Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents

Mediators of Inflammation

Volumn 2015, Issue , 2015, Pages

  Quiñones, Mar ^a,b   Folgueira, Cintia ^a,b,c   Sánchez Rebordelo, Estrella ^a,b   Al Massadi, Omar ^a,b  

^a Universidade de Santiago de Compostela and Instituto de Investigación Sanitaria de Santiago de Compostela   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; IRISIN; LEPTIN; FIBRONECTIN; FNDC5 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CONTROLLED STUDY; CORRELATIONAL STUDY; DIET INDUCED OBESITY; ENERGY BALANCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FOOD INTAKE; HOMEOSTASIS; LEPTIN DEFICIENCY; MALE; MOUSE; NONHUMAN; NUTRITIONAL STATUS; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; ANIMAL; BLOOD; OBESITY; SPRAGUE DAWLEY RAT;

ANIMALS; BODY COMPOSITION; FIBRONECTINS; LEPTIN; MALE; NUTRITIONAL STATUS; OBESITY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84947976509     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2015/620919     Document Type: Article

References (47)

1. G. S. Hotamisligil, "Inflammation and endoplasmic reticulum stress in obesity and diabetes," International Journal of Obesity, vol. 32, supplement 7, pp. S52-S54, 2008.
2. J. A. Timmons, K. Baar, P. K. Davidsen, and P. J. Atherton, "Is irisin a human exercise gene?" Nature, vol. 488, no. 7413, pp. E9-E11, 2012.
3. B. K. Pedersen and M. A. Febbraio, "Muscle as an endocrine organ: focus on muscle-derived interleukin-6," Physiological Reviews, vol. 88, no. 4, pp. 1379-1406, 2008.
4. P. Keller, N.B. J. Vollaard, T. Gustafsson et al., "A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype," Journal of Applied Physiology, vol. 110, no. 1, pp. 46-59, 2011.
5. K. Baar, A. R. Wende, T. E. Jones et al., "Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1," The FASEB Journal, vol. 16, no. 14, pp. 1879-1886, 2002.
6. J. Lin, H. Wu, P. T. Tarr et al., "Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres," Nature, vol. 418, no. 6899, pp. 797-801, 2002.
7. P. Puigserver, Z. Wu, C.W. Park, R. Graves, M. Wright, andB.M. Spiegelman, "A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis," Cell, vol. 92, no. 6, pp. 829-839, 1998.
8. P. Boström, J. Wu, M. P. Jedrychowski et al., "A PGC1-alphadependent myokine that drives brown-fat-like development of white fat and thermogenesis," Nature, vol. 481, no. 7382, pp. 463-468, 2012.
9. A. Teufel, N. Malik, M. Mukhopadhyay, andH. Westphal, "Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes," Gene, vol. 297, no. 1-2, pp. 79-83, 2002.
10. A. Ferrer-Martínez, P. Ruiz-Lozano, and K. R. Chien, "Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development," Developmental Dynamics, vol. 224, no. 2, pp. 154-167, 2002.
11. P. Lee, J. D. Linderman, S. Smith et al., "Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans," Cell Metabolism, vol. 19, no. 2, pp. 302-309, 2014.
12. Y. Zhang, R. Li, Y. Meng et al., "Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERKMAP kinase signaling," Diabetes, vol. 63, no. 2, pp. 514-525, 2014.
13. S. Raschke, M. Elsen, H. Gassenhuber et al., "Evidence against a beneficial effect of irisin in humans," PloS ONE, vol. 8, no. 9, Article ID e73680, 2013.
14. T. Hofmann, U. Elbelt, A. Ahnis, P. Kobelt, M. Rose, andA. Stengel, "Irisin levels are not affected by physical activity in patients with anorexia nervosa," Frontiers in Endocrinology, vol. 4, article 202, 2014.
