-
1
-
-
33747830764
-
Hepatocellular carcinoma pathogenesis: From genes to environment
-
P.A. Farazi, and R.A. DePinho Hepatocellular carcinoma pathogenesis: from genes to environment Nat Rev Cancer 6 2006 674 687
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 674-687
-
-
Farazi, P.A.1
Depinho, R.A.2
-
2
-
-
33745521748
-
Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity
-
L.B. Seeff, and J.H. Hoofnagle Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity Oncogene 25 2006 3771 3777
-
(2006)
Oncogene
, vol.25
, pp. 3771-3777
-
-
Seeff, L.B.1
Hoofnagle, J.H.2
-
3
-
-
80053088189
-
Hepatocellular carcinoma
-
H.B. El-Serag Hepatocellular carcinoma N Engl J Med 365 2011 1118 1127
-
(2011)
N Engl J Med
, vol.365
, pp. 1118-1127
-
-
El-Serag, H.B.1
-
4
-
-
54449083925
-
Molecular targeted therapies in hepatocellular carcinoma
-
J.M. Llovet, and J. Bruix Molecular targeted therapies in hepatocellular carcinoma Hepatology 48 2008 1312 1327
-
(2008)
Hepatology
, vol.48
, pp. 1312-1327
-
-
Llovet, J.M.1
Bruix, J.2
-
5
-
-
63049133092
-
Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
-
S.F. Altekruse, K.A. McGlynn, and M.E. Reichman Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005 J Clin Oncol 27 2009 1485 1491
-
(2009)
J Clin Oncol
, vol.27
, pp. 1485-1491
-
-
Altekruse, S.F.1
McGlynn, K.A.2
Reichman, M.E.3
-
6
-
-
84859212951
-
Hepatocellular carcinoma
-
A. Forner, J.M. Llovet, and J. Bruix Hepatocellular carcinoma Lancet 379 2012 1245 1255
-
(2012)
Lancet
, vol.379
, pp. 1245-1255
-
-
Forner, A.1
Llovet, J.M.2
Bruix, J.3
-
8
-
-
79955433548
-
Targeted therapies for hepatocellular carcinoma
-
A. Villanueva, and J.M. Llovet Targeted therapies for hepatocellular carcinoma Gastroenterology 140 2011 1410 1426
-
(2011)
Gastroenterology
, vol.140
, pp. 1410-1426
-
-
Villanueva, A.1
Llovet, J.M.2
-
9
-
-
33644768174
-
Control of translation and mRNA degradation by miRNAs and siRNAs
-
M.A. Valencia-Sanchez, J. Liu, G.J. Hannon, and R. Parker Control of translation and mRNA degradation by miRNAs and siRNAs Genes Dev 20 2006 515 524
-
(2006)
Genes Dev
, vol.20
, pp. 515-524
-
-
Valencia-Sanchez, M.A.1
Liu, J.2
Hannon, G.J.3
Parker, R.4
-
11
-
-
58149376548
-
Molecular mechanisms of hepatocellular carcinoma
-
R.N. Aravalli, C.J. Steer, and E.N. Cressman Molecular mechanisms of hepatocellular carcinoma Hepatology 48 2008 2047 2063
-
(2008)
Hepatology
, vol.48
, pp. 2047-2063
-
-
Aravalli, R.N.1
Steer, C.J.2
Cressman, E.N.3
-
12
-
-
84873296666
-
MicroRNAs: New tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma?
