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Volumn 11, Issue 12, 2015, Pages 988-993

MicroRNAs regulate the immunometabolic response to viral infection in the liver

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYCHOLESTEROL; MICRORNA; MICRORNA 130B; MICRORNA 185; UNCLASSIFIED DRUG; 25-HYDROXYCHOLESTEROL; ANTIVIRUS AGENT; CHOLESTEROL DERIVATIVE;

EID: 84947287935     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1940     Document Type: Article
Times cited : (57)

References (59)
  • 1
    • 35748931458 scopus 로고    scopus 로고
    • Lipids as modulators of membrane fusion mediated by viral fusion proteins
    • Teissier, E. & Pécheur, E.I. Lipids as modulators of membrane fusion mediated by viral fusion proteins. Eur. Biophys. J. 36, 887-899 (2007).
    • (2007) Eur. Biophys. J. , vol.36 , pp. 887-899
    • Teissier, E.1    Pécheur, E.I.2
  • 3
    • 42349086670 scopus 로고    scopus 로고
    • Modification of intracellular membrane structures for virus replication
    • Miller, S. & Krijnse-Locker, J. Modification of intracellular membrane structures for virus replication. Nat. Rev. Microbiol. 6, 363-374 (2008).
    • (2008) Nat. Rev. Microbiol. , vol.6 , pp. 363-374
    • Miller, S.1    Krijnse-Locker, J.2
  • 4
    • 84867654401 scopus 로고    scopus 로고
    • Emerging roles for lipid droplets in immunity and host-pathogen interactions
    • Saka, H.A. & Valdivia, R. Emerging roles for lipid droplets in immunity and host-pathogen interactions. Annu. Rev. Cell Dev. Biol. 28, 411-437 (2012).
    • (2012) Annu. Rev. Cell Dev. Biol. , vol.28 , pp. 411-437
    • Saka, H.A.1    Valdivia, R.2
  • 5
    • 84886071901 scopus 로고    scopus 로고
    • Lipids in innate antiviral defense
    • Schoggins, J.W. & Randall, G. Lipids in innate antiviral defense. Cell Host Microbe 14, 379-385 (2013).
    • (2013) Cell Host Microbe , vol.14 , pp. 379-385
    • Schoggins, J.W.1    Randall, G.2
  • 6
    • 84872794099 scopus 로고    scopus 로고
    • The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response
    • Blanc, M. et al. The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity 38, 106-118 (2013).
    • (2013) Immunity , vol.38 , pp. 106-118
    • Blanc, M.1
  • 7
    • 84872790828 scopus 로고    scopus 로고
    • Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol
    • Liu, S.Y. et al. Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. Immunity 38, 92-105 (2013).
    • (2013) Immunity , vol.38 , pp. 92-105
    • Liu, S.Y.1
  • 8
    • 61849117274 scopus 로고    scopus 로고
    • Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus
    • Pezacki, J.P. et al. Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. BMC Chem. Biol. 9, 2 (2009).
    • (2009) BMC Chem. Biol. , vol.9 , pp. 2
    • Pezacki, J.P.1
  • 9
    • 78649752711 scopus 로고    scopus 로고
    • Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons
    • Park, K. & Scott, A.L. Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons. J. Leukoc. Biol. 88, 1081-1087 (2010).
    • (2010) J. Leukoc. Biol. , vol.88 , pp. 1081-1087
    • Park, K.1    Scott, A.L.2
  • 10
    • 60149088848 scopus 로고    scopus 로고
    • Origins and mechanisms of miRNAs and siRNAs
    • Carthew, R.W. & Sontheimer, E.J. Origins and mechanisms of miRNAs and siRNAs. Cell 136, 642-655 (2009).
    • (2009) Cell , vol.136 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 11
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • Friedman, R.C., Farh, K.K.H., Burge, C.B. & Bartel, D.P. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19, 92-105 (2009).
    • (2009) Genome Res. , vol.19 , pp. 92-105
    • Friedman, R.C.1    Farh, K.K.H.2    Burge, C.B.3    Bartel, D.P.4
  • 12
    • 84858776574 scopus 로고    scopus 로고
    • MicroRNAs in metabolism and metabolic disorders
    • Rottiers, V. & Näär, A.M. MicroRNAs in metabolism and metabolic disorders. Nat. Rev. Mol. Cell Biol. 13, 239-250 (2012).