15. A. Hecksteden, M. Wegmann, A. Steffen et al., "Irisin and exercise training in humans - results from a randomized controlled training trial," BMC Medicine, vol. 11, article 235, 2013.
16. M. G. Novelle, C. Contreras, A. Romero-Picó, M. López, and C. Diéguez, "Irisin, two years later," International Journal of Endocrinology, vol. 2013, Article ID 746281, 8 pages, 2013.
17. S. Pekkala, P. K. Wiklund, J. J. Hulmi et al., "Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?" Journal of Physiology, vol. 591, no. 21, pp. 5393-5400, 2013.
18. C. D. Wrann, J. P. White, J. Salogiannnis et al., "Exercise induces hippocampal BDNF through a PGC-1alpha/FNDC5 pathway," Cell Metabolism, vol. 18, no. 5, pp. 649-659, 2013.
19. A. Stengel, T. Hofmann, M. Goebel-Stengel, U. Elbelt, P. Kobelt, and B. F. Klapp, "Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity - correlation with bodymass index," Peptides, vol. 39, no. 1, pp. 125-130, 2013.
20. A. B. Crujeiras, M. Pardo, A. Roca-Rivada et al., "Longitudinal variation of circulating irisin after an energy restrictioninduced weight loss and following weight regain in obese men and women," American Journal of Human Biology, vol. 26, no. 2, pp. 198-207, 2014.
21. J. M. Moreno-Navarrete, F. Ortega, M. Serrano et al., "Irisin is expressed and produced by humanmuscle and adipose tissue in association with obesity and insulin resistance," The Journal of Clinical Endocrinology andMetabolism, vol. 98, no. 4, pp.E769- E778, 2013.
22. F. Sanchis-Gomar, R. Alis, H. Pareja-Galeano et al., "Circulating irisin levels are not correlated with BMI, age, and other biological parameters in obese and diabetic patients," Endocrine, vol. 46, no. 3, pp. 674-677, 2014.
23. J. Y. Huh, G. Panagiotou, V. Mougios et al., "FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise," Metabolism: Clinical and Experimental, vol. 61, no. 12, pp. 1725-1738, 2012.
24. P. Lopez-Legarrea, R. de la Iglesia, A. B. Crujeiras et al., "Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects," Nutrition & Diabetes, vol. 4, no. 2, article e110, 2014.
25. M. D. Roberts, D. S. Bayless, J. M. Company et al., "Elevated skeletalmuscle irisin precursor FNDC5mRNAin obeseOLETF rats," Metabolism: Clinical and Experimental, vol. 62, no. 8, pp. 1052-1056, 2013.
26. A. Roca-Rivada, C. Castelao, L. L. Senin et al., "FNDC5/irisin is not only a myokine but also an adipokine," PLoS ONE, vol. 8, no. 4, Article ID e60563, 2013.
27. C. R. González, J. E. Caminos, M. J. Vázquez et al., "Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue," The Journal of Physiology, vol. 587, no. 14, pp. 3741-3750, 2009.
28. M. Imbernon, L. Whyte, A. Diaz-Arteaga et al., "Regulation of GPR55 in rat white adipose tissue and serumLPI by nutritional status, gestation, gender and pituitary factors," Molecular and Cellular Endocrinology, vol. 383, no. 1-2, pp. 159-169, 2014.
29. G. Légràdi, C. H. Emerson, R. S. Ahima, J. S. Flier, and R. M. Lechan, "Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus," Endocrinology, vol. 138, no. 6, pp. 2569-2576, 1997.
30. M. Pardo, A. Roca-Rivada, O. Al-Massadi, L. M. Seoane, J. P. Camiña, and F. F. Casanueva, "Peripheral leptin and ghrelin receptors are regulated in a tissue-specific manner in activitybased anorexia," Peptides, vol. 31, no. 10, pp. 1912-1919, 2010.
31. K. M. Habegger, O. Al-Massadi, K. M. Heppner et al., "Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia," Gut, vol. 63, no. 8, pp. 1238-1246, 2014.
