Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

EMBO Journal

Volumn 34, Issue 14, 2015, Pages 1875-1888

  Gutiérrez Fernández, Ana ^a   Soria Valles, Clara ^a   Osorio, Fernando G ^a   Gutiérrez Abril, Jesús ^a   Garabaya, Cecilia ^a   Aguirre, Alina ^a   Fueyo, Antonio ^a   Fernández García, María Soledad ^b   Puente, Xose S ^a   Lõpez Otín, Carlos ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

Author keywords

aging; extracellular matrix; metalloprotease; nuclear lamina; retinoids

Indexed keywords

BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MATRIX METALLOPROTEINASE 14; PROTEINASE; RETINOIC ACID; GLUCOSE BLOOD LEVEL; MMP14 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRESS; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GROWTH HORMONE SECRETING CELL; HUMAN; HUMAN CELL; LIFESPAN; MOUSE; NONHUMAN; NUCLEAR LAMINA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SENESCENCE; SIGNAL TRANSDUCTION; UPREGULATION; ADIPOSE TISSUE; ANALYSIS; ANIMAL; C57BL MOUSE; CELL AGING; CELL NUCLEUS MEMBRANE; DRUG EFFECTS; GENETICS; GLUCOSE BLOOD LEVEL; HEART MUSCLE CELL; HEK293 CELL LINE; HYPOGLYCEMIA; KNOCKOUT MOUSE; LONGEVITY; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; CELL AGING; EXTRACELLULAR MATRIX; HEK293 CELLS; HUMANS; HYPOGLYCEMIA; LONGEVITY; MATRIX METALLOPROTEINASE 14; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCYTES, CARDIAC; NUCLEAR ENVELOPE; TRETINOIN;

EID: 84948573147     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201490594     Document Type: Article

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