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 239-250
    • Rottiers, V.1    Näär, A.M.2
  • 13
    • 78349277671 scopus 로고    scopus 로고
    • Evidence of aberrant lipid metabolism in hepatitis C and hepatocellular carcinoma
    • Wu, J.M., Skill, N.J. & Maluccio, M.A. Evidence of aberrant lipid metabolism in hepatitis C and hepatocellular carcinoma. HPB (Oxford) 12, 625-636 (2010).
    • (2010) HPB (Oxford) , vol.12 , pp. 625-636
    • Wu, J.M.1    Skill, N.J.2    Maluccio, M.A.3
  • 14
    • 10644239801 scopus 로고    scopus 로고
    • Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs
    • Adams, C.M. et al. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. J. Biol. Chem. 279, 52772-52780 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 52772-52780
    • Adams, C.M.1
  • 15
    • 34249848111 scopus 로고    scopus 로고
    • Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig
    • Radhakrishnan, A., Ikeda, Y., Kwon, H.J., Brown, M.S. & Goldstein, J.L. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proc. Natl. Acad. Sci. USA 104, 6511-6518 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 6511-6518
    • Radhakrishnan, A.1    Ikeda, Y.2    Kwon, H.J.3    Brown, M.S.4    Goldstein, J.L.5
  • 16
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXRα
    • Janowski, B.A., Willy, P.J., Devi, T.R., Falck, J.R. & Mangelsdorf, D.J. An oxysterol signalling pathway mediated by the nuclear receptor LXRα. Nature 383, 728-731 (1996).
    • (1996) Nature , vol.383 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3    Falck, J.R.4    Mangelsdorf, D.J.5
  • 17
    • 30344473341 scopus 로고    scopus 로고
    • Protein sensors for membrane sterols
    • Goldstein, J.L., DeBose-Boyd, R.A. & Brown, M.S. Protein sensors for membrane sterols. Cell 124, 35-46 (2006).
    • (2006) Cell , vol.124 , pp. 35-46
    • Goldstein, J.L.1    DeBose-Boyd, R.A.2    Brown, M.S.3
  • 18
    • 0037180553 scopus 로고    scopus 로고
    • Genomic analysis of the host response to hepatitis C virus infection
    • Su, A.I. et al. Genomic analysis of the host response to hepatitis C virus infection. Proc. Natl. Acad. Sci. USA 99, 15669-15674 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 15669-15674
    • Su, A.I.1
  • 19
    • 84865302624 scopus 로고    scopus 로고
    • Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner
    • Zeng, J. et al. Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner. Antiviral Res. 95, 245-256 (2012).
    • (2012) Antiviral Res. , vol.95 , pp. 245-256
    • Zeng, J.1
  • 20
    • 41949086805 scopus 로고    scopus 로고
    • Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus
    • Russell, R.S. et al. Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus. Proc. Natl. Acad. Sci. USA 105, 4370-4375 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 4370-4375
    • Russell, R.S.1
  • 21
    • 84864464973 scopus 로고    scopus 로고
    • DIANA miRPath v.2.0: Investigating the combinatorial effect of microRNAs in pathways
    • Vlachos, I.S. et al. DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways. Nucleic Acids Res. 40, W498-W504 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. W498-W504
    • Vlachos, I.S.1
  • 22
    • 84924561760 scopus 로고    scopus 로고
    • Hepatitis C virus RNA functionally sequesters miR-122
    • Luna, J.M. et al. Hepatitis C virus RNA functionally sequesters miR-122. Cell 160, 1099-1110 (2015).
    • (2015) Cell , vol.160 , pp. 1099-1110
    • Luna, J.M.1
  • 23
    • 84904618392 scopus 로고    scopus 로고
    • miR-185 inhibits hepatocellular carcinoma growth by targeting the DNMT1/PTEN/Akt pathway
    • Qadir, X.V., Han, C., Lu, D., Zhang, J. & Wu, T. miR-185 inhibits hepatocellular carcinoma growth by targeting the DNMT1/PTEN/Akt pathway. Am. J. Pathol. 184, 2355-2364 (2014).
    • (2014) Am. J. Pathol. , vol.184 , pp. 2355-2364
    • Qadir, X.V.1    Han, C.2    Lu, D.3    Zhang, J.4    Wu, T.5
  • 24
    • 84905014931 scopus 로고    scopus 로고
    • A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis
    • Xiao, F. et al. A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis. Diabetes 63, 2631-2642 (2014).