-
S. Giordano, and A. Columbano MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma? Hepatology 57 2013 840 847
-
(2013)
Hepatology
, vol.57
, pp. 840-847
-
-
Giordano, S.1
Columbano, A.2
-
13
-
-
84861195622
-
Diagnostic and therapeutic potential of miRNA signatures in patients with hepatocellular carcinoma
-
F. Borel, P. Konstantinova, and P.L. Jansen Diagnostic and therapeutic potential of miRNA signatures in patients with hepatocellular carcinoma J Hepatol 56 2012 1371 1383
-
(2012)
J Hepatol
, vol.56
, pp. 1371-1383
-
-
Borel, F.1
Konstantinova, P.2
Jansen, P.L.3
-
14
-
-
80053309537
-
Intercellular nanovesicle-mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growth
-
T. Kogure, W.L. Lin, I.K. Yan, C. Braconi, and T. Patel Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth Hepatology 54 2011 1237 1248
-
(2011)
Hepatology
, vol.54
, pp. 1237-1248
-
-
Kogure, T.1
Lin, W.L.2
Yan, I.K.3
Braconi, C.4
Patel, T.5
-
16
-
-
84863983719
-
MicroRNA silencing and the development of novel therapies for liver disease
-
G. Szabo, P. Sarnow, and S. Bala MicroRNA silencing and the development of novel therapies for liver disease J Hepatol 57 2012 462 466
-
(2012)
J Hepatol
, vol.57
, pp. 462-466
-
-
Szabo, G.1
Sarnow, P.2
Bala, S.3
-
17
-
-
40949087185
-
Identification of metastasis-related microRNAs in hepatocellular carcinoma
-
A. Budhu, H.L. Jia, M. Forgues, C.G. Liu, D. Goldstein, A. Lam, K.A. Zanetti, Q.H. Ye, L.X. Qin, C.M. Croce, Z.Y. Tang, and X.W. Wang Identification of metastasis-related microRNAs in hepatocellular carcinoma Hepatology 47 2008 897 907
-
(2008)
Hepatology
, vol.47
, pp. 897-907
-
-
Budhu, A.1
Jia, H.L.2
Forgues, M.3
Liu, C.G.4
Goldstein, D.5
Lam, A.6
Zanetti, K.A.7
Ye, Q.H.8
Qin, L.X.9
Croce, C.M.10
Tang, Z.Y.11
Wang, X.W.12
-
18
-
-
84878354625
-
Metastasis-related miR-185 is a potential prognostic biomarker for hepatocellular carcinoma in early stage
-
Q. Zhi, J. Zhu, X. Guo, S. He, X. Xue, J. Zhou, B. Hu, H. Li, S. Chen, H. Zhao, and Y. Kuang Metastasis-related miR-185 is a potential prognostic biomarker for hepatocellular carcinoma in early stage Biomed Pharmacother 67 2013 393 398
-
(2013)
Biomed Pharmacother
, vol.67
, pp. 393-398
-
-
Zhi, Q.1
Zhu, J.2
Guo, X.3
He, S.4
Xue, X.5
Zhou, J.6
Hu, B.7
Li, H.8
Chen, S.9
Zhao, H.10
Kuang, Y.11
-
19
-
-
84877863675
-
Analysis of PTEN methylation patterns in soft tissue sarcomas by MassARRAY spectrometry
-
L. Yin, W.J. Cai, C.X. Liu, Y.Z. Chen, J.M. Hu, J.F. Jiang, H.A. Li, X.B. Cui, X.Y. Chang, W.J. Zhang, K. Sun, and F. Li Analysis of PTEN methylation patterns in soft tissue sarcomas by MassARRAY spectrometry PLoS One 8 2013 e62971
-
(2013)
PLoS One
, vol.8
, pp. 62971
-
-
Yin, L.1
Cai, W.J.2
Liu, C.X.3
Chen, Y.Z.4
Hu, J.M.5
Jiang, J.F.6
Li, H.A.7
Cui, X.B.8
Chang, X.Y.9
Zhang, W.J.10
Sun, K.11
Li, F.12
-
20
-
-
33847293264
-
Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells
-
T. Chen, S. Hevi, F. Gay, N. Tsujimoto, T. He, B. Zhang, Y. Ueda, and E. Li Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells Nat Genet 39 2007 391 396
-
(2007)
Nat Genet
, vol.39
, pp. 391-396
-
-