32. A. B. Crujeiras, M. A. Zulet, P. Lopez-Legarrea et al., "Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients," Metabolism: Clinical and Experimental, vol. 63, no. 4, pp. 520-531, 2014.
33. R. de la Iglesia, P. Lopez-Legarrea, A. B. Crujeiras et al., "Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients," Clinical Endocrinology, vol. 81, no. 2, pp. 306-311, 2014.
34. T. Kuloglu, S. Aydin, M. N. Eren et al., "Irisin: a potentially candidate marker for myocardial infarction," Peptides, vol. 55, pp. 85-91, 2014.
35. B. Porteiro, A. Díaz-Ruíz, G. Martínez et al., "Ghrelin requires p53 to stimulate lipid storage in fat and liver," Endocrinology, vol. 154, no. 10, pp. 3671-3679, 2013.
36. O. Al-Massadi, A. B. Crujeiras, R. C. González et al., "Age, sex, and lactating status regulate ghrelin secretion and GOAT mRNA levels from isolated rat stomach," The American Journal of Physiology - Endocrinology and Metabolism, vol. 299, no. 3, pp. E341-E350, 2010.
37. L. L. Senin, O. Al-Massadi, C. Folgueira et al., "The gastric CB1 receptormodulates ghrelin production through themTOR pathway to regulate food intake," PLoS ONE, vol. 8, no. 11, Article ID e80339, 2013.
38. V. Wallenius, K. Wallenius, B. Ahrén et al., "Interleukin-6- deficient mice develop mature-onset obesity," Nature Medicine, vol. 8, no. 1, pp. 75-79, 2002.
39. J. D. Browning, J. Baxter, S. Satapati, and S. C. Burgess, "The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men," Journal of Lipid Research, vol. 53, no. 3, pp. 577-586, 2012.
40. L. M. Seoane, O. Al-Massadi, J. E. Caminos, S. A. Tovar, C. Dieguez, and F. F. Casanueva, "Sensory stimuli directly acting at the central nervous system regulate gastric ghrelin secretion. An ex vivo organ culture study," Endocrinology, vol. 148, no. 8, pp. 3998-4006, 2007.
41. G.-F. Luo, T.-Y. Yu, X.-H. Wen, Y. Li, and G.-S. Yang, "Alteration of mitochondrial oxidative capacity during porcine preadipocyte differentiation and in response to leptin," Molecular and Cellular Biochemistry, vol. 307, no. 1-2, pp. 83-91, 2008.
42. S. Yasari, D. Wang, D. Prud'homme, M. Jankowski, J. Gutkowska, and J.-M. Lavoie, "Exercise training decreases plasma leptin levels and the expression of hepatic leptin receptor-a, -b, and, -e in rats," Molecular and Cellular Biochemistry, vol. 324, no. 1-2, pp. 13-20, 2009.
43. K. H. Park, L. Zaichenko, M. Brinkoetter et al., "Circulating irisin in relation to insulin resistance and the metabolic syndrome," The Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 12, pp. 4899-4907, 2013.
44. J.-J. Liu, M. D. S. Wong, W.C. Toy et al., "Lower circulating irisin is associated with type 2 diabetes mellitus," Journal of Diabetes and its Complications, vol. 27, no. 4, pp. 365-369, 2013.
45. Y.-K. Choi, M.-K. Kim, K. H. Bae et al., "Serum irisin levels in new-onset type 2 diabetes," Diabetes Research and Clinical Practice, vol. 100, no. 1, pp. 96-101, 2013.
46. N. Sharma, C. M. Castorena, and G. D. Cartee, "Greater insulin sensitivity in calorie restricted rats occurswith unaltered circulating levels of several importantmyokines and cytokines," Nutrition and Metabolism, vol. 9, article 90, 2012.
47. A. Rodríguez, S. Becerril, L. Méndez-Giménez et al., "Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice," International Journal of Obesity, vol. 39, pp. 397-407, 2015.