    • (2014) Diabetes , vol.63 , pp. 2631-2642
    • Xiao, F.1
  • 25
    • 84888285942 scopus 로고    scopus 로고
    • Human serum leads to differentiation of human hepatoma cells, restoration of very-low-density lipoprotein secretion, and a 1000-fold increase in HCV Japanese fulminant hepatitis type 1 titers
    • Steenbergen, R.H.G. et al. Human serum leads to differentiation of human hepatoma cells, restoration of very-low-density lipoprotein secretion, and a 1000-fold increase in HCV Japanese fulminant hepatitis type 1 titers. Hepatology 58, 1907-1917 (2013).
    • (2013) Hepatology , vol.58 , pp. 1907-1917
    • Steenbergen, R.H.G.1
  • 26
    • 79954522888 scopus 로고    scopus 로고
    • Hepatitis C virus and host cell lipids: An intimate connection
    • Alvisi, G., Madan, V. & Bartenschlager, R. Hepatitis C virus and host cell lipids: an intimate connection. RNA Biol. 8, 258-269 (2011).
    • (2011) RNA Biol. , vol.8 , pp. 258-269
    • Alvisi, G.1    Madan, V.2    Bartenschlager, R.3
  • 27
    • 77953560365 scopus 로고    scopus 로고
    • Host-virus interactions during hepatitis C virus infection: A complex and dynamic molecular biosystem
    • Pezacki, J.P., Singaravelu, R. & Lyn, R.K. Host-virus interactions during hepatitis C virus infection: a complex and dynamic molecular biosystem. Mol. Biosyst. 6, 1131-1142 (2010).
    • (2010) Mol. Biosyst. , vol.6 , pp. 1131-1142
    • Pezacki, J.P.1    Singaravelu, R.2    Lyn, R.K.3
  • 28
    • 84864475305 scopus 로고    scopus 로고
    • Liver X receptor α-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication
    • García-Mediavilla, M.V. et al. Liver X receptor α-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication. Lab. Invest. 92, 1191-1202 (2012).
    • (2012) Lab. Invest. , vol.92 , pp. 1191-1202
    • García-Mediavilla, M.V.1
  • 29
    • 34547097746 scopus 로고    scopus 로고
    • Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress
    • Waris, G., Felmlee, D.J., Negro, F. & Siddiqui, A. Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J. Virol. 81, 8122-8130 (2007).
    • (2007) J. Virol. , vol.81 , pp. 8122-8130
    • Waris, G.1    Felmlee, D.J.2    Negro, F.3    Siddiqui, A.4
  • 30
    • 79951821202 scopus 로고    scopus 로고
    • Chemical contrast for imaging living systems: Molecular vibrations drive CARS microscopy
    • Pezacki, J.P. et al. Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy. Nat. Chem. Biol. 7, 137-145 (2011).
    • (2011) Nat. Chem. Biol. , vol.7 , pp. 137-145
    • Pezacki, J.P.1
  • 31
    • 84893357948 scopus 로고    scopus 로고
    • Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake
    • Yang, M. et al. Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake. J. Lipid Res. 55, 226-238 (2014).
    • (2014) J. Lipid Res. , vol.55 , pp. 226-238
    • Yang, M.1
  • 32
    • 84878967914 scopus 로고    scopus 로고
    • MicroRNAs 185, 96, and 223 repress selective high-density lipoprotein cholesterol uptake through posttranscriptional inhibition
    • Wang, L. et al. MicroRNAs 185, 96, and 223 repress selective high-density lipoprotein cholesterol uptake through posttranscriptional inhibition. Mol. Cell. Biol. 33, 1956-1964 (2013).
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 1956-1964
    • Wang, L.1
  • 33
    • 84892647657 scopus 로고    scopus 로고
    • Microvesicle-shuttled miR-130b reduces Fat deposition in recipient primary cultured porcine adipocytes by inhibiting PPAR-γ expression
    • Pan, S., Yang, X., Jia, Y., Li, R. & Zhao, R. Microvesicle-shuttled miR-130b reduces Fat deposition in recipient primary cultured porcine adipocytes by inhibiting PPAR-γ expression. J. Cell. Physiol. 229, 631-639 (2014).
    • (2014) J. Cell. Physiol. , vol.229 , pp. 631-639
    • Pan, S.1    Yang, X.2    Jia, Y.3    Li, R.4    Zhao, R.5
  • 35
    • 84897376553 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes
    • Lyn, R.K. et al. Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes. Sci. Rep. 4, 4549 (2014).