Chen, T.1
Hevi, S.2
Gay, F.3
Tsujimoto, N.4
He, T.5
Zhang, B.6
Ueda, Y.7
Li, E.8
-
21
-
-
34247190634
-
Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein
-
I.Y. Park, B.H. Sohn, E. Yu, D.J. Suh, Y.H. Chung, J.H. Lee, S.J. Surzycki, and Y.I. Lee Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein Gastroenterology 132 2007 1476 1494
-
(2007)
Gastroenterology
, vol.132
, pp. 1476-1494
-
-
Park, I.Y.1
Sohn, B.H.2
Yu, E.3
Suh, D.J.4
Chung, Y.H.5
Lee, J.H.6
Surzycki, S.J.7
Lee, Y.I.8
-
22
-
-
77951460399
-
Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta
-
H. You, W. Ding, and C.B. Rountree Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta Hepatology 51 2010 1635 1644
-
(2010)
Hepatology
, vol.51
, pp. 1635-1644
-
-
You, H.1
Ding, W.2
Rountree, C.B.3
-
23
-
-
66149101689
-
Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma
-
R. Hino, H. Uozaki, N. Murakami, T. Ushiku, A. Shinozaki, S. Ishikawa, T. Morikawa, T. Nakaya, T. Sakatani, K. Takada, and M. Fukayama Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma Cancer Res 69 2009 2766 2774
-
(2009)
Cancer Res
, vol.69
, pp. 2766-2774
-
-
Hino, R.1
Uozaki, H.2
Murakami, N.3
Ushiku, T.4
Shinozaki, A.5
Ishikawa, S.6
Morikawa, T.7
Nakaya, T.8
Sakatani, T.9
Takada, K.10
Fukayama, M.11
-
24
-
-
82455192395
-
Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells
-
N.T. Phuong, S.K. Kim, S.C. Lim, H.S. Kim, T.H. Kim, K.Y. Lee, S.G. Ahn, J.H. Yoon, and K.W. Kang Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells Breast Cancer Res Treat 130 2011 73 83
-
(2011)
Breast Cancer Res Treat
, vol.130
, pp. 73-83
-
-
Phuong, N.T.1
Kim, S.K.2
Lim, S.C.3
Kim, H.S.4
Kim, T.H.5
Lee, K.Y.6
Ahn, S.G.7
Yoon, J.H.8
Kang, K.W.9
-
25
-
-
77952575909
-
PTEN in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and cancer
-
M. Peyrou, L. Bourgoin, and M. Foti PTEN in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and cancer Dig Dis 28 2010 236 246
-
(2010)
Dig Dis
, vol.28
, pp. 236-246
-
-
Peyrou, M.1
Bourgoin, L.2
Foti, M.3
-
26
-
-
79955110863
-
Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance
-
K.M. Sze, K.L. Wong, G.K. Chu, J.M. Lee, T.O. Yau, and I.O. Ng Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance Hepatology 53 2011 1558 1569
-
(2011)
Hepatology
, vol.53
, pp. 1558-1569
-
-
Sze, K.M.1
Wong, K.L.2
Chu, G.K.3
Lee, J.M.4
Yau, T.O.5
Ng, I.O.6
-
27
-
-
34547524771
-
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
-
F. Meng, R. Henson, H. Wehbe-Janek, K. Ghoshal, S.T. Jacob, and T. Patel MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer Gastroenterology 133 2007 647 658
-
(2007)
Gastroenterology
, vol.133
, pp. 647-658
-
-
Meng, F.1
Henson, R.2
Wehbe-Janek, H.3
Ghoshal, K.4
Jacob, S.T.5
Patel, T.6
-
28
-
-
77951722798
-
PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway
-
T. Tian, K.J. Nan, H. Guo, W.J. Wang, Z.P. Ruan, S.H. Wang, X. Liang, and C.X. Lu PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway Oncol Rep 23 2010 1593 1600
-
(2010)
Oncol Rep
, vol.23
, pp. 1593-1600
-
-
Tian, T.1
Nan, K.J.2
Guo, H.3
Wang, W.J.4
Ruan, Z.P.5
Wang, S.H.6
Liang, X.7
