Carbon black nanoparticles induce biphasic gene expression changes associated with inflammatory responses in the lungs of C57BL/6 mice following a single intratracheal instillation

Toxicology and Applied Pharmacology

Volumn 289, Issue 3, 2015, Pages 573-588

  Husain, Mainul ^a   Kyjovska, Zdenka O ^b   Bourdon Lacombe, Julie ^a   Saber, Anne T ^b   Jensen, Keld A ^b   Jacobsen, Nicklas R ^b   Williams, Andrew ^a   Wallin, Håkan ^b,c   Halappanavar, Sabina ^a   Vogel, Ulla ^b,d   Yauk, Carole L ^a  

^a Environmental Health Center   (Canada)

^b NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Biphasic response; Carbon black nanoparticles; Cell cycle regulation; DNA repair; Inflammation; Muscle contraction

Indexed keywords

C TYPE LECTIN DOMAIN FAMILY 4 MEMBER D; CARBON BLACK NANOPARTICLE; CARBON NANOPARTICLE; CD14 ANTIGEN; COLONY STIMULATING FACTOR; COMPLEMENT COMPONENT C3; DNA; EOTAXIN 2; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 33; MONOCYTE CHEMOTACTIC PROTEIN 5; SERUM AMYLOID A; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG; NANOPARTICLE; SOOT;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; FEMALE; GENE EXPRESSION; IMMUNE RESPONSE; LEUKOCYTE DIFFERENTIAL COUNT; LUNG LAVAGE; LUNG PARENCHYMA; MOUSE; MUSCLE CONTRACTION; NANOTOXICOLOGY; NEUTROPHIL COUNT; NONHUMAN; PNEUMONIA; RNA EXTRACTION; ADVERSE EFFECTS; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; CELL CYCLE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; GENETICS; INHALATIONAL DRUG ADMINISTRATION; LUNG; OCCUPATIONAL EXPOSURE; SOOT; TRACHEA;

ADMINISTRATION, INHALATION; ANIMALS; APOPTOSIS; BRONCHOALVEOLAR LAVAGE FLUID; CELL CYCLE; DNA DAMAGE; DNA REPAIR; FEMALE; GENE EXPRESSION; LUNG; MICE; MICE, INBRED C57BL; NANOPARTICLES; OCCUPATIONAL EXPOSURE; PNEUMONIA; SOOT; TRACHEA;

EID: 84947917434     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.11.003     Document Type: Article

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