    • (2014) Sci. Rep. , vol.4 , pp. 4549
    • Lyn, R.K.1
  • 36
    • 56549098864 scopus 로고    scopus 로고
    • Entry of pseudotyped hepatitis C virus into primary human hepatocytes depends on the scavenger class B type I receptor
    • Régeard, M., Trotard, M., Lepère, C., Gripon, P. & Le Seyec, J. Entry of pseudotyped hepatitis C virus into primary human hepatocytes depends on the scavenger class B type I receptor. J. Viral Hepat. 15, 865-870 (2008).
    • (2008) J. Viral Hepat. , vol.15 , pp. 865-870
    • Régeard, M.1    Trotard, M.2    Lepère, C.3    Gripon, P.4    Le Seyec, J.5
  • 37
    • 84880633341 scopus 로고    scopus 로고
    • Different requirements for scavenger receptor class B type I in hepatitis C virus cell-free versus cell-to-cell transmission
    • Catanese, M.T. et al. Different requirements for scavenger receptor class B type I in hepatitis C virus cell-free versus cell-to-cell transmission. J. Virol. 87, 8282-8293 (2013).
    • (2013) J. Virol. , vol.87 , pp. 8282-8293
    • Catanese, M.T.1
  • 38
    • 84880290533 scopus 로고    scopus 로고
    • Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly
    • Li, Q., Pene, V., Krishnamurthy, S., Cha, H. & Liang, T.J. Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly. Nat. Med. 19, 722-729 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 722-729
    • Li, Q.1    Pene, V.2    Krishnamurthy, S.3    Cha, H.4    Liang, T.J.5
  • 39
    • 84896689449 scopus 로고    scopus 로고
    • Hepatitis C Virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation
    • Syed, G.H. et al. Hepatitis C Virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation. J. Virol. 88, 2519-2529 (2014).
    • (2014) J. Virol. , vol.88 , pp. 2519-2529
    • Syed, G.H.1
  • 40
    • 0345251979 scopus 로고    scopus 로고
    • Low density lipoprotein receptor as a candidate receptor for hepatitis C virus
    • Monazahian, M. et al. Low density lipoprotein receptor as a candidate receptor for hepatitis C virus. J. Med. Virol. 57, 223-229 (1999).
    • (1999) J. Med. Virol. , vol.57 , pp. 223-229
    • Monazahian, M.1
  • 41
    • 66849089697 scopus 로고    scopus 로고
    • Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
    • Takeuchi, K. & Reue, K. Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis. Am. J. Physiol. Endocrinol. Metab. 296, E1195-E1209 (2009).
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296 , pp. E1195-E1209
    • Takeuchi, K.1    Reue, K.2
  • 42
    • 17944379233 scopus 로고    scopus 로고
    • Hepatitis C virus replication in mice with chimeric human livers
    • Mercer, D.F. et al. Hepatitis C virus replication in mice with chimeric human livers. Nat. Med. 7, 927-933 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 927-933
    • Mercer, D.F.1
  • 43
    • 84894864720 scopus 로고    scopus 로고
    • Hepatitis C virus induced up-regulation of microRNA-27: A novel mechanism for hepatic steatosis
    • Singaravelu, R. et al. Hepatitis C virus induced up-regulation of microRNA-27: A novel mechanism for hepatic steatosis. Hepatology 59, 98-108 (2014).
    • (2014) Hepatology , vol.59 , pp. 98-108
    • Singaravelu, R.1
  • 44
    • 84885995316 scopus 로고    scopus 로고
    • Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment
    • Paul, D., Hoppe, S., Saher, G., Krijnse-Locker, J. & Bartenschlager, R. Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment. J. Virol. 87, 10612-10627 (2013).
    • (2013) J. Virol. , vol.87 , pp. 10612-10627
    • Paul, D.1    Hoppe, S.2    Saher, G.3    Krijnse-Locker, J.4    Bartenschlager, R.5
  • 45
    • 30744445243 scopus 로고    scopus 로고
    • The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication
    • Sagan, S.M. et al. The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication. Biochem. Cell Biol. 84, 67-79 (2006).
    • (2006) Biochem. Cell Biol. , vol.84 , pp. 67-79
    • Sagan, S.M.1
  • 46
    • 84891837132 scopus 로고    scopus 로고
    • MicroRNA-130a inhibits HCV replication by restoring the innate immune response
    • Li, S. et al. MicroRNA-130a inhibits HCV replication by restoring the innate immune response. J. Viral Hepat. 21, 121-128 (2014).
