Biological clustering supports both "dutch" and "british" hypotheses of asthma and chronic obstructive pulmonary disease

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 1, 2015, Pages 63-72.e10

  Ghebre, Michael A ^a,b   Bafadhel, Mona ^c   Desai, Dhananjay ^a   Cohen, Suzanne E ^d   Newbold, Paul ^d   Rapley, Laura ^d   Woods, Jo ^d   Rugman, Paul ^d   Pavord, Ian D ^c   Newby, Chris ^a,b   Burton, Paul R ^b,e   May, Richard D ^d   Brightling, Chris E ^a  

^a UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d MEDIMMUNE   (United States)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Asthma and COPD overlap; cytokines; factor and cluster analyses

Indexed keywords

CXCL11 CHEMOKINE; EOTAXIN 3; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

ADULT; AGE; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; BACTERIAL COLONIZATION; BODY MASS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL FEATURE; COHORT ANALYSIS; DISEASE SEVERITY; EOSINOPHIL COUNT; EOSINOPHILIA; FEMALE; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEUTROPHIL COUNT; NEUTROPHILIA; PATHOGENESIS; PROTEIN EXPRESSION; RESPIRATORY TRACT DISEASE; SMOKING; SPUTUM ANALYSIS; VALIDATION STUDY; AGED; CLUSTER ANALYSIS; CYTOLOGY; FORCED EXPIRATORY VOLUME; IMMUNOLOGY; LEUKOCYTE COUNT; PATHOPHYSIOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SPUTUM; UNITED KINGDOM;

AGED; ASTHMA; CLUSTER ANALYSIS; CYTOKINES; FEMALE; FORCED EXPIRATORY VOLUME; GREAT BRITAIN; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SPUTUM;

EID: 84920593779     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.06.035     Document Type: Article

References (43)