Lu, C.X.8
-
29
-
-
59149105815
-
Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9
-
J.S. Chen, Q. Wang, X.H. Fu, X.H. Huang, X.L. Chen, L.Q. Cao, L.Z. Chen, H.X. Tan, W. Li, J. Bi, and L.J. Zhang Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: association with MMP-9 Hepatol Res 39 2009 177 186
-
(2009)
Hepatol Res
, vol.39
, pp. 177-186
-
-
Chen, J.S.1
Wang, Q.2
Fu, X.H.3
Huang, X.H.4
Chen, X.L.5
Cao, L.Q.6
Chen, L.Z.7
Tan, H.X.8
Li, W.9
Bi, J.10
Zhang, L.J.11
-
30
-
-
33645214725
-
Review of genetic and epigenetic alterations in hepatocarcinogenesis
-
N.I. Herath, B.A. Leggett, and G.A. MacDonald Review of genetic and epigenetic alterations in hepatocarcinogenesis J Gastroenterol Hepatol 21 2006 15 21
-
(2006)
J Gastroenterol Hepatol
, vol.21
, pp. 15-21
-
-
Herath, N.I.1
Leggett, B.A.2
Macdonald, G.A.3
-
31
-
-
78649327715
-
Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation
-
G.L. Gravina, C. Festuccia, F. Marampon, V.M. Popov, R.G. Pestell, B.M. Zani, and V. Tombolini Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation Mol Cancer 9 2010 305
-
(2010)
Mol Cancer
, vol.9
, pp. 305
-
-
Gravina, G.L.1
Festuccia, C.2
Marampon, F.3
Popov, V.M.4
Pestell, R.G.5
Zani, B.M.6
Tombolini, V.7
-
33
-
-
36949016699
-
Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state
-
Y. Kanai, and S. Hirohashi Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state Carcinogenesis 28 2007 2434 2442
-
(2007)
Carcinogenesis
, vol.28
, pp. 2434-2442
-
-
Kanai, Y.1
Hirohashi, S.2
-
34
-
-
79956330964
-
CpG islands and the regulation of transcription
-
A.M. Deaton, and A. Bird CpG islands and the regulation of transcription Genes Dev 25 2011 1010 1022
-
(2011)
Genes Dev
, vol.25
, pp. 1010-1022
-
-
Deaton, A.M.1
Bird, A.2
-
35
-
-
0037468934
-
Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma
-
U. Schagdarsurengin, L. Wilkens, D. Steinemann, P. Flemming, H.H. Kreipe, G.P. Pfeifer, B. Schlegelberger, and R. Dammann Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma Oncogene 22 2003 1866 1871
-
(2003)
Oncogene
, vol.22
, pp. 1866-1871
-
-
Schagdarsurengin, U.1
Wilkens, L.2
Steinemann, D.3
Flemming, P.4
Kreipe, H.H.5
Pfeifer, G.P.6
Schlegelberger, B.7
Dammann, R.8
-
36
-
-
3042707323
-
Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
-
J. Yu, M. Ni, J. Xu, H. Zhang, B. Gao, J. Gu, J. Chen, L. Zhang, M. Wu, S. Zhen, and J. Zhu Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis BMC Cancer 2 2002 29
-
(2002)
BMC Cancer
, vol.2
, pp. 29
-
-
Yu, J.1
Ni, M.2
Xu, J.3
Zhang, H.4
Gao, B.5
Gu, J.6
Chen, J.7
Zhang, L.8
Wu, M.9
Zhen, S.10
Zhu, J.11
-
37
-
-
78149478781
-
Aberrant epigenetic landscape in cancer: How cellular identity goes awry
-
M. Berdasco, and M. Esteller Aberrant epigenetic landscape in cancer: how cellular identity goes awry Dev Cell 19 2010 698 711
-
(2010)
Dev Cell
, vol.19
, pp. 698-711
-
-
Berdasco, M.1
Esteller, M.2
-
38
-
-
77957355926
-
Epigenetics and miRNAs in human cancer
-
M. Fabbri, and G.A. Calin Epigenetics and miRNAs in human cancer Adv Genet 70 2010 87 99
-
(2010)
Adv Genet
, vol.70
, pp. 87-99
-
-
Fabbri, M.1
Calin, G.A.2
|