    • (2014) J. Viral Hepat. , vol.21 , pp. 121-128
    • Li, S.1
  • 47
    • 0242492530 scopus 로고    scopus 로고
    • Membrane synthesis, specific lipid requirements, and localized lipid composition changes associated with a positive-strand RNA Virus RNA replication protein
    • Lee, W.M. & Ahlquist, P. Membrane synthesis, specific lipid requirements, and localized lipid composition changes associated with a positive-strand RNA Virus RNA replication protein. J. Virol. 77, 12819-12828 (2003).
    • (2003) J. Virol. , vol.77 , pp. 12819-12828
    • Lee, W.M.1    Ahlquist, P.2
  • 48
    • 84930902202 scopus 로고    scopus 로고
    • Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol
    • Civra, A. et al. Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol. Sci. Rep. 4, 7487 (2014).
    • (2014) Sci. Rep. , vol.4 , pp. 7487
    • Civra, A.1
  • 49
    • 35349009932 scopus 로고    scopus 로고
    • Interferon modulation of cellular microRNAs as an antiviral mechanism
    • Pedersen, I.M. et al. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature 449, 919-922 (2007).
    • (2007) Nature , vol.449 , pp. 919-922
    • Pedersen, I.M.1
  • 51
    • 0034623816 scopus 로고    scopus 로고
    • Efficient initiation of HCV RNA replication in cell culture
    • Blight, K.J., Kolykhalov, A.A. & Rice, C.M. Efficient initiation of HCV RNA replication in cell culture. Science 290, 1972-1974 (2000).
    • (2000) Science , vol.290 , pp. 1972-1974
    • Blight, K.J.1    Kolykhalov, A.A.2    Rice, C.M.3
  • 53
    • 84875802186 scopus 로고    scopus 로고
    • Nuclear localization of Dengue virus nonstructural protein 5 Does Not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling
    • Kumar, A. et al. Nuclear localization of Dengue virus nonstructural protein 5 Does Not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling. J. Virol. 87, 4545-4557 (2013).
    • (2013) J. Virol. , vol.87 , pp. 4545-4557
    • Kumar, A.1
  • 54
    • 10744223476 scopus 로고    scopus 로고
    • VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents
    • Stojdl, D.F. et al. VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents. Cancer Cell 4, 263-275 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 263-275
    • Stojdl, D.F.1
  • 55
    • 84980052130 scopus 로고    scopus 로고
    • Identification of microRNAs involved in Alzheimer's progression using a rabbit model of the disease
    • Liu, Q.Y. et al. Identification of microRNAs involved in Alzheimer's progression using a rabbit model of the disease. Am. J. Neurodegener. Dis. 3, 33-44 (2014).
    • (2014) Am. J. Neurodegener. Dis. , vol.3 , pp. 33-44
    • Liu, Q.Y.1
  • 56
    • 67849130563 scopus 로고    scopus 로고
    • ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
    • Chen, J., Bardes, E.E., Aronow, B.J. & Jegga, A.G. ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res. 37, W305-W311 (2009).
    • (2009) Nucleic Acids Res. , vol.37 , pp. W305-W311
    • Chen, J.1    Bardes, E.E.2    Aronow, B.J.3    Jegga, A.G.4
  • 57
    • 0034660683 scopus 로고    scopus 로고
    • A noncommercial dual luciferase enzyme assay system for reporter gene analysis
    • Dyer, B.W., Ferrer, F.A., Klinedinst, D.K. & Rodriguez, R. A noncommercial dual luciferase enzyme assay system for reporter gene analysis. Anal. Biochem. 282, 158-161 (2000).
    • (2000) Anal. Biochem. , vol.282 , pp. 158-161
    • Dyer, B.W.1    Ferrer, F.A.2    Klinedinst, D.K.3    Rodriguez, R.4
  • 58
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch, J., Lees, M. & Stanley, G.H.S. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509 (1957).
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Stanley, G.H.S.3
  • 59
    • 67049116050 scopus 로고    scopus 로고
    • Improved separation and quantification of neutral and polar lipid classes by HPLC-ELSD using a monolithic silica phase: Application to exceptional marine lipids
    • Graeve, M. & Janssen, D. Improved separation and quantification of neutral and polar lipid classes by HPLC-ELSD using a monolithic silica phase: application to exceptional marine lipids. J. Chromatogr. B 877, 1815-1819 (2009).
    • (2009) J. Chromatogr. B , vol.877 , pp. 1815-1819
    • Graeve, M.1    Janssen, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.