1. Global Initiative for Asthma Guidelines. Available at: www.ginasthma.org/Guidelines/guidelines-resources.html. Accessed January 22, 2014.
2. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD). Available at: www.goldcopd.org. Accessed January 22, 2014.
3. P.J. Barnes The cytokine network in asthma and chronic obstructive pulmonary disease J Clin Investig 118 2008 3546 3556
4. P.J. Barnes Mechanisms in COPD: differences from asthma Chest 117 2000 10S 14S
5. P. Haldar, I.D. Pavord, D.E. Shaw, M.A. Berry, M. Thomas, and C.E. Brightling Cluster analysis and clinical asthma phenotypes Am J Respir Crit Care Med 178 2008 218 224
6. W.C. Moore, D.A. Meyers, S.E. Wenzel, W.G. Teague, H.S. Li, and X.N. Li Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program Am J Respir Crit Care Med 181 2010 315 323
7. C.E. Brightling, S. Gupta, S. Gonem, and S. Siddiqui Lung damage and airway remodelling in severe asthma Clin Exp Allergy 42 2012 638 649
8. P.R. Burgel, J.L. Paillasseur, D. Caillaud, I. Tillie-Leblond, P. Chanez, and R. Escamilla Clinical COPD phenotypes: a novel approach using principal component and cluster analyses Eur Respir J 36 2010 531 539
9. J. Garcia-Aymerich, F.P. Gomez, M. Benet, E. Farrero, X. Basagana, and A. Gayete Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes Thorax 66 2011 430 437
10. M. Weatherall, J. Travers, P.M. Shirtcliffe, S.E. Marsh, M.V. Williams, and M.R. Nowitz Distinct clinical phenotypes of airways disease defined by cluster analysis Eur Respir J 34 2009 812 818
11. B.L. Barker, and C.E. Brightling Phenotyping the heterogeneity of chronic obstructive pulmonary disease Clin Sci 124 2013 371 387
12. P.G. Gibson, and J.L. Simpson The overlap syndrome of asthma and COPD: what are its features and how important is it? Thorax 64 2009 728 735
13. L.E. Vanfleteren, J.W. Kocks, I.S. Stone, R. Breyer-Kohansal, T. Greulich, and D. Lacedonia Moving from the Oslerian paradigm to the post-genomic era: are asthma and COPD outdated terms? Thorax 69 2014 72 79
14. H. Iwamoto, J. Gao, J. Kosela, V. Kinnula, H. Kobayashi, and T. Laitinen Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap Eur Respir J 43 2014 421 429
15. P.J. Barnes Against the Dutch hypothesis: asthma and chronic obstructive pulmonary disease are distinct diseases Am J Respir Crit Care Med 174 2006 240 243
16. M. Bafadhel, M. McCormick, S. Saha, S. McKenna, M. Shelley, and B. Hargadon Profiling of sputum inflammatory mediators in asthma and chronic obstructive pulmonary disease Respiration 83 2012 36 44
17. D. Desai, and C. Brightling Cytokines and cytokine-specific therapy in asthma Adv Clin Chem 57 2012 57 97
18. P. Haldar, C.E. Brightling, B. Hargadon, S. Gupta, W. Monteiro, and A. Sousa Mepolizumab and exacerbations of refractory eosinophilic asthma New Engl J Med 360 2009 973 984
19. I.D. Pavord, S. Korn, P. Howarth, E.R. Bleecker, R. Buhl, and O.N. Keene Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial Lancet 380 2012 651 659
20. M. Bafadhel, S. McKenna, S. Terry, V. Mistry, C. Reid, and P. Haldar Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers Am J Respir Crit Care Med 184 2011 662 671
21. M. Bafadhel, S. McKenna, S. Terry, V. Mistry, M. Pancholi, and P. Venge Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial Am J Respir Crit Care Med 186 2012 48 55
22. D. Desai, C. Newby, F.A. Symon, P. Haldar, S. Shah, and S. Gupta Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma Am J Respir Crit Care Med 188 2013 657 663
23. R.H. Green, C.E. Brightling, S. McKenna, B. Hargadon, D. Parker, and P. Bradding Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial Lancet 360 2002 1715 1721
24. I.D. Pavord, C.E. Brightling, G. Woltmann, and A.J. Wardlaw Non-eosinophilic corticosteroid unresponsive asthma Lancet 353 1999 2213 2214
25. J.L. Simpson, R. Scott, M.J. Boyle, and P.G. Gibson Inflammatory subtypes in asthma: assessment and identification using induced sputum Respirology 11 2006 54 61
26. A.R. Brasier, S. Victor, G. Boetticher, H. Ju, C. Lee, and E.R. Bleecker Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines J Allergy Clin Immunol 121 2008 30 37
27. J. Corren, R.F. Lemanske Jr., N.A. Hanania, P.E. Korenblat, M.V. Parsey, and J.R. Arron Lebrikizumab treatment in adults with asthma New Engl J Med 365 2011 1088 1098
28. E. Piper, C. Brightling, R. Niven, C. Oh, R. Faggioni, and K. Poon A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma Eur Respir J 41 2013 330 338
29. C.E. Brightling, W. Monteiro, R. Ward, D. Parker, M.D.L. Morgan, and A.J. Wardlaw Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial Lancet 356 2000 1480 1485
30. C.E. Brightling, S. McKenna, B. Hargadon, S. Birring, R. Green, and R. Siva Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease Thorax 60 2005 193 198
31. R.K. Albert, J. Connett, W.C. Bailey, R. Casaburi, J.A.D. Cooper Jr., and G.J. Criner Azithromycin for prevention of exacerbations of COPD New Engl J Med 365 2011 689 698
32. G.G. Brusselle, C. VanderStichele, P. Jordens, R. Deman, H. Slabbynck, and V. Ringoet Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial Thorax 68 2013 322 329
33. P. Nair, M. Gaga, E. Zervas, K. Alagha, F.E. Hargreave, and P.M. O'Byrne Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial Clin Exp Allergy 42 2012 1097 1103
34. S.E. Wenzel, P.J. Barnes, E.R. Bleecker, J. Bousquet, W. Busse, and S.E. Dahlen A Randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma Am J Respir Crit Care Med 179 2009 549 558
35. C. Brightling, M. Berry, and Y. Amrani Targeting TNF-alpha: a novel therapeutic approach for asthma J Allergy Clin Immunol 121 2008 5 10
36. M. Frankenberger, C. Eder, T.P.J. Hofer, I. Heimbeck, K. Skokann, and G. Kassner Chemokine expression by small sputum macrophages in COPD Mol Med 17 2011 762 770
37. K.J. Baines, J.L. Simpson, L.G. Wood, R.J. Scott, N.L. Fibbens, and H. Powell Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes J Allergy Clin Immunol 133 2014 997 1007
38. H.F. Kaiser The application of electronic computers to factor analysis Educ Psychol Meas 20 1960 141
39. P. Hinton, C. Brownlow, and I. McMurray SPSS explained 2nd revised ed. 2004 Routledge Oxford
40. L.L. Harlow The essence of multivariate thinking: basic themes and methods (Multivariate Applications Series) Har/Cdr ed. 2005 Psychology Press Oxford
41. G.R. Funkhouser A note on the reliability of certain clustering algorithms J Marketing Res 20 1983 99 100
42. J. Claude Morphometrics with R 2008 Springer New York
43. Therneau TM, Atkinson EJ. An introduction to recursive partitioning using the RPART routines. Rochester, MN: Mayo Foundation; 2011.