godet, S. Del Giacco, and et al. Fungal allergy in asthma-state of the art and research needs Clin Transl Allergy 4 2014 14
12. A.G. Vicencio, H. Muzumdar, K. Tsirilakis, A. Kessel, K. Nandalike, and D.L. Goldman Severe asthma with fungal sensitization in a child: response to itraconazole therapy Pediatrics 125 2010 e1255 e1258
13. L. Chishimba, R.M. Niven, J. Cooley, and D.W. Denning Voriconazole and posaconazole improve asthma severity in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization J Asthma 49 2012 423 433
14. D.W. Denning, B.R. O'Driscoll, G. Powell, F. Chew, G.T. Atherton, A. Vyas, and et al. Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study Am J Respir Crit Care Med 179 2009 11 18
15. J. Agbetile, M. Bourne, A. Fairs, B. Hargadon, D. Desai, C. Broad, and et al. Effectiveness of voriconazole in the treatment of Aspergillus fumigatus-associated asthma (EVITA3 study) J Allergy Clin Immunol 134 2014 33 39
16. R.J. Snelgrove, L.G. Gregory, T. Peiro, S. Akthar, G.A. Campbell, S.A. Walker, and et al. Alternaria-derived serine protease activity drives IL-33 mediated asthma exacerbations J Allergy Clin Immunol 134 2014 583 592.e6
17. M. Bracken, L. Fleming, P. Hall, N. Van Stiphout, C. Bossley, E. Biggart, and et al. The importance of nurse-led home visits in the assessment of children with problematic asthma Arch Dis Child 94 2009 780 784
18. R.A. Nathan, C.A. Sorkness, M. Kosinski, M. Schatz, J.T. Li, P. Marcus, and et al. Development of the asthma control test: a survey for assessing asthma control J Allergy Clin Immunol 113 2004 59 65
19. Standardization of spirometry, 1994 update. American Thoracic Society Am J Respir Crit Care Med 152 1995 1107 1136
20. S. Marinho, A. Simpson, L. Soderstrom, A. Woodcock, S. Ahlstedt, and A. Custovic Quantification of atopy and the probability of rhinitis in preschool children: a population-based birth cohort study Allergy 62 2007 1379 1386
21. S. Saglani, S. Lui, N. Ullmann, G.A. Campbell, R.T. Sherburn, S.A. Mathie, and et al. IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma J Allergy Clin Immunol 132 2013 676 685
22. S. Saglani, S.A. Mathie, L.G. Gregory, M.J. Bell, A. Bush, and C.M. Lloyd Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice Am J Respir Cell Mol Biol 41 2009 281 289
23. J.L. Barlow, A. Bellosi, C.S. Hardman, L.F. Drynan, S.H. Wong, J.P. Cruickshank, and et al. Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity J Allergy Clin Immunol 129 2012 191 198
24. B.R. O'Driscoll, L.C. Hopkinson, and D.W. Denning Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions BMC Pulm Med 5 2005 4
25. K.R. Bartemes, K. Iijima, T. Kobayashi, G.M. Kephart, A.N. McKenzie, and H. Kita IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs J Immunol 188 2012 1503 1513
26. T.A. Doherty, N. Khorram, S. Lund, A.K. Mehta, M. Croft, and D.H. Broide Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production J Allergy Clin Immunol 132 2013 205 213
27. H.K. Kim, S. Lund, R. Baum, P. Rosenthal, N. Khorram, and T.A. Doherty Innate type 2 response to Alternaria extract enhances ryegrass-induced lung inflammation Int Arch Allergy Immunol 163 2014 92 105
28. A. Flaczyk, C.U. Duerr, M. Shourian, E.I. Lafferty, J.H. Fritz, and S.T. Qureshi IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans J Immunol 191 2013 2503 2513
29. H.T. Le, V.G. Tran, W. Kim, J. Kim, H.R. Cho, and B. Kwon IL-33 priming regulates multiple steps of the neutrophil-mediated anti-Candida albicans response by modulating TLR and dectin-1 signals J Immunol 189 2012 287 295
30. M.C. Blondin, H. Beauregard, and O. Serri Iatrogenic Cushing syndrome in patients receiving inhaled budesonide and itraconazole or ritonavir: two cases and literature review Endocr Pract 19 2013 e138 e141
31. H. Matsuse, C. Fukushima, S. Fukahori, T. Tsuchida, T. Kawano, T. Nishino, and et al. Differential effects of dexamethasone and itraconazole on Aspergillus fumigatus-exacerbated allergic airway inflammation in a murine model of mite-sensitized asthma Respiration 85 2013 429 435
32. D.N. Payne, A.V. Rogers, E. Adelroth, V. Bandi, K.K. Guntupalli, A. Bush, and et al. Early thickening of the reticular basement membrane in children with difficult asthma Am J Respir Crit Care Med 167 2003 78 82
33. W. Mattos, S. Lim, R. Russell, A. Jatakanon, K.F. Chung, and P.J. Barnes Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids Chest 122 2002 1543 1552
34. D.H. Broide Immunologic and inflammatory mechanisms that drive asthma progression to remodeling J Allergy Clin Immunol 121 2008 560 570
35. D. Desai, S. Gupta, S. Siddiqui, A. Singapuri, W. Monteiro, J. Entwisle, and et al. Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma Respir Res 14 2013 17
36. A.P. Knutsen, R.K. Bush, J.G. Demain, D.W. Denning, A. Dixit, A. Fairs, and et al. Fungi and allergic lower respiratory tract diseases J Allergy Clin Immunol 129 2012 280 291