Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 47, 2015, Pages E6496-E6505

  Ling, Shaoping ^a   Hu, Zheng ^a   Yang, Zuyu ^a   Yang, Fang ^a   Li, Yawei ^a   Lin, Pei ^b   Chen, Ke ^a   Dong, Lili ^a   Cao, Lihua ^a   Tao, Yong ^a   Hao, Lingtong ^a   Chen, Qingjian ^b   Gong, Qiang ^a   Wu, Dafei ^a   Li, Wenjie ^a   Zhao, Wenming ^a   Tian, Xiuyun ^c   Hao, Chunyi ^c   Hungate, Eric A ^d   Catenacci, Daniel V T ^d   Hudson, Richard R ^d   Li, Wen Hsiung ^e   Lu, Xuemei ^a   Wu, Chung I ^a,b,d   more..

^a Chinese Academy of Sciences   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c PEKING UNIVERSITY   (China)

^d UNIVERSITY OF CHICAGO   (United States)

^e BIODIVERSITY RESEARCH CENTER   (Taiwan)

Author keywords

Cancer evolution; Genetic diversity; Intratumor heterogeneity; Natural selection; Neutral evolution

Indexed keywords

AGED; CELL CLONE; CONFERENCE PAPER; DNA SEQUENCE; EXOME; GENE FREQUENCY; GENEALOGY; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; MALE; MOLECULAR EVOLUTION; MUTATION RATE; POPULATION GENETICS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; BIOLOGICAL MODEL; CELL COUNT; COMPUTER SIMULATION; EVOLUTION; GENE LIBRARY; GENETIC SELECTION; GENETIC VARIATION; GENETICS; MICRODISSECTION; MOLECULAR GENETICS; MUTATION; NEOPLASM; NUCLEOTIDE SEQUENCE; PATHOLOGY; REPRODUCIBILITY; TUMOR CELL LINE; TUMOR GENE;

AGED; BASE SEQUENCE; BIOLOGICAL EVOLUTION; CELL COUNT; CELL LINE, TUMOR; CLONE CELLS; COMPUTER SIMULATION; GENE LIBRARY; GENES, NEOPLASM; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; MICRODISSECTION; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; MUTATION RATE; NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS; SELECTION, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 84948428646     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1519556112     Document Type: Article

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