Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?

Journal of Physiology

Volumn 591, Issue 21, 2013, Pages 5393-5400

  Pekkala, Satu ^a   Wiklund, Petri K ^a   Hulmi, Juha J ^a   Ahtiainen, Juha P ^a   Horttanainen, Mia ^a   Pöllänen, Eija ^a   Mäkelä, Kari A ^b   Kainulainen, Heikki ^a   Häkkinen, Keijo ^a   Nyman, Kai ^c   Alén, Markku ^d   Herzig, Karl Heinz ^b,e   Cheng, Sulin ^a  

^a UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c JYVÄSKYLÄ CENTRAL HOSPITAL   (Finland)

^d OULU UNIVERSITY HOSPITAL   (Finland)

^e KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLUCOSE; IRISIN PROTEIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; UNCLASSIFIED DRUG; FIBRONECTIN; FNDC5 PROTEIN, HUMAN; PPARGC1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADULT; AEROBIC EXERCISE; AGE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDURANCE TRAINING; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; EXERCISE INTENSITY; FNDC5 GENE; GENE; GENE EXPRESSION REGULATION; GLUCOSE METABOLISM; HEALTH STATUS; HUMAN; MALE; MEN'S HEALTH; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; RESISTANCE TRAINING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; AGED; BLOOD; CASE CONTROL STUDY; ENDURANCE; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADULT; AGE FACTORS; AGED; CASE-CONTROL STUDIES; FIBRONECTINS; HUMANS; MALE; MIDDLE AGED; MUSCLE, SKELETAL; PHYSICAL ENDURANCE; RESISTANCE TRAINING; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84886769757     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.263707     Document Type: Article

References (16)

1. Ahtiainen JP, Hulmi JJ, Kraemer WJ, Lehti M, Pakarinen A, Mero AA, Karavirta L, Sillanpaa E, Selanne H, Alen M, Komulainen J, Kovanen V, Nyman K & Hakkinen K (2009). Strength [corrected], endurance or combined training elicit diverse skeletal muscle myosin heavy chain isoform proportion but unaltered androgen receptor concentration in older men. Int J Sports Med 30, 879-887.
2. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP & Spiegelman BM (2012). A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481, 463-468.
3. Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE & Mantzoros CS (2012). FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 61, 1725-1738.
4. Hulmi JJ, Kovanen V, Lisko I, Selanne H & Mero AA (2008). The effects of whey protein on myostatin and cell cycle-related gene expression responses to a single heavy resistance exercise bout in trained older men. Eur J Appl Physiol 102, 205-213.
5. Hulmi JJ, Kovanen V, Selänne H, Kraemer WJ, Häkkinen K & Mero AA (2009a). Acute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression. Amino Acids 37, 297-308.
6. Hulmi JJ, Tannerstedt J, Selänne H, Kainulainen H, Kovanen V & Mero AA (2009b). Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men. J Appl Physiol 106, 1720-1729.
7. Karavirta L, Häkkinen A, Sillanpää E, García-López D, Kauhanen A, Haapasaari A, Alen M, Pakarinen A, Kraemer WJ, Izquierdo M, Gorostiaga E & Häkkinen K (2010). Effects of combined endurance and strength training on muscle strength, power and hypertrophy in 40-67-year-old men. Scand J Med Sci Sports 21, 402-411.
8. Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F, Ricart W & Manuel-Fernández-Real J (2013). Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab 98, E769-778.
9. Roberts MD, Bayless DS, Company JM, Jenkins NT, Padilla J, Childs TE, Martin JS, Dalbo VJ, Booth FW, Rector RS & Laughlin MH (2013). Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats. Metabolism 62, 1052-1056.
10. Roca-Rivada A, Castelao C, Senin LL, Landrove MO, Baltar J, Crujeiras AB, Seoane LM, Casanueva FF & Pardo M (2013). FNDC5/irisin is not only a myokine but also an adipokine. PLoS One 8, e60563.
11. Rodgers JT, Lerin C, Gerhart-Hines Z & Puigserver P (2008). Metabolic adaptations through the PGC-1α and SIRT1 pathways. FEBS Lett 582, 46-53.
12. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM & Puigserver P (2005). Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 434, 113-118.
13. Roth J, Zuber C, Park S, Jang I, Lee Y, Kysela KG, Le Fourn V, Santimaria R, Guhl B & Cho JW (2010). Protein N-glycosylation, protein folding, and protein quality control. Mol Cells 30, 497-506.
14. Sharma N, Castorena CM & Cartee GD (2012). Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines. Nutr Metab (Lond) 9, 90.
15. Timmons JA, Baar K, Davidsen PK & Atherton PJ (2012). Is irisin a human exercise gene Nature 488, E9-10; discussion E10-11.
16. Vagin O, Kraut JA & Sachs G (2009). Role of N-glycosylation in trafficking of apical membrane proteins in epithelia. Am J Physiol Renal Physiol 296, F